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Conserved domains on  [gi|1235591|emb|CAA65407|]
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dendrin, partial [Rattus norvegicus]

Protein Classification

Dendrin domain-containing protein( domain architecture ID 12173826)

Dendrin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dendrin pfam15498
Nephrin and CD2AP-binding protein, Dendrin; Dendrin is a family of eukaryotic proteins found ...
68-719 0e+00

Nephrin and CD2AP-binding protein, Dendrin; Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.


:

Pssm-ID: 464749 [Multi-domain]  Cd Length: 656  Bit Score: 928.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591     68 MDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 147
Cdd:pfam15498   1 MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    148 AD----GVPRSAPPRAPerlRAAQPTGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGDRRPGPPSYEAHLLLRG 223
Cdd:pfam15498  81 ARrsplGRPRPEPRNAP---RAAQPAGLPAPSRPERLGPAGRAPRPSAQPQSDPGAAWAGPWGGRRPGPPSYEAHLLLRG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    224 AAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGR 303
Cdd:pfam15498 158 AAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSQAPASSAPAPTPARTEGGRAKKRLDPRIYRDVLGAWGLRQGR 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    304 GLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAKTTG-PVTEVALSGST--ISSPPRPVPRSRQHLRGS 380
Cdd:pfam15498 238 GLLGGSPGCGAARARPESGKGAAEKSSGLAAAGLNSGSDSHFQAKAAGsPGTETAPARSAtaTSSPPRPAPRSRHQLRGS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    381 RKGKEGSEEMWLPTCWLSSPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAGRE 460
Cdd:pfam15498 318 REGKEGREQIWLPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESPGQGEGAGPETLEDWKETRRAHTLPRSSRGPAGGE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    461 GIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPClEEEGKGAAANPSVCQKRLLSSRVLNPPSEGREF 540
Cdd:pfam15498 398 GVFVIDATCVVIRSQYVPTPRTQQVQLLPSGEPRVVGDSPSQPKPG-KEEGEGASAFPSPCQKLLLSSRLLHQPSGGREC 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    541 EAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPTHPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAG 620
Cdd:pfam15498 477 EAEGGKPGDSSLEERASRILGLPVGEVNLRDAPAQPGSPEHPALGPAAPACAGSARGSEVAAVPRRAGGGWARTPGPYAG 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    621 ALREAVSRIRRHTAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDSIGEILDVISQ 700
Cdd:pfam15498 557 ALREAVSRIRRHTAPDSDSDEAEELSVHSGSSDGSDTEAPGASWRNERTLPGTGNTSPEEGGKTAELSDSIREILDVISQ 636
                         650       660
                  ....*....|....*....|
gi 1235591    701 TEEGLVR-EDTRKTPQGKRE 719
Cdd:pfam15498 637 TEEALFGaRDSAGTPQGNRE 656
 
Name Accession Description Interval E-value
Dendrin pfam15498
Nephrin and CD2AP-binding protein, Dendrin; Dendrin is a family of eukaryotic proteins found ...
68-719 0e+00

Nephrin and CD2AP-binding protein, Dendrin; Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.


Pssm-ID: 464749 [Multi-domain]  Cd Length: 656  Bit Score: 928.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591     68 MDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 147
Cdd:pfam15498   1 MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    148 AD----GVPRSAPPRAPerlRAAQPTGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGDRRPGPPSYEAHLLLRG 223
Cdd:pfam15498  81 ARrsplGRPRPEPRNAP---RAAQPAGLPAPSRPERLGPAGRAPRPSAQPQSDPGAAWAGPWGGRRPGPPSYEAHLLLRG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    224 AAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGR 303
Cdd:pfam15498 158 AAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSQAPASSAPAPTPARTEGGRAKKRLDPRIYRDVLGAWGLRQGR 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    304 GLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAKTTG-PVTEVALSGST--ISSPPRPVPRSRQHLRGS 380
Cdd:pfam15498 238 GLLGGSPGCGAARARPESGKGAAEKSSGLAAAGLNSGSDSHFQAKAAGsPGTETAPARSAtaTSSPPRPAPRSRHQLRGS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    381 RKGKEGSEEMWLPTCWLSSPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAGRE 460
Cdd:pfam15498 318 REGKEGREQIWLPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESPGQGEGAGPETLEDWKETRRAHTLPRSSRGPAGGE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    461 GIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPClEEEGKGAAANPSVCQKRLLSSRVLNPPSEGREF 540
Cdd:pfam15498 398 GVFVIDATCVVIRSQYVPTPRTQQVQLLPSGEPRVVGDSPSQPKPG-KEEGEGASAFPSPCQKLLLSSRLLHQPSGGREC 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    541 EAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPTHPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAG 620
Cdd:pfam15498 477 EAEGGKPGDSSLEERASRILGLPVGEVNLRDAPAQPGSPEHPALGPAAPACAGSARGSEVAAVPRRAGGGWARTPGPYAG 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    621 ALREAVSRIRRHTAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDSIGEILDVISQ 700
Cdd:pfam15498 557 ALREAVSRIRRHTAPDSDSDEAEELSVHSGSSDGSDTEAPGASWRNERTLPGTGNTSPEEGGKTAELSDSIREILDVISQ 636
                         650       660
                  ....*....|....*....|
gi 1235591    701 TEEGLVR-EDTRKTPQGKRE 719
Cdd:pfam15498 637 TEEALFGaRDSAGTPQGNRE 656
PHA03247 PHA03247
large tegument protein UL36; Provisional
93-417 1.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591     93 PPPRRPWASRvlqEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGADgvprSAPPRAPerlraAQPTGFP 172
Cdd:PHA03247 2551 PPPPLPPAAP---PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDD----RGDPRGP-----APPSPLP 2618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    173 VFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGDRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTL 252
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL 2698
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    253 GTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRD-----------VLGAWGLRQGRGLLGGAPGCAAARARPES 321
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAApappavpagpaTPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    322 CKGAVEKSSGL-AAAGLNSGGDGHSQAKTTGPVTEVALSGSTISSPPRPVPRSRQHLRGSRKGKEGSEEMWLPTCWLSSP 400
Cdd:PHA03247 2779 PPRRLTRPAVAsLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
                         330
                  ....*....|....*..
gi 1235591    401 KKPPVRHSQTLPRPWAP 417
Cdd:PHA03247 2859 GGDVRRRPPSRSPAAKP 2875
 
Name Accession Description Interval E-value
Dendrin pfam15498
Nephrin and CD2AP-binding protein, Dendrin; Dendrin is a family of eukaryotic proteins found ...
68-719 0e+00

Nephrin and CD2AP-binding protein, Dendrin; Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.


Pssm-ID: 464749 [Multi-domain]  Cd Length: 656  Bit Score: 928.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591     68 MDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 147
Cdd:pfam15498   1 MDFQASHWARGPQSRTCGPRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    148 AD----GVPRSAPPRAPerlRAAQPTGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGDRRPGPPSYEAHLLLRG 223
Cdd:pfam15498  81 ARrsplGRPRPEPRNAP---RAAQPAGLPAPSRPERLGPAGRAPRPSAQPQSDPGAAWAGPWGGRRPGPPSYEAHLLLRG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    224 AAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGR 303
Cdd:pfam15498 158 AAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSQAPASSAPAPTPARTEGGRAKKRLDPRIYRDVLGAWGLRQGR 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    304 GLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAKTTG-PVTEVALSGST--ISSPPRPVPRSRQHLRGS 380
Cdd:pfam15498 238 GLLGGSPGCGAARARPESGKGAAEKSSGLAAAGLNSGSDSHFQAKAAGsPGTETAPARSAtaTSSPPRPAPRSRHQLRGS 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    381 RKGKEGSEEMWLPTCWLSSPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAGRE 460
Cdd:pfam15498 318 REGKEGREQIWLPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESPGQGEGAGPETLEDWKETRRAHTLPRSSRGPAGGE 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    461 GIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPClEEEGKGAAANPSVCQKRLLSSRVLNPPSEGREF 540
Cdd:pfam15498 398 GVFVIDATCVVIRSQYVPTPRTQQVQLLPSGEPRVVGDSPSQPKPG-KEEGEGASAFPSPCQKLLLSSRLLHQPSGGREC 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    541 EAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPTHPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAG 620
Cdd:pfam15498 477 EAEGGKPGDSSLEERASRILGLPVGEVNLRDAPAQPGSPEHPALGPAAPACAGSARGSEVAAVPRRAGGGWARTPGPYAG 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    621 ALREAVSRIRRHTAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDSIGEILDVISQ 700
Cdd:pfam15498 557 ALREAVSRIRRHTAPDSDSDEAEELSVHSGSSDGSDTEAPGASWRNERTLPGTGNTSPEEGGKTAELSDSIREILDVISQ 636
                         650       660
                  ....*....|....*....|
gi 1235591    701 TEEGLVR-EDTRKTPQGKRE 719
Cdd:pfam15498 637 TEEALFGaRDSAGTPQGNRE 656
PHA03247 PHA03247
large tegument protein UL36; Provisional
93-417 1.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591     93 PPPRRPWASRvlqEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGADgvprSAPPRAPerlraAQPTGFP 172
Cdd:PHA03247 2551 PPPPLPPAAP---PAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDD----RGDPRGP-----APPSPLP 2618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    173 VFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGDRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTL 252
Cdd:PHA03247 2619 PDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL 2698
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    253 GTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRD-----------VLGAWGLRQGRGLLGGAPGCAAARARPES 321
Cdd:PHA03247 2699 ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAApappavpagpaTPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    322 CKGAVEKSSGL-AAAGLNSGGDGHSQAKTTGPVTEVALSGSTISSPPRPVPRSRQHLRGSRKGKEGSEEMWLPTCWLSSP 400
Cdd:PHA03247 2779 PPRRLTRPAVAsLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAP 2858
                         330
                  ....*....|....*..
gi 1235591    401 KKPPVRHSQTLPRPWAP 417
Cdd:PHA03247 2859 GGDVRRRPPSRSPAAKP 2875
PHA03247 PHA03247
large tegument protein UL36; Provisional
77-417 1.32e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591     77 RGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAAsqereAKETERKRRKAGGADGVPRSAP 156
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA-----PGRVSRPRRARRLGRAAQASSP 2679
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    157 PRAPERlRAAQPTGFPV--FSRPERFGQVgRAPRPSALPQGDPGVAWAGPWGDRRPGPPSYEAHLLLRGAAGTAPRRRWD 234
Cdd:PHA03247 2680 PQRPRR-RAARPTVGSLtsLADPPPPPPT-PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    235 RPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSApvpATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAA 314
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASL---SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    315 ARARPESCKGAVEKSSGLaAAGLNSGGDGHSQAKTTGPVTEVAlsgstisSPPRPVPRSRQHLRGSRKgkegSEEMWLPT 394
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPL-GGSVAPGGDVRRRPPSRSPAAKPA-------APARPPVRRLARPAVSRS----TESFALPP 2902
                         330       340
                  ....*....|....*....|...
gi 1235591    395 cwlSSPKKPPVRHSQTLPRPWAP 417
Cdd:PHA03247 2903 ---DQPERPPQPQAPPPPQPQPQ 2922
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
79-280 3.33e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591    79 PQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKA--ASQEREAKETERKRRKAGGADGVPRSAP 156
Cdd:PRK12323 383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAlaAARQASARGPGGAPAPAPAPAAAPAAAA 462
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1235591   157 PRAPERLRAAQPTGFPVFSRPErfgqvgRAPRPSALPQGDPgvawagPWGDRRPGPPSYEahlLLRGAAGTAPRRRWDRP 236
Cdd:PRK12323 463 RPAAAGPRPVAAAAAAAPARAA------PAAAPAPADDDPP------PWEELPPEFASPA---PAQPDAAPAGWVAESIP 527
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 1235591   237 PPYVAPPSYEGPHRTLGTKRGPeLSRAPTSSAPVPATTRTEGGR 280
Cdd:PRK12323 528 DPATADPDDAFETLAPAPAAAP-APRAAAATEPVVAPRPPRASA 570
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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