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Conserved domains on  [gi|12052792|emb|CAB66568|]
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hypothetical protein [Homo sapiens]

Protein Classification

50S ribosomal protein L18( domain architecture ID 10087302)

50S ribosomal protein L18 is part of the 5S rRNA/L5/L18/L25 subcomplex; it contacts 5S and 23S rRNAs

Gene Ontology:  GO:0005840|GO:0003735
PubMed:  24362565|11470155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
 68-170 4.82e-30

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


:

Pssm-ID: 238246  Cd Length: 103  Bit Score: 105.70  E-value: 4.82e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12052792  68 WRTVFPSREFWHRLRVIRTQHHVEALVEH-QNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVY 146
Cdd:cd00432   1 RRRKRLGTQERPRLVVRKSNKHIYAQIIDdSGDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIKKVVF 80

                        90       100
                ....*....|....*....|....
gi 12052792 147 QPTPWeAASDSMKRLQSAMTEGGV 170
Cdd:cd00432  81 DRGGY-RYHGRVKALAKGAREGGL 103
 
Name Accession Description Interval E-value
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
 68-170 4.82e-30

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 105.70  E-value: 4.82e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12052792  68 WRTVFPSREFWHRLRVIRTQHHVEALVEH-QNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVY 146
Cdd:cd00432   1 RRRKRLGTQERPRLVVRKSNKHIYAQIIDdSGDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIKKVVF 80

                        90       100
                ....*....|....*....|....
gi 12052792 147 QPTPWeAASDSMKRLQSAMTEGGV 170
Cdd:cd00432  81 DRGGY-RYHGRVKALAKGAREGGL 103
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 80-141 8.60e-11

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440026  Cd Length: 119  Bit Score: 56.26  E-value: 8.60e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12052792  80 RLRVIRTQHHVEA-LVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGI 141
Cdd:COG0256  27 RLVVFRSNKHIYAqIIDDTGGKTLASASTLEKELRKKLGSGGNTEAAYLVGKLIAERAKAKGI 89
rpl18 CHL00139
ribosomal protein L18; Validated
 80-146 2.45e-08

ribosomal protein L18; Validated


Pssm-ID: 214373  Cd Length: 109  Bit Score: 49.64  E-value: 2.45e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12052792   80 RLRVIRTQHHVEA-LVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVY 146
Cdd:CHL00139  17 RLSVFRSNKHIYAqIIDDTNGKTLVACSTLEPDVKSSLSSTSTCDASKLVGQKLAKKSLKKGITKVVF 84
Ribosomal_L18p pfam00861
Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large ...
 80-146 1.03e-06

Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large subunit ribosomal proteins from bacteria, archaea, the mitochondria and the chloroplast. It does not include the 60S L18 or L5 proteins from Metazoa.


Pssm-ID: 395691  Cd Length: 116  Bit Score: 45.43  E-value: 1.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12052792    80 RLRVIRTQHHVEA-LVEHQNGKVVVSASTREWAIKkhLYSTRNVVACESIGRVLAQRCLEAGINFMVY 146
Cdd:pfam00861  26 RLVVFRSNRHIYAqVIDDVKGHTLASASTLEKDLK--GLSGGNQDAAKKVGELIAERAKAKGITAVVF 91
 
Name Accession Description Interval E-value
Ribosomal_L18_L5e cd00432
Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of ...
 68-170 4.82e-30

Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA depends on the binding of L18 and L5 to 5S rRNA. L18/L5e is generally described as L18 in prokaryotes and archaea, and as L5e (or L5) in eukaryotes. In bacteria, the CP proteins L5, L18, and L25 are required for the ribosome to incorporate 5S rRNA into the large subunit, one of the last steps in ribosome assembly. In archaea, both L18 and L5 bind 5S rRNA; in eukaryotes, only the L18 homolog (L5e) binds 5S rRNA but a homolog to L5 is also identified.


Pssm-ID: 238246  Cd Length: 103  Bit Score: 105.70  E-value: 4.82e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12052792  68 WRTVFPSREFWHRLRVIRTQHHVEALVEH-QNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVY 146
Cdd:cd00432   1 RRRKRLGTQERPRLVVRKSNKHIYAQIIDdSGDKTLVSASTLELAIKGVLGSGNNVEAAYLVGRLLAKRALEKGIKKVVF 80

                        90       100
                ....*....|....*....|....
gi 12052792 147 QPTPWeAASDSMKRLQSAMTEGGV 170
Cdd:cd00432  81 DRGGY-RYHGRVKALAKGAREGGL 103
RplR COG0256
Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 ...
 80-141 8.60e-11

Ribosomal protein L18 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L18 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440026  Cd Length: 119  Bit Score: 56.26  E-value: 8.60e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12052792  80 RLRVIRTQHHVEA-LVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGI 141
Cdd:COG0256  27 RLVVFRSNKHIYAqIIDDTGGKTLASASTLEKELRKKLGSGGNTEAAYLVGKLIAERAKAKGI 89
rpl18 CHL00139
ribosomal protein L18; Validated
 80-146 2.45e-08

ribosomal protein L18; Validated


Pssm-ID: 214373  Cd Length: 109  Bit Score: 49.64  E-value: 2.45e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12052792   80 RLRVIRTQHHVEA-LVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVY 146
Cdd:CHL00139  17 RLSVFRSNKHIYAqIIDDTNGKTLVACSTLEPDVKSSLSSTSTCDASKLVGQKLAKKSLKKGITKVVF 84
Ribosomal_L18p pfam00861
Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large ...
 80-146 1.03e-06

Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast; This family includes the large subunit ribosomal proteins from bacteria, archaea, the mitochondria and the chloroplast. It does not include the 60S L18 or L5 proteins from Metazoa.


Pssm-ID: 395691  Cd Length: 116  Bit Score: 45.43  E-value: 1.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12052792    80 RLRVIRTQHHVEA-LVEHQNGKVVVSASTREWAIKkhLYSTRNVVACESIGRVLAQRCLEAGINFMVY 146
Cdd:pfam00861  26 RLVVFRSNRHIYAqVIDDVKGHTLASASTLEKDLK--GLSGGNQDAAKKVGELIAERAKAKGITAVVF 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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