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Conserved domains on  [gi|1370340|emb|CAA97865|]
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CDC60 [Saccharomyces cerevisiae]

Protein Classification

nucleotidyl transferase family protein; glutamine/glutamate--tRNA ligase( domain architecture ID 11489131)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases| glutamine/glutamate--tRNA ligase catalyzes the attachment of glutamate or glutamine to tRNA(Glu) or tRNA(Gln); in some organisms, the non-discriminating form of glutamate--tRNA ligase aminoacylates both tRNA(Glu) and tRNA(Gln) with Glu, which is converted to Gln when appropriate by a transamidation enzyme

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
leuS_arch TIGR00395
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ...
 17-1088 0e+00

leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]


:

Pssm-ID: 273056 [Multi-domain]  Cd Length: 938  Bit Score: 1453.49  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      17 IAIEKKYQKIWAEEHQFEIDapsiedepitMDSEElhrtypKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEAD----------PDDRE------KFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKN 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      97 ALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPaeeeeikeetpaekdhedvtkfkakkskaaakkgrgkyqfeiml 176
Cdd:TIGR00395   65 VLFPLGFHVTGTPILGLAELIKRRDELTIKNYTEVH-------------------------------------------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     177 qlGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSE 256
Cdd:TIGR00395  101 --AIPREELLKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCP 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     257 KDGQACMDHDRQSGEGVTPQEYIGVKIEALEFAddaakiidsssdldkskkFYFVAATLRPETMYGQTCCFVSPTIEYGI 336
Cdd:TIGR00395  177 KDGNPVEDHDLLSGEGVTIVEYILIKFELEDGA------------------FYFVAATLRPETVYGVTNCWVNPTITYVI 238

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     337 FDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNS 416
Cdd:TIGR00395  239 AEVGGEKWITSKEAFENLSYQKLK-----YKPIEEVPGKQFIGKKVHNP-VVGPEVPILPAEFVDTTKGTGVVMSVPAHA 312

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     417 PDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYG 496
Cdd:TIGR00395  313 PDDYIALEDLLHDPEYLGIKPVVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIYN 392

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     497 --PYKGEKVEQAKNKVKADMIAAGEAFVYNEP-ESQVMSRSGDDCIVS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPE 572
Cdd:TIGR00395  393 ipPYKGMKVSEAKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKvVEDQWFVKYSDESWKELAHECLEGMRIIPEE 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     573 VKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEigplgisadQMTDEVFDY 652
Cdd:TIGR00395  473 VKNAFEGKIDWLKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDYYGNE---------QMTDEFFDY 543

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     653 IFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSK 732
Cdd:TIGR00395  544 IFLGKGDVKNTNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPEKFWPRGIVVNGYVMLEGKKMSK 623

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     733 STGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHE 812
Cdd:TIGR00395  624 SKGNVLTLEQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEEITKESNLETGEETSFIDRWLESR 703

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     813 MNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVlGNQTSV 892
Cdd:TIGR00395  704 MNAAIKETYEAMENFQTRKAVKYALFDLQADVDWYRRRGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEV-GNEGFV 782

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     893 QNAKFPRASKP-VDKGVLAALDYLRNLQRSIREgegqalkkkkgkSAEIDASKPVKLTLLISEsfpEWQSQCVEIVRKLF 971
Cdd:TIGR00395  783 SLAKFPEASEPaVDKEVEAAEEYLRNLVRDIQE------------IAKIDASKPKRVYLYTSE---DWKSQCLKIVAELF 847

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     972 SEQTLDDNKKVREhiEPKEMKRAMPFISLLKQRLANEKPEDvferELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFP 1051
Cdd:TIGR00395  848 GEDTGEDMKKVME--EPEERKRGKEVISLVKQIIKDEKKED----ELQISEIEVLKAAARFIKKEVGALVIIEFSADSFP 921

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 1370340    1052 YGAKTgkdiftgeeveippvtkiveNAVPGNPGVVFQ 1088
Cdd:TIGR00395  922 ENKKR--------------------NAVPGKPAIYLE 938
 
Name Accession Description Interval E-value
leuS_arch TIGR00395
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ...
 17-1088 0e+00

leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273056 [Multi-domain]  Cd Length: 938  Bit Score: 1453.49  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      17 IAIEKKYQKIWAEEHQFEIDapsiedepitMDSEElhrtypKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEAD----------PDDRE------KFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKN 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      97 ALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPaeeeeikeetpaekdhedvtkfkakkskaaakkgrgkyqfeiml 176
Cdd:TIGR00395   65 VLFPLGFHVTGTPILGLAELIKRRDELTIKNYTEVH-------------------------------------------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     177 qlGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSE 256
Cdd:TIGR00395  101 --AIPREELLKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCP 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     257 KDGQACMDHDRQSGEGVTPQEYIGVKIEALEFAddaakiidsssdldkskkFYFVAATLRPETMYGQTCCFVSPTIEYGI 336
Cdd:TIGR00395  177 KDGNPVEDHDLLSGEGVTIVEYILIKFELEDGA------------------FYFVAATLRPETVYGVTNCWVNPTITYVI 238

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     337 FDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNS 416
Cdd:TIGR00395  239 AEVGGEKWITSKEAFENLSYQKLK-----YKPIEEVPGKQFIGKKVHNP-VVGPEVPILPAEFVDTTKGTGVVMSVPAHA 312

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     417 PDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYG 496
Cdd:TIGR00395  313 PDDYIALEDLLHDPEYLGIKPVVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIYN 392

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     497 --PYKGEKVEQAKNKVKADMIAAGEAFVYNEP-ESQVMSRSGDDCIVS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPE 572
Cdd:TIGR00395  393 ipPYKGMKVSEAKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKvVEDQWFVKYSDESWKELAHECLEGMRIIPEE 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     573 VKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEigplgisadQMTDEVFDY 652
Cdd:TIGR00395  473 VKNAFEGKIDWLKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDYYGNE---------QMTDEFFDY 543

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     653 IFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSK 732
Cdd:TIGR00395  544 IFLGKGDVKNTNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPEKFWPRGIVVNGYVMLEGKKMSK 623

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     733 STGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHE 812
Cdd:TIGR00395  624 SKGNVLTLEQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEEITKESNLETGEETSFIDRWLESR 703

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     813 MNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVlGNQTSV 892
Cdd:TIGR00395  704 MNAAIKETYEAMENFQTRKAVKYALFDLQADVDWYRRRGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEV-GNEGFV 782

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     893 QNAKFPRASKP-VDKGVLAALDYLRNLQRSIREgegqalkkkkgkSAEIDASKPVKLTLLISEsfpEWQSQCVEIVRKLF 971
Cdd:TIGR00395  783 SLAKFPEASEPaVDKEVEAAEEYLRNLVRDIQE------------IAKIDASKPKRVYLYTSE---DWKSQCLKIVAELF 847

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     972 SEQTLDDNKKVREhiEPKEMKRAMPFISLLKQRLANEKPEDvferELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFP 1051
Cdd:TIGR00395  848 GEDTGEDMKKVME--EPEERKRGKEVISLVKQIIKDEKKED----ELQISEIEVLKAAARFIKKEVGALVIIEFSADSFP 921

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 1370340    1052 YGAKTgkdiftgeeveippvtkiveNAVPGNPGVVFQ 1088
Cdd:TIGR00395  922 ENKKR--------------------NAVPGKPAIYLE 938
PLN02959 PLN02959
aminoacyl-tRNA ligase
 8-1087 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 1174.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      8 ENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPItmdseelhrtyPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSI 87
Cdd:PLN02959    7 KSTARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPPKPG-----------EKFFGNFPYPYMNGLLHLGHAFSLSKLEFAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     88 GFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGkNFDNVPAEEEEIKEETPAEKDHEDV-----TKFKAKKSKAA 162
Cdd:PLN02959   76 AYHRLRGANVLLPFAFHCTGMPIKASADKLAREIQQYG-NPPVFPEEDEDEAAAVAAAKAEAEAaaappDKFKGKKSKAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    163 AKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAA 242
Cdd:PLN02959  155 AKSGTQKYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    243 GKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEAL-EFADDAAKIidsssdldKSKKFYFVAATLRPETMY 321
Cdd:PLN02959  235 GKIVKDKRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLpPFPGKLKAL--------EGKKVFLAAATLRPETMY 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    322 GQTCCFVSPTIEYGIFDAGDS-YFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETV 400
Cdd:PLN02959  307 GQTNCWVLPDGKYGAYEINDTeVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTI 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    401 IATKGTGVVTCVPSNSPDDYITTKDLLHKP---EYYGIKPEWID-HEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLL 476
Cdd:PLN02959  387 LTDKGTGVVTSVPSDSPDDYMALSDLKAKPalrAKYGVKDEWVLpFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKL 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    477 AEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWK 556
Cdd:PLN02959  467 AEAKRLTYLKGFTDGTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWK 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    557 KQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFK-DYYGNEI 635
Cdd:PLN02959  547 KKAEKCLSKMNLYSDETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGgDMYGKDK 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    636 GPlgISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPK 715
Cdd:PLN02959  627 SS--IKPEQMTDEVWDFVFCGGPLPKSSDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAEEHWPR 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    716 GIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITK-ES 794
Cdd:PLN02959  705 GFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAaES 784

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    795 NLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGV--MHKDLIARYIETQALLLAP 872
Cdd:PLN02959  785 SLRTGPPSTYADRVFENEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRLSCGSggMNRDLVWRFMDVQTRLITP 864

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    873 IAPHFAEYIYREVLGNQTSVQNAKFPRASKPvDKGVLAALDYLRNLQRSIREGEGQALK--KKKGKSAEIDASKPVKLTL 950
Cdd:PLN02959  865 ICPHYAEHVWREILKKEGFAVTAGWPVAGEP-DLTLKRANKYLQDSIVSFRKLLQKQLAgsKKAKKGGAPVTLPEKKLAG 943

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    951 LI--SESFPEWQSQCVEIVRKLFSEQT------------LDDNKKVREHIEPKEMKRAMPFISlLKQRLANEKPEDVFER 1016
Cdd:PLN02959  944 LIyvAEKYDGWKEECLRILQSKFDSQSrtfapdaeileaLKESSVGQEANFKQVQKLCMPFVK-FKKDEAIAVGPQALDL 1022

                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370340   1017 ELQFSEIDTVKaaaRNVKKAAQALKIAEFSAISfpyGAKTGKDIFTGEEVEIPPVTkiveNAVPGNPGVVF 1087
Cdd:PLN02959 1023 KLPFDEIEVLQ---ENLELIKRQLGLEEVEILS---ASDPDAVAKAGAHASLLKQN----PPSPGNPVAIF 1083
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 542-770 2.02e-75

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 251.40  E-value: 2.02e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   542 LEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDwlknwaVCRTYGLGTRLPWdeKYLVESLSDSTIYQSFYT 621
Cdd:cd00812  128 LLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARYT 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   622 IAHLLFKDYYGneigplgisadqmtdevfdyifqhqddvkntniplpALQKLRREFEYFYPLDVSISGKDLIPNHLTFFI 701
Cdd:cd00812  200 DAHNLEQPYEG------------------------------------DLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSR 243

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370340   702 YTHVALFPKK----FWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDtvEDANFDE 770
Cdd:cd00812  244 FNHKALFDEGlvtdEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 22-769 1.07e-27

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 119.82  E-value: 1.07e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      22 KYQKIWAEEHQFEIdapsiedepitmdSEELHRTYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPL 101
Cdd:pfam00133    1 QIYEFWDEQGYFKP-------------ELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVP 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     102 GFHCTGMPIlacadKLKREAELfgknfdnvpaeeeeikeetpAEKDHEDVtkfkakkskaaAKKGRGKYqfeimlqlgip 181
Cdd:pfam00133   68 GWDHHGLPT-----EQVVEKKL--------------------GIKEKKTR-----------HKYGREEF----------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     182 REEIikfadaKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQA 261
Cdd:pfam00133  101 REKC------REWKMEYADEIRKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTA 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     262 CMDhdrqsgegvtpqeyigvkIEAlEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIfdaGD 341
Cdd:pfam00133  173 LSN------------------LEV-EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI---TG 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     342 SYFITTERAFKNMsYQKLTPkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYI 421
Cdd:pfam00133  231 EGYILAEALLKSL-YKKGTD----KKILEDFRGKELEGKEAIHP-FVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYE 304

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     422 TTKdllhkpeyygikpewiDHEIVPIMHTEKYGDLTAKAiveekkiqspkdknllaeakkiaykedyytgtmiyGPYKGE 501
Cdd:pfam00133  305 VGQ----------------RHNLEVINPVDDDGTFTEEA-----------------------------------PDFQGV 333

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     502 KVEQAKNKVKADMIAAG-----EAFVYNEPESqvmSRSGDDCIVSLEDQWYVDYGEesWKKQAIECLEGMQlFAPEVKNA 576
Cdd:pfam00133  334 YRFDARKKIVELLTEKGlllkiEPFTHSYPFC---WRSGTPIIPRATPQWFVRMDE--LADQALEAVEKVQ-FVPKSGEK 407

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     577 FegVLDWLKN---WAVCRTYGLGTRLP-W-----DEKYLVESLSD--STIYQSFYTIA--HLLFKDYYGNEIGPLgisad 643
Cdd:pfam00133  408 R--YFNWLANiqdWCISRQRWWGHPIPaWvskdtEEVVCRGELFElvAGRFEEEGSIKwlHREAKDKLGYGKGTL----- 480

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     644 QMTDEVFDYIFqhqDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALF---PKKFwpkgIRAN 720
Cdd:pfam00133  481 EQDEDVLDTWF---SSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTgsvPFKN----VLVH 553

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 1370340     721 GHLM-LNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAgDTVEDANFD 769
Cdd:pfam00133  554 GLVRdEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINLS 602
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
 720-900 1.06e-12

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 72.39  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   720 NGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAAR--IAFadAGDTVEDANFDESNANAA---ILRLFNLkewAEEITKES 794
Cdd:COG0495  580 DGVVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRlfEMF--AGPPERDLEWSDSGVEGAyrfLNRVWRL---VVDEAEAL 654

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   795 NLRTGEITDfFDIAFEHEMNALIEKT---YEQY-------ALTNYKNALKYGLFDFQAARDYYREAsgvmhkdliaryIE 864
Cdd:COG0495  655 KLDVADLSE-ADKELRRALHKTIKKVtedIERLrfntaiaALMELVNALYKAKDSGEADRAVLREA------------LE 721

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 1370340   865 TQALLLAPIAPHFAEYIYrEVLGNQTSVQNAKFPRA 900
Cdd:COG0495  722 TLVLLLAPFAPHIAEELW-ERLGHEGSVADAPWPEA 756
 
Name Accession Description Interval E-value
leuS_arch TIGR00395
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ...
 17-1088 0e+00

leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273056 [Multi-domain]  Cd Length: 938  Bit Score: 1453.49  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      17 IAIEKKYQKIWAEEHQFEIDapsiedepitMDSEElhrtypKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEAD----------PDDRE------KFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKN 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      97 ALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPaeeeeikeetpaekdhedvtkfkakkskaaakkgrgkyqfeiml 176
Cdd:TIGR00395   65 VLFPLGFHVTGTPILGLAELIKRRDELTIKNYTEVH-------------------------------------------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     177 qlGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSE 256
Cdd:TIGR00395  101 --AIPREELLKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCP 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     257 KDGQACMDHDRQSGEGVTPQEYIGVKIEALEFAddaakiidsssdldkskkFYFVAATLRPETMYGQTCCFVSPTIEYGI 336
Cdd:TIGR00395  177 KDGNPVEDHDLLSGEGVTIVEYILIKFELEDGA------------------FYFVAATLRPETVYGVTNCWVNPTITYVI 238

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     337 FDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNS 416
Cdd:TIGR00395  239 AEVGGEKWITSKEAFENLSYQKLK-----YKPIEEVPGKQFIGKKVHNP-VVGPEVPILPAEFVDTTKGTGVVMSVPAHA 312

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     417 PDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYG 496
Cdd:TIGR00395  313 PDDYIALEDLLHDPEYLGIKPVVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIYN 392

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     497 --PYKGEKVEQAKNKVKADMIAAGEAFVYNEP-ESQVMSRSGDDCIVS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPE 572
Cdd:TIGR00395  393 ipPYKGMKVSEAKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKvVEDQWFVKYSDESWKELAHECLEGMRIIPEE 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     573 VKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEigplgisadQMTDEVFDY 652
Cdd:TIGR00395  473 VKNAFEGKIDWLKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDYYGNE---------QMTDEFFDY 543

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     653 IFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSK 732
Cdd:TIGR00395  544 IFLGKGDVKNTNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPEKFWPRGIVVNGYVMLEGKKMSK 623

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     733 STGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHE 812
Cdd:TIGR00395  624 SKGNVLTLEQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEEITKESNLETGEETSFIDRWLESR 703

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     813 MNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVlGNQTSV 892
Cdd:TIGR00395  704 MNAAIKETYEAMENFQTRKAVKYALFDLQADVDWYRRRGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEV-GNEGFV 782

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     893 QNAKFPRASKP-VDKGVLAALDYLRNLQRSIREgegqalkkkkgkSAEIDASKPVKLTLLISEsfpEWQSQCVEIVRKLF 971
Cdd:TIGR00395  783 SLAKFPEASEPaVDKEVEAAEEYLRNLVRDIQE------------IAKIDASKPKRVYLYTSE---DWKSQCLKIVAELF 847

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     972 SEQTLDDNKKVREhiEPKEMKRAMPFISLLKQRLANEKPEDvferELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFP 1051
Cdd:TIGR00395  848 GEDTGEDMKKVME--EPEERKRGKEVISLVKQIIKDEKKED----ELQISEIEVLKAAARFIKKEVGALVIIEFSADSFP 921

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 1370340    1052 YGAKTgkdiftgeeveippvtkiveNAVPGNPGVVFQ 1088
Cdd:TIGR00395  922 ENKKR--------------------NAVPGKPAIYLE 938
PLN02959 PLN02959
aminoacyl-tRNA ligase
 8-1087 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 1174.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      8 ENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPItmdseelhrtyPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSI 87
Cdd:PLN02959    7 KSTARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPPKPG-----------EKFFGNFPYPYMNGLLHLGHAFSLSKLEFAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     88 GFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGkNFDNVPAEEEEIKEETPAEKDHEDV-----TKFKAKKSKAA 162
Cdd:PLN02959   76 AYHRLRGANVLLPFAFHCTGMPIKASADKLAREIQQYG-NPPVFPEEDEDEAAAVAAAKAEAEAaaappDKFKGKKSKAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    163 AKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAA 242
Cdd:PLN02959  155 AKSGTQKYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    243 GKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEAL-EFADDAAKIidsssdldKSKKFYFVAATLRPETMY 321
Cdd:PLN02959  235 GKIVKDKRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLpPFPGKLKAL--------EGKKVFLAAATLRPETMY 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    322 GQTCCFVSPTIEYGIFDAGDS-YFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETV 400
Cdd:PLN02959  307 GQTNCWVLPDGKYGAYEINDTeVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTI 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    401 IATKGTGVVTCVPSNSPDDYITTKDLLHKP---EYYGIKPEWID-HEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLL 476
Cdd:PLN02959  387 LTDKGTGVVTSVPSDSPDDYMALSDLKAKPalrAKYGVKDEWVLpFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKL 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    477 AEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWK 556
Cdd:PLN02959  467 AEAKRLTYLKGFTDGTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWK 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    557 KQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFK-DYYGNEI 635
Cdd:PLN02959  547 KKAEKCLSKMNLYSDETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGgDMYGKDK 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    636 GPlgISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPK 715
Cdd:PLN02959  627 SS--IKPEQMTDEVWDFVFCGGPLPKSSDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAEEHWPR 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    716 GIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITK-ES 794
Cdd:PLN02959  705 GFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAaES 784

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    795 NLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGV--MHKDLIARYIETQALLLAP 872
Cdd:PLN02959  785 SLRTGPPSTYADRVFENEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRLSCGSggMNRDLVWRFMDVQTRLITP 864

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    873 IAPHFAEYIYREVLGNQTSVQNAKFPRASKPvDKGVLAALDYLRNLQRSIREGEGQALK--KKKGKSAEIDASKPVKLTL 950
Cdd:PLN02959  865 ICPHYAEHVWREILKKEGFAVTAGWPVAGEP-DLTLKRANKYLQDSIVSFRKLLQKQLAgsKKAKKGGAPVTLPEKKLAG 943

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    951 LI--SESFPEWQSQCVEIVRKLFSEQT------------LDDNKKVREHIEPKEMKRAMPFISlLKQRLANEKPEDVFER 1016
Cdd:PLN02959  944 LIyvAEKYDGWKEECLRILQSKFDSQSrtfapdaeileaLKESSVGQEANFKQVQKLCMPFVK-FKKDEAIAVGPQALDL 1022

                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370340   1017 ELQFSEIDTVKaaaRNVKKAAQALKIAEFSAISfpyGAKTGKDIFTGEEVEIPPVTkiveNAVPGNPGVVF 1087
Cdd:PLN02959 1023 KLPFDEIEVLQ---ENLELIKRQLGLEEVEILS---ASDPDAVAKAGAHASLLKQN----PPSPGNPVAIF 1083
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
 72-1086 0e+00

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 653.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     72 MHAGHCFTlskveFSIG-----FERMNGKRALFPLGFHCTGMPILACADKLKREAELFGKNFDNVpaeeeeikeetpaek 146
Cdd:PRK12300    1 LHVGHGRT-----YTIGdviarYKRMRGYNVLFPMAFHVTGTPILGIAERIARGDPETIELYKSL--------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    147 dhedvtkfkakkskaaakkgrgkyqfeimlqLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanP 226
Cdd:PRK12300   61 -------------------------------YGIPEEELEKFKDPEYIVEYFSEEAKEDMKRIGYSIDWRREFTTTD--P 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    227 YYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEalefaddaakiidsssdldKSK 306
Cdd:PRK12300  108 EYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEEPEIVEYTLIKFE-------------------ESE 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    307 KFYFVAATLRPETMYGQTCCFVSPTIEYGIFDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIhapq 386
Cdd:PRK12300  169 DLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWIVSKEAAEKLSFQDRD-----VEIIEEIKGSELIGKKV---- 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    387 sVYP----ELRILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEYYGIKpewidhEIVPIMHTEKYGDLTAKAIV 462
Cdd:PRK12300  240 -KNPvtgkEVPILPADFVDPDNGTGVVMSVPAHAPYDYVALRDLKKNKELLDVI------EPIPLIEVEGYGEFPAKEVV 312

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    463 EEKKIQSPKDKNLlAEAKKIAYKEDYYTGTMI--YGPYKGEKVEQAKNKVKADMIAAGEAFVYNE-PESQVMSRSGDDCI 539
Cdd:PRK12300  313 EKLGIKSQEDPEL-EEATKEVYRAEFHKGVLKenTGEYAGKPVREAREKITKDLIEKGIADIMYEfSNRPVYCRCGTECV 391

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    540 VS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQS 618
Cdd:PRK12300  392 VKvVKDQWFIDYSDPEWKELAHKALDNMEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPWDEEWIIESLSDSTIYMA 471

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    619 FYTIAHLLfKDYygneigplGISADQMTDEVFDYIFQHQDDV----KNTNIPLPALQKLRREFEYFYPLDVSISGKDLIP 694
Cdd:PRK12300  472 YYTIAHKI-REY--------GIKPEQLTPEFFDYVFLGKGDPeevsKKTGIPKEILEEMREEFLYWYPVDWRHSGKDLIP 542

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    695 NHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNAN 774
Cdd:PRK12300  543 NHLTFFIFNHVAIFPEEKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVE 622

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    775 AAILRlfnLKEWAEEITKESNLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVM 854
Cdd:PRK12300  623 SVRRQ---LERFYELAKELIEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWYLRRVGEA 699

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    855 HKDLIARYIETQALLLAPIAPHFAEYIYrEVLGNQTSVQNAKFPRASK-PVDKGVLAALDYLRNLQRSIREgegqaLKKK 933
Cdd:PRK12300  700 NNKVLREVLEIWIRLLAPFTPHLAEELW-HKLGGEGFVSLEKWPEPDEsKIDEEAELAEEYVKRLIEDIRE-----ILKV 773

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    934 KGKsaeidasKPVKLTLLISesfPEWQSQCVEIVRKLfseqtLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDV 1013
Cdd:PRK12300  774 AKI-------KPKKVYIYVA---PDWKYEVLEIAAEN-----GDVKEAIKELMKDEELRKHGKEVAKLAQKIVKEVLKLD 838

                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370340   1014 FE-RELQFSEIDTVKAaarnVKKAAQALKIAefsaisfpygaktgkdifTGEEVEI-----PPVTKIVENAVPGNPGVV 1086
Cdd:PRK12300  839 KEvRKLILKNIDEEEV----LEEAKDFLEKE------------------LGVEVEIygaddPGKKKKKKKALPLKPAIY 895
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 542-770 2.02e-75

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 251.40  E-value: 2.02e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   542 LEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDwlknwaVCRTYGLGTRLPWdeKYLVESLSDSTIYQSFYT 621
Cdd:cd00812  128 LLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARYT 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   622 IAHLLFKDYYGneigplgisadqmtdevfdyifqhqddvkntniplpALQKLRREFEYFYPLDVSISGKDLIPNHLTFFI 701
Cdd:cd00812  200 DAHNLEQPYEG------------------------------------DLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSR 243

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370340   702 YTHVALFPKK----FWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDtvEDANFDE 770
Cdd:cd00812  244 FNHKALFDEGlvtdEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
 768-885 6.73e-39

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 140.42  E-value: 6.73e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   768 FDESNANAAILRLFNLKEWAEEITKESnlRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYY 847
Cdd:cd07959    1 FREEEANSAILRLERFYELAEELIETE--GELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLDWY 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 1370340   848 REASGV-MHKDLIARYIETQALLLAPIAPHFAEYIYREV 885
Cdd:cd07959   79 RERGGAgMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 58-217 1.90e-32

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 128.90  E-value: 1.90e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    58 KFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKReaelfgknfdnvpaeeee 137
Cdd:cd00812    1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGR------------------ 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   138 ikeetpaekDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLGIPreeiiKFADAKYWLTYFPPLCeSDCTSLGARIDWRR 217
Cdd:cd00812   63 ---------DPEDWTEYNIKKMKEQLKRMGFSYDWRREFTTCDP-----EYYKFTQWLFLKLYEK-GLAYKKEAPVNWCK 127
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
 17-950 6.79e-32

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 134.42  E-value: 6.79e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      17 IAIEKKYQKIWAEEHQFEIDapsiEDEPItmdseelhrtyPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00422    8 HEVEKKWYKKWEKSGFFKPD----GNSNK-----------PPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYN 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      97 ALFPLGFHCTGMPIlacadKLKREAELFGKNfdnvpaeeeeikeetpaeKDHEDVtkfkakkskaaakkGRGKYqfeiml 176
Cdd:TIGR00422   73 VLWLPGTDHAGIAT-----QVKVEKKLGAEG------------------KTKHDL--------------GREEF------ 109

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     177 qlgipREEIIKFADakywltyfpplcESDCT------SLGARIDWRRSFVTTDANPYY---DAFIRWQMNklkaaGKIKF 247
Cdd:TIGR00422  110 -----REKIWEWKE------------ESGGTiknqikRLGASLDWSRERFTMDEGLSKavkEAFVRLYEK-----GLIYR 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     248 GERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEalefaddaakiiDSSSDldkskkfYFVAATLRPETMYGQTCCF 327
Cdd:TIGR00422  168 GEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLA------------NGSKD-------YLVVATTRPETMFGDTAVA 228

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     328 VSPTieygifdagdsyfitTERaFKNMSYQKltpkrgfykpiVTVPgkaFIGTKIhapqsvypelRILPMETVIATKGTG 407
Cdd:TIGR00422  229 VHPE---------------DER-YKHLIGKK-----------VILP---LTGRKI----------PIIADEYVDMEFGTG 268

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     408 VVTCVPSNSPDDYITTKDllHKPEYYGIkpewIDHEivpimhtekyGDLTAKAiveekkiqspkdknllaeakkiayked 487
Cdd:TIGR00422  269 AVKVTPAHDFNDYEWGKR--HNLEFINI----LDED----------GLLNENA--------------------------- 305

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     488 yytgtmiyGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQV--MSRSGDDCIVSLEDQWYVDYgeESWKKQAIECLEG 565
Cdd:TIGR00422  306 --------GKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVgtCWRSGTVVEPLLSKQWFVKV--EKLADKALEAAEE 375

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     566 MQL-FAPevKNAFEGVLDWLKN---WAVCRTYGLGTRLP-WdekYLVEslsdstiyqsfytiahllFKDYYgneIGPLGI 640
Cdd:TIGR00422  376 GEIkFVP--KRMEKRYLNWLRNikdWCISRQLIWGHRIPvW---YCKE------------------CGEVY---VAKEEP 429

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     641 SADQMTDEVFDYIFQHQDDVKNTNI-----PLPAL--QKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFW 713
Cdd:TIGR00422  430 LPDDKTNTGPSVELEQDTDVLDTWFssslwPFSTLgwPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPF 509

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     714 pKGIRANGhlML---NNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFD----ESNA-------NAAILR 779
Cdd:TIGR00422  510 -KEVYIHG--LVrdeQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDwkrvESARnflnklwNASRFV 586

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     780 LFNLKEWAEEITKESNLRtgeitdFFDIAFEHEMNALIEKTYEqyALTNYKNAL------KYGLFDFQaarDYYREASGV 853
Cdd:TIGR00422  587 LMNLSDDLELSGGEEKLS------LADRWILSKLNRTIKEVRK--ALDKYRFAEaakalyEFIWNDFC---DWYIELVKY 655

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     854 -----------MHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRA-SKPVDKGVLAALDYLRNLQRS 921
Cdd:TIGR00422  656 rlyngneaekkAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYPVVdAEFVDEEAEKAFELLKEIIVS 735

                          970       980
                   ....*....|....*....|....*....
gi 1370340     922 IREgegqaLKKKKGksaeIDASKPVKLTL 950
Cdd:TIGR00422  736 IRN-----LKAESN----IPPNAPLKVLL 755
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 22-769 1.07e-27

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 119.82  E-value: 1.07e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340      22 KYQKIWAEEHQFEIdapsiedepitmdSEELHRTYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPL 101
Cdd:pfam00133    1 QIYEFWDEQGYFKP-------------ELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVP 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     102 GFHCTGMPIlacadKLKREAELfgknfdnvpaeeeeikeetpAEKDHEDVtkfkakkskaaAKKGRGKYqfeimlqlgip 181
Cdd:pfam00133   68 GWDHHGLPT-----EQVVEKKL--------------------GIKEKKTR-----------HKYGREEF----------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     182 REEIikfadaKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQA 261
Cdd:pfam00133  101 REKC------REWKMEYADEIRKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTA 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     262 CMDhdrqsgegvtpqeyigvkIEAlEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIfdaGD 341
Cdd:pfam00133  173 LSN------------------LEV-EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI---TG 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     342 SYFITTERAFKNMsYQKLTPkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYI 421
Cdd:pfam00133  231 EGYILAEALLKSL-YKKGTD----KKILEDFRGKELEGKEAIHP-FVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYE 304

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     422 TTKdllhkpeyygikpewiDHEIVPIMHTEKYGDLTAKAiveekkiqspkdknllaeakkiaykedyytgtmiyGPYKGE 501
Cdd:pfam00133  305 VGQ----------------RHNLEVINPVDDDGTFTEEA-----------------------------------PDFQGV 333

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     502 KVEQAKNKVKADMIAAG-----EAFVYNEPESqvmSRSGDDCIVSLEDQWYVDYGEesWKKQAIECLEGMQlFAPEVKNA 576
Cdd:pfam00133  334 YRFDARKKIVELLTEKGlllkiEPFTHSYPFC---WRSGTPIIPRATPQWFVRMDE--LADQALEAVEKVQ-FVPKSGEK 407

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     577 FegVLDWLKN---WAVCRTYGLGTRLP-W-----DEKYLVESLSD--STIYQSFYTIA--HLLFKDYYGNEIGPLgisad 643
Cdd:pfam00133  408 R--YFNWLANiqdWCISRQRWWGHPIPaWvskdtEEVVCRGELFElvAGRFEEEGSIKwlHREAKDKLGYGKGTL----- 480

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     644 QMTDEVFDYIFqhqDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALF---PKKFwpkgIRAN 720
Cdd:pfam00133  481 EQDEDVLDTWF---SSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTgsvPFKN----VLVH 553

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 1370340     721 GHLM-LNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAgDTVEDANFD 769
Cdd:pfam00133  554 GLVRdEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINLS 602
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
 540-753 1.86e-27

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 114.05  E-value: 1.86e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   540 VSLEDQWYVDYGEesWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPwdeKYLVESLSDSTIYqsf 619
Cdd:cd00668  136 VRITEQWFFDMPK--FKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP---EDVFDVWFDSGIG--- 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   620 ytiahllfkdyygneigPLGIsadqmtdevFDYIFQHqddvkntniplpalqklrREFEYFYPLDVSISGKDLIPNHLTF 699
Cdd:cd00668  208 -----------------PLGS---------LGYPEEK------------------EWFKDSYPADWHLIGKDILRGWANF 243

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 1370340   700 FIYTHVALFpKKFWPKGIRANGHLMLNNS-KMSKSTGNFMTLEQTVEKFGADAAR 753
Cdd:cd00668  244 WITMLVALF-GEIPPKNLLVHGFVLDEGGqKMSKSKGNVIDPSDVVEKYGADALR 297
valS PRK13208
valyl-tRNA synthetase; Reviewed
 16-941 3.87e-20

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 96.42  E-value: 3.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     16 LIAIEKKYQKIWAEEHQFEIDaPSIEDEPITMDseelhrTYPkfmssmayPYMNGVMHAGHCFTLSKVEFSIGFERMNGK 95
Cdd:PRK13208   12 PEELEEKWQKIWEEEGTYKFD-PDERKPVYSID------TPP--------PTVSGSLHIGHVFSYTHTDFIARYQRMRGY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     96 RALFPLGFHCTGMPIlacadklkreaELFGKNFDNVPAEEeeikeetpaekdhedvtkfkakkskaaakkgrgkyqfeim 175
Cdd:PRK13208   77 NVFFPQGWDDNGLPT-----------ERKVEKYYGIRKDD---------------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    176 lqlgIPREEIIKfadakywltyfppLCESDC-----------TSLGARIDWRRSFVTTDanPYY-----DAFIRwqmnkL 239
Cdd:PRK13208  106 ----ISREEFIE-------------LCRELTdedekkfrelwRRLGLSVDWSLEYQTIS--PEYrrisqKSFLD-----L 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    240 KAAGKIKFGERYTIYSEKDG----QACMDHDRQSGEGVtpqeYIGVKIEALEfaddaakiidsssdldkskkfYFVAATL 315
Cdd:PRK13208  162 YKKGLIYRAEAPVLWCPRCEtaiaQAEVEYREREGKLN----YIKFPVEDGE---------------------EIEIATT 216

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    316 RPETMYGqtCC--FVSPtieygifdaGDsyfittERafknmsYQKLTPKRgfykpiVTVP--GKafigtkihapqsvypE 391
Cdd:PRK13208  217 RPELLPA--CVavVVHP---------DD------ER------YKHLVGKT------AIVPlfGV---------------E 252

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    392 LRILPMETVIATKGTGVVtcvpsnspddYITTkdllhkpeyygikpewidheivpimhtekYGDLTAKAIVeekkiqspK 471
Cdd:PRK13208  253 VPILADPLVDPDFGTGAV----------MICT-----------------------------FGDKTDVTWW--------R 285

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    472 DKNLlaeAKKIAYKEDyytGTM--IYGPYKGEKVEQAKNKVKADMIAAGeaFVYnEPES-----QVMSRsgddC-----I 539
Cdd:PRK13208  286 ELNL---PTRIIIDED---GRMteAAGKLAGLTIEEARKKIVEDLKSGG--LLG-KQEPikhnvKFCER----CdtpleI 352

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    540 VSlEDQWYVDYGEesWKKQAIECLEGMQlFAPE-----VKNAFEGvLDWlkNWAVCRTYGLGTRLP-W------------ 601
Cdd:PRK13208  353 LV-TRQWFIKVLD--LKEELLERGKEIN-WYPEhmrvrLENWIEG-LNW--DWCISRQRYFGTPIPvWyckdcghpilpd 425

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    602 DEKYLVESLSDstiyqsfytiahllfkdyygneiGPLGISADQMTDEVF--DyifqhqDDVKNT----NI-PLPALQKLR 674
Cdd:PRK13208  426 EEDLPVDPTKD-----------------------EPPGYKCPQCGSPGFegE------TDVMDTwatsSItPLIVTGWER 476

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    675 RE--FEYFYPLDVSISGKDLIPnhlTFFIYTHV---ALFPKKFWpKGIRANGH-LMLNNSKMSKSTGNFMTLEQTVEKFG 748
Cdd:PRK13208  477 DEdlFEKVFPMDLRPQGHDIIR---TWLFYTILrayLLTGKLPW-KNIMISGMvLDPDGKKMSKSKGNVVTPEELLEKYG 552

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    749 ADAARIAFADA--GDtveDANFDESNANAAilRLFNLKEW-----AEEITKESNLRTGEITDFFDIAFEHEMNALIEKT- 820
Cdd:PRK13208  553 ADAVRYWAASArlGS---DTPFDEKQVKIG--RRLLTKLWnasrfVLHFSADPEPDKAEVLEPLDRWILAKLAKVVEKAt 627

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    821 --YEQYaltNYKNALK--YGLF--DFqaARDY--------YREASGvmHKDLIARY-----IETQALLLAPIAPHFAEYI 881
Cdd:PRK13208  628 eaLENY---DFAKALEeiESFFwhVF--CDDYlelvksraYGEDEE--EEQKSARYtlytvLDTLLRLLAPFLPFITEEV 700

                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370340    882 YREVLGNqtSVQNAKFPRASKP-VDKGVLAALDYLRNLQRSIRegegqALKKKKGKS--AEID 941
Cdd:PRK13208  701 WSWLYGG--SVHRASWPEPDEElIDEEDEELGELAKEILSAVR-----KYKSEAGLSlnAPLK 756
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
 720-900 1.06e-12

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 72.39  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   720 NGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAAR--IAFadAGDTVEDANFDESNANAA---ILRLFNLkewAEEITKES 794
Cdd:COG0495  580 DGVVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRlfEMF--AGPPERDLEWSDSGVEGAyrfLNRVWRL---VVDEAEAL 654

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   795 NLRTGEITDfFDIAFEHEMNALIEKT---YEQY-------ALTNYKNALKYGLFDFQAARDYYREAsgvmhkdliaryIE 864
Cdd:COG0495  655 KLDVADLSE-ADKELRRALHKTIKKVtedIERLrfntaiaALMELVNALYKAKDSGEADRAVLREA------------LE 721

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 1370340   865 TQALLLAPIAPHFAEYIYrEVLGNQTSVQNAKFPRA 900
Cdd:COG0495  722 TLVLLLAPFAPHIAEELW-ERLGHEGSVADAPWPEA 756
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
 806-950 1.34e-12

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 66.27  E-value: 1.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     806 DIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAAR-DYYREAS---------GVMHKDLIARYIETQALLLAPIAP 875
Cdd:pfam08264    1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLsDWYLELIkdrlygeepDSRAQTTLYEVLETLLRLLAPFMP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370340     876 HFAEYIYREvlgnqTSVQNAKFPRASKPVDKGVLAALDYLRNLQRSIRegegqALKKKKGksaeIDASKPVKLTL 950
Cdd:pfam08264   81 FITEELWQK-----ESIHLAPWPEDAELEEAELEEAFELRQEIVQAIR-----KLRSELK----IKKSLPLEVVI 141
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 530-768 2.95e-09

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 60.34  E-value: 2.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   530 VMSRSGDDCIVSLEDQWYVDYGEEswKKQAIECLEGMQL-FAPEvkNAFEGVLDWLKN---WAVCRTYGLGTRLP-W--- 601
Cdd:cd00817  155 VCSRSGDVIEPLLKPQWFVKVKDL--AKKALEAVKEGDIkFVPE--RMEKRYENWLENirdWCISRQLWWGHRIPaWyck 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   602 DEKYLVESLSDstiyQSFYTIAHLLFKDYYGneigplGISADQMTDeVFD----------YIFQHQDDVKntniplpalq 671
Cdd:cd00817  231 DGGHWVVAREE----DEAIDKAAPEACVPCG------GEELKQDED-VLDtwfssslwpfSTLGWPEETK---------- 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   672 klrrEFEYFYPLDVSISGKDLIpnhltFFIYTHVALFPKKF-----WpKGIRANGhLML--NNSKMSKSTGNFMTLEQTV 744
Cdd:cd00817  290 ----DLKKFYPTSLLVTGHDII-----FFWVARMIMRGLKLtgklpF-KEVYLHG-LVRdeDGRKMSKSLGNVIDPLDVI 358

                        250       260
                 ....*....|....*....|....
gi 1370340   745 EKFGADAARIAFADAGDTVEDANF 768
Cdd:cd00817  359 DGYGADALRFTLASAATQGRDINL 382
valS PRK05729
valyl-tRNA synthetase; Reviewed
 676-950 4.50e-09

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 60.89  E-value: 4.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    676 EFEYFYPLDVSISGKDLIpnhltFF--------------------IYTHvALfpkkfwpkgIR-ANGHlmlnnsKMSKST 734
Cdd:PRK05729  467 DLKRFYPTSVLVTGFDII-----FFwvarmimmglhftgqvpfkdVYIH-GL---------VRdEQGR------KMSKSK 525

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    735 GNF---MTLeqtVEKFGADAAR---IAFADAGdtvEDANFDESNA-----------NAAILRLFNLKEWAEEITKESNLR 797
Cdd:PRK05729  526 GNVidpLDL---IDKYGADALRftlAALASPG---RDIRFDEERVegyrnfanklwNASRFVLMNLEGADVGELPDPEEL 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    798 TGEitdffDIAFEHEMNALIEKT---YEQYALTNYKNALkYGLF--DFQaarDYYREASgvmhKDLI--ARYIETQALLL 870
Cdd:PRK05729  600 SLA-----DRWILSRLNRTVAEVteaLDKYRFDEAARAL-YEFIwnEFC---DWYLELA----KPVLqeAAKRATRATLA 666

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    871 A----------PIAPHFAEYIYREV--LGNQTSVQNAKFPRASKPVDKGVLAALDYLRNLQRSIRegegqALKKKKGksa 938
Cdd:PRK05729  667 YvleqilrllhPFMPFITEELWQKLapLGIEESIMLAPWPEADEAIDEAAEAEFEWLKELITAIR-----NIRAEMN--- 738

                         330
                  ....*....|..
gi 1370340    939 eIDASKPVKLTL 950
Cdd:PRK05729  739 -IPPSKKLPLLL 749
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
 418-768 6.01e-08

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 56.14  E-value: 6.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     418 DDYITTKDLLHkpeyygikpewidHEIVpimhTEKYGDLTAKAIVEEKKIQ---SPKDKNLLAEAkkiaykedYYTGTMI 494
Cdd:pfam09334   86 DDYGRTTSERH-------------HELV----QEFFLKLYENGYIYEKEIEqfyCPSDERFLPDR--------YVEGTCP 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     495 YGPY---KGEKVEQAKNKVkadmiaagEAFVYNEPESQVmsrSGDDCIVSLEDQWYVDYGEesWKKQAIECLEGMQLFAP 571
Cdd:pfam09334  141 HCGSedaRGDQCENCGRHL--------EPTELINPKCVI---CGTTPEVKETEHYFFDLSK--FQDKLREWIEENNPEWP 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     572 EvkNAFEGVLDWLKN----WAVCRTYGLGTRLPWDEKYLVESLSDSTI-YQSFytiahllFKDYYGNEigplgisadqmt 646
Cdd:pfam09334  208 E--NVKNMVLEWLKEglkdRAISRDLDWGIPVPGAEGKVFYVWLDAPIgYISA-------TKELSGNE------------ 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     647 devfdyifqhqddvkntniplpalqklrREFEYFYPLD-----VSISGKDLIPNHLTFF-IYTHVALFPKkfwPKGIRAN 720
Cdd:pfam09334  267 ----------------------------EKWKEWWPNDpdtelVHFIGKDIIYFHTIFWpAMLLGAGYRL---PTTVFAH 315

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1370340     721 GHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANF 768
Cdd:pfam09334  316 GYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDF 363
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
 729-933 1.29e-07

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 55.86  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   729 KMSKSTGNFMTLEQTVEKFGADAARIAFAdAGDTVEDANFDEsnanaailrlfnlkewaeEITKES--NLRT-------- 798
Cdd:COG0060  603 KMSKSLGNVVDPQEVIDKYGADILRLWVA-SSDYWGDLRFSD------------------EILKEVrdVYRRlrntyrfl 663

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   799 -GEITDF----FDIAFE----------HEMNALIEKT---YEQYALTNYKNALkyglFDF----------QAARD-YYRE 849
Cdd:COG0060  664 lANLDDFdpaeDAVPYEdlpeldrwilSRLNELIKEVteaYDNYDFHRAYRAL----HNFcvedlsnwylDISKDrLYTE 739

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   850 AsgvmhKDLIAR-------Y--IETQALLLAPIAPHFAEYIYRE-VLGNQTSVQNAKFPRA-SKPVDKGVLAALDYLRNL 918
Cdd:COG0060  740 A-----ADSLDRraaqttlYevLETLVRLLAPILPFTAEEIWQNlPGEAEESVHLADWPEVdEELIDEELEAKWDLVREV 814

                        250
                 ....*....|....*
gi 1370340   919 QRSIREGEGQALKKK 933
Cdd:COG0060  815 RSAVLKALEAARKEK 829
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
 683-756 2.15e-07

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 52.58  E-value: 2.15e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370340   683 LDVSISGKDLIPNHLTFFIYTHVALFPKKF---WPKgiraNGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAF 756
Cdd:cd00672  129 FDIHGGGVDLIFPHHENEIAQSEAATGKPFaryWLH----TGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
 720-864 4.12e-07

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 53.95  E-value: 4.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   720 NGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAAR-----------IAFADagDTVEDanfdesnANAAILRLFNLKEWAE 788
Cdd:COG0215  256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRffllsahyrspLDFSE--EALEE-------AEKALERLYNALRRLE 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   789 EITKESNLRTGEITDF-----------FDIA------FE--HEMNALIEKTYEQYALTNYKNALKY-----GLFDfQAAR 844
Cdd:COG0215  327 EALGAADSSAEEIEELreefiaamdddFNTPealavlFElvREINKALDEGEDKAALAALAALLRAlggvlGLLL-LEPE 405

                        170       180
                 ....*....|....*....|
gi 1370340   845 DYYREASGVMHKDLIARYIE 864
Cdd:COG0215  406 AWQGAAEDELLDALIEALIE 425
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
 677-759 9.92e-06

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 48.90  E-value: 9.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     677 FEYF-YPLDVSISGKDLIPNHLTFFIYTHVALFPK---KFWPKgiraNGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAA 752
Cdd:pfam01406  201 RKYLgDQIDIHGGGIDLAFPHHENEIAQSEAAFDKqlaNYWLH----NGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEIL 276


                   ....*..
gi 1370340     753 RIAFADA 759
Cdd:pfam01406  277 RYFLLSV 283
metG PRK00133
methionyl-tRNA synthetase; Reviewed
 689-906 1.07e-05

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 49.38  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    689 GKDLIPNHltffiythvALFpkkfWP---KG--------IRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFA 757
Cdd:PRK00133  291 GKDIIYFH---------TLF----WPamlEGagyrlptnVFAHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLA 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    758 -DAGDTVEDANfdesnanaailrlFNLKEWAEEITKE-----SNL--RT-GEITDFF---------DIAFEHEMNALIEK 819
Cdd:PRK00133  358 aKLPETIDDLD-------------FNWEDFQQRVNSElvgkvVNFasRTaGFINKRFdgklpdalaDPELLEEFEAAAEK 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    820 T---YEQYaltNYKNAL-----------KYglFDFQA----ARDYYREASGVMHKDL-IARYIetqALLLAPIAPHFAEY 880
Cdd:PRK00133  425 IaeaYEAR---EFRKALreimaladfanKY--VDDNEpwklAKQDGERLQAVCSVGLnLFRAL---AIYLKPVLPELAER 496

                         250       260
                  ....*....|....*....|....*..
gi 1370340    881 IyREVLGNQTSV-QNAKFPRASKPVDK 906
Cdd:PRK00133  497 A-EAFLNLEELTwDDAQQPLAGHPINK 522
PLN02224 PLN02224
methionine-tRNA ligase
 647-885 2.46e-05

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 48.17  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    647 DEVFDYIFQHQDDVKNtniplpalQKLRREFEYFYPLDVSISGKDLIPNHLTFfiYTHVALFPKKFWPKGIRANGHLMLN 726
Cdd:PLN02224  294 DALLGYISALTEDNKQ--------QNLETAVSFGWPASLHLIGKDILRFHAVY--WPAMLMSAGLELPKMVFGHGFLTKD 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    727 NSKMSKSTGNFMTLEQTVEKFGADAAR------IAFADAGDTVEDANFDESNANAA--ILRLFNLKEWAEEITKESNLRT 798
Cdd:PLN02224  364 GMKMGKSLGNTLEPFELVQKFGPDAVRyfflreVEFGNDGDYSEDRFIKIVNAHLAntIGNLLNRTLGLLKKNCESTLVE 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    799 GEITDFFDIAFEHEMNALIEK---TYEQYALTNYKNA-LKYG----LFDFQAARDYYREASGV----MHKDL--IARYIE 864
Cdd:PLN02224  444 DSTVAAEGVPLKDTVEKLVEKaqtNYENLSLSSACEAvLEIGnagnTYMDQRAPWFLFKQGGVsaeeAAKDLviILEVMR 523

                         250       260
                  ....*....|....*....|.
gi 1370340    865 TQALLLAPIAPHFAEYIYREV 885
Cdd:PLN02224  524 VIAVALSPIAPCLSLRIYSQL 544
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
 668-883 2.72e-05

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 47.95  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    668 PALQKLRREFEYFYPLDVSISGKDLIPNHLtffIYthvalfpkkfW-----------PKGIRANGHLMLNNSKMSKSTGN 736
Cdd:PRK11893  240 DDEELLAELFNKYWPADVHLIGKDILRFHA---VY----------WpaflmaaglplPKRVFAHGFLTLDGEKMSKSLGN 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    737 FMTLEQTVEKFGADAAR------IAFADAGDTVEDANFDESNANAA------ILRLFN-LKEWAEEITKESNLRTGEitd 803
Cdd:PRK11893  307 VIDPFDLVDEYGVDAVRyfllreIPFGQDGDFSREAFINRINADLAndlgnlAQRTLSmIAKNFDGKVPEPGALTEA--- 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    804 ffDIAFEHEMNALIEKTYEQYALTNYKNALKY---------GLFDFQA----ARDYYREASGVMHKDLiaRYIETQALLL 870
Cdd:PRK11893  384 --DEALLEAAAALLERVRAAMDNLAFDKALEAilalvraanKYIDEQApwslAKTDPERLATVLYTLL--EVLRGIAVLL 459

                         250
                  ....*....|...
gi 1370340    871 APIAPHFAEYIYR 883
Cdd:PRK11893  460 QPVMPELAAKILD 472
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 57-109 2.93e-05

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 47.63  E-value: 2.93e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1370340    57 PKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMP 109
Cdd:cd00817    1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIA 53
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
 677-772 1.49e-04

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 45.95  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    677 FEYFYPLDVSISGKDLIPNHLtffIYthvalfpkkfWP-----------KGIRANGHLMLNNSKMSKSTGNFMTLEQTVE 745
Cdd:PRK12267  249 FKKFWPADVHLVGKDILRFHA---IY----------WPimlmalglplpKKVFAHGWWLMKDGKMSKSKGNVVDPEELVD 315

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1370340    746 KFGADAAR------IAFADAGDTVEDA-----NFDESN 772
Cdd:PRK12267  316 RYGLDALRyyllreVPFGSDGDFSPEAlveriNSDLAN 353
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 721-757 3.79e-04

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 44.64  E-value: 3.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370340    721 GHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFA 757
Cdd:PTZ00399  307 GHLHIKGLKMSKSLKNFITIRQALSKYTARQIRLLFL 343
cysS PRK14536
cysteinyl-tRNA synthetase; Provisional
 684-814 4.04e-04

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 184731 [Multi-domain]  Cd Length: 490  Bit Score: 44.14  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340    684 DVSISGKDLIPNHLTFFIYTHVALFPKKfWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEK------------FGADA 751
Cdd:PRK14536  235 DIHIGGVDHIRVHHTNEIAQCEAATGKP-WVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKgfqpldyrffllGGHYR 313

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370340    752 ARIAFA-DAGDTVEDAN----------FDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHEMN 814
Cdd:PRK14536  314 SQLAFSwEALKTAKAARrslvrrvarvVDAARATTGSVRGTLAECAAERVAESRASESELLLTDFRAALEDDFS 387
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
 849-884 1.11e-03

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 39.90  E-value: 1.11e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 1370340   849 EASGVMHKDLIARYIETQALLLAPIAPHFAEYIYRE 884
Cdd:cd07958   81 KKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEE 116
PLN02563 PLN02563
aminoacyl-tRNA ligase
 19-109 2.79e-03

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 41.73  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340     19 IEKKYQKIWAEEHQFEIdapsiedePITMDSeelhrTYPKFMSSMAYPYMNGV-MHAGHCFTLSKVEFSIGFERMNGKRA 97
Cdd:PLN02563   85 IEPKWQRYWEENRTFRT--------PDDVDT-----SKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNV 151

                          90
                  ....*....|..
gi 1370340     98 LFPLGFHCTGMP 109
Cdd:PLN02563  152 LHPMGWDAFGLP 163
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
 864-918 6.95e-03

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 38.69  E-value: 6.95e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370340   864 ETQALLLAPIAPHFAEYIY----REVLGNQTSVQNAKFPRA-SKPVDKGVLAALDYLRNL 918
Cdd:cd07961  119 LTLSRLMAPFTPFITEEIYqnlrRELGDAPESVHLLDWPEVdESLIDEELEEAMELVREI 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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