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Conserved domains on  [gi|7269786|emb|CAB77786|]
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putative leucine-rich repeat protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 13746049)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 85-365 4.37e-34

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 134.21  E-value: 4.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    85 LSGRIDPAIGKLSALTELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPS 164
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   165 IGSLPELSNLILCHNHLNGSIP----------------QFLS----------QSLTRIDLKRNNLTGII--SLTSLpPSL 216
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPpsifslqklisldlsdNSLSgeipelviqlQNLEILHLFSNNFTGKIpvALTSL-PRL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   217 QYLSLAWNQLTGPVYRVLLRLNQLNYLDLSLNRFTGAIP------GQIFTF-------------------PITNLQLQRN 271
Cdd:PLN00113 335 QVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPeglcssGNLFKLilfsnslegeipkslgacrSLRRVRLQDN 414

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   272 FFYGVIqPPNQVTIPTV---------------------------DLSYNRFSGELSPLL--SNVQNLYLNNNRFTGQVPV 322
Cdd:PLN00113 415 SFSGEL-PSEFTKLPLVyfldisnnnlqgrinsrkwdmpslqmlSLARNKFFGGLPDSFgsKRLENLDLSRNQFSGAVPR 493

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7269786   323 SF-------------------VDRLLAS--NIQTLYLQHNFLTGIQISPAADIPVSSSLCLQYN 365
Cdd:PLN00113 494 KLgslselmqlklsenklsgeIPDELSSckKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 28-66 6.09e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 45.75  E-value: 6.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 7269786     28 DFLALQAIRKSLDDLPGsnFFDSWD-FTSDPCNFAGVYCD 66
Cdd:pfam08263   4 DGQALLAFKSSLNDPPG--ALSSWNsSSSDPCSWTGVTCD 41
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-365 4.37e-34

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 134.21  E-value: 4.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    85 LSGRIDPAIGKLSALTELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPS 164
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   165 IGSLPELSNLILCHNHLNGSIP----------------QFLS----------QSLTRIDLKRNNLTGII--SLTSLpPSL 216
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPpsifslqklisldlsdNSLSgeipelviqlQNLEILHLFSNNFTGKIpvALTSL-PRL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   217 QYLSLAWNQLTGPVYRVLLRLNQLNYLDLSLNRFTGAIP------GQIFTF-------------------PITNLQLQRN 271
Cdd:PLN00113 335 QVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPeglcssGNLFKLilfsnslegeipkslgacrSLRRVRLQDN 414

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   272 FFYGVIqPPNQVTIPTV---------------------------DLSYNRFSGELSPLL--SNVQNLYLNNNRFTGQVPV 322
Cdd:PLN00113 415 SFSGEL-PSEFTKLPLVyfldisnnnlqgrinsrkwdmpslqmlSLARNKFFGGLPDSFgsKRLENLDLSRNQFSGAVPR 493

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7269786   323 SF-------------------VDRLLAS--NIQTLYLQHNFLTGIQISPAADIPVSSSLCLQYN 365
Cdd:PLN00113 494 KLgslselmqlklsenklsgeIPDELSSckKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-346 4.63e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 4.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   89 IDPAIGKLSALTELSIVPGRImGSLPHTISQSKNLRFLAISRNFISgEIPASLSELRGLKTLDLSYNQLTgSIPPSIGSL 168
Cdd:COG4886 128 LPEELANLTNLKELDLSNNQL-TDLPEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNL 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  169 PELSNLILCHNHLNgSIPQFLSQ--SLTRIDLKRNNLTGIISLTSLPpSLQYLSLAWNQLTGpvYRVLLRLNQLNYLDLS 246
Cdd:COG4886 205 TNLEELDLSGNQLT-DLPEPLANltNLETLDLSNNQLTDLPELGNLT-NLEELDLSNNQLTD--LPPLANLTNLKTLDLS 280

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  247 LNRFTGAIPGQIFTFPITNLQLQRNFFYGVIQPPNQVTIPTVDLSYNRFSGELSPLLSNVQNLYLNNNRFTGQVPVSFVD 326
Cdd:COG4886 281 NNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360

                       250       260
                ....*....|....*....|
gi 7269786  327 RLLASNIQTLYLQHNFLTGI 346
Cdd:COG4886 361 LLLTLLLTLGLLGLLEATLL 380
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 28-66 6.09e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 45.75  E-value: 6.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 7269786     28 DFLALQAIRKSLDDLPGsnFFDSWD-FTSDPCNFAGVYCD 66
Cdd:pfam08263   4 DGQALLAFKSSLNDPPG--ALSSWNsSSSDPCSWTGVTCD 41
LRR_8 pfam13855
Leucine rich repeat;
122-181 7.62e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 7.62e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    122 NLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPSIGSLPELSNLILCHNHL 181
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 122-259 4.11e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 4.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  122 NLRFLAISRNFISGEIPASLSEL----RGLKTLDLSYNQLTGSIPPSIG-SLPELSNLILCHNHLNGSIPQ---FLS--- 190
Cdd:cd00116 138 ALEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIGDAGIRALAeGLKANCNLEVLDLNNNGLTDEgasALAetl 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  191 ---QSLTRIDLKRNNLTGII------SLTSLPPSLQYLSLAWNQLT----GPVYRVLLRLNQLNYLDLSLNRFTGAIPGQ 257
Cdd:cd00116 218 aslKSLEVLNLGDNNLTDAGaaalasALLSPNISLLTLSLSCNDITddgaKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297


                ..
gi 7269786  258 IF 259
Cdd:cd00116 298 LA 299
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-365 4.37e-34

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 134.21  E-value: 4.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    85 LSGRIDPAIGKLSALTELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPS 164
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   165 IGSLPELSNLILCHNHLNGSIP----------------QFLS----------QSLTRIDLKRNNLTGII--SLTSLpPSL 216
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSGPIPpsifslqklisldlsdNSLSgeipelviqlQNLEILHLFSNNFTGKIpvALTSL-PRL 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   217 QYLSLAWNQLTGPVYRVLLRLNQLNYLDLSLNRFTGAIP------GQIFTF-------------------PITNLQLQRN 271
Cdd:PLN00113 335 QVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPeglcssGNLFKLilfsnslegeipkslgacrSLRRVRLQDN 414

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   272 FFYGVIqPPNQVTIPTV---------------------------DLSYNRFSGELSPLL--SNVQNLYLNNNRFTGQVPV 322
Cdd:PLN00113 415 SFSGEL-PSEFTKLPLVyfldisnnnlqgrinsrkwdmpslqmlSLARNKFFGGLPDSFgsKRLENLDLSRNQFSGAVPR 493

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7269786   323 SF-------------------VDRLLAS--NIQTLYLQHNFLTGIQISPAADIPVSSSLCLQYN 365
Cdd:PLN00113 494 KLgslselmqlklsenklsgeIPDELSSckKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-345 2.50e-33

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 132.28  E-value: 2.50e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    32 LQAIRKSLDDlpGSNFFDSWDFTSDPCNFAGVYCDD-DKVTALNLgdpraGSPGLSGRIDPAIGKLSALTELSIVPGRIM 110
Cdd:PLN00113  34 LLSFKSSIND--PLKYLSNWNSSADVCLWQGITCNNsSRVVSIDL-----SGKNISGKISSAIFRLPYIQTINLSNNQLS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   111 GSLPHTISQ-SKNLRFLAISRNFISGEIPAslSELRGLKTLDLSYNQLTGSIPPSIGSLPELSNLILCHNHLNGSIPQFL 189
Cdd:PLN00113 107 GPIPDDIFTtSSSLRYLNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   190 SQ--SLTRIDLKRNNLTG-IISLTSLPPSLQYLSLAWNQLTGPVYRVLLRLNQLNYLDLSLNRFTGAIPGQIFTfpITNL 266
Cdd:PLN00113 185 TNltSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGN--LKNL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   267 Q---LQRNFFYGVIQPP--NQVTIPTVDLSYNRFSGELSPLLSNVQN---LYLNNNRFTGQVPVSfvdrlLAS--NIQTL 336
Cdd:PLN00113 263 QylfLYQNKLSGPIPPSifSLQKLISLDLSDNSLSGEIPELVIQLQNleiLHLFSNNFTGKIPVA-----LTSlpRLQVL 337


                 ....*....
gi 7269786   337 YLQHNFLTG 345
Cdd:PLN00113 338 QLWSNKFSG 346
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-345 4.08e-33

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 131.51  E-value: 4.08e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    85 LSGRIDPAIGKLSALTELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPS 164
Cdd:PLN00113 296 LSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEG 375

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   165 IGSLPELSNLILCHNHLNGSIPQFLS--QSLTRIDLKRNNLTGIIS--LTSLPpSLQYLSLAWNQLTGPVYRVLLRLNQL 240
Cdd:PLN00113 376 LCSSGNLFKLILFSNSLEGEIPKSLGacRSLRRVRLQDNSFSGELPseFTKLP-LVYFLDISNNNLQGRINSRKWDMPSL 454

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   241 NYLDLSLNRFTGAIPGQIFTFPITNLQLQRNFFYGVIqPPNQVTIPTV---DLSYNRFSGELSPLLS---NVQNLYLNNN 314
Cdd:PLN00113 455 QMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAV-PRKLGSLSELmqlKLSENKLSGEIPDELSsckKLVSLDLSHN 533

                        250       260       270
                 ....*....|....*....|....*....|.
gi 7269786   315 RFTGQVPVSFVDRLLASNiqtLYLQHNFLTG 345
Cdd:PLN00113 534 QLSGQIPASFSEMPVLSQ---LDLSQNQLSG 561
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-346 4.63e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 4.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   89 IDPAIGKLSALTELSIVPGRImGSLPHTISQSKNLRFLAISRNFISgEIPASLSELRGLKTLDLSYNQLTgSIPPSIGSL 168
Cdd:COG4886 128 LPEELANLTNLKELDLSNNQL-TDLPEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNL 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  169 PELSNLILCHNHLNgSIPQFLSQ--SLTRIDLKRNNLTGIISLTSLPpSLQYLSLAWNQLTGpvYRVLLRLNQLNYLDLS 246
Cdd:COG4886 205 TNLEELDLSGNQLT-DLPEPLANltNLETLDLSNNQLTDLPELGNLT-NLEELDLSNNQLTD--LPPLANLTNLKTLDLS 280

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  247 LNRFTGAIPGQIFTFPITNLQLQRNFFYGVIQPPNQVTIPTVDLSYNRFSGELSPLLSNVQNLYLNNNRFTGQVPVSFVD 326
Cdd:COG4886 281 NNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360

                       250       260
                ....*....|....*....|
gi 7269786  327 RLLASNIQTLYLQHNFLTGI 346
Cdd:COG4886 361 LLLTLLLTLGLLGLLEATLL 380
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-321 2.27e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 102.62  E-value: 2.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    82 SPGLSGRIDPAIGKLSALTELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKT------------ 149
Cdd:PLN00113 341 SNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRvrlqdnsfsgel 420

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   150 ------------LDLSYNQLTGSIPPSIGSLPELSNLILCHNHLNGSIPQ-FLSQSLTRIDLKRNNLTGII--SLTSLPP 214
Cdd:PLN00113 421 pseftklplvyfLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDsFGSKRLENLDLSRNQFSGAVprKLGSLSE 500

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   215 SLQyLSLAWNQLTGPVYRVLLRLNQLNYLDLSLNRFTGAIPGQIFTFPITNLqlqrnffygviqppnqvtiptVDLSYNR 294
Cdd:PLN00113 501 LMQ-LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQ---------------------LDLSQNQ 558

                        250       260       270
                 ....*....|....*....|....*....|
gi 7269786   295 FSGELSPLLSNVQNLY---LNNNRFTGQVP 321
Cdd:PLN00113 559 LSGEIPKNLGNVESLVqvnISHNHLHGSLP 588
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-370 5.13e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 5.13e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   85 LSGRIDPAIGKLSALTELSIVPGRImGSLPHTISQSKNLRFLAISRNFISgEIPASLSELRGLKTLDLSYNQLTgSIPPS 164
Cdd:COG4886 101 LDLSGNEELSNLTNLESLDLSGNQL-TDLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLT-DLPEE 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  165 IGSLPELSNLILCHNHLNgSIPQFLSQ--SLTRIDLKRNNLTGI-ISLTSLPpSLQYLSLAWNQLTGPVYrvLLRLNQLN 241
Cdd:COG4886 178 LGNLTNLKELDLSNNQIT-DLPEPLGNltNLEELDLSGNQLTDLpEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLE 253

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  242 YLDLSLNRFTGaIPgqiFTFPITNLQlqrnffygviqppnqvtipTVDLSYNRFSGELSPLLSNVQNLYLNNNRFTGQVP 321
Cdd:COG4886 254 ELDLSNNQLTD-LP---PLANLTNLK-------------------TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 7269786  322 VSFVDRLLASNIQTLYLQHNFLTGIQISPAADIPVSSSLCLQYNCMVLP 370
Cdd:COG4886 311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLL 359
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-344 9.90e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 9.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   89 IDPAIGKLSALTELSIVPGRImGSLPHTISQSKNLRFLAISRNFISgEIPASLSELRGLKTLDLSYNQLTgSIPPSIGSL 168
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQL-TDLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANL 227

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  169 PELSNLILCHNHLNgSIPQFLS-QSLTRIDLKRNNLTGIISLTSLpPSLQYLSLAWNQLTGPVYRVLLRLNQLNYLDLSL 247
Cdd:COG4886 228 TNLETLDLSNNQLT-DLPELGNlTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  248 NRFTGAIPGQIFTFPITNLQLQRNFFYGVIQPPNQVTIPTVDLSYNRFSGELSPLLSNVQNLYLNNNRFTGQVPVSFVDR 327
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                       250
                ....*....|....*..
gi 7269786  328 LLASNIQTLYLQHNFLT 344
Cdd:COG4886 386 LLTLLLLLLTTTAGVLL 402
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-214 1.41e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    85 LSGRIDPAIGKLSALTELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPS 164
Cdd:PLN00113 487 FSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKN 566

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 7269786   165 IGSLPELSNLILCHNHLNGSIPQ---FLSQSLTRIDlKRNNLTGIISLTSLPP 214
Cdd:PLN00113 567 LGNVESLVQVNISHNHLHGSLPStgaFLAINASAVA-GNIDLCGGDTTSGLPP 618
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-332 2.09e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 2.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   89 IDPAIGKLSALTELSIVPGRImGSLPHTISQSKNLRFLAISRNFISgEIPASLSELRGLKTLDLSYNQLTgSIPpSIGSL 168
Cdd:COG4886 174 LPEELGNLTNLKELDLSNNQI-TDLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLP-ELGNL 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  169 PELSNLILCHNHLNGSIPQFLSQSLTRIDLKRNNLTGiISLTSLPPSLQYLSLAWNQLTGPVYRVLLRLNQLNYLDLSLN 248
Cdd:COG4886 250 TNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD-LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  249 RFTGAIPGQIFTFPITNLQLQRNFFYGVIQPPNQVTIPTVDLSYNRFSGELSPLLSNVQNLYLNNNRFTGQVPVSFVDRL 328
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408


                ....
gi 7269786  329 LASN 332
Cdd:COG4886 409 DAVN 412
PLN03150 PLN03150
hypothetical protein; Provisional
 111-222 4.80e-16

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 79.86  E-value: 4.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   111 GSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPSIGSLPELSNLILCHNHLNGSIPQFL- 189
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALg 511

                         90       100       110
                 ....*....|....*....|....*....|...
gi 7269786   190 SQSLTRIDLKRNNLTGIISLTSLPPSLQYLSLA 222
Cdd:PLN03150 512 GRLLHRASFNFTDNAGLCGIPGLRACGPHLSVG 544
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-221 4.89e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 80.28  E-value: 4.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    99 LTELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPSIGSLPELSNLILCH 178
Cdd:PLN00113 477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 7269786   179 NHLNGSIPQFLS--QSLTRIDLKRNNLTGiisltSLPPSLQYLSL 221
Cdd:PLN00113 557 NQLSGEIPKNLGnvESLVQVNISHNHLHG-----SLPSTGAFLAI 596
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
137-385 4.47e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 4.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   137 IPASLSElrGLKTLDLSYNQLTgSIPPSI-GSLPELSnliLCHNHLNgSIPQFLSQSLTRIDLKRNNLTGIISltSLPPS 215
Cdd:PRK15370 193 IPACIPE--QITTLILDNNELK-SLPENLqGNIKTLY---ANSNQLT-SIPATLPDTIQEMELSINRITELPE--RLPSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   216 LQYLSLAWNQLTG-----PvyrvllrlNQLNYLDLSLNRFTgAIPGQIFTfPITNLQLQRN--FFYGVIQPPNQVTIPTV 288
Cdd:PRK15370 264 LQSLDLFHNKISClpenlP--------EELRYLSVYDNSIR-TLPAHLPS-GITHLNVQSNslTALPETLPPGLKTLEAG 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   289 DLSYNRFSGELSPLLsnvQNLYLNNNRFTgqvpvsFVDRLLASNIQTLYLQHNFLTGI-QISPAADIPVSSSlclqYNCM 367
Cdd:PRK15370 334 ENALTSLPASLPPEL---QVLDVSKNQIT------VLPETLPPTITTLDVSRNALTNLpENLPAALQIMQAS----RNNL 400

                        250
                 ....*....|....*....
gi 7269786   368 V-LPVQTPCPVKAGLQKTR 385
Cdd:PRK15370 401 VrLPESLPHFRGEGPQPTR 419
PLN03150 PLN03150
hypothetical protein; Provisional
 31-169 4.99e-12

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 67.53  E-value: 4.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    31 ALQAIRKSLDdLPgSNFfdSWDftSDPC-----NFAGVYCDDDK------VTALNLGDPragspGLSGRIDPAIGKLSAL 99
Cdd:PLN03150 376 ALQTLKSSLG-LP-LRF--GWN--GDPCvpqqhPWSGADCQFDStkgkwfIDGLGLDNQ-----GLRGFIPNDISKLRHL 444

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   100 TELSIVPGRIMGSLPHTISQSKNLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPSIGSLP 169
Cdd:PLN03150 445 QSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRL 514
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 28-66 6.09e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 45.75  E-value: 6.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 7269786     28 DFLALQAIRKSLDDLPGsnFFDSWD-FTSDPCNFAGVYCD 66
Cdd:pfam08263   4 DGQALLAFKSSLNDPPG--ALSSWNsSSSDPCSWTGVTCD 41
LRR_8 pfam13855
Leucine rich repeat;
122-181 7.62e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 7.62e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786    122 NLRFLAISRNFISGEIPASLSELRGLKTLDLSYNQLTGSIPPSIGSLPELSNLILCHNHL 181
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 236-368 9.27e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 9.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   236 RLNQLNYLDLSLNRFTGAIPGQIFTfpITNLQLqrnffygviqppnqvtiptVDLSYNRFSGELSP---LLSNVQNLYLN 312
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPSLGS--ITSLEV-------------------LDLSYNSFNGSIPEslgQLTSLRILNLN 498

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7269786   313 NNRFTGQVPVSFVDRLLASNIqtlylqHNF-----LTGI--------QISPAADIPVSSSLCLQYNCMV 368
Cdd:PLN03150 499 GNSLSGRVPAALGGRLLHRAS------FNFtdnagLCGIpglracgpHLSVGAKIGIAFGVSVAFLFLV 561
PLN03150 PLN03150
hypothetical protein; Provisional
 135-263 3.65e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   135 GEIPASLSELRGLKTLDLSYNQLTGSIPPSIGSLPelsnlilchnhlngsipqflsqsltridlkrnnltgiisltslpp 214
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSIT--------------------------------------------- 466

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 7269786   215 SLQYLSLAWNQLTGPVYRVLLRLNQLNYLDLSLNRFTGAIPGQIFTFPI 263
Cdd:PLN03150 467 SLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLL 515
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 122-259 4.11e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 4.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  122 NLRFLAISRNFISGEIPASLSEL----RGLKTLDLSYNQLTGSIPPSIG-SLPELSNLILCHNHLNGSIPQ---FLS--- 190
Cdd:cd00116 138 ALEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIGDAGIRALAeGLKANCNLEVLDLNNNGLTDEgasALAetl 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  191 ---QSLTRIDLKRNNLTGII------SLTSLPPSLQYLSLAWNQLT----GPVYRVLLRLNQLNYLDLSLNRFTGAIPGQ 257
Cdd:cd00116 218 aslKSLEVLNLGDNNLTDAGaaalasALLSPNISLLTLSLSCNDITddgaKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297


                ..
gi 7269786  258 IF 259
Cdd:cd00116 298 LA 299
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-251 4.68e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 4.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  117 ISQSKNLRFLAISRNFISgEIPaSLSELRGLKTLDLSYNQLTgsippsigslpELSNLILCHN----HLN---------- 182
Cdd:cd21340  42 LEFLTNLTHLYLQNNQIE-KIE-NLENLVNLKKLYLGGNRIS-----------VVEGLENLTNleelHIEnqrlppgekl 108

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7269786  183 ----GSIpQFLSQSLTRIDLKRNNLTGIISLTSLpPSLQYLSLAWNQLT--GPVYRVLLRLNQLNYLDLSLNRFT 251
Cdd:cd21340 109 tfdpRSL-AALSNSLRVLNISGNNIDSLEPLAPL-RNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGNPVC 181
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 117-344 8.40e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 8.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  117 ISQSKNLRFLAISRNFI----SGEIPASLSELRGLKTLDLSYNQLTGsippsigslPELSNLI--LCHNHlngsipqfls 190
Cdd:COG5238 204 LTQNTTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIGD---------EGVIALAeaLKNNT---------- 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  191 qSLTRIDLKRNNLT--GIISLTSL---PPSLQYLSLAWNQLTGPVYRVL---LRLNQ-LNYLDLSLNRFTGAipGQIFTF 261
Cdd:COG5238 265 -TVETLYLSGNQIGaeGAIALAKAlqgNTTLTSLDLSVNRIGDEGAIALaegLQGNKtLHTLNLAYNGIGAQ--GAIALA 341

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  262 piTNLQLQRnffygviqppnqvTIPTVDLSYNRFSGELSPLL-------SNVQNLYLNNNRFTGQVPVSFVDRLLASNIQ 334
Cdd:COG5238 342 --KALQENT-------------TLHSLDLSDNQIGDEGAIALakylegnTTLRELNLGKNNIGKQGAEALIDALQTNRLH 406

                       250
                ....*....|
gi 7269786  335 TLYLQHNFLT 344
Cdd:COG5238 407 TLILDGNLIG 416
LRR_8 pfam13855
Leucine rich repeat;
191-250 9.60e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7269786    191 QSLTRIDLKRNNLTGI--ISLTSLPpSLQYLSLAWNQLTGPVYRVLLRLNQLNYLDLSLNRF 250
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-199 1.50e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   95 KLSALTELSI-----VPGRIMGSLPHTI-SQSKNLRFLAISRNFISgeIPASLSELRGLKTLDLSYNQLT--GSIPPSIG 166
Cdd:cd21340  88 NLTNLEELHIenqrlPPGEKLTFDPRSLaALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISdlEELLDLLS 165

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 7269786  167 SLPELSNLILCHNHLNgSIPQF------LSQSLTRIDLK 199
Cdd:cd21340 166 SWPSLRELDLTGNPVC-KKPKYrdkiilASKSLEVLDGK 203
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-259 5.43e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 5.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786   60 FAGVYCDDDKVTALNLGDPRAGSPGLSgridpAIGKL----SALTELSIVPGRI----MGSLPHTISQSKNLRFLAISRN 131
Cdd:COG5238 228 LAEALKGNKSLTTLDLSNNQIGDEGVI-----ALAEAlknnTTVETLYLSGNQIgaegAIALAKALQGNTTLTSLDLSVN 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7269786  132 FISGEIPASLSE-LRG---LKTLDLSYNQLTG----SIPPSIGSLPELSNLILCHNHLNG----SIPQFL--SQSLTRID 197
Cdd:COG5238 303 RIGDEGAIALAEgLQGnktLHTLNLAYNGIGAqgaiALAKALQENTTLHSLDLSDNQIGDegaiALAKYLegNTTLRELN 382

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7269786  198 LKRNNLT--GIISLTSLppslqylslawnqltgpvyrvlLRLNQLNYLDLSLNRFTGAIPGQIF 259
Cdd:COG5238 383 LGKNNIGkqGAEALIDA----------------------LQTNRLHTLILDGNLIGAEAQQRLE 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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