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Conserved domains on  [gi|7270731|emb|CAB80414|]
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cyclin cyc1 [Arabidopsis thaliana]

Protein Classification

cyclin( domain architecture ID 15334709)

cyclin is a cell cycle regulator that regulates cyclin dependent kinases (CDKs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 145-290 7.94e-93

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410270  Cd Length: 147  Bit Score: 276.15  E-value: 7.94e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  145 KEKIVDIDSADVENDLAAVEYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVN 223
Cdd:cd20567   1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPpYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7270731  224 ILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20567  81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 295-417 7.25e-64

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410215  Cd Length: 117  Bit Score: 200.99  E-value: 7.25e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQVPIWTSTLKHHTGYSETQLM 374
Cdd:cd20511   1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYE-MLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLM 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 7270731  375 DCAKLLAYQQWKQQEegsesSTKGALRKKYSKDERFAVALIPP 417
Cdd:cd20511  80 ECARLMVRLHSKAGT-----GKLTAVYKKYSSSKFGAVALLPP 117
 
Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 145-290 7.94e-93

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 276.15  E-value: 7.94e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  145 KEKIVDIDSADVENDLAAVEYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVN 223
Cdd:cd20567   1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPpYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7270731  224 ILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20567  81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 295-417 7.25e-64

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 200.99  E-value: 7.25e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQVPIWTSTLKHHTGYSETQLM 374
Cdd:cd20511   1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYE-MLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLM 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 7270731  375 DCAKLLAYQQWKQQEegsesSTKGALRKKYSKDERFAVALIPP 417
Cdd:cd20511  80 ECARLMVRLHSKAGT-----GKLTAVYKKYSSSKFGAVALLPP 117
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 168-293 6.11e-61

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 193.89  E-value: 6.11e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731    168 DIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSA 246
Cdd:pfam00134   1 DIFQYLRELELKYLPKpDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 7270731    247 LLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEWYLT 293
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
129-406 1.40e-49

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 174.19  E-value: 1.40e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  129 VLTARSKAACGLEKKQKEKivDIDSADVENDLAAVEYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDV 207
Cdd:COG5024 146 QLALDEKQAESKRESQSWQ--DLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNpNYLIKQSLYEWSMRSILVDWLVEV 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  208 HVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILST 287
Cdd:COG5024 224 HGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEV 303

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  288 LEWYLTVPTHYVFLARFIKASIADEKMENMVHYLAELGVMHYdTMIMFSPSMVAASAIYAARSSLRQVPiWTSTLKHHTG 367
Cdd:COG5024 304 LDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDY-KFIQISPSWCAAAAMYLSRKILSQNQ-WDRTLIHYSG 381

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 7270731  368 -YSETQLMDCA-KLLAYQQwkqqeegSESSTKGALRKKYSK 406
Cdd:COG5024 382 nYTNPDLKPLNeSNKENLQ-------NPSVHHDAIFPKYPS 415
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 295-418 9.19e-38

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 133.13  E-value: 9.19e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731    295 PTHYVFLARFIKASIA--DEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLrQVPIWTSTLKHHTGYSETQ 372
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYD-FLKYPPSLIAAAAVYLARKTL-NSPEWTETLEHYTGYSEED 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 7270731    373 LMDCAKLLAyqqwkQQEEGSESSTKGALRKKYSKDERFAVALIPPA 418
Cdd:pfam02984  79 LKPCVKLLL-----ELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 203-286 9.65e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 85.72  E-value: 9.65e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731     203 WLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADhaYSHKQILVMEK 282
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRMER 79


                   ....
gi 7270731     283 TILS 286
Cdd:smart00385  80 LLLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 299-380 9.44e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 71.85  E-value: 9.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731     299 VFLARFIKASIADEKMENMVHYLAELGVMHYdTMIMFSPSMVAASAIYAArSSLRQVPIWTSTLKHHTGY-SETQLMDCA 377
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDY-KFLKYSPSLIAAAALYLA-SKTEETPPWTKELVHYTGYfTEEEILRME 78


                   ...
gi 7270731     378 KLL 380
Cdd:smart00385  79 RLL 81
 
Name Accession Description Interval E-value
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 145-290 7.94e-93

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 276.15  E-value: 7.94e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  145 KEKIVDIDSADVENDLAAVEYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVN 223
Cdd:cd20567   1 EEPLPDIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPpYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7270731  224 ILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20567  81 LIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 164-289 9.62e-66

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 206.23  E-value: 9.62e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  164 EYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLV 242
Cdd:cd20507   3 EYVKDIYKYLRQLEKKYAIDpDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLV 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 7270731  243 GLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLE 289
Cdd:cd20507  83 GVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 295-417 7.25e-64

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 200.99  E-value: 7.25e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQVPIWTSTLKHHTGYSETQLM 374
Cdd:cd20511   1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYE-MLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLM 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 7270731  375 DCAKLLAYQQWKQQEegsesSTKGALRKKYSKDERFAVALIPP 417
Cdd:cd20511  80 ECARLMVRLHSKAGT-----GKLTAVYKKYSSSKFGAVALLPP 117
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 168-293 6.11e-61

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 193.89  E-value: 6.11e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731    168 DIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSA 246
Cdd:pfam00134   1 DIFQYLRELELKYLPKpDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 7270731    247 LLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEWYLT 293
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 164-289 8.31e-50

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 165.11  E-value: 8.31e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  164 EYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLV 242
Cdd:cd20504   1 EYADDIYEYLRESELKHRPKpDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 7270731  243 GLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLE 289
Cdd:cd20504  81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 150-289 1.25e-49

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 165.12  E-value: 1.25e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  150 DIDSADVENDLAAVEYVEDIYSFYKSVESEWRPRDYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFL 229
Cdd:cd20508   1 DIDEENSDDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYL 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  230 SVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLE 289
Cdd:cd20508  81 SKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLD 140
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
129-406 1.40e-49

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 174.19  E-value: 1.40e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  129 VLTARSKAACGLEKKQKEKivDIDSADVENDLAAVEYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDV 207
Cdd:COG5024 146 QLALDEKQAESKRESQSWQ--DLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNpNYLIKQSLYEWSMRSILVDWLVEV 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  208 HVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILST 287
Cdd:COG5024 224 HGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEV 303

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  288 LEWYLTVPTHYVFLARFIKASIADEKMENMVHYLAELGVMHYdTMIMFSPSMVAASAIYAARSSLRQVPiWTSTLKHHTG 367
Cdd:COG5024 304 LDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDY-KFIQISPSWCAAAAMYLSRKILSQNQ-WDRTLIHYSG 381

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 7270731  368 -YSETQLMDCA-KLLAYQQwkqqeegSESSTKGALRKKYSK 406
Cdd:COG5024 382 nYTNPDLKPLNeSNKENLQ-------NPSVHHDAIFPKYPS 415
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 160-290 7.64e-47

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 157.46  E-value: 7.64e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  160 LAAVEYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKE 238
Cdd:cd20568   3 LMVAEYVPEIFEYLRELELKTLPNpNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNK 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 7270731  239 LQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20568  83 LQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 164-290 3.38e-41

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 142.69  E-value: 3.38e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  164 EYVEDIYSFYKSVESEW--RPRdYMASQpDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQL 241
Cdd:cd20566   7 DYVKDIYQYLRQLEVQQsiRPH-YLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQL 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 7270731  242 VGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20566  85 VGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 152-288 4.74e-41

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 143.44  E-value: 4.74e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  152 DSADVENDLAAVEYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLS 230
Cdd:cd20560  23 DSAADVDVLAVPEYAEDIHQYLREAELKHRPKpGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLS 102

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 7270731  231 VKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTL 288
Cdd:cd20560 103 CMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 165-290 1.70e-38

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 135.62  E-value: 1.70e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  165 YVEDIYSFYKSVESEWRP-RDYMAS-QPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLV 242
Cdd:cd20562   8 YATDIYLNLRVAELKRRPlPDYMEKiQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLL 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 7270731  243 GLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20562  88 GVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 164-290 4.36e-38

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 134.42  E-value: 4.36e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  164 EYVEDIYSFYKSVESEWRPR-DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLV 242
Cdd:cd20561   3 DYHEDIHTYLREMEVKCKPKvGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLV 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 7270731  243 GLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20561  83 GTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 295-418 9.19e-38

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 133.13  E-value: 9.19e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731    295 PTHYVFLARFIKASIA--DEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLrQVPIWTSTLKHHTGYSETQ 372
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYD-FLKYPPSLIAAAAVYLARKTL-NSPEWTETLEHYTGYSEED 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 7270731    373 LMDCAKLLAyqqwkQQEEGSESSTKGALRKKYSKDERFAVALIPPA 418
Cdd:pfam02984  79 LKPCVKLLL-----ELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 164-290 3.89e-37

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 131.92  E-value: 3.89e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  164 EYVEDIYSFYKSVESEW--RPRdYMASQpDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQL 241
Cdd:cd20565   3 EYVKDIYAYLRQLEEEQavRPK-YLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 7270731  242 VGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20565  81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 196-288 3.69e-32

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 117.43  E-value: 3.69e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  196 MRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHK 275
Cdd:cd20536   1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                        90
                ....*....|...
gi 7270731  276 QILVMEKTILSTL 288
Cdd:cd20536  81 QICNLECIILTKL 93
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 181-290 7.71e-31

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 115.10  E-value: 7.71e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  181 RPRDYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSV-KPVPRKELQLVGLSALLMSAKYEEIWPP 259
Cdd:cd20519  21 RDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTqTNVPKTQLQLIGITCLFIAAKLEEIYPP 100

                        90       100       110
                ....*....|....*....|....*....|.
gi 7270731  260 QVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20519 101 KLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 197-292 6.24e-28

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 105.87  E-value: 6.24e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  197 RLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHKQ 276
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 7270731  277 ILVMEKTILSTLEWYL 292
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 181-290 8.08e-24

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 96.10  E-value: 8.08e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  181 RPRDYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSV-KPVPRKELQLVGLSALLMSAKYEEIWPP 259
Cdd:cd20579  27 RDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATqENVVKTRLQLIGISSLFIAAKLEEIYPP 106

                        90       100       110
                ....*....|....*....|....*....|.
gi 7270731  260 QVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20579 107 KLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 295-406 1.36e-23

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 94.62  E-value: 1.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKA---SIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQVPiWTSTLKHHTGYSET 371
Cdd:cd20506   1 PTIKTFLRRFLRAaqaSVPDLKLEFLANYLAELSLLDYE-FLKYLPSLIAASAVFLARHTLNPHP-WNPTLEHYTGYKAA 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 7270731  372 QLMDCAKLLAyqqwkQQEEGSESSTKGALRKKYSK 406
Cdd:cd20506  79 DLKPCVQALH-----DLQLNASGSSLQAVREKYKQ 108
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 295-381 7.02e-23

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 91.99  E-value: 7.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQVPIWTSTLKHHTGYSETQLM 374
Cdd:cd20537   1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYE-FLKYRPSLIAAAALYLARKILGEPPPSPQLLQLVTGYSENDLQ 79


                ....*..
gi 7270731  375 DCAKLLA 381
Cdd:cd20537  80 ECAKELL 86
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 200-290 2.75e-22

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 90.52  E-value: 2.75e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  200 LVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWP--PQVEDLVDIADHAYSHKQI 277
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                        90
                ....*....|...
gi 7270731  278 LVMEKTILSTLEW 290
Cdd:cd20559  82 IQMEMHILNTLNW 94
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 183-290 1.35e-21

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 89.91  E-value: 1.35e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  183 RDYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRF-LSVKPVPRKELQLVGLSALLMSAKYEEIWPPQV 261
Cdd:cd20580  29 KHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASKLEEIYPPKL 108

                        90       100
                ....*....|....*....|....*....
gi 7270731  262 EDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20580 109 HEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 203-286 9.65e-21

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 85.72  E-value: 9.65e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731     203 WLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADhaYSHKQILVMEK 282
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRMER 79


                   ....
gi 7270731     283 TILS 286
Cdd:smart00385  80 LLLE 83
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 295-408 3.07e-20

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 85.42  E-value: 3.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDTMIMFSPSMVAASAIYAARSSLRQvPIWTSTLKHHTGYSETQLM 374
Cdd:cd20505   1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADPYLKYLPSVIAAAAVCLANHTLGN-EVWPQKLARSTGYSLEDLL 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 7270731  375 DCAKLLaYQQWKQqeegSESSTKGALRKKYSKDE 408
Cdd:cd20505  80 PCLRDL-HRTFLN----APSSPQQAIREKYKSSK 108
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 170-290 8.88e-18

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 79.65  E-value: 8.88e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  170 YSFYKSVESEWRPRdymasqpdinekMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLM 249
Cdd:cd20515  41 ASYFKCVQTEIQPF------------MRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFL 108

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 7270731  250 SAKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20515 109 ASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKW 149
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 195-290 1.29e-17

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 77.64  E-value: 1.29e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  195 KMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWP--PQVEDLVDIAD-HA 271
Cdd:cd20528   5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLNRYLCnSV 84

                        90
                ....*....|....*....
gi 7270731  272 YSHKQILVMEKTILSTLEW 290
Cdd:cd20528  85 YSKQEYLQMELLILEFFQW 103
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 197-290 1.82e-17

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 77.36  E-value: 1.82e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  197 RLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKE---LQLVGLSALLMSAKYEEIWPPQVEDL-VDIADHAY 272
Cdd:cd20543   2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLqVEEPKYVF 81

                        90
                ....*....|....*...
gi 7270731  273 SHKQILVMEKTILSTLEW 290
Cdd:cd20543  82 EAKTIQRMELLVLSTLEW 99
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 300-405 2.11e-17

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 77.65  E-value: 2.11e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  300 FLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQVPiWTSTLKHHTGYSETQLMDCAKL 379
Cdd:cd20509   6 FLRRFSKAGGADAQKHTLAKYLMELTLLDYD-MVHYKPSEIAAAALCLSRKILDEPE-WTPTLEHYSTYSEEDLLPIVQK 83

                        90       100       110
                ....*....|....*....|....*....|.
gi 7270731  380 LA-----YQQWKQQeegsesstkgALRKKYS 405
Cdd:cd20509  84 MAklvvkSQTSKYQ----------AVKNKYS 104
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 295-416 7.74e-17

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 76.17  E-value: 7.74e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSsLRQVPIWTSTLKHHTGYSETQLM 374
Cdd:cd20510   1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQ-FVQERASKLAAAALLLALK-MKNLGEWTPTLEYYSGYSAEDLL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 7270731  375 DCAK----LLAYQQWKQQEegsesstkgALRKKYSKDERFAVALIP 416
Cdd:cd20510  79 PLVRklnaMLTKPPNKKLK---------TVRSKYSHKVFFEVAKIP 115
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 194-288 1.55e-16

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 74.66  E-value: 1.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  194 EKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEiwppqvEDLVDI------ 267
Cdd:cd20521   1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLG------KDILTIreaawl 74

                        90       100
                ....*....|....*....|.
gi 7270731  268 ADHAYSHKQILVMEKTILSTL 288
Cdd:cd20521  75 TDNTYKYEDVVRMMGEIVAAL 95
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 175-290 3.97e-16

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 75.03  E-value: 3.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  175 SVESEWRPRD--YMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAK 252
Cdd:cd20575  32 RLEERYVPRVsyFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASK 111

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 7270731  253 YEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20575 112 LRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKW 149
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 299-380 9.44e-16

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 71.85  E-value: 9.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731     299 VFLARFIKASIADEKMENMVHYLAELGVMHYdTMIMFSPSMVAASAIYAArSSLRQVPIWTSTLKHHTGY-SETQLMDCA 377
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDY-KFLKYSPSLIAAAALYLA-SKTEETPPWTKELVHYTGYfTEEEILRME 78


                   ...
gi 7270731     378 KLL 380
Cdd:smart00385  79 RLL 81
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 171-290 1.15e-15

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 73.86  E-value: 1.15e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  171 SFYKSVESEWRPrdymasqpdineKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMS 250
Cdd:cd20573  41 SYFKCVQKEILP------------SMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLA 108

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 7270731  251 AKYEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20573 109 SKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 201-292 1.66e-15

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 71.96  E-value: 1.66e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  201 VEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEE----IwpPQVEDLVDIADHAYSHKQ 276
Cdd:cd20526   6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEedevI--PSTKDLVRVSKCGCSVAE 83

                        90
                ....*....|....*.
gi 7270731  277 ILVMEKTILSTLEWYL 292
Cdd:cd20526  84 VLRMERIILDKLHWDL 99
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 283-380 2.31e-15

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 71.63  E-value: 2.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  283 TILSTLEWYLTVPTHYVFLARFIKASIADEKMENM---VHYLAELGVMHYdTMIMFSPSMVAASAIYAARSSLRQVPIWT 359
Cdd:cd20529   2 TPAHFLEYYLSQGVLFVDDHDGLPSELLEKVKEYVrkyADFFLDLSLQDY-AFLNYKPSLLAAACIAAARKALGLSPTWP 80

                        90       100
                ....*....|....*....|.
gi 7270731  360 STLKHHTGYSETQLMDCAKLL 380
Cdd:cd20529  81 EELEKLTGYSEDELEPCVELL 101
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 175-290 1.48e-13

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 67.71  E-value: 1.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  175 SVESEWRPR--DYMASQPDINEKMRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAK 252
Cdd:cd20574  32 TIEERYLPQcsYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASK 111

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 7270731  253 YEEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTLEW 290
Cdd:cd20574 112 LKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 196-290 1.26e-12

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 63.73  E-value: 1.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  196 MRLILVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIWPPQVEDLVDIADHAYSHK 275
Cdd:cd20517   5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTNL 84

                        90
                ....*....|....*
gi 7270731  276 QILVMEKTILSTLEW 290
Cdd:cd20517  85 ELINQEKDILEALKW 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 200-282 1.67e-12

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 62.81  E-value: 1.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  200 LVEWLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIwPPQVEDLVDIADhaYSHKQILV 279
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEEL-PRTLKEIAKVSG--VSEKELRK 78


                ...
gi 7270731  280 MEK 282
Cdd:cd00043  79 AEK 81
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 300-415 2.20e-12

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 63.40  E-value: 2.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  300 FLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQvPIWTSTLKHHTGYSETQLMDCAKL 379
Cdd:cd20512   5 FLRRISKADDYDIQTRTLAKYLLEITILDHR-FLGYPPSLLAAAAMYLARKMLGR-GDWNDNLVHYSGYTESQLIPCADI 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 7270731  380 LAyqqwkqqEEGSESSTKG-ALRKKYSKDERFAVALI 415
Cdd:cd20512  83 ML-------EYLVKPIKHHdAFFKKYSSKKFLKASIF 112
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 294-416 4.92e-11

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 59.90  E-value: 4.92e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  294 VPTHyvFLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLRQVPiWTSTLKHHTGYSETQL 373
Cdd:cd20570   2 LPLH--FLRRASKAGSADVEKHTLAKYLMELTLIDYD-MVHYHPSEIAAAALCLSQKVLDGGK-WSLTQQYYTGYTEDDL 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 7270731  374 MDCAKLLAyqqwKQQEEGSESSTKG-ALRKKYSKDERFAVALIP 416
Cdd:cd20570  78 KPIMQHMA----KNVVKVNEGLTKHvAVKNKYASSKLMKISTIP 117
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 208-288 5.44e-11

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 58.90  E-value: 5.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  208 HVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKY--EEIWPPQVEDLVDIADHAYSHKQILVMEKTIL 285
Cdd:cd20523  12 HRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGIIL 91


                ...
gi 7270731  286 STL 288
Cdd:cd20523  92 EKL 94
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 295-422 1.07e-10

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 59.05  E-value: 1.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDTMIMFSPSMVAASAIYAARSSLRQVpIWTSTLKHHTGYSETQ-- 372
Cdd:cd20563   1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDPFLKYLPSLTAAAAYCLANYTVNKV-FWPETLAAFTGYSLSEiv 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 7270731  373 --LMDCAKLLAYQQWKQQEegsesstkgALRKKYSKDERFAVALI-PPAKALL 422
Cdd:cd20563  80 pcLSDLHKACLGAPHRPQQ---------AIREKYKGSKYMQVSLLePPAVLPL 123
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 211-290 1.54e-10

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 57.53  E-value: 1.54e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  211 FELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKY--EEIWPPQVEDLVDIADHAYSHKQILVMEKTILSTL 288
Cdd:cd20583  16 FGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRMEKIILEKL 95


                ..
gi 7270731  289 EW 290
Cdd:cd20583  96 CW 97
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 316-380 4.77e-09

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 53.78  E-value: 4.77e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7270731  316 NMVHYLAELGVMHYDTMiMFSPSMVAASAIYAARSSLRQVPIWTSTLKHHTGYSETQLMDCAKLL 380
Cdd:cd20522   1 CLASYICELSLLHTELG-RYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSCVLHL 64
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 211-284 1.61e-07

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 49.07  E-value: 1.61e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7270731  211 FELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKY--EEIWPPQVEDLVDIADHAYSHKQILVMEKTI 284
Cdd:cd20584  16 FGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKII 91
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 294-420 3.76e-07

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 48.73  E-value: 3.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  294 VPTHyvFLARFIKASIADEKMENMVHYLAELGVMHYDtMIMFSPSMVAASAIYAARSSLrQVPIWTSTLKHHTGYSETQL 373
Cdd:cd20569   2 LPLH--FLRRASKIGEVDVEQHTLAKYLMELTMVDYD-MVHFPPSQIAAAAFCLALKIL-DNGEWTPTLQHYMSYTEESL 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 7270731  374 MDCAKLLAyqqwKQQEEGSESSTKG-ALRKKYSKDERFAVALIPPAKA 420
Cdd:cd20569  78 LPVMQHMA----KNVVKVNQGLTKHmTVKNKYASSKQMKISTLPQLNS 121
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 295-404 1.48e-05

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 43.66  E-value: 1.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  295 PTHYVFLARFIKASIADEKMENMVHYLAELGVMHYDTMIMFSPSMVAASAIYAARSSLRQVPiWTSTLKHHTGYSETQLM 374
Cdd:cd20564   1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQS-WPESLVQKTGYTLESLK 79

                        90       100       110
                ....*....|....*....|....*....|
gi 7270731  375 DCAKLLaYQQWKQQEEGSESStkgaLRKKY 404
Cdd:cd20564  80 PCLMDL-HQTYLKAPQHAQQS----IREKY 104
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 300-376 4.60e-04

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 39.13  E-value: 4.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  300 FLARFIKASIADEKMENMVHYLAELGVMHYdTMIMFSPSMVAASAIYAARSSLRQVPIWTST-----LKHHTGYSETQLM 374
Cdd:cd20516   9 ILHRLPLDSEDVDKVRKHAETFIALCATDY-KFSSYPPSMIAAASILAALRGLLLHSGNSKEdllekLQQLTRIDEDLLR 87


                ..
gi 7270731  375 DC 376
Cdd:cd20516  88 AC 89
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 327-388 7.49e-04

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 38.80  E-value: 7.49e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7270731  327 MHYDTMIMFSPSMVAASAIYAARSSLRQVpiwtstlKHHTGYSETQLMDCAKLLA--YQQWKQQ 388
Cdd:cd20520  49 ILDIGSLQFSYSVLAASALYLVSPDDEAI-------EQVTGYSWEQLAPCVEWMTpfAEVLEEE 105
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 203-360 8.31e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 41.26  E-value: 8.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  203 WLIDVHVRFELNPETFYLTVNILDRFLSVKPVPRKELQLVGLSALLMSAKYEEIwPPQVEDLVDIADHAYSH------KQ 276
Cdd:COG5333  51 LIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDT-PRDISIESFEARDLWSEepkssrER 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7270731  277 ILVMEKTILSTLEWYLTVPTHYVFLARFIKASIADEKMEnmVHYLAELGV---MHYDTMIMFSPSMVAASAIYAARSSLR 353
Cdd:COG5333 130 ILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKDKYK--LLQIAWKIIndaLRTDLCLLYPPHIIALAALLIACEVLG 207


                ....*..
gi 7270731  354 QvPIWTS 360
Cdd:COG5333 208 M-PIIKL 213
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 295-358 9.13e-04

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 38.65  E-value: 9.13e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7270731  295 PTHYVFLARFIK-------ASIADEKMENMVHYLAELGVMHYdTMIMFSPSMVAASAIYAARSSLRQVPIW 358
Cdd:cd20721   1 PTILTFLRMYIErlslesgAAHASRPLERLAMFLAEISLLHY-SFLQFRPSTVAAACLVLAEIMHNRPAAW 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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