|
Name |
Accession |
Description |
Interval |
E-value |
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
1-314 |
1.48e-172 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 480.33 E-value: 1.48e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 1 MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 81 SSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENia 160
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 161 EWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG 240
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 35700 241 ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKmKHCTKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
4-313 |
4.16e-162 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 453.81 E-value: 4.16e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 4 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEwk 163
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 164 NCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATK 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 244 VYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
4-314 |
1.43e-155 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 437.48 E-value: 1.43e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 4 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASS 82
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIaeW 162
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI--L 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 163 KNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGA 241
Cdd:TIGR01251 159 DNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 35700 242 TKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEdkmKHCTKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
4-120 |
3.49e-70 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 213.44 E-value: 3.49e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 4 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 35700 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
147-274 |
4.73e-25 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 97.47 E-value: 4.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 147 AEPAVLQWIRENIaeWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223 1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 35700 221 DMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAisRINNAAFEAVVVTNT 274
Cdd:cd06223 79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PrsA |
COG0462 |
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ... |
1-314 |
1.48e-172 |
|
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis
Pssm-ID: 440230 [Multi-domain] Cd Length: 311 Bit Score: 480.33 E-value: 1.48e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 1 MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 80
Cdd:COG0462 1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 81 SSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENia 160
Cdd:COG0462 81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 161 EWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG 240
Cdd:COG0462 159 DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 35700 241 ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKmKHCTKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:COG0462 239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEE-KRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
|
|
| PRK01259 |
PRK01259 |
ribose-phosphate diphosphokinase; |
4-313 |
4.16e-162 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 234929 [Multi-domain] Cd Length: 309 Bit Score: 453.81 E-value: 4.16e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 4 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:PRK01259 1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEwk 163
Cdd:PRK01259 81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNLE-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 164 NCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATK 243
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 244 VYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLF 308
|
|
| ribP_PPkin |
TIGR01251 |
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ... |
4-314 |
1.43e-155 |
|
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273523 [Multi-domain] Cd Length: 308 Bit Score: 437.48 E-value: 1.43e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 4 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASS 82
Cdd:TIGR01251 1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIaeW 162
Cdd:TIGR01251 81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI--L 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 163 KNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK-KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGA 241
Cdd:TIGR01251 159 DNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 35700 242 TKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEdkmKHCTKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHE---KHKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
|
|
| PLN02369 |
PLN02369 |
ribose-phosphate pyrophosphokinase |
14-313 |
7.69e-114 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 215209 [Multi-domain] Cd Length: 302 Bit Score: 331.27 E-value: 7.69e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 14 DLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFP 93
Cdd:PLN02369 2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 94 YARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAG 173
Cdd:PLN02369 82 YARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDVG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 174 GAKRVTSIADRL-NVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGI 252
Cdd:PLN02369 162 GVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAV 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 35700 253 FSGPAISRINNAAFEAVVVTNTIPQEDKmKHCTKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PLN02369 242 FSPPAIERLSSGLFQEVIVTNTIPVSEK-NYFPQLTVLSVANLLGETIWRVHDDCSVSSIF 301
|
|
| PRK02269 |
PRK02269 |
ribose-phosphate diphosphokinase; |
3-313 |
6.01e-113 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 167353 [Multi-domain] Cd Length: 320 Bit Score: 329.83 E-value: 6.01e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 3 NIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASS 82
Cdd:PRK02269 5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEW 162
Cdd:PRK02269 85 ESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLVG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 163 KNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK--KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAG 240
Cdd:PRK02269 165 DDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAG 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 35700 241 ATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTI--PQEdkmKHCTKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02269 245 ATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIylPEE---RLIDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
|
|
| PRK02812 |
PRK02812 |
ribose-phosphate pyrophosphokinase; Provisional |
6-313 |
1.16e-111 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235072 [Multi-domain] Cd Length: 330 Bit Score: 327.08 E-value: 1.16e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 6 LFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRV 85
Cdd:PRK02812 24 LFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASARQI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 86 TAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENiaEWKNC 165
Cdd:PRK02812 104 TAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASK--NLEDI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 166 IIVSPDAGGAKRVTSIADRLN-VEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKV 244
Cdd:PRK02812 182 VVVSPDVGGVARARAFAKKLNdAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQV 261
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 35700 245 YAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKmKHCTKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK02812 262 YACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPEE-RRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
|
|
| PTZ00145 |
PTZ00145 |
phosphoribosylpyrophosphate synthetase; Provisional |
1-313 |
1.65e-111 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 240290 [Multi-domain] Cd Length: 439 Bit Score: 330.30 E-value: 1.65e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 1 MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 80
Cdd:PTZ00145 117 MENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRA 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 81 SSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD--IPVDNLYAEPAVLQWIREN 158
Cdd:PTZ00145 197 SAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTKK 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 159 iaEWKNCIIVSPDAGGAKRVTSIADRLN------VEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHA 232
Cdd:PTZ00145 277 --DLYKPVIVSPDAGGVYRARKFQDGLNhrgisdCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEA 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 233 ADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYL 312
Cdd:PTZ00145 355 AKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDL 434
|
.
gi 35700 313 F 313
Cdd:PTZ00145 435 F 435
|
|
| PRK04923 |
PRK04923 |
ribose-phosphate diphosphokinase; |
2-313 |
6.28e-111 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179893 [Multi-domain] Cd Length: 319 Bit Score: 324.57 E-value: 6.28e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 2 PNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK04923 5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 82 SSRVTAVIPCFPYARQDKKDKS-RAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIrenia 160
Cdd:PRK04923 85 AASVTAVIPYFGYSRQDRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADI----- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 161 eWK-----NCIIVSPDAGGAKRVTSIADRL-NVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAAD 234
Cdd:PRK04923 160 -WRaygtdNLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 35700 235 KLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK04923 239 ALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
|
|
| PRK03092 |
PRK03092 |
ribose-phosphate diphosphokinase; |
15-313 |
1.56e-110 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 179535 [Multi-domain] Cd Length: 304 Bit Score: 323.05 E-value: 1.56e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 15 LSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPY 94
Cdd:PRK03092 1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 95 ARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEwKNCIIVSPDAGG 174
Cdd:PRK03092 81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 175 AKRVTSIADRL-NVEFALIHKER--KKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHG 251
Cdd:PRK03092 160 VRVAEQWADRLgGAPLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 35700 252 IFSGPAISRINNAAFEAVVVTNTIPQEDKmKHCTKIQVIDISMILAEAIRRTHNGESVSYLF 313
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEE-KRFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
|
|
| PRK02458 |
PRK02458 |
ribose-phosphate pyrophosphokinase; Provisional |
2-317 |
1.20e-94 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 235039 [Multi-domain] Cd Length: 323 Bit Score: 283.17 E-value: 1.20e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 2 PNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIAS 81
Cdd:PRK02458 8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 82 SSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAE 161
Cdd:PRK02458 88 ANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 162 WKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVlVGDVKDRVAILVDDMADTCGTICHAADKLLSAGA 241
Cdd:PRK02458 168 GSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYI-IGDVAGKKAILIDDILNTGKTFAEAAKIVEREGA 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 35700 242 TKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDkmKHCTKIQVIDISMILAEAIRRTHNGESVSYLFSHVP 317
Cdd:PRK02458 247 TEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKE--RVPKNVTYLSASELIADAIIRIHERKPLSPLFAYNK 320
|
|
| PRK00553 |
PRK00553 |
ribose-phosphate pyrophosphokinase; Provisional |
3-314 |
1.77e-85 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 179062 [Multi-domain] Cd Length: 332 Bit Score: 260.23 E-value: 1.77e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 3 NIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASS 82
Cdd:PRK00553 9 NHVIFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 83 SRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEw 162
Cdd:PRK00553 89 KSITAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLELLGK- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 163 KNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGAT 242
Cdd:PRK00553 168 KDLVVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAK 247
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 35700 243 KVYAILTHGIFSGPAISRINNAAFEAVV----VTNTIPQEdKMKHCTKIQVIDISMILAEAIRRTHNGESVSYLFS 314
Cdd:PRK00553 248 KVCVMATHGLFNKNAIQLFDEAFKKKLIdklfVSNSIPQT-KFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIYT 322
|
|
| Pribosyltran_N |
pfam13793 |
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ... |
4-120 |
3.49e-70 |
|
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.
Pssm-ID: 433483 [Multi-domain] Cd Length: 117 Bit Score: 213.44 E-value: 3.49e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 4 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:pfam13793 1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 35700 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAG 120
Cdd:pfam13793 81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
|
|
| PRK00934 |
PRK00934 |
ribose-phosphate pyrophosphokinase; Provisional |
8-302 |
2.06e-67 |
|
ribose-phosphate pyrophosphokinase; Provisional
Pssm-ID: 234868 [Multi-domain] Cd Length: 285 Bit Score: 212.47 E-value: 2.06e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 8 SGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEiNDNLMELLIMINACKIASSSRVTA 87
Cdd:PRK00934 4 GGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKSITL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 88 VIPCFPYARQDKKDKSRAPISAKLVANMLSVAGaDHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIaewKNCII 167
Cdd:PRK00934 83 VIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKL---DDPLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 168 VSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAI 247
Cdd:PRK00934 159 LAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 35700 248 LTHGIFSGPAISRINNAAFEAVVVTNTIPqedkmkhcTKIQVIDISMILAEAIRR 302
Cdd:PRK00934 239 CVHPVLVGDAILKLYNAGVDEIIVTDTLE--------SEVSKISVAPLIADLLKK 285
|
|
| PRK07199 |
PRK07199 |
ribose-phosphate diphosphokinase; |
4-302 |
6.56e-46 |
|
ribose-phosphate diphosphokinase;
Pssm-ID: 235960 [Multi-domain] Cd Length: 301 Bit Score: 157.41 E-value: 6.56e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 4 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVyIIQSGCGEINDNLMELLIMINACKIASSS 83
Cdd:PRK07199 3 PLLLALPGNEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTV-VLVCSLDRPDEKLLPLLFAAEAARELGAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 84 RVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSvAGADHIITMD--LH-ASQIQGFFDIPVDNLYAEPAVLQWIRENIA 160
Cdd:PRK07199 82 RVGLVAPYLAYMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDphLHrYPSLSEVYPIPAVVLSAAPAIAAWIRAHVP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 161 EWkncIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDrmVLVGDV---KDRVAILVDDMADTCGTICHAADKLL 237
Cdd:PRK07199 161 RP---LLIGPDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVE--ISLPDAapwAGRTPVLVDDIVSTGRTLIEAARQLR 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 35700 238 SAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPqedkmkHCTkiQVIDISMILAEAIRR 302
Cdd:PRK07199 236 AAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVP------HPS--NAISLAPLLAEALRR 292
|
|
| Pribosyl_synth |
pfam14572 |
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ... |
161-313 |
8.57e-46 |
|
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.
Pssm-ID: 434046 Cd Length: 184 Bit Score: 153.43 E-value: 8.57e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 161 EWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKA--NEVDR----------------------------MVLVGD 210
Cdd:pfam14572 1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAesDEVDGrqspppyrsrtvsrslglpeiipkekppMTVVGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 211 VKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVI 290
Cdd:pfam14572 81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160
|
170 180
....*....|....*....|...
gi 35700 291 DISMILAEAIRRTHNGESVSYLF 313
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLF 183
|
|
| PRK06827 |
PRK06827 |
phosphoribosylpyrophosphate synthetase; Provisional |
29-312 |
4.86e-39 |
|
phosphoribosylpyrophosphate synthetase; Provisional
Pssm-ID: 180714 [Multi-domain] Cd Length: 382 Bit Score: 141.63 E-value: 4.86e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 29 KVVTKKFSNQETSVEIGESVRGEDVYIIQ---------SGCGE-----INDNLMELLIMINACKiASSSRVTAVIPCFPY 94
Cdd:PRK06827 56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 95 ARQDKKdKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI-PVDNLYAEpavLQWIRENIAEWKNC-------I 166
Cdd:PRK06827 135 SRQHKR-KGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLmGFENLYPS---YQIIKALLKNEKDLeidkdhlM 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 167 IVSPDAGGAKRVTSIADRLNVEFALIHKERK-------KANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSA 239
Cdd:PRK06827 211 VISPDTGAMDRAKYYASVLGVDLGLFYKRRDysrvvngRNPIVAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSR 290
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 35700 240 GATKVYAILTHGIFSGpAISRINNA----AFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVSYL 312
Cdd:PRK06827 291 GAKKIIVAATFGFFTN-GLEKFDKAyeegYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKL 366
|
|
| PRTases_typeI |
cd06223 |
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ... |
147-274 |
4.73e-25 |
|
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.
Pssm-ID: 206754 [Multi-domain] Cd Length: 130 Bit Score: 97.47 E-value: 4.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 147 AEPAVLQWIRENIaeWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRM------VLVGDVKDRVAILVD 220
Cdd:cd06223 1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 35700 221 DMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAisRINNAAFEAVVVTNT 274
Cdd:cd06223 79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
|
|
| PLN02297 |
PLN02297 |
ribose-phosphate pyrophosphokinase |
3-277 |
9.09e-12 |
|
ribose-phosphate pyrophosphokinase
Pssm-ID: 177934 [Multi-domain] Cd Length: 326 Bit Score: 64.71 E-value: 9.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 3 NIVLFSGSSHQDLSQRVADRLG-LELGKVVTKKFSNQETSVEIG--ESVRGEDVYIIQSGcgEINDNLMELL-IMINACK 78
Cdd:PLN02297 16 QVHLFYCEETEELARKIAAESDaIELGSINWRKFPDGFPNLFINnaHGIRGQHVAFLASF--SSPAVIFEQLsVIYALPK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 79 IASSSrVTAVIPCFP---YAR-QDKKDKSRAPISAKLVANM-LSVAGADHIITMDLHASQIQGFFDIPVDNLYAE--PAV 151
Cdd:PLN02297 94 LFVAS-FTLVLPFFPtgtSERvEREGDVATAFTLARILSNIpISRGGPTSLVIFDIHALQERFYFGDNVLPCFESgiPLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 152 LQWIREnIAEWKNCIIVSPDAGGAKRVTSIADrlNVEFALIHKERkkanEVD-RMVLV--GDVKDRVAILVDDMADTCGT 228
Cdd:PLN02297 173 KKRLQQ-LPDSDNIVIAFPDDGAWKRFHKQFE--HFPMVVCTKVR----EGDkRIVRIkeGNPAGRHVVIVDDLVQSGGT 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 35700 229 ICHAADKLLSAGATKVYAILTHGIFSGPAISRINN------AAFEAVVVTNTIPQ 277
Cdd:PLN02297 246 LIECQKVLAAHGAAKVSAYVTHGVFPNESWERFTHdnggpeAGFAYFWITDSCPQ 300
|
|
| Pribosyltran |
pfam00156 |
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ... |
141-244 |
3.92e-11 |
|
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.
Pssm-ID: 425489 [Multi-domain] Cd Length: 150 Bit Score: 60.07 E-value: 3.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 35700 141 PVDNLYAEPAVLQWIRENIAE------WKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKAN---EVDRMVLVGDV 211
Cdd:pfam00156 1 SVDEILDNPAILKAVARLAAQinedygGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDtseVMKTSSALPDL 80
|
90 100 110
....*....|....*....|....*....|...
gi 35700 212 KDRVAILVDDMADTCGTICHAADKLLSAGATKV 244
Cdd:pfam00156 81 KGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
|
|
| upp |
PRK00129 |
uracil phosphoribosyltransferase; Reviewed |
207-247 |
6.67e-03 |
|
uracil phosphoribosyltransferase; Reviewed
Pssm-ID: 234653 Cd Length: 209 Bit Score: 37.38 E-value: 6.67e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 35700 207 LVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAI 247
Cdd:PRK00129 118 LPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVL 158
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