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Conserved domains on  [gi|3880137|emb|CAA92202|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 17778750)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 148-288 5.58e-40

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 137.32  E-value: 5.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3880137    148 LSKLIETLKKVEIVKARKLRLNRLSTKEITAVLQFFEPQLLETIQIEHAGKADQFNEIVQLQQWRSANTVTVRFLHDkPT 227
Cdd:pfam01827   4 IESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL-SS 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3880137    228 VPLENYFHFNVFQTFVVDFSVDDAIKIRDILLKSPNFIFCHLDFPpySLNLNDIARVFCPG 288
Cdd:pfam01827  83 FPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSP--DLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 26-69 3.00e-11

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 57.50  E-value: 3.00e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 3880137   26 LSDLPNELISQVMKNLDPQNRLTLRKVSRKLKDGIDM--CGFKSIT 69
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNqdPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 148-288 5.58e-40

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 137.32  E-value: 5.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3880137    148 LSKLIETLKKVEIVKARKLRLNRLSTKEITAVLQFFEPQLLETIQIEHAGKADQFNEIVQLQQWRSANTVTVRFLHDkPT 227
Cdd:pfam01827   4 IESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL-SS 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3880137    228 VPLENYFHFNVFQTFVVDFSVDDAIKIRDILLKSPNFIFCHLDFPpySLNLNDIARVFCPG 288
Cdd:pfam01827  83 FPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSP--DLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 26-69 3.00e-11

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 57.50  E-value: 3.00e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 3880137   26 LSDLPNELISQVMKNLDPQNRLTLRKVSRKLKDGIDM--CGFKSIT 69
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNqdPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
29-65 3.28e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 3.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 3880137      29 LPNELISQVMKNLDPQNRLTLRKVSRKLKDGIDMCGF 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 26-66 2.08e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.07  E-value: 2.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 3880137     26 LSDLPNELISQVMKNLDPQNRLTLRKVSRKLKDGIDMCGFK 66
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLW 41
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 148-288 5.58e-40

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 137.32  E-value: 5.58e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3880137    148 LSKLIETLKKVEIVKARKLRLNRLSTKEITAVLQFFEPQLLETIQIEHAGKADQFNEIVQLQQWRSANTVTVRFLHDkPT 227
Cdd:pfam01827   4 IESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL-SS 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3880137    228 VPLENYFHFNVFQTFVVDFSVDDAIKIRDILLKSPNFIFCHLDFPpySLNLNDIARVFCPG 288
Cdd:pfam01827  83 FPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSP--DLNPIEIAKVFDPD 141
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 26-69 3.00e-11

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 57.50  E-value: 3.00e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 3880137   26 LSDLPNELISQVMKNLDPQNRLTLRKVSRKLKDGIDM--CGFKSIT 69
Cdd:cd22150   1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNqdPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
29-65 3.28e-07

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 46.28  E-value: 3.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 3880137      29 LPNELISQVMKNLDPQNRLTLRKVSRKLKDGIDMCGF 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 26-66 2.08e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.07  E-value: 2.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 3880137     26 LSDLPNELISQVMKNLDPQNRLTLRKVSRKLKDGIDMCGFK 66
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLW 41
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 26-58 1.29e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 35.92  E-value: 1.29e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 3880137     26 LSDLPNELISQVMKNLDPQNRLTLRKVSRKLKD 58
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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