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Conserved domains on  [gi|7523413|emb|CAB86432|]
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putative protein [Arabidopsis thaliana]

Protein Classification

Bax inhibitor 1 family protein( domain architecture ID 1847)

Bax inhibitor 1 family protein similar to Saccharomyces cerevisiae Bax inhibitor 1 that links the unfolded protein response and programmed cell death, and mediates mitochondrial-dependent apoptosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BI-1-like super family cl00473
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 22-225 3.75e-78

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


The actual alignment was detected with superfamily member cd10429:

Pssm-ID: 469783  Cd Length: 233  Bit Score: 234.80  E-value: 3.75e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   22 SPELRWSFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAgfaLYILLILTPLIVMCPLYYYHQKHPVNYLLLGI 101
Cdd:cd10429  23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPW---LFLISLIGSLILLIALYWKRHSHPVNLILLSL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  102 FTVALAFAVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKRGHDFNFLGPFLFGAVIVLmvfSFIQILFPLGKISV 181
Cdd:cd10429 100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILL---ALIFQFFPYSPTFE 176

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 7523413  182 MIYGCLASIIFCGYIVYDTDNLIKRHSYDEYIWAAVSLYLDVIN 225
Cdd:cd10429 177 LVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIIN 220
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 22-225 3.75e-78

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 234.80  E-value: 3.75e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   22 SPELRWSFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAgfaLYILLILTPLIVMCPLYYYHQKHPVNYLLLGI 101
Cdd:cd10429  23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPW---LFLISLIGSLILLIALYWKRHSHPVNLILLSL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  102 FTVALAFAVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKRGHDFNFLGPFLFGAVIVLmvfSFIQILFPLGKISV 181
Cdd:cd10429 100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILL---ALIFQFFPYSPTFE 176

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 7523413  182 MIYGCLASIIFCGYIVYDTDNLIKRHSYDEYIWAAVSLYLDVIN 225
Cdd:cd10429 177 LVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIIN 220
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 27-225 7.72e-37

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 128.45  E-value: 7.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413     27 WSFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAGFALYILLILTPLIVMCPLYYYHQKHPVNYLLLGIFTVAL 106
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413    107 AFAVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKrghDFNFLGPFLFGAVIVLMVFSFIQILFPlGKISVMIYGC 186
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKR---DLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISY 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 7523413    187 LASIIFCGYIVYDTDNLIKRH-SYDEY--IWAAVSLYLDVIN 225
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYgEYGDYdaILAALSLYLDFIN 198
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 28-225 2.16e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 83.31  E-value: 2.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   28 SFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAGFalyILLILTPLIVMCPLYYYHQKH--PVNYLLLGIFTVA 105
Cdd:COG0670  21 KVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLF---WVLLIAPLGLVFLLSKLANRAnsAAALALLFAYTAL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  106 LAFAVGLTCAFTSGKVILESV----ILTAVVVISLTLYTFwAAKRghDFNFLGPFLFGAVIVLMVFSFIQILFPLGKISV 181
Cdd:COG0670  98 MGLTLSPILLVYTGLSGPASIaqafGGTAATFGGLSLYGY-TTKR--DLSFLGSFLFMGLIGLIIASLVNIFLQSPALSL 174

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 7523413  182 MIyGCLASIIFCGYIVYDTDNlIKRHSYD--EYIWAAVSLYLDVIN 225
Cdd:COG0670 175 AI-SVAGVLLFSGLTLYDTQR-IKHGYETnkQYIMAALSLYLDFIN 218
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 22-225 3.75e-78

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 234.80  E-value: 3.75e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   22 SPELRWSFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAgfaLYILLILTPLIVMCPLYYYHQKHPVNYLLLGI 101
Cdd:cd10429  23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPW---LFLISLIGSLILLIALYWKRHSHPVNLILLSL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  102 FTVALAFAVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKRGHDFNFLGPFLFGAVIVLmvfSFIQILFPLGKISV 181
Cdd:cd10429 100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILL---ALIFQFFPYSPTFE 176

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 7523413  182 MIYGCLASIIFCGYIVYDTDNLIKRHSYDEYIWAAVSLYLDVIN 225
Cdd:cd10429 177 LVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIIN 220
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 27-225 7.72e-37

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 128.45  E-value: 7.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413     27 WSFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAGFALYILLILTPLIVMCPLYYYHQKHPVNYLLLGIFTVAL 106
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413    107 AFAVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKrghDFNFLGPFLFGAVIVLMVFSFIQILFPlGKISVMIYGC 186
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKR---DLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISY 156

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 7523413    187 LASIIFCGYIVYDTDNLIKRH-SYDEY--IWAAVSLYLDVIN 225
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYgEYGDYdaILAALSLYLDFIN 198
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 21-225 2.42e-34

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 122.26  E-value: 2.42e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   21 ESPELRWSFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTtttAGFALYILLILTPLIVMCPLY---YYHQKHPVNYL 97
Cdd:cd10428   3 DDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVR---KNPWLYYVSYIVFFITYIALAcceGLRRRFPWNLI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   98 LLGIFTVALAFAVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKrghDFNFLGPFLFGAVIVLMVFSFIQILFPlG 177
Cdd:cd10428  80 LLGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKY---DFTSCGGVLFVLSIVLLIFGIVAIFFY-V 155

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 7523413  178 KISVMIYGCLASIIFCGYIVYDTDNLIKRHSY----DEYIWAAVSLYLDVIN 225
Cdd:cd10428 156 KWLHIVYASLGALLFSLYLAVDTQLLMGGRKYelspEEYIFAALNIYVDIVN 207
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 29-225 9.97e-21

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 86.31  E-value: 9.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   29 FIRKVYSIISIQLLVTIAVAATVVKVHSISvffttttAGFALYILLILTPLIVMCPLYYYHQKHPVNYLLLGIFTVALAF 108
Cdd:cd06181   5 FLRKVYMILALQLLLTAATATAFTVCDPGW-------YWSPALMGLLTSMLALMATAAMIRAKMPVNLILLFGFTGLMGY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  109 AVGLTCAFTSGKVILESVILTAVVVISLTLYTFWAAKrghDFNFLGPFLFgAVIVLMVFSFIQILFPLGKISVMIYGCLA 188
Cdd:cd06181  78 VVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARK---DFLFLGGPLM-AGLGFLLLSFLLNTFFYSPWLHLVAAAVG 153

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 7523413  189 SIIFCGYIVYDTDNLIKR--HSYDEYIWAAVSLYLDVIN 225
Cdd:cd06181 154 LVLFCGFLLYDTQLIIHKaeVGPEDYINACISLYLDIIN 192
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 28-225 3.13e-20

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 85.31  E-value: 3.13e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   28 SFIRKVYSIISIQLLVTIAVAATVVkvhsiSVFFTTTTAGFALYILLILTPLIVMCPLYY--YHQKHPVNYLLLGIFTVA 105
Cdd:cd10432   4 SFMKKVYGLMAAGLLLTAVGAYVGA-----STPALLLIAGSPLMWVLLIAELALVFGLSFriNKMSVATALPLFFAFAAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  106 LAFAVGLTCAFTSGKVILESVILTAVVVISLTLYtfwAAKRGHDFNFLGPFLFGAVIVLMVFSFIQILFPLGKISvMIYG 185
Cdd:cd10432  79 TGLTLSPILLVYTGASIAQAFFTTAATFGGLSLY---GYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQ-FAIS 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 7523413  186 CLASIIFCGYIVYDTDNLIKRH-------SYDEYIWAAVSLYLDVIN 225
Cdd:cd10432 155 AIGVLIFSGLIAYDTQRIKRMYeagggesGYKDAIMGALSLYLDFIN 201
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 28-225 2.16e-19

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 83.31  E-value: 2.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   28 SFIRKVYSIISIQLLVTIAVAATVVKVHSISVFFTTTTAGFalyILLILTPLIVMCPLYYYHQKH--PVNYLLLGIFTVA 105
Cdd:COG0670  21 KVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLF---WVLLIAPLGLVFLLSKLANRAnsAAALALLFAYTAL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  106 LAFAVGLTCAFTSGKVILESV----ILTAVVVISLTLYTFwAAKRghDFNFLGPFLFGAVIVLMVFSFIQILFPLGKISV 181
Cdd:COG0670  98 MGLTLSPILLVYTGLSGPASIaqafGGTAATFGGLSLYGY-TTKR--DLSFLGSFLFMGLIGLIIASLVNIFLQSPALSL 174

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 7523413  182 MIyGCLASIIFCGYIVYDTDNlIKRHSYD--EYIWAAVSLYLDVIN 225
Cdd:COG0670 175 AI-SVAGVLLFSGLTLYDTQR-IKHGYETnkQYIMAALSLYLDFIN 218
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 32-225 3.18e-10

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 58.00  E-value: 3.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   32 KVYSIISIQLLVTiAVAAtvvkvhsisVFFTTTTAGFALYILLILTPLIVMCPLYYYHQKHPVNYLLLGIFT----VALA 107
Cdd:cd10430  14 KVYLTLAVALLAA-AVGA---------YVHMVINIGGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAfltgASLG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  108 FAVGLTCAFTSGkVILESVILTAVVVISLTLYTFWAAKRghDFNFLGPFLFGAVIVLMVFSFIQILFPlGKISVMIYGCL 187
Cdd:cd10430  84 PLLDLVIAINPS-IIVTAFLGTAVIFACFSLAALLAKRR--EYLYLGGLLSSALSILLLVSLANIFGG-SKFLFQAELYL 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 7523413  188 ASIIFCGYIVYDTDNLIKR--HSYDEYIWAAVSLYLDVIN 225
Cdd:cd10430 160 GLLVFCGFVLFDTQMIIEKaeNGDRDYIWHALDLFVDFVA 199
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 56-225 2.10e-08

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 52.59  E-value: 2.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   56 SISVFFTTTTAGFALYILLILTPLIVMCPLYY--YHQKHPVNYLLLGIFTV-ALAFAVGLTC---------AFTSGKVIL 123
Cdd:cd10433  15 SMTLAFSALGAGVSMAGGSPIMGLLLTLVGAYglLFLIEKTRNSAWGIVLVfAFTGFMGYTLgpilnmylaLPNGGQIIM 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  124 ESVILTAVVVISLTLYTFWAAKrghDFNFLGPFLFGAVIVLMVFSFIQILFPLGKISVMIyGCLASIIFCGYIVYDTDNL 203
Cdd:cd10433  95 TALGGTAAIFFGLSAYALTTKK---DFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAI-SAAFVLFSSGFILYDTSRI 170

                       170       180
                ....*....|....*....|..
gi 7523413  204 IKRHSyDEYIWAAVSLYLDVIN 225
Cdd:cd10433 171 IHGGE-TNYIMATVSLYVSIYN 191
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
 42-225 3.47e-06

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 46.60  E-value: 3.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413   42 LVTIAVAAtvVKVHSISVFFTTTTAGFALYILLILTPLI---VMCPLYYYHQKHPVNYLLLGIFTVALAFAVGLTCaFTS 118
Cdd:cd10431  55 LGLTALAA--VALSRSPALMRLMAAGPWLAIGATLAAMIgsgMLVRSYTYPENPGAKHLAWLGHSGVQGAVLAPLC-FLG 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7523413  119 GKVILESVILTAVVVISLTlYTFWAAKRGHDFNFLGPFLFGAVIVLMVfSFIQILFPLGKI------SVMIYGCLAsiIF 192
Cdd:cd10431 132 GPLLIRAALYTAGIVGGLS-TVAACAPSEKFLYMGGPLAIGLGVVFAS-SLGSMFLPPTTAlgaglySVSLYGGLV--LF 207

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 7523413  193 CGYIVYDTDNLIKR---------HSYDEyIWAAVSLYLDVIN 225
Cdd:cd10431 208 GGFLLYDTQKIIKRaethplygvRKYDP-INASMSIYMDTIN 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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