|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
113-463 |
5.78e-99 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 304.38 E-value: 5.78e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 113 NFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredeanlgKKTKPR 192
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRL------------DPSRPR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 193 RPRTVVLCPTRELSEQVC--LHQDYHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLV 270
Cdd:COG0513 71 APQALILAPTRELALQVAeeLRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 271 LDEADTMFDRGFGPEIRKFLAPLNQHIKVVneIVS---FQAVQKLVDEEFQGIEHLRTSTLHKKIANARHDFIKLSgGED 347
Cdd:COG0513 151 LDEADRMLDMGFIEDIERILKLLPKERQTL--LFSatmPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVD-KRD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 348 KLEALLQVLEpsLAKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeGDCPTLVCTDLAAR 427
Cdd:COG0513 228 KLELLRRLLR--DEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRN--GKIRVLVATDVAAR 303
|
330 340 350
....*....|....*....|....*....|....*..
gi 4538903 428 GLDLD-VDHVVMFDFPKNSIDYLHRTGRTARMGAKGL 463
Cdd:COG0513 304 GIDIDdVSHVINYDLPEDPEDYVHRIGRTGRAGAEGT 340
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
113-472 |
9.96e-63 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 210.57 E-value: 9.96e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 113 NFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVvLGSH-TGSGKTLAYLLPIVQVLSELMRedeanlgkkTKP 191
Cdd:PRK11192 2 TFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDV-LGSApTGTGKTAAFLLPALQHLLDFPR---------RKS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 192 RRPRTVVLCPTRELSEQVClHQDYHHARFRSI---LVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAY 268
Cdd:PRK11192 72 GPPRILILTPTRELAMQVA-DQARELAKHTHLdiaTITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVET 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 269 LVLDEADTMFDRGFGPEI---------RK----FLAPLNQhikvvNEIVSFqAVQKLVDEEFQGIEHLRTStlHKKIana 335
Cdd:PRK11192 151 LILDEADRMLDMGFAQDIetiaaetrwRKqtllFSATLEG-----DAVQDF-AERLLNDPVEVEAEPSRRE--RKKI--- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 336 rHDFIKLSGG-EDKLEALLQVLEPSLAKgsKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeG 414
Cdd:PRK11192 220 -HQWYYRADDlEHKTALLCHLLKQPEVT--RSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTD--G 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 4538903 415 DCPTLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMGAKGlfhtSRLSLV 472
Cdd:PRK11192 295 RVNVLVATDVAARGIDIdDVSHVINFDMPRSADTYLHRIGRTGRAGRKG----TAISLV 349
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
123-294 |
1.82e-61 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 199.59 E-value: 1.82e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSElmredeanlGKKTKPRRPRTVVLCPT 202
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLP---------EPKKKGRGPQALVLAPT 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 203 RELSEQVclHQDYH----HARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMF 278
Cdd:cd00268 72 RELAMQI--AEVARklgkGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRML 149
|
170
....*....|....*.
gi 4538903 279 DRGFGPEIRKFLAPLN 294
Cdd:cd00268 150 DMGFEEDVEKILSALP 165
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
114-463 |
3.60e-52 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 183.08 E-value: 3.60e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQvlselmredeanlgkKTKPRR 193
Cdd:PRK11776 6 FSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQ---------------KLDVKR 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRT--VVLCPTRELSEQVC-----LhqdyhhARFRS---ILV-SGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMV 262
Cdd:PRK11776 71 FRVqaLVLCPTRELADQVAkeirrL------ARFIPnikVLTlCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLD 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 263 YGDIAYLVLDEADTMFDRGFGPEIrkflaplnqhikvvNEIVSF--QAVQKLVdeeF-----QGIEHLRTSTLHK----K 331
Cdd:PRK11776 145 LDALNTLVLDEADRMLDMGFQDAI--------------DAIIRQapARRQTLL---FsatypEGIAAISQRFQRDpvevK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 332 IAnARHD-------FIKLSgGEDKLEALLQVLepSLAKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVpaEQ--R 402
Cdd:PRK11776 208 VE-STHDlpaieqrFYEVS-PDERLPALQRLL--LHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDL--EQrdR 281
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4538903 403 VENLKKFKDeeGDCPTLVCTDLAARGLDLD-VDHVVMFDFPKNSIDYLHRTGRTARMGAKGL 463
Cdd:PRK11776 282 DQVLVRFAN--RSCSVLVATDVAARGLDIKaLEAVINYELARDPEVHVHRIGRTGRAGSKGL 341
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
113-472 |
7.83e-50 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 176.92 E-value: 7.83e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 113 NFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSElmREDEAnlgkktKPR 192
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLIT--RQPHA------KGR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 193 RP-RTVVLCPTRELSEQVCLH-QDY-HHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQhIEEGNMVYGD-IAY 268
Cdd:PRK10590 74 RPvRALILTPTRELAAQIGENvRDYsKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVKLDqVEI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 269 LVLDEADTMFDRGFGPEIRKFLAPL---NQHI----KVVNEIVSFqaVQKLVDEEFQgIEHLRTSTLHKKIANARHDFIK 341
Cdd:PRK10590 153 LVLDEADRMLDMGFIHDIRRVLAKLpakRQNLlfsaTFSDDIKAL--AEKLLHNPLE-IEVARRNTASEQVTQHVHFVDK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 342 LSGGEdkleaLLQVLepsLAKGS--KVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeGDCPTL 419
Cdd:PRK10590 230 KRKRE-----LLSQM---IGKGNwqQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKS--GDIRVL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 4538903 420 VCTDLAARGLDLD-VDHVVMFDFPKNSIDYLHRTGRTARMGAKGlfhtSRLSLV 472
Cdd:PRK10590 300 VATDIAARGLDIEeLPHVVNYELPNVPEDYVHRIGRTGRAAATG----EALSLV 349
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
98-466 |
2.72e-49 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 177.27 E-value: 2.72e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 98 EEESSIRKKSK----------KLVENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYL 167
Cdd:PTZ00110 106 KEVDEIRKEKEitiiagenvpKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFL 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 168 LP-IVQVLSE-LMREDEAnlgkktkprrPRTVVLCPTRELSEQV---CLhQDYHHARFRSILVSGGSRIRPQEDSLNNAI 242
Cdd:PTZ00110 186 LPaIVHINAQpLLRYGDG----------PIVLVLAPTRELAEQIreqCN-KFGASSKIRNTVAYGGVPKRGQIYALRRGV 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 243 DMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFDRGFGPEIRKFLAplnqHIKVVNEIVSFQA-----VQKLV-DEE 316
Cdd:PTZ00110 255 EILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVS----QIRPDRQTLMWSAtwpkeVQSLArDLC 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 317 FQGIEHLRTSTLHKKIANARHDFIKLSGGEDKLEALLQVLEPSLAKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGE 396
Cdd:PTZ00110 331 KEEPVHVNVGSLDLTACHNIKQEVFVVEEHEKRGKLKMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGD 410
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4538903 397 VPAEQRVENLKKFKDeeGDCPTLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMGAKGLFHT 466
Cdd:PTZ00110 411 KKQEERTWVLNEFKT--GKSPIMIATDVASRGLDVkDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYT 479
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
114-462 |
1.24e-45 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 164.76 E-value: 1.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLlpiVQVLSELMREDEAnlgKKTKPRR 193
Cdd:PRK04837 10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFL---TATFHYLLSHPAP---EDRKVNQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQVclHQD----YHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYL 269
Cdd:PRK04837 84 PRALIMAPTRELAVQI--HADaeplAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 270 VLDEADTMFDRGFGPEIRkFL----APLNQHIKVVneivsFQA-----VQKLVDEEFQGIEHLRTSTLHKKIANARHDFI 340
Cdd:PRK04837 162 VLDEADRMFDLGFIKDIR-WLfrrmPPANQRLNML-----FSAtlsyrVRELAFEHMNNPEYVEVEPEQKTGHRIKEELF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 341 KLSGgEDKLEALLQVLE---PSlakgsKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeGDCP 417
Cdd:PRK04837 236 YPSN-EEKMRLLQTLIEeewPD-----RAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTR--GDLD 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 4538903 418 TLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMGAKG 462
Cdd:PRK04837 308 ILVATDVAARGLHIpAVTHVFNYDLPDDCEDYVHRIGRTGRAGASG 353
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
113-462 |
1.01e-44 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 165.12 E-value: 1.01e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 113 NFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLseLMREDEANlgkkTKPR 192
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRL--LSRPALAD----RKPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 193 RPRTVVLCPTRELSEQVclHQDyhHARF------RSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDI 266
Cdd:PRK04537 84 DPRALILAPTRELAIQI--HKD--AVKFgadlglRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 267 AYL-VLDEADTMFDRGFGPEIRKFLAPLNQhiKVVNEIVSFQA-----VQKLVDEEFQGIEHLRTSTLHKKIANARHDfI 340
Cdd:PRK04537 160 CEIcVLDEADRMFDLGFIKDIRFLLRRMPE--RGTRQTLLFSAtlshrVLELAYEHMNEPEKLVVETETITAARVRQR-I 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 341 KLSGGEDKLEALLQVLepSLAKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFkdEEGDCPTLV 420
Cdd:PRK04537 237 YFPADEEKQTLLLGLL--SRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRF--QKGQLEILV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 4538903 421 CTDLAARGLDLD-VDHVVMFDFPKNSIDYLHRTGRTARMGAKG 462
Cdd:PRK04537 313 ATDVAARGLHIDgVKYVYNYDLPFDAEDYVHRIGRTARLGEEG 355
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
114-462 |
1.91e-41 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 155.33 E-value: 1.91e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVqvlselMREDEANLGKKTKPRR 193
Cdd:PLN00206 123 FSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPII------SRCCTIRSGHPSEQRN 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQVclhqdYHHAR-------FRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDI 266
Cdd:PLN00206 197 PLAMVLTPTRELCVQV-----EDQAKvlgkglpFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNV 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 267 AYLVLDEADTMFDRGFGPEIRKFLAPLNQHIKVVNEIVSFQAVQKLvdeefqgiehlrTSTLHKKIA-----------NA 335
Cdd:PLN00206 272 SVLVLDEVDCMLERGFRDQVMQIFQALSQPQVLLFSATVSPEVEKF------------ASSLAKDIIlisignpnrpnKA 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 336 RHDFIKLSGGEDKLEALLQVLEPSLAKGSKVMVFCNtlnsSRAVDHYLSeNQISTV------NYHGEVPAEQRVENLKKF 409
Cdd:PLN00206 340 VKQLAIWVETKQKKQKLFDILKSKQHFKPPAVVFVS----SRLGADLLA-NAITVVtglkalSIHGEKSMKERREVMKSF 414
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 4538903 410 KdeEGDCPTLVCTDLAARGLDL-DVDHVVMFDFPkNSID-YLHRTGRTARMGAKG 462
Cdd:PLN00206 415 L--VGEVPVIVATGVLGRGVDLlRVRQVIIFDMP-NTIKeYIHQIGRASRMGEKG 466
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
114-290 |
7.86e-41 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 146.09 E-value: 7.86e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIvqvLSELMREDEANLGKKTKPRR 193
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPI---ISKLLEDGPPSVGRGRRKAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQVclhqdYHHAR---FRSIL----VSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDI 266
Cdd:cd17967 79 PSALILAPTRELAIQI-----YEEARkfsYRSGVrsvvVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSI 153
|
170 180
....*....|....*....|....
gi 4538903 267 AYLVLDEADTMFDRGFGPEIRKFL 290
Cdd:cd17967 154 KFLVLDEADRMLDMGFEPQIRKIV 177
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
85-462 |
2.53e-39 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 148.52 E-value: 2.53e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 85 KPPQQRPSSVVGVEEESSIRKKSKKLVENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTL 164
Cdd:PRK01297 60 KPRRERKPKPASLWKLEDFVVEPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 165 AYLLPIVQVLSELMREDEANLGKktkprrPRTVVLCPTRELSEQVClhQDYHH-ARFRSILVS---GGSRIRPQEDSLN- 239
Cdd:PRK01297 140 AFLISIINQLLQTPPPKERYMGE------PRALIIAPTRELVVQIA--KDAAAlTKYTGLNVMtfvGGMDFDKQLKQLEa 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 240 NAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFDRGFGPEIRKFL--APLNQHIKVVNEIVSFQ------AVQK 311
Cdd:PRK01297 212 RFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIrqTPRKEERQTLLFSATFTddvmnlAKQW 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 312 LVDEEFQGIEHLrtstlhKKIANARHDFIKLSGGEDKLEALLQVLEPSlaKGSKVMVFCNTLNSSRAVDHYLSENQISTV 391
Cdd:PRK01297 292 TTDPAIVEIEPE------NVASDTVEQHVYAVAGSDKYKLLYNLVTQN--PWERVMVFANRKDEVRRIEERLVKDGINAA 363
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4538903 392 NYHGEVPAEQRVENLKKFKdeEGDCPTLVCTDLAARGLDLD-VDHVVMFDFPKNSIDYLHRTGRTARMGAKG 462
Cdd:PRK01297 364 QLSGDVPQHKRIKTLEGFR--EGKIRVLVATDVAGRGIHIDgISHVINFTLPEDPDDYVHRIGRTGRAGASG 433
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
336-463 |
5.14e-39 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 138.02 E-value: 5.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 336 RHDFIKLSGGEDKLEALLQVLEpsLAKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeGD 415
Cdd:cd18787 2 KQLYVVVEEEEKKLLLLLLLLE--KLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRS--GK 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 4538903 416 CPTLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMGAKGL 463
Cdd:cd18787 78 VRVLVATDVAARGLDIpGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGT 126
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
136-300 |
2.61e-38 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 137.37 E-value: 2.61e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 136 TEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredeanlgkKTKPRRPRTVVLCPTRELSEQVC--LHQ 213
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL-------------DKLDNGPQALVLAPTRELAEQIYeeLKK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 214 DYHHARFRSILVSGGSRIRPQEDSLNNaIDMVVGTPGRILQHIEEGNmVYGDIAYLVLDEADTMFDRGFGPEIRKFLAPL 293
Cdd:pfam00270 68 LGKGLGLKVASLLGGDSRKEQLEKLKG-PDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL 145
|
....*..
gi 4538903 294 NQHIKVV 300
Cdd:pfam00270 146 PKKRQIL 152
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
114-468 |
5.84e-38 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 146.92 E-value: 5.84e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREdeanlgkktkprr 193
Cdd:PRK11634 8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKA------------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQV---CLHQDYHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLV 270
Cdd:PRK11634 75 PQILVLAPTRELAVQVaeaMTDFSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 271 LDEADTMFDRGFGPEIRKFLAPL-NQHIKVVNEIVSFQAVQKLVDEEFQGIEHLRTSTlhkkIANARHDfIKLS----GG 345
Cdd:PRK11634 155 LDEADEMLRMGFIEDVETIMAQIpEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQS----SVTTRPD-ISQSywtvWG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 346 EDKLEALLQVLEPSlaKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeGDCPTLVCTDLA 425
Cdd:PRK11634 230 MRKNEALVRFLEAE--DFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKD--GRLDILIATDVA 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 4538903 426 ARGLDLD-VDHVVMFDFPKNSIDYLHRTGRTARMGAKG---LFHTSR 468
Cdd:PRK11634 306 ARGLDVErISLVVNYDIPMDSESYVHRIGRTGRAGRAGralLFVENR 352
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
113-293 |
2.88e-36 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 133.20 E-value: 2.88e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 113 NFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVqvlsELMREDEANLGKktkpr 192
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMI----EKLKAHSPTVGA----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 193 rpRTVVLCPTRELSEQVcLHQDYHHARF---RSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYL 269
Cdd:cd17959 73 --RALILSPTRELALQT-LKVTKELGKFtdlRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYV 149
|
170 180
....*....|....*....|....
gi 4538903 270 VLDEADTMFDRGFGPEIRKFLAPL 293
Cdd:cd17959 150 VFDEADRLFEMGFAEQLHEILSRL 173
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
111-312 |
2.79e-35 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 132.40 E-value: 2.79e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 111 VENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIvqvLSELMREDEANlGKKTK 190
Cdd:cd18052 42 ILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPV---LTGMMKEGLTA-SSFSE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 191 PRRPRTVVLCPTRELSEQVclhqdYHHAR-------FRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVY 263
Cdd:cd18052 118 VQEPQALIVAPTRELANQI-----FLEARkfsygtcIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISL 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 4538903 264 GDIAYLVLDEADTMFDRGFGPEIRKFLAPLNQHIKVVNEIVSFQA-----VQKL 312
Cdd:cd18052 193 SKLKYLILDEADRMLDMGFGPEIRKLVSEPGMPSKEDRQTLMFSAtfpeeIQRL 246
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
127-300 |
4.06e-35 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 129.92 E-value: 4.06e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 127 LQELNIEVPTEIQCIGIPAVMER-KSVVLGSHTGSGKTLAYLLPIVQVLSELmredeanlgkktkpRRPRTVVLCPTREL 205
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRG--------------KGGRVLVLVPTREL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 206 SEQVC--LHQDYHHARFRSILVSGGSRIRPQEDSL-NNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFDRGF 282
Cdd:smart00487 67 AEQWAeeLKKLGPSLGLKVVGLYGGDSKREQLRKLeSGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGF 146
|
170
....*....|....*...
gi 4538903 283 GPEIRKFLAPLNQHIKVV 300
Cdd:smart00487 147 GDQLEKLLKLLPKNVQLL 164
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
123-293 |
6.46e-35 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 130.13 E-value: 6.46e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREDEanlgkKTKPRRPRTVVLCPT 202
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDE-----ETKDDGPYALILAPT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 203 RELSEQVclhQD-----YHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTM 277
Cdd:cd17945 76 RELAQQI---EEetqkfAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRM 152
|
170
....*....|....*.
gi 4538903 278 FDRGFGPEIRKFLAPL 293
Cdd:cd17945 153 IDMGFEPQVTKILDAM 168
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
126-293 |
2.95e-33 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 125.00 E-value: 2.95e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 126 ALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLseLMREDEAnlgkkTKPRRPRTVVLCPTREL 205
Cdd:cd17961 8 AIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKI--LKAKAES-----GEEQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 206 SEQVCLHQD----YHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGD-IAYLVLDEADTMFDR 280
Cdd:cd17961 81 AQQVSKVLEqltaYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLStLKYLVIDEADLVLSY 160
|
170
....*....|...
gi 4538903 281 GFGPEIRKFLAPL 293
Cdd:cd17961 161 GYEEDLKSLLSYL 173
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
84-463 |
8.70e-33 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 128.79 E-value: 8.70e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 84 AKPPQQRPSSVVGVEEEssIRKKSKKLVENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKT 163
Cdd:PTZ00424 2 ATSEQKNQSEQVASTGT--IESNYDEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 164 LAYLLPIVQVLSELMREDEAnlgkktkprrprtVVLCPTRELSEQ----VCLHQDYHHARFRSILvsGGSRIRPQEDSLN 239
Cdd:PTZ00424 80 ATFVIAALQLIDYDLNACQA-------------LILAPTRELAQQiqkvVLALGDYLKVRCHACV--GGTVVRDDINKLK 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 240 NAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFDRGFGPEIRKFLAPLNQHIKVV-------NEIVSFQA---- 308
Cdd:PTZ00424 145 AGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLPPDVQVAlfsatmpNEILELTTkfmr 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 309 --VQKLVDEEFQGIEHLRTStlhkkianarhdFIKLSGGEDKLEALLQVLEpSLAKgSKVMVFCNTlnsSRAVDHY---L 383
Cdd:PTZ00424 225 dpKRILVKKDELTLEGIRQF------------YVAVEKEEWKFDTLCDLYE-TLTI-TQAIIYCNT---RRKVDYLtkkM 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 384 SENQISTVNYHGEVPAEQRVENLKKFKdeEGDCPTLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMGAKG 462
Cdd:PTZ00424 288 HERDFTVSCMHGDMDQKDRDLIMREFR--SGSTRVLITTDLLARGIDVqQVSLVINYDLPASPENYIHRIGRSGRFGRKG 365
|
.
gi 4538903 463 L 463
Cdd:PTZ00424 366 V 366
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
123-296 |
1.25e-32 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 124.27 E-value: 1.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLG-SHTGSGKTLAYLLPIVQ-VLSELMREDEANLGKKtkprrPRTVVLC 200
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGKDVIGaAETGSGKTLAFGIPILErLLSQKSSNGVGGKQKP-----LRALILT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 201 PTRELSEQVCLHQD--YHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYG---DIAYLVLDEAD 275
Cdd:cd17946 76 PTRELAVQVKDHLKaiAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLAnlkSLRFLVLDEAD 155
|
170 180
....*....|....*....|.
gi 4538903 276 TMFDRGFGPEIRKFLAPLNQH 296
Cdd:cd17946 156 RMLEKGHFAELEKILELLNKD 176
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
119-340 |
3.52e-32 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 122.31 E-value: 3.52e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 119 LSEEVMGALQELNIEVPTEIQCIGIPAVME-RKSVVLGSHTGSGKTLAYLLPIVQVLselmredeANLGKKTKPRRPRTV 197
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSL--------LNTKPAGRRSGVSAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 198 VLCPTRELSEQVC-----LHQdyHHARFRSILVSGGSRIRPQEDSL-NNAIDMVVGTPGRILQHIEEGNM--VYGDIAYL 269
Cdd:cd17964 73 IISPTRELALQIAaeakkLLQ--GLRKLRVQSAVGGTSRRAELNRLrRGRPDILVATPGRLIDHLENPGVakAFTDLDYL 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4538903 270 VLDEADTMFDRGFGPEIRKFLAPLNQHIKVVNEIVSFQAVqklVDEEFQGIEHLrtstlhkkIANARHDFI 340
Cdd:cd17964 151 VLDEADRLLDMGFRPDLEQILRHLPEKNADPRQTLLFSAT---VPDEVQQIARL--------TLKKDYKFI 210
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
127-282 |
4.32e-32 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 121.54 E-value: 4.32e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 127 LQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQvlselmredeaNLGKKTKPRRPRTVVLCPTRELS 206
Cdd:cd17957 5 LEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQ-----------KLGKPRKKKGLRALILAPTRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 207 EQVclhqdYHHAR-------FRSILVSGGSRIRpQEDSLN--NAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTM 277
Cdd:cd17957 74 SQI-----YRELLklskgtgLRIVLLSKSLEAK-AKDGPKsiTKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKL 147
|
....*
gi 4538903 278 FDRGF 282
Cdd:cd17957 148 FEPGF 152
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
128-330 |
6.57e-32 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 121.54 E-value: 6.57e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 128 QELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredeanLGKKTKPRR---PRTVVLCPTRE 204
Cdd:cd17949 7 SKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRL----------LSLEPRVDRsdgTLALVLVPTRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 205 LSEQVclhqdYHHAR-----FRSI---LVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEE-GNMVYGDIAYLVLDEAD 275
Cdd:cd17949 77 LALQI-----YEVLEkllkpFHWIvpgYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEAD 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 276 TMFDRGFGPEIRKFLAPLNQHI----KVVNEIVSFQAVqkLVDEE-FQGIEHLRTSTLHK 330
Cdd:cd17949 152 RLLDMGFEKDITKILELLDDKRskagGEKSKPSRRQTV--LVSATlTDGVKRLAGLSLKD 209
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
114-290 |
1.41e-31 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 120.50 E-value: 1.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSElmredeanlgkktKPRR 193
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLE-------------NPQR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQVCLHQDYHHAR--FRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMV-YGDIAYLV 270
Cdd:cd17954 69 FFALVLAPTRELAQQISEQFEALGSSigLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFsLKSLKFLV 148
|
170 180
....*....|....*....|
gi 4538903 271 LDEADTMFDRGFGPEIRKFL 290
Cdd:cd17954 149 MDEADRLLNMDFEPEIDKIL 168
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
109-288 |
3.64e-31 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 119.79 E-value: 3.64e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 109 KLVENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIV-QVLSELMREDEANlgk 187
Cdd:cd17953 9 KPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrHIKDQRPVKPGEG--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 188 ktkprrPRTVVLCPTRELSEQVclhqdYHHAR-------FRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGN 260
Cdd:cd17953 86 ------PIGLIMAPTRELALQI-----YVECKkfskalgLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANN 154
|
170 180 190
....*....|....*....|....*....|....
gi 4538903 261 mvyGDI------AYLVLDEADTMFDRGFGPEIRK 288
Cdd:cd17953 155 ---GRVtnlrrvTYVVLDEADRMFDMGFEPQIMK 185
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
123-332 |
7.19e-31 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 118.29 E-value: 7.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLP-IVQVLSElmREDEANLGkktkprrPRTVVLCP 201
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPmLVHIMDQ--RELEKGEG-------PIAVIVAP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 202 TRELSEQVCLHQDYHHARF--RSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFD 279
Cdd:cd17952 72 TRELAQQIYLEAKKFGKAYnlRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFD 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 4538903 280 RGFGPEIRKFLAplnqHIKVVNEIVSFQAVQKlvdeefQGIEHLRTSTLHKKI 332
Cdd:cd17952 152 MGFEYQVRSIVG----HVRPDRQTLLFSATFK------KKIEQLARDILSDPI 194
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
123-290 |
7.51e-31 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 118.13 E-value: 7.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredeanLGKKTKPRRPRTVVLCPT 202
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERL----------LYRPKKKAATRVLVLVPT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 203 RELSEQvCLHQDYHHARFRSI---LVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVY-GDIAYLVLDEADTMF 278
Cdd:cd17947 71 RELAMQ-CFSVLQQLAQFTDItfaLAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDlDSIEILVLDEADRML 149
|
170
....*....|..
gi 4538903 279 DRGFGPEIRKFL 290
Cdd:cd17947 150 EEGFADELKEIL 161
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
114-296 |
1.00e-30 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 118.19 E-value: 1.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREdeanlgkktkprr 193
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVVALILE------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 prtvvlcPTRELSEQV--CLHQDYHH---ARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAY 268
Cdd:cd17938 68 -------PSRELAEQTynCIENFKKYldnPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRF 140
|
170 180
....*....|....*....|....*...
gi 4538903 269 LVLDEADTMFDRGFGPEIRKFLAPLNQH 296
Cdd:cd17938 141 FVLDEADRLLSQGNLETINRIYNRIPKI 168
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
111-288 |
1.04e-30 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 119.37 E-value: 1.04e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 111 VENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREDEANLGKKTK 190
Cdd:cd18051 20 IETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGESLPSESGYY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 191 PRR---PRTVVLCPTRELSEQVclhqdYHHAR---FRS----ILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGN 260
Cdd:cd18051 100 GRRkqyPLALVLAPTRELASQI-----YDEARkfaYRSrvrpCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGK 174
|
170 180
....*....|....*....|....*...
gi 4538903 261 MVYGDIAYLVLDEADTMFDRGFGPEIRK 288
Cdd:cd18051 175 IGLDYCKYLVLDEADRMLDMGFEPQIRR 202
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
123-290 |
1.88e-30 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 117.09 E-value: 1.88e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLP-IVQVLS-ELMREDEAnlgkktkprrPRTVVLC 200
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPaIVHINAqPPLERGDG----------PIVLVLA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 201 PTRELSEQVclhQDY-----HHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEAD 275
Cdd:cd17966 71 PTRELAQQI---QQEankfgGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEAD 147
|
170
....*....|....*
gi 4538903 276 TMFDRGFGPEIRKFL 290
Cdd:cd17966 148 RMLDMGFEPQIRKIV 162
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
109-290 |
2.38e-30 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 118.96 E-value: 2.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 109 KLVENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLP-IVQVLSE--LMREDEanl 185
Cdd:cd18050 59 KPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPaIVHINHQpyLERGDG--- 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 186 gkktkprrPRTVVLCPTRELSEQVC-LHQDY-HHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVY 263
Cdd:cd18050 136 --------PICLVLAPTRELAQQVQqVADDYgKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNL 207
|
170 180
....*....|....*....|....*..
gi 4538903 264 GDIAYLVLDEADTMFDRGFGPEIRKFL 290
Cdd:cd18050 208 RRCTYLVLDEADRMLDMGFEPQIRKIV 234
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
114-293 |
6.51e-30 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 115.78 E-value: 6.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSElmredeanlgkktKPRR 193
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSE-------------DPYG 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTREL----SEQV-----CLHqdyhharFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYG 264
Cdd:cd17955 68 IFALVLTPTRELayqiAEQFralgaPLG-------LRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDTTK 140
|
170 180 190
....*....|....*....|....*....|..
gi 4538903 265 DIA---YLVLDEADTMFDRGFGPEIRKFLAPL 293
Cdd:cd17955 141 VLSrvkFLVLDEADRLLTGSFEDDLATILSAL 172
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
109-290 |
8.25e-30 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 116.65 E-value: 8.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 109 KLVENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLP-IVQVLSE--LMREDEanl 185
Cdd:cd18049 21 KPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPaIVHINHQpfLERGDG--- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 186 gkktkprrPRTVVLCPTRELSEQVC-LHQDYHHA-RFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVY 263
Cdd:cd18049 98 --------PICLVLAPTRELAQQVQqVAAEYGRAcRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNL 169
|
170 180
....*....|....*....|....*..
gi 4538903 264 GDIAYLVLDEADTMFDRGFGPEIRKFL 290
Cdd:cd18049 170 RRCTYLVLDEADRMLDMGFEPQIRKIV 196
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
123-293 |
8.29e-30 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 115.37 E-value: 8.29e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVqvlsELMREDEANLgkktKPRRPRTVVLCPT 202
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVL----EILLKRKANL----KKGQVGALIISPT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 203 RELSEQ---VCLH-QDYHHARFRSILVSGGSRIRPQEDSL-NNAIDMVVGTPGR---ILQHIEEGNMVyGDIAYLVLDEA 274
Cdd:cd17960 73 RELATQiyeVLQSfLEHHLPKLKCQLLIGGTNVEEDVKKFkRNGPNILVGTPGRleeLLSRKADKVKV-KSLEVLVLDEA 151
|
170
....*....|....*....
gi 4538903 275 DTMFDRGFGPEIRKFLAPL 293
Cdd:cd17960 152 DRLLDLGFEADLNRILSKL 170
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
347-459 |
3.41e-29 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 110.76 E-value: 3.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 347 DKLEALLQVLEpsLAKGSKVMVFCNTLNSSRAvDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeGDCPTLVCTDLAA 426
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRK--GKIDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 4538903 427 RGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMG 459
Cdd:pfam00271 76 RGLDLpDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
123-290 |
1.53e-28 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 111.79 E-value: 1.53e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPivqvlsELMREDEANLGKKTKPrRPRTVVLCPT 202
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLP------GFIHLDLQPIPREQRN-GPGVLVLTPT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 203 RELSEQVCLH-QDYHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFDRG 281
Cdd:cd17958 74 RELALQIEAEcSKYSYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMG 153
|
....*....
gi 4538903 282 FGPEIRKFL 290
Cdd:cd17958 154 FEPQIRKIL 162
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
124-290 |
2.46e-28 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 111.30 E-value: 2.46e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 124 MGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELmredeanlgkKTKPRRPRTV-VLCPT 202
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKL----------KFKPRNGTGViIISPT 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 203 RELSEQV-CLHQD---YHHARFRsiLVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIE-EGNMVYGDIAYLVLDEADTM 277
Cdd:cd17942 72 RELALQIyGVAKEllkYHSQTFG--IVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQnTKGFLYKNLQCLIIDEADRI 149
|
170
....*....|...
gi 4538903 278 FDRGFGPEIRKFL 290
Cdd:cd17942 150 LEIGFEEEMRQII 162
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
126-290 |
2.10e-27 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 109.76 E-value: 2.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 126 ALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQvlsELMREDEAnlgKKTKPRRPRTVVLCPTREL 205
Cdd:cd17948 4 ILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQ---RLLRYKLL---AEGPFNAPRGLVITPSREL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 206 SEQVCLHQDYHHARF----RSILvsGGSRIRPQEDSLNNAIDMVVGTPGRILQ----HIEEGNMVYgdiaYLVLDEADTM 277
Cdd:cd17948 78 AEQIGSVAQSLTEGLglkvKVIT--GGRTKRQIRNPHFEEVDILVATPGALSKlltsRIYSLEQLR----HLVLDEADTL 151
|
170
....*....|...
gi 4538903 278 FDRGFGPEIRKFL 290
Cdd:cd17948 152 LDDSFNEKLSHFL 164
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
128-330 |
7.02e-27 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 109.00 E-value: 7.02e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 128 QELNIEvPTEIQCIGIPAV----MERKSV------------VLGSHTGSGKTLAYLLPIVQVLSE------LMREDEANL 185
Cdd:cd17965 25 TDEEIK-PSPIQTLAIKKLlktlMRKVTKqtsneepklevfLLAAETGSGKTLAYLAPLLDYLKRqeqepfEEAEEEYES 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 186 GKKTKprRPRTVVLCPTRELSEQV--CLHQDYHHARFRSILVS---GGSRIRPQEdSLNNAIDMVVGTPGRILQHIEEGN 260
Cdd:cd17965 104 AKDTG--RPRSVILVPTHELVEQVysVLKKLSHTVKLGIKTFSsgfGPSYQRLQL-AFKGRIDILVTTPGKLASLAKSRP 180
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4538903 261 MVYGDIAYLVLDEADTMFDRGFGP---EIRKFLAPLNQHIKVVNEIVsfQAVQKLVDEEFQGIEHLRTSTLHK 330
Cdd:cd17965 181 KILSRVTHLVVDEADTLFDRSFLQdttSIIKRAPKLKHLILCSATIP--KEFDKTLRKLFPDVVRIATPRLHA 251
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
126-296 |
2.27e-25 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 103.14 E-value: 2.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 126 ALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREDEANLGkktkprrprTVVLCPTREL 205
Cdd:cd17941 4 GLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLG---------ALIISPTREL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 206 SEQV--CLHQDYHHARFRSILVSGGSRIRPQEDSLnNAIDMVVGTPGRILQHIEEG-NMVYGDIAYLVLDEADTMFDRGF 282
Cdd:cd17941 75 AMQIfeVLRKVGKYHSFSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETpGFDTSNLQMLVLDEADRILDMGF 153
|
170
....*....|....
gi 4538903 283 GPEIRKFLAPLNQH 296
Cdd:cd17941 154 KETLDAIVENLPKS 167
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
123-287 |
3.60e-25 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 102.80 E-value: 3.60e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLP-IVQVLSELMRED-EANLGkktkprrPRTVVLC 200
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPlIMFALEQEKKLPfIKGEG-------PYGLIVC 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 201 PTRELS-------EQVCLH-QDYHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLD 272
Cdd:cd17951 74 PSRELArqtheviEYYCKAlQEGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLD 153
|
170
....*....|....*
gi 4538903 273 EADTMFDRGFGPEIR 287
Cdd:cd17951 154 EADRMIDMGFEEDIR 168
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
114-293 |
9.28e-24 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 98.52 E-value: 9.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredeanlgkKTKPRR 193
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI-------------DPKKDV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQVC--LHQDYHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVL 271
Cdd:cd17940 68 IQALILVPTRELALQTSqvCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVL 147
|
170 180
....*....|....*....|..
gi 4538903 272 DEADTMFDRGFGPEIRKFLAPL 293
Cdd:cd17940 148 DEADKLLSQDFQPIIEKILNFL 169
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
133-332 |
1.30e-23 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 98.00 E-value: 1.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 133 EVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVqvlselMRedeanlgKKTKPRRPRTVVLCPTRELSEQVclh 212
Cdd:cd17962 11 EVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVI------IR-------CLTEHRNPSALILTPTRELAVQI--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 213 QDYHHA------RFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFDRGFGPEI 286
Cdd:cd17962 75 EDQAKElmkglpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQV 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 4538903 287 RKFLaplnQHIKVVNEIVSFQAVQKlvdeefQGIEHLRTSTLHKKI 332
Cdd:cd17962 155 LDIL----ENISHDHQTILVSATIP------RGIEQLAGQLLQNPV 190
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
138-290 |
5.56e-23 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 96.46 E-value: 5.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 138 IQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredEANLGKKTKPRRPRTVVLCPTRELSEQVClhQDYHH 217
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKL-------QEDQQPRKRGRAPKVLVLAPTRELANQVT--KDFKD 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4538903 218 ARfRSILVS---GGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFDRGFGPEIRKFL 290
Cdd:cd17944 87 IT-RKLSVAcfyGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEIL 161
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
381-459 |
1.51e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 88.42 E-value: 1.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 381 HYLSENQISTVNYHGEVPAEQRVENLKKFKdeEGDCPTLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMG 459
Cdd:smart00490 5 ELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLpGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
116-300 |
6.35e-21 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 90.46 E-value: 6.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 116 ELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREDEAnlgkktkprrpr 195
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQA------------ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 196 tVVLCPTRELSEQVclhqdyhHARFRSI---------LVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDI 266
Cdd:cd17939 69 -LVLAPTRELAQQI-------QKVVKALgdymgvkvhACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKI 140
|
170 180 190
....*....|....*....|....*....|....
gi 4538903 267 AYLVLDEADTMFDRGFGPEIRKFLAPLNQHIKVV 300
Cdd:cd17939 141 KMFVLDEADEMLSRGFKDQIYDIFQFLPPETQVV 174
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
114-300 |
8.49e-20 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 87.50 E-value: 8.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREDEAnlgkktkprr 193
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQA---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 prtVVLCPTRELSEQ----VCLHQDYHHARFRSILvsGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYL 269
Cdd:cd18046 71 ---LVLAPTRELAQQiqkvVMALGDYMGIKCHACI--GGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMF 145
|
170 180 190
....*....|....*....|....*....|.
gi 4538903 270 VLDEADTMFDRGFGPEIRKFLAPLNQHIKVV 300
Cdd:cd18046 146 VLDEADEMLSRGFKDQIYDIFQKLPPDTQVV 176
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
114-279 |
2.28e-19 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 86.24 E-value: 2.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredeanlgkKTKPRR 193
Cdd:cd17950 4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL-------------EPVDGQ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQVClhQDYhhARFRSIL-------VSGGSRIRPQEDSLNNAI-DMVVGTPGRILQHIEEGNMVYGD 265
Cdd:cd17950 71 VSVLVICHTRELAFQIS--NEY--ERFSKYMpnvktavFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSH 146
|
170
....*....|....
gi 4538903 266 IAYLVLDEADTMFD 279
Cdd:cd17950 147 VKHFVLDECDKMLE 160
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
114-299 |
1.19e-17 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 81.36 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 114 FQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREdeanlgkktkprr 193
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRE------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQ---VCLHQDyHHARFRSILVSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIEEGNMVYGDIAYLV 270
Cdd:cd18045 68 TQALILSPTRELAVQiqkVLLALG-DYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLV 146
|
170 180 190
....*....|....*....|....*....|..
gi 4538903 271 LDEADTMFDRGFGPEIR---KFLAPLNQHIKV 299
Cdd:cd18045 147 LDEADEMLNKGFKEQIYdvyRYLPPATQVVLV 178
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
119-300 |
3.82e-17 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 79.54 E-value: 3.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 119 LSEEVMGALQELNIEVPTEIQCIGIPAVME--RKSVVLGSHTGSGKTLAYllpivqVLSELMREDEANlgkktkpRRPRT 196
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSdpPENLIAQSQSGTGKTAAF------VLAMLSRVDPTL-------KSPQA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 197 VVLCPTRELSEQ---VCLHQdyhhARFRSILVsgGSRIRPQEDSLNNAID--MVVGTPGRILQHIEEGNMVYGDIAYLVL 271
Cdd:cd17963 68 LCLAPTRELARQigeVVEKM----GKFTGVKV--ALAVPGNDVPRGKKITaqIVIGTPGTVLDWLKKRQLDLKKIKILVL 141
|
170 180 190
....*....|....*....|....*....|
gi 4538903 272 DEADTMFD-RGFGPEIRKFLAPLNQHIKVV 300
Cdd:cd17963 142 DEADVMLDtQGHGDQSIRIKRMLPRNCQIL 171
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
123-282 |
5.29e-17 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 79.98 E-value: 5.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIE---------VPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSelmredeanlgkKTKPRR 193
Cdd:cd17956 1 LLKNLQNNGITsafpvqaavIPWLLPSSKSTPPYRPGDLCVSAPTGSGKTLAYVLPIVQALS------------KRVVPR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 194 PRTVVLCPTRELSEQVC--LHQDYHHARFRSILVSGGSRIRPQEDSL--------NNAIDMVVGTPGRILQHIEEG-NMV 262
Cdd:cd17956 69 LRALIVVPTKELVQQVYkvFESLCKGTGLKVVSLSGQKSFKKEQKLLlvdtsgryLSRVDILVATPGRLVDHLNSTpGFT 148
|
170 180
....*....|....*....|
gi 4538903 263 YGDIAYLVLDEADTMFDRGF 282
Cdd:cd17956 149 LKHLRFLVIDEADRLLNQSF 168
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
123-300 |
3.80e-16 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 76.53 E-value: 3.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 123 VMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLselmredeanlgkKTKPRRPRTVVLCPT 202
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESL-------------DLERRHPQVLILAPT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 203 RELSEQV--CLHQDYHHAR-FRSILVSGGSRIRPQEDSLNNAiDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEADTMFD 279
Cdd:cd17943 68 REIAVQIhdVFKKIGKKLEgLKCEVFIGGTPVKEDKKKLKGC-HIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLME 146
|
170 180
....*....|....*....|.
gi 4538903 280 RGFGPEIRKFLAPLNQHIKVV 300
Cdd:cd17943 147 GSFQKDVNWIFSSLPKNKQVI 167
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
158-457 |
4.70e-14 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 74.68 E-value: 4.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 158 TGSGKTLayllpivqVLSELMREdeanlgkktKPRRPRTVVLCPTRELSEQvcLHQDYHHArFRSILVSGGSR------- 230
Cdd:COG1061 109 TGTGKTV--------LALALAAE---------LLRGKRVLVLVPRRELLEQ--WAEELRRF-LGDPLAGGGKKdsdapit 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 231 --------IRPQEDSLNNAIDMVV-------GTPG--RILQHI------------------EEGNMVYGDIAY-LVLDEA 274
Cdd:COG1061 169 vatyqslaRRAHLDELGDRFGLVIideahhaGAPSyrRILEAFpaayrlgltatpfrsdgrEILLFLFDGIVYeYSLKEA 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 275 dtmfdrgfgpEIRKFLAPlnqhIKVVNEIVSFQAVQKLVDEEfqgiehlrTSTLHKKIANarhdfiklsGGEDKLEALLQ 354
Cdd:COG1061 249 ----------IEDGYLAP----PEYYGIRVDLTDERAEYDAL--------SERLREALAA---------DAERKDKILRE 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 355 VLEpSLAKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDeeGDCPTLVCTDLAARGLDL-DV 433
Cdd:COG1061 298 LLR-EHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRD--GELRILVTVDVLNEGVDVpRL 374
|
330 340
....*....|....*....|....
gi 4538903 434 DHVVMFDFPKNSIDYLHRTGRTAR 457
Cdd:COG1061 375 DVAILLRPTGSPREFIQRLGRGLR 398
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
348-461 |
5.38e-14 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 68.66 E-value: 5.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 348 KLEALLQVLEPSLAKGSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDEEGDCPTLVCTDLAAR 427
Cdd:cd18793 12 KLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAGGV 91
|
90 100 110
....*....|....*....|....*....|....*.
gi 4538903 428 GLDL-DVDHVVMFDFPKN-SIDyLHRTGRTARMGAK 461
Cdd:cd18793 92 GLNLtAANRVILYDPWWNpAVE-EQAIDRAHRIGQK 126
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
150-297 |
1.32e-12 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 65.12 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 150 KSVVLGSHTGSGKTLAYLLPIVQVLSElmredeanlgkktkpRRPRTVVLCPTRELSEQvclhqdyHHARFRSIL----- 224
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLK---------------KGKKVLVLVPTKALALQ-------TAERLRELFgpgir 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 225 ---VSGGSRIRPQEDSLNNAIDMVVGTPGRILQHIE-EGNMVYGDIAYLVLDEADTMFDRGFG-----PEIRKFLAPLNQ 295
Cdd:cd00046 60 vavLVGGSSAEEREKNKLGDADIIIATPDMLLNLLLrEDRLFLKDLKLIIVDEAHALLIDSRGalildLAVRKAGLKNAQ 139
|
..
gi 4538903 296 HI 297
Cdd:cd00046 140 VI 141
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
307-455 |
2.29e-11 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 66.02 E-value: 2.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 307 QAVQKLVDEEFQGIEHLRTS-------TLHKKIAN----ARHDFIKLSGGEDKLEALLQVLEPSLAKGSKVMVFC---NT 372
Cdd:COG0553 482 EAVLEYLRRELEGAEGIRRRglilaalTRLRQICShpalLLEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSqftDT 561
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 373 LnssRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDEEGdCPT-LVCTDLAARGLDL-DVDHVVMFDFPKN------ 444
Cdd:COG0553 562 L---DLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPE-APVfLISLKAGGEGLNLtAADHVIHYDLWWNpaveeq 637
|
170
....*....|.
gi 4538903 445 SIDYLHRTGRT 455
Cdd:COG0553 638 AIDRAHRIGQT 648
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
348-461 |
5.92e-11 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 64.75 E-value: 5.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 348 KLEALLQVLEPSLAK--GSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAE--------QRVENLKKFKDeeGDCP 417
Cdd:COG1111 336 KLSKLREILKEQLGTnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQASKEgdkgltqkEQIEILERFRA--GEFN 413
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 4538903 418 TLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARMGAK 461
Cdd:COG1111 414 VLVATSVAEEGLDIpEVDLVIFYEPVPSEIRSIQRKGRTGRKREG 458
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
111-279 |
1.29e-09 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 58.49 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 111 VENFQELGLSEEVMGALQELNIEVPTEIQCIGIPAVMER--KSVVLGSHTGSGKTLAYllpivqVLSELMREDeanlgkk 188
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAF------VLAMLSRVD------- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 189 TKPRRPRTVVLCPTRELSEQV----------CLHQDYHHArFRSILVSGGSRIRPQedslnnaidMVVGTPGRILQHIEE 258
Cdd:cd18048 84 ALKLYPQCLCLSPTFELALQTgkvveemgkfCVGIQVIYA-IRGNRPGKGTDIEAQ---------IVIGTPGTVLDWCFK 153
|
170 180
....*....|....*....|..
gi 4538903 259 GNMV-YGDIAYLVLDEADTMFD 279
Cdd:cd18048 154 LRLIdVTNISVFVLDEADVMIN 175
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
118-233 |
1.33e-09 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 60.62 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 118 GLSEEVMGALQELNIEVPTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPivqVLSELMREdeanlgkktkpRRPRTV 197
Cdd:COG1205 40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLP---VLEALLED-----------PGATAL 105
|
90 100 110
....*....|....*....|....*....|....*.
gi 4538903 198 VLCPTRELSeqvclhQDyHHARFRSILVSGGSRIRP 233
Cdd:COG1205 106 YLYPTKALA------RD-QLRRLRELAEALGLGVRV 134
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
136-281 |
4.46e-09 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 55.73 E-value: 4.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 136 TEIQCIGIPAVM-ERKSVVLGSHTGSGKTLAYLLPIVQVLSELMRedeanlgkktkprrpRTVVLCPTRELSEQVC--LH 212
Cdd:cd17921 3 NPIQREALRALYlSGDSVLVSAPTSSGKTLIAELAILRALATSGG---------------KAVYIAPTRALVNQKEadLR 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4538903 213 QDYHHARFRSILVSGGSRIRPQEDSLNnaiDMVVGTPGR---ILQHIEEGNMVygDIAYLVLDEADTMFD--RG 281
Cdd:cd17921 68 ERFGPLGKNVGLLTGDPSVNKLLLAEA---DILVATPEKldlLLRNGGERLIQ--DVRLVVVDEAHLIGDgeRG 136
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
158-437 |
6.86e-08 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 55.09 E-value: 6.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 158 TGSGKTLAYLLPIvqvlselmredeANLGKKTKPRRpRTVVLcPTRELSEQvcLHQDY----------HHARFRSILVSG 227
Cdd:COG1203 156 TGGGKTEAALLFA------------LRLAAKHGGRR-IIYAL-PFTSIINQ--TYDRLrdlfgedvllHHSLADLDLLEE 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 228 GSRIRPQEDSLNNAI-----DMVVGTPGRILQHIEEG----NMVYGDIAY--LVLDEADtMFDRGFGPEIRKFLAPL-NQ 295
Cdd:COG1203 220 EEEYESEARWLKLLKelwdaPVVVTTIDQLFESLFSNrkgqERRLHNLANsvIILDEVQ-AYPPYMLALLLRLLEWLkNL 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 296 HIKVVneIVS-----------FQAVQKLVDEEFQGIEHLRTSTLHKkianarhdfIKLSGGEDKLEALLQVLEPSLAKGS 364
Cdd:COG1203 299 GGSVI--LMTatlppllreelLEAYELIPDEPEELPEYFRAFVRKR---------VELKEGPLSDEELAELILEALHKGK 367
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4538903 365 KVMVFCNTLNSSRAVDHYLSE--NQISTVNYHGEVPAEQRVENLKKFKD--EEGDCPTLVCTDLAARGLDLDVDHVV 437
Cdd:COG1203 368 SVLVIVNTVKDAQELYEALKEklPDEEVYLLHSRFCPADRSEIEKEIKErlERGKPCILVSTQVVEAGVDIDFDVVI 444
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
145-276 |
4.03e-07 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 50.28 E-value: 4.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 145 AVMERKSVVLGSHTGSGKTLAYLLPIVQvlsELMREdeanlgkktkpRRPRTVVLCPTRELSeqvclhQDyHHARFRSIL 224
Cdd:cd17923 11 AARAGRSVVVTTGTASGKSLCYQLPILE---ALLRD-----------PGSRALYLYPTKALA------QD-QLRSLRELL 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4538903 225 VSGGSRIRPQ-----------EDSLNNAIDMVVGTPGR----ILQHIEEGNMVYGDIAYLVLDEADT 276
Cdd:cd17923 70 EQLGLGIRVAtydgdtpreerRAIIRNPPRILLTNPDMlhyaLLPHHDRWARFLRNLRYVVLDEAHT 136
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
348-457 |
6.88e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 48.51 E-value: 6.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 348 KLEALLQVL-----EPSLAKGSKVMVFCNTLNSSRAVDHYLSEN--QISTVNYHGEVPAE--------QRVENLKKFKDE 412
Cdd:cd18801 10 KLEKLEEIVkehfkKKQEGSDTRVIIFSEFRDSAEEIVNFLSKIrpGIRATRFIGQASGKsskgmsqkEQKEVIEQFRKG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 4538903 413 EGDcpTLVCTDLAARGLDL-DVDHVVMFDFPKNSIDYLHRTGRTAR 457
Cdd:cd18801 90 GYN--VLVATSIGEEGLDIgEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
419-457 |
3.16e-06 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 45.00 E-value: 3.16e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 4538903 419 LVCTDLAARGLD-LDVDHVVMFDFPKNSIDYLHRTGRTAR 457
Cdd:cd18785 26 LVATNVLGEGIDvPSLDTVIFFDPPSSAASYIQRVGRAGR 65
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
348-457 |
4.07e-06 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 49.49 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 348 KLEALLQVLEPSLAK--GSKVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAE--------QRVENLKKFKDEEGDCp 417
Cdd:PRK13766 348 KLEKLREIVKEQLGKnpDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQASKDgdkgmsqkEQIEILDKFRAGEFNV- 426
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 4538903 418 tLVCTDLAARGLDL-DVDHVVMFDfPKNS-IDYLHRTGRTAR 457
Cdd:PRK13766 427 -LVSTSVAEEGLDIpSVDLVIFYE-PVPSeIRSIQRKGRTGR 466
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
269-461 |
6.08e-06 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 48.19 E-value: 6.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 269 LVLDEADTmfdrgFGPEIRKFLAPLNQHIKVVNE--IVSFQAVQKLVDEEFQGIEHLRTSTLHKKIANARHDFIKLSGGE 346
Cdd:cd09639 127 LIFDEVHF-----YDEYTLALILAVLEVLKDNDVpiLLMSATLPKFLKEYAEKIGYVEENEPLDLKPNERAPFIKIESDK 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 347 DKLEALLQVLEPSLAKGSKVMVFCNTLNSSRAVDHYLSE--NQISTVNYHGEVPAEQRVENLKKFKDEEGDCPT--LVCT 422
Cdd:cd09639 202 VGEISSLERLLEFIKKGGSVAIIVNTVDRAQEFYQQLKEkgPEEEIMLIHSRFTEKDRAKKEAELLLEFKKSEKfvIVAT 281
|
170 180 190
....*....|....*....|....*....|....*....
gi 4538903 423 DLAARGLDLDVDHVVMFDFPKNSIdyLHRTGRTARMGAK 461
Cdd:cd09639 282 QVIEASLDISVDVMITELAPIDSL--IQRLGRLHRYGEK 318
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
368-459 |
8.27e-06 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 45.28 E-value: 8.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 368 VFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKdeEGDCPTLVCTDLAARGLD-LDVDHVVMFDFPKNSI 446
Cdd:cd18794 35 IYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWL--RDKIQVIVATVAFGMGIDkPDVRFVIHYSLPKSME 112
|
90
....*....|...
gi 4538903 447 DYLHRTGRTARMG 459
Cdd:cd18794 113 SYYQESGRAGRDG 125
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
145-274 |
5.32e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 44.18 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 145 AVMERKS-VVLGshTGSGKTLayllpiVQVLseLMREdEANLGKKTKPRRPRTVVLCPTRELSEQVC----LHQDYHHAR 219
Cdd:cd18034 13 AALKRNTiVVLP--TGSGKTL------IAVM--LIKE-MGELNRKEKNPKKRAVFLVPTVPLVAQQAeairSHTDLKVGE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 4538903 220 FRSIL-VSGGSRIRPQEDSLNNaiDMVVGTPGRILQHIEEGNMVYGDIAYLVLDEA 274
Cdd:cd18034 82 YSGEMgVDKWTKERWKEELEKY--DVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
346-454 |
6.10e-05 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 45.52 E-value: 6.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 346 EDKLEALLQVLEpSLAKGSkVMVFCNTLNSSRAVDHYLSENQISTVNYHGEVPAEQRVENLKKFKDEEGDCptLVCT--- 422
Cdd:COG0514 215 DDKLAQLLDFLK-EHPGGS-GIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDV--IVATiaf 290
|
90 100 110
....*....|....*....|....*....|....*.
gi 4538903 423 ----DLAargldlDVDHVVMFDFPKNSIDYLHRTGR 454
Cdd:COG0514 291 gmgiDKP------DVRFVIHYDLPKSIEAYYQEIGR 320
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
135-206 |
6.23e-05 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 45.86 E-value: 6.23e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4538903 135 PTEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIvqvLSELMREDEanlgKKTKPRRPRTVVLCPTRELS 206
Cdd:COG1201 25 PTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPA---LDELARRPR----PGELPDGLRVLYISPLKALA 89
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
338-472 |
5.76e-04 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 40.33 E-value: 5.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4538903 338 DFIKLSGGEDKLEALLQVLEpSLAKGSKVMVFCNTLNSSRAVDHYL------SENQISTVNYHGEVPAEQRVENLKKFKD 411
Cdd:cd18796 14 PEIFPWAGESGADAYAEVIF-LLERHKSTLVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAALKR 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4538903 412 eeGDCPTLVCT---DLaarGLDL-DVDHVVMFDFPKNSIDYLHRTGRTARmgakGLFHTSRLSLV 472
Cdd:cd18796 93 --GDLKVVVATsslEL---GIDIgDVDLVIQIGSPKSVARLLQRLGRSGH----RPGAASKGRLV 148
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
136-208 |
1.62e-03 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 40.03 E-value: 1.62e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4538903 136 TEIQCIGIPAVME-RKSVVLGSHTGSGKTLAYLLPIVQVLSELMREDEANlgkktkprrPRTVVLCPTRELSEQ 208
Cdd:cd18023 3 NRIQSEVFPDLLYsDKNFVVSAPTGSGKTVLFELAILRLLKERNPLPWGN---------RKVVYIAPIKALCSE 67
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
136-182 |
5.19e-03 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 39.48 E-value: 5.19e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 4538903 136 TEIQCIGIPAVMERKSVVLGSHTGSGKTLAYLLPIVQVLSELMREDE 182
Cdd:PRK13767 34 TPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRLGREGE 80
|
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