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Conserved domains on  [gi|3114861|emb|CAA72732|]
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putative LR11/gp250 receptor protein, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 439-512 7.76e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 7.76e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3114861  439 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 512
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
39-74 2.90e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 2.90e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 3114861     39 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 74
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 207-241 6.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 6.01e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861  207 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 241
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 255-285 6.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 6.82e-09
                        10        20        30
                ....*....|....*....|....*....|.
gi 3114861  255 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 285
Cdd:cd00112   5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
80-112 1.34e-08

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.34e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 3114861     80 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 112
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
424-581 1.60e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 1.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  424 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTSTVL 496
Cdd:COG3401 213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  497 KVLKPDTTYQVKVQVhcLNKVHNTNDF---VTLRTPEGLPDAPRNLQLSlNREEEGVILGhWAPPvhTHGLIREYIVEYS 573
Cdd:COG3401 290 TGLTNGTTYYYRVTA--VDAAGNESAPsnvVSVTTDLTPPAAPSGLTAT-AVGSSSITLS-WTAS--SDADVTGYNVYRS 363


                ....*...
gi 3114861  574 RSGSKMWA 581
Cdd:COG3401 364 TSGGGTYT 371
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 122-153 2.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 2.48e-08
                        10        20        30
                ....*....|....*....|....*....|..
gi 3114861  122 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 153
Cdd:cd00112   4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 301-335 3.14e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 3.14e-08
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861  301 CLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 335
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2-35 4.83e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.83e-06
                        10        20        30
                ....*....|....*....|....*....|....
gi 3114861    2 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 35
Cdd:cd00112   3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 353-388 1.68e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.68e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 3114861  353 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 388
Cdd:cd00112   1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 396-431 5.57e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 5.57e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 3114861  396 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 431
Cdd:cd00112   1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 439-512 7.76e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 7.76e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3114861  439 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 512
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 440-512 9.28e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 9.28e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3114861     440 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTSTVLKVLKPDTTYQVKVQVH 512
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
39-74 2.90e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 2.90e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 3114861     39 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 74
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 40-74 1.77e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.77e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861   40 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 74
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 207-241 6.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 6.01e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861  207 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 241
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
fn3 pfam00041
Fibronectin type III domain;
439-510 6.46e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 6.46e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3114861    439 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQ 510
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 255-285 6.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 6.82e-09
                        10        20        30
                ....*....|....*....|....*....|.
gi 3114861  255 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 285
Cdd:cd00112   5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
80-112 1.34e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.34e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 3114861     80 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 112
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
424-581 1.60e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 1.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  424 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTSTVL 496
Cdd:COG3401 213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  497 KVLKPDTTYQVKVQVhcLNKVHNTNDF---VTLRTPEGLPDAPRNLQLSlNREEEGVILGhWAPPvhTHGLIREYIVEYS 573
Cdd:COG3401 290 TGLTNGTTYYYRVTA--VDAAGNESAPsnvVSVTTDLTPPAAPSGLTAT-AVGSSSITLS-WTAS--SDADVTGYNVYRS 363


                ....*...
gi 3114861  574 RSGSKMWA 581
Cdd:COG3401 364 TSGGGTYT 371
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 80-112 1.84e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.84e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861      80 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 112
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 81-113 1.96e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.96e-08
                        10        20        30
                ....*....|....*....|....*....|...
gi 3114861   81 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 113
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 122-153 2.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 2.48e-08
                        10        20        30
                ....*....|....*....|....*....|..
gi 3114861  122 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 153
Cdd:cd00112   4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 301-335 3.14e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 3.14e-08
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861  301 CLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 335
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 39-71 8.99e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 8.99e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861      39 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 71
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
255-285 2.38e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 2.38e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 3114861    255 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 285
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
207-241 2.71e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 3114861    207 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 241
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 206-238 3.54e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.54e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861     206 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 238
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 255-282 3.98e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.98e-07
                           10        20
                   ....*....|....*....|....*...
gi 3114861     255 QFHCENGHCIPNRWKCDRENDCGDWSDE 282
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
122-153 4.55e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 4.55e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 3114861    122 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 153
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 300-332 4.94e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.94e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861     300 TCLPNYFRCSSGACVMGTWVCDGYRDCADGSDE 332
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 121-150 9.07e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.32  E-value: 9.07e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 3114861     121 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 150
Cdd:smart00192   4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
299-335 1.06e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.32  E-value: 1.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3114861    299 STCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 335
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2-35 4.83e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.83e-06
                        10        20        30
                ....*....|....*....|....*....|....
gi 3114861    2 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 35
Cdd:cd00112   3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
428-509 1.51e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  428 EKACSDELTVYK-------VQNLQWTADFSGDVTLTWmrpkKMPSASCV--YNVYYRVVGESIWKTLETHSNKTSTVLKV 498
Cdd:COG3401 311 ESAPSNVVSVTTdltppaaPSGLTATAVGSSSITLSW----TASSDADVtgYNVYRSTSGGGTYTKIAETVTTTSYTDTG 386

                        90
                ....*....|.
gi 3114861  499 LKPDTTYQVKV 509
Cdd:COG3401 387 LTPGTTYYYKV 397
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 353-388 1.68e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.68e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 3114861  353 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 388
Cdd:cd00112   1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 396-431 5.57e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 5.57e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 3114861  396 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 431
Cdd:cd00112   1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 533-580 8.86e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 8.86e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 3114861  533 PDAPRNLQLSlNREEEGVILgHWAPPVHTHGLIREYIVEYSRSGSKMW 580
Cdd:cd00063   1 PSPPTNLRVT-DVTSTSVTL-SWTPPEDDGGPITGYVVEYREKGSGDW 46
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
352-388 1.16e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 1.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3114861    352 QCDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 388
Cdd:pfam00057   2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3-32 1.30e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.15  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 3114861       3 TQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 32
Cdd:smart00192   5 GEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 395-428 2.36e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.77  E-value: 2.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 3114861     395 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDE 428
Cdd:smart00192   1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 352-385 6.01e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 6.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 3114861     352 QCDRFEFECHqPKKCIPNWKRCDGHQDCQDGQDE 385
Cdd:smart00192   1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
4-35 1.21e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 36.84  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 3114861      4 QFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 35
Cdd:pfam00057   7 EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
395-431 4.95e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 4.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3114861    395 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 431
Cdd:pfam00057   2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 439-512 7.76e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 7.76e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3114861  439 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETH-SNKTSTVLKVLKPDTTYQVKVQVH 512
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTpGSETSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 440-512 9.28e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.39  E-value: 9.28e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3114861     440 VQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESI---WKTLETHSNKTSTVLKVLKPDTTYQVKVQVH 512
Cdd:smart00060   4 PSNLRVTDVTSTSVTLSWEPPPDDGITG--YIVGYRVEYREEgseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
39-74 2.90e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.33  E-value: 2.90e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 3114861     39 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 74
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 40-74 1.77e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 52.98  E-value: 1.77e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861   40 CRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANC 74
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 207-241 6.01e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.82  E-value: 6.01e-09
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861  207 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 241
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
fn3 pfam00041
Fibronectin type III domain;
439-510 6.46e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 6.46e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3114861    439 KVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVG-ESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQ 510
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 255-285 6.82e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 51.44  E-value: 6.82e-09
                        10        20        30
                ....*....|....*....|....*....|.
gi 3114861  255 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 285
Cdd:cd00112   5 EFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
80-112 1.34e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 50.71  E-value: 1.34e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 3114861     80 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 112
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
424-581 1.60e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 57.32  E-value: 1.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  424 DESDEKACSDELTVY-------KVQNLQWTADFSGDVTLTWMRPKKMPSAScvYNVYYRVVGESIWKTLEThSNKTSTVL 496
Cdd:COG3401 213 DTGGESAPSNEVSVTtpttppsAPTGLTATADTPGSVTLSWDPVTESDATG--YRVYRSNSGDGPFTKVAT-VTTTSYTD 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  497 KVLKPDTTYQVKVQVhcLNKVHNTNDF---VTLRTPEGLPDAPRNLQLSlNREEEGVILGhWAPPvhTHGLIREYIVEYS 573
Cdd:COG3401 290 TGLTNGTTYYYRVTA--VDAAGNESAPsnvVSVTTDLTPPAAPSGLTAT-AVGSSSITLS-WTAS--SDADVTGYNVYRS 363


                ....*...
gi 3114861  574 RSGSKMWA 581
Cdd:COG3401 364 TSGGGTYT 371
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 80-112 1.84e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 50.32  E-value: 1.84e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861      80 TCEASNFQCHNGHCIPQRWACDGDADCQDGSDE 112
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 81-113 1.96e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 50.28  E-value: 1.96e-08
                        10        20        30
                ....*....|....*....|....*....|...
gi 3114861   81 CEASNFQCHNGHCIPQRWACDGDADCQDGSDED 113
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 122-153 2.48e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.90  E-value: 2.48e-08
                        10        20        30
                ....*....|....*....|....*....|..
gi 3114861  122 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 153
Cdd:cd00112   4 NEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 301-335 3.14e-08

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 49.51  E-value: 3.14e-08
                        10        20        30
                ....*....|....*....|....*....|....*
gi 3114861  301 CLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 335
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 39-71 8.99e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 8.99e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861      39 QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDE 71
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
255-285 2.38e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 47.24  E-value: 2.38e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 3114861    255 QFHCENGHCIPNRWKCDRENDCGDWSDEKDC 285
Cdd:pfam00057   7 EFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
207-241 2.71e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.86  E-value: 2.71e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 3114861    207 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 241
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 206-238 3.54e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.54e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861     206 ECDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 238
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 255-282 3.98e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.47  E-value: 3.98e-07
                           10        20
                   ....*....|....*....|....*...
gi 3114861     255 QFHCENGHCIPNRWKCDRENDCGDWSDE 282
Cdd:smart00192   6 EFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
122-153 4.55e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.47  E-value: 4.55e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 3114861    122 NGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHC 153
Cdd:pfam00057   6 NEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 300-332 4.94e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 46.09  E-value: 4.94e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 3114861     300 TCLPNYFRCSSGACVMGTWVCDGYRDCADGSDE 332
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 121-150 9.07e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 45.32  E-value: 9.07e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 3114861     121 CNGFHCPNGTCIPSSKHCDGLRDCPDGSDE 150
Cdd:smart00192   4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
299-335 1.06e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.32  E-value: 1.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3114861    299 STCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEAC 335
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 2-35 4.83e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.35  E-value: 4.83e-06
                        10        20        30
                ....*....|....*....|....*....|....
gi 3114861    2 DTQFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 35
Cdd:cd00112   3 PNEFRCA-NGRCIPSSWVCDGEDDCGDGSDEENC 35
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
428-509 1.51e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.07  E-value: 1.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861  428 EKACSDELTVYK-------VQNLQWTADFSGDVTLTWmrpkKMPSASCV--YNVYYRVVGESIWKTLETHSNKTSTVLKV 498
Cdd:COG3401 311 ESAPSNVVSVTTdltppaaPSGLTATAVGSSSITLSW----TASSDADVtgYNVYRSTSGGGTYTKIAETVTTTSYTDTG 386

                        90
                ....*....|.
gi 3114861  499 LKPDTTYQVKV 509
Cdd:COG3401 387 LTPGTTYYYKV 397
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 353-388 1.68e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 41.81  E-value: 1.68e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 3114861  353 CDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 388
Cdd:cd00112   1 CPPNEFRCAN-GRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 396-431 5.57e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 40.27  E-value: 5.57e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 3114861  396 CTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 431
Cdd:cd00112   1 CPPNEFRCANGR-CIPSSWVCDGEDDCGDGSDEENC 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 533-580 8.86e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 8.86e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 3114861  533 PDAPRNLQLSlNREEEGVILgHWAPPVHTHGLIREYIVEYSRSGSKMW 580
Cdd:cd00063   1 PSPPTNLRVT-DVTSTSVTL-SWTPPEDDGGPITGYVVEYREKGSGDW 46
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
352-388 1.16e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 1.16e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3114861    352 QCDRFEFECHQpKKCIPNWKRCDGHQDCQDGQDEANC 388
Cdd:pfam00057   2 TCSPNEFQCGS-GECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 3-32 1.30e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.15  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 3114861       3 TQFRCQeSGTCIPLSYKCDLEDDCGDNSDE 32
Cdd:smart00192   5 GEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 395-428 2.36e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 38.77  E-value: 2.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 3114861     395 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDE 428
Cdd:smart00192   1 TCPPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 352-385 6.01e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 37.61  E-value: 6.01e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 3114861     352 QCDRFEFECHqPKKCIPNWKRCDGHQDCQDGQDE 385
Cdd:smart00192   1 TCPPGEFQCD-NGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
4-35 1.21e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 36.84  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 3114861      4 QFRCQeSGTCIPLSYKCDLEDDCGDNSDESHC 35
Cdd:pfam00057   7 EFQCG-SGECIPRSWVCDGDPDCGDGSDEENC 37
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 48-122 3.19e-03

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 39.00  E-value: 3.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3114861     48 SSGMCIRSSWVCDGDNDCRDWSDEANCTAiyhtCEASNFQCHN-GHC---IPQRWACDGDAD---CQDGSDEDPVSCEKK 120
Cdd:pfam12999  43 HSEIKLSFDQVNDDYCDCPDGSDEPGTNA----CSNGKFYCANeGFIpgyIPSFKVDDGVCDydiCCDGSDEALGKCPNK 118


                  ..
gi 3114861    121 CN 122
Cdd:pfam12999 119 CG 120
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
395-431 4.95e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 34.92  E-value: 4.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 3114861    395 TCTSREFKCEDGEaCIVLSERCDGFLDCSDESDEKAC 431
Cdd:pfam00057   2 TCSPNEFQCGSGE-CIPRSWVCDGDPDCGDGSDEENC 37
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 442-509 7.69e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 36.23  E-value: 7.69e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3114861    442 NLQWTADfSGDVTLTWMRPKKMPSAScvynVYYRVVGESIW-------KTLETHSNKTSTVLKV----LKPDTTYQVKV 509
Cdd:pfam16656   5 HLSLTGD-STSMTVSWVTPSAVTSPV----VQYGTSSSALTstatatsSTYTTGDGGTGYIHRAtltgLEPGTTYYYRV 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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