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Conserved domains on  [gi|22265921|emb|CAA92014|]
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Apple domain-containing protein [Caenorhabditis elegans]

Protein Classification

thrombospondin type-1 domain-containing protein( domain architecture ID 10649344)

thrombospondin type-1 (TSP1) domain-containing protein similar to Mus musculus thrombospondin type-1 domain-containing protein 1, which is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 505-552 2.26e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 2.26e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    505 WSEWCEWSTCSASCGSGQRERTRFCHL-----GTNRCEGKDYESEQCSAGPCP 552
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 554-604 3.09e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.36  E-value: 3.09e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    554 WSQWEDWGQCSVTCGQGVAVRQRTCLGGV--FGDHLCQGPKTEQRACDGGPCS 604
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 458-502 3.69e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.36  E-value: 3.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    458 WHDWSDWSTCSCTCGDGAKSRRRECSTNN-------CQGADYETEPCNLGPC 502
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 606-651 8.23e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.20  E-value: 8.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    606 WSPWQEWSTCSASCGSGMKRRQRVCQF------GTDCQGPNEESQFCYGPPC 651
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPC 52
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 35-108 1.02e-08

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


:

Pssm-ID: 214680  Cd Length: 78  Bit Score: 52.58  E-value: 1.02e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22265921     35 DLCARMHNNTALEGSSPLLMMQATAYECQKKCVDIFPECSAVVYYYlhnetKKHFCYLFSDNSVQDKIDLVEQK 108
Cdd:smart00473   3 DDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSNCSCRSFTYNN-----GTKGCLLWSESSLGDARLFPSGG 71
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 654-704 1.67e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.67e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    654 WTEWCEWSGCSSKCGPGQRTRTRGCLGPNGQE-ATTCQGPSIETTLCEGQSC 704
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 707-759 1.68e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.68e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    707 WSEWCHWSMCDKECGGGQSIRTRTCLNSAGSPDSScHCDGPDREEKECNSQSC 759
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGG-PCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 765-809 3.94e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 3.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 22265921    765 WNTWCEWSPCSTQlaCEVGVQSRSRQCV----GESGCHCIGLAEESQQC 809
Cdd:smart00209   1 WSEWSEWSPCSVT--CGGGVQTRTRSCCspppQNGGGPCTGEDVETRAC 47
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 505-552 2.26e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 2.26e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    505 WSEWCEWSTCSASCGSGQRERTRFCHL-----GTNRCEGKDYESEQCSAGPCP 552
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 554-604 3.09e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.36  E-value: 3.09e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    554 WSQWEDWGQCSVTCGQGVAVRQRTCLGGV--FGDHLCQGPKTEQRACDGGPCS 604
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 458-502 3.69e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.36  E-value: 3.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    458 WHDWSDWSTCSCTCGDGAKSRRRECSTNN-------CQGADYETEPCNLGPC 502
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 606-651 8.23e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.20  E-value: 8.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    606 WSPWQEWSTCSASCGSGMKRRQRVCQF------GTDCQGPNEESQFCYGPPC 651
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPC 52
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 35-108 1.02e-08

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 52.58  E-value: 1.02e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22265921     35 DLCARMHNNTALEGSSPLLMMQATAYECQKKCVDIFPECSAVVYYYlhnetKKHFCYLFSDNSVQDKIDLVEQK 108
Cdd:smart00473   3 DDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSNCSCRSFTYNN-----GTKGCLLWSESSLGDARLFPSGG 71
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 654-704 1.67e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.67e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    654 WTEWCEWSGCSSKCGPGQRTRTRGCLGPNGQE-ATTCQGPSIETTLCEGQSC 704
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 707-759 1.68e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.68e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    707 WSEWCHWSMCDKECGGGQSIRTRTCLNSAGSPDSScHCDGPDREEKECNSQSC 759
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGG-PCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
607-651 5.40e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.03  E-value: 5.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22265921   607 SPWQEWSTCSASCGSGMKRRQRVC----QFGTDCQGPNEESQFCYGPPC 651
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
555-603 5.61e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.03  E-value: 5.61e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22265921   555 SQWEDWGQCSVTCGQGVAVRQRTCLGGVFGDHLCQGPKTEQRACDGGPC 603
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
506-551 2.23e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.41  E-value: 2.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22265921   506 SEWCEWSTCSASCGSGQRERTRFC---HLGTNRCEGKDYESEQCSAGPC 551
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkspFPGGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 460-502 1.14e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.34  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 22265921   460 DWSDWSTCSCTCGDGAKSRRRECSTNNCQG-----ADYETEPCNLGPC 502
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRTVIVEPQNGgrpcpELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
655-704 3.11e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.94  E-value: 3.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 22265921   655 TEWCEWSGCSSKCGPGQRTRTRGCLGPNgQEATTCQGPSIETTLCEGQSC 704
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPF-PGGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 765-809 3.94e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 3.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 22265921    765 WNTWCEWSPCSTQlaCEVGVQSRSRQCV----GESGCHCIGLAEESQQC 809
Cdd:smart00209   1 WSEWSEWSPCSVT--CGGGVQTRTRSCCspppQNGGGPCTGEDVETRAC 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
708-759 1.02e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.78  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22265921   708 SEWCHWSMCDKECGGGQSIRTRTClnsAGSPDSSCHCDGPDREEKECNSQSC 759
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTC---KSPFPGGEPCTGDDIETQACKMDKC 49
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 458-513 1.98e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 41.08  E-value: 1.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22265921  458 WHDWSDWSTCSCTCG--DGAKSRRRECS--TNNCQGADY-ETEPCN--LGPCQTWSEWCEWST 513
Cdd:PTZ00087 233 YTEWGEWSNCSMECDhpDNVQIRERKCAhpSGDCFKGDLkETRPCQvpLPPCNSLFEHKESST 295
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 765-821 7.53e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 39.54  E-value: 7.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 22265921  765 WNTWCEWSPCSTQLACEVGVQSRSRQCVGESGCHCIGLAEESQQCRgltqcPPKPPC 821
Cdd:PTZ00087 233 YTEWGEWSNCSMECDHPDNVQIRERKCAHPSGDCFKGDLKETRPCQ-----VPLPPC 284
 
Name Accession Description Interval E-value
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 505-552 2.26e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.74  E-value: 2.26e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    505 WSEWCEWSTCSASCGSGQRERTRFCHL-----GTNRCEGKDYESEQCSAGPCP 552
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 554-604 3.09e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.36  E-value: 3.09e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    554 WSQWEDWGQCSVTCGQGVAVRQRTCLGGV--FGDHLCQGPKTEQRACDGGPCS 604
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 458-502 3.69e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 53.36  E-value: 3.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    458 WHDWSDWSTCSCTCGDGAKSRRRECSTNN-------CQGADYETEPCNLGPC 502
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 606-651 8.23e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.20  E-value: 8.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    606 WSPWQEWSTCSASCGSGMKRRQRVCQF------GTDCQGPNEESQFCYGPPC 651
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqngGGPCTGEDVETRACNEQPC 52
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 35-108 1.02e-08

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 52.58  E-value: 1.02e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22265921     35 DLCARMHNNTALEGSSPLLMMQATAYECQKKCVDIFPECSAVVYYYlhnetKKHFCYLFSDNSVQDKIDLVEQK 108
Cdd:smart00473   3 DDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSNCSCRSFTYNN-----GTKGCLLWSESSLGDARLFPSGG 71
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 654-704 1.67e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.67e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 22265921    654 WTEWCEWSGCSSKCGPGQRTRTRGCLGPNGQE-ATTCQGPSIETTLCEGQSC 704
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 707-759 1.68e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.43  E-value: 1.68e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 22265921    707 WSEWCHWSMCDKECGGGQSIRTRTCLNSAGSPDSScHCDGPDREEKECNSQSC 759
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGG-PCTGEDVETRACNEQPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
607-651 5.40e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.03  E-value: 5.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22265921   607 SPWQEWSTCSASCGSGMKRRQRVC----QFGTDCQGPNEESQFCYGPPC 651
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
555-603 5.61e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.03  E-value: 5.61e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22265921   555 SQWEDWGQCSVTCGQGVAVRQRTCLGGVFGDHLCQGPKTEQRACDGGPC 603
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
506-551 2.23e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.41  E-value: 2.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 22265921   506 SEWCEWSTCSASCGSGQRERTRFC---HLGTNRCEGKDYESEQCSAGPC 551
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCkspFPGGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 607-651 3.41e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 41.88  E-value: 3.41e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 22265921   607 SPWQEWSTCSASCGSGMKRRQR-VCQF----GTDCqGPNEESQFCYGPPC 651
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRtVIVEpqngGRPC-PELLERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 460-502 1.14e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.34  E-value: 1.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 22265921   460 DWSDWSTCSCTCGDGAKSRRRECSTNNCQG-----ADYETEPCNLGPC 502
Cdd:pfam19028   5 EWSEWSECSVTCGGGVQTRTRTVIVEPQNGgrpcpELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
460-502 1.26e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.09  E-value: 1.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 22265921   460 DWSDWSTCSCTCGDGAKSRRRECSTN-----NCQGADYETEPCNLGPC 502
Cdd:pfam00090   2 PWSPWSPCSVTCGKGIQVRQRTCKSPfpggePCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 555-603 1.41e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.34  E-value: 1.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 22265921   555 SQWEDWGQCSVTCGQGVAVRQRTCL-----GGvfgdHLCqGPKTEQRACDGGPC 603
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTRTVIvepqnGG----RPC-PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
655-704 3.11e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.94  E-value: 3.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 22265921   655 TEWCEWSGCSSKCGPGQRTRTRGCLGPNgQEATTCQGPSIETTLCEGQSC 704
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPF-PGGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 765-809 3.94e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.11  E-value: 3.94e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 22265921    765 WNTWCEWSPCSTQlaCEVGVQSRSRQCV----GESGCHCIGLAEESQQC 809
Cdd:smart00209   1 WSEWSEWSPCSVT--CGGGVQTRTRSCCspppQNGGGPCTGEDVETRAC 47
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 506-527 4.81e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 38.80  E-value: 4.81e-04
                          10        20
                  ....*....|....*....|..
gi 22265921   506 SEWCEWSTCSASCGSGQRERTR 527
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTR 25
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 559-603 8.54e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.20  E-value: 8.54e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 22265921   559 DWGQCSVTCGQGVAVRQRTCL----GGVFGDHLCQGPK--TEQRACDGGPC 603
Cdd:pfam19030   5 PWGECSVTCGGGVQTRLVQCVqkggGSIVPDSECSAQKkpPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
708-759 1.02e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 37.78  E-value: 1.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 22265921   708 SEWCHWSMCDKECGGGQSIRTRTClnsAGSPDSSCHCDGPDREEKECNSQSC 759
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTC---KSPFPGGEPCTGDDIETQACKMDKC 49
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 458-513 1.98e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 41.08  E-value: 1.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22265921  458 WHDWSDWSTCSCTCG--DGAKSRRRECS--TNNCQGADY-ETEPCN--LGPCQTWSEWCEWST 513
Cdd:PTZ00087 233 YTEWGEWSNCSMECDhpDNVQIRERKCAhpSGDCFKGDLkETRPCQvpLPPCNSLFEHKESST 295
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 461-502 2.03e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 41.49  E-value: 2.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 22265921  461 WSDWSTCSCTCGDGAKSRRRECSTNNCqgADYETEPCNLGPC 502
Cdd:PTZ00441 243 WDEWTPCSVTCGKGTHSRSRPILHEGC--TTHMVEECEEEEC 282
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 655-676 4.24e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.10  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|..
gi 22265921   655 TEWCEWSGCSSKCGPGQRTRTR 676
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTR 25
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 765-821 7.53e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 39.54  E-value: 7.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 22265921  765 WNTWCEWSPCSTQLACEVGVQSRSRQCVGESGCHCIGLAEESQQCRgltqcPPKPPC 821
Cdd:PTZ00087 233 YTEWGEWSNCSMECDHPDNVQIRERKCAHPSGDCFKGDLKETRPCQ-----VPLPPC 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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