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Conserved domains on  [gi|6580220|emb|CAB63200|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-308 2.45e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 289.83  E-value: 2.45e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     10 ASDINYSKFLHAFTILEIFIHSFGAYIIIAKTPKRLESVKASMLFLHFVGAFVDVYFSVLIMPVLHLPVCGGHPLGLLSF 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     90 FGVPVLLQTYVGLSLPAVIVATIVVFLDDRRYRLVNGQKSSKiRKWYRLLFVTSSYVSATMYPAPVFFLLPDQESGRLVL 169
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRIT-WKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220    170 KSKSQCIPTDVFDHPNFFLLDLNGNNIAICMLLLMIILISQLLMQFGLIFRHLLKSTP--ISRSTIRLQQQFFIAMSMQV 247
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKssLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6580220    248 ILPIVIIAFPAFYILFSIISGYHNQGATNIAFMVMSIHGVLSTLTMLMAYRHYRESILEML 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-308 2.45e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 289.83  E-value: 2.45e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     10 ASDINYSKFLHAFTILEIFIHSFGAYIIIAKTPKRLESVKASMLFLHFVGAFVDVYFSVLIMPVLHLPVCGGHPLGLLSF 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     90 FGVPVLLQTYVGLSLPAVIVATIVVFLDDRRYRLVNGQKSSKiRKWYRLLFVTSSYVSATMYPAPVFFLLPDQESGRLVL 169
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRIT-WKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220    170 KSKSQCIPTDVFDHPNFFLLDLNGNNIAICMLLLMIILISQLLMQFGLIFRHLLKSTP--ISRSTIRLQQQFFIAMSMQV 247
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKssLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6580220    248 ILPIVIIAFPAFYILFSIISGYHNQGATNIAFMVMSIHGVLSTLTMLMAYRHYRESILEML 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
10-308 2.45e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 289.83  E-value: 2.45e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     10 ASDINYSKFLHAFTILEIFIHSFGAYIIIAKTPKRLESVKASMLFLHFVGAFVDVYFSVLIMPVLHLPVCGGHPLGLLSF 89
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     90 FGVPVLLQTYVGLSLPAVIVATIVVFLDDRRYRLVNGQKSSKiRKWYRLLFVTSSYVSATMYPAPVFFLLPDQESGRLVL 169
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRIT-WKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220    170 KSKSQCIPTDVFDHPNFFLLDLNGNNIAICMLLLMIILISQLLMQFGLIFRHLLKSTP--ISRSTIRLQQQFFIAMSMQV 247
Cdd:pfam10318 160 LKKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKssLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6580220    248 ILPIVIIAFPAFYILFSIISGYHNQGATNIAFMVMSIHGVLSTLTMLMAYRHYRESILEML 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
15-301 4.45e-12

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 65.64  E-value: 4.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     15 YSKFLHAFTILEIFIHSFGAYIIIAKTPKrLESVKASMLFLHFVGAFVDVYFSVLIMPVLHLPVCGGHPLGLLS-FFGVP 93
Cdd:pfam10327  11 LILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLAtVFGIS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     94 V-LLQTYVGLSLPAVIVATIVVFLddRRYrlvngQKSSKIRKWYRL--LFVTSSYVSATMYPAPVFFL-----LPDQESG 165
Cdd:pfam10327  90 ShYLMTIFVFLLSFQLESLLLCFV--RKH-----QAIAKILSKHVIpkWLYIFLYILCHIFPFLTAFLfyqsgLSREEQL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220    166 RLVLKSKSQCIPtDVFDHPNFFLLDLNGNNIA-ICMLLLMIILISQLLMQFGL-IFRHL--LKSTpISRSTIRLQQQFFI 241
Cdd:pfam10327 163 EYVKENYPEYLS-QFSSLPNFAIYDYNPWLIVfGILAIFGGSLSFLILVYLTVdMFRMLkrLRKK-ISAQTYQKHRAALR 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220    242 AMSMQVILPIVIIAFPAFYILFSIISGYHNQGATNIAFMVMSIHGVLSTLTMLMAYRHYR 301
Cdd:pfam10327 241 SLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYR 300
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
18-305 3.19e-07

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 50.92  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     18 FLHAFTILEIFIHSFGAYIIIAKTPKRLESVKASMLFLHFVG---AFVDVyfsvLIMPVLH-----LPVCGGHPLGLLSF 89
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGiffSILEF----IVKPFIHsynssFIVFVDLKDLGLSK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220     90 FGVPVLLQTYVGLSlpAVIVATIVV-FLddrrYR---LVNGQKSSKIRKWYRLLFVTSSYVSATMYPAPVFFLLPDQESG 165
Cdd:pfam10326  80 SVGQILLALYCGFY--GVSISLLAVqFI----YRylaLCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEET 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6580220    166 RLVLK---SKSQCIPTD--VFDHPNFFLLDLNGNNI-----AICMLLLMIILISQLL--MQFGL-IFRHLLK-STPISRS 231
Cdd:pfam10326 154 DEYLReelLENYNLDIDevAYVGPVYYPTDENGSKVirwrsLIGLLIMTFIIGISFSiiIYCGIkMYFKMKKlKSLGSEK 233
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6580220    232 TIRLQQQFFIAMSMQVILPIVIIAFPAFYILFSIISGYHNQGATNIAFMVMSIHGVLSTLTMLMAYRHYRESIL 305
Cdd:pfam10326 234 TRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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