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Conserved domains on  [gi|1789585050|emb|CAA0385278|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

nascent polypeptide-associated complex subunit alpha( domain architecture ID 15349518)

nascent polypeptide-associated complex subunit alpha (NACA) is a component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting

CATH:  1.10.8.10
Gene Ontology:  GO:0005854|GO:0015031|GO:0006612|GO:0051082
PubMed:  12429939|19468686
SCOP:  4000749

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAC_NACA cd22054
nascent polypeptide-associated complex (NAC), alpha subunit; The nascent ...
 84-131 2.62e-23

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.


:

Pssm-ID: 409233  Cd Length: 48  Bit Score: 88.00  E-value: 2.62e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1789585050  84 GMKPVTGVSRVTIKRTKNVLFFISKPDVFKSPHSETYVIFGEAKIEDL 131
Cdd:cd22054     1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDTYIVFGEAKIEDL 48
UBA_NAC_euk cd14358
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its ...
 180-216 2.23e-17

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes; The subfamily contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. All family members contain an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


:

Pssm-ID: 270541 [Multi-domain]  Cd Length: 37  Bit Score: 72.27  E-value: 2.23e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1789585050 180 ARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14358     1 PKDIELVMQQANVSRAKAVKALKENDNDIVNAIMELT 37
 
Name Accession Description Interval E-value
NAC_NACA cd22054
nascent polypeptide-associated complex (NAC), alpha subunit; The nascent ...
 84-131 2.62e-23

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 409233  Cd Length: 48  Bit Score: 88.00  E-value: 2.62e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1789585050  84 GMKPVTGVSRVTIKRTKNVLFFISKPDVFKSPHSETYVIFGEAKIEDL 131
Cdd:cd22054     1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDTYIVFGEAKIEDL 48
NAC pfam01849
NAC domain;
75-128 1.66e-19

NAC domain;


Pssm-ID: 426474  Cd Length: 54  Bit Score: 78.28  E-value: 1.66e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1789585050  75 KSRKAMLKLGMKPVTGVSRVTIKRTKNVLFFISKPDVFKSPHSETYVIFGEAKI 128
Cdd:pfam01849   1 KLQKALKKLGLKPIPGVEEVNIFKSDGKVLVFNNPKVQKSPGSNTYVVFGEAEE 54
UBA_NAC_euk cd14358
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its ...
 180-216 2.23e-17

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes; The subfamily contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. All family members contain an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 270541 [Multi-domain]  Cd Length: 37  Bit Score: 72.27  E-value: 2.23e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1789585050 180 ARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14358     1 PKDIELVMQQANVSRAKAVKALKENDNDIVNAIMELT 37
EGD2 COG1308
Transcription factor homologous to NACalpha-BTF3 [Transcription];
74-216 3.27e-10

Transcription factor homologous to NACalpha-BTF3 [Transcription];


Pssm-ID: 440919 [Multi-domain]  Cd Length: 116  Bit Score: 55.62  E-value: 3.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789585050  74 KKSRKAMLKLGMKPVT-GVSRVTIkRTKNVLFFISKPDV--FKSPHSETYVIFGEAKIEDLSSQlqtqaaqqfrmpeiga 150
Cdd:COG1308     8 RKMKQMMKQMGIKVEEiDAEEVII-RTKDKEIVFENPQVtvMKAQGQETYQIVGEPEEVEKGAE---------------- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1789585050 151 tsqraeastatveaqveedeeeIDETGVEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:COG1308    71 ----------------------EAEVEIPEEDVELVAEQTGVSEEEAREALEEANGDLAEAILKLE 114
HYPK_UBA pfam19026
HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK ...
 176-216 7.82e-10

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.


Pssm-ID: 436907  Cd Length: 41  Bit Score: 52.56  E-value: 7.82e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1789585050 176 TGVEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:pfam19026   1 VKVKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41
nac PRK06369
nascent polypeptide-associated complex protein; Reviewed
 74-216 1.94e-08

nascent polypeptide-associated complex protein; Reviewed


Pssm-ID: 235786 [Multi-domain]  Cd Length: 115  Bit Score: 50.63  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789585050  74 KKSRKAMLKLGMKpVT--GVSRVTIkRTKNVLFFISKPDV--FKSPHSETYVIFGEAKIEdlssqlQTQAAQQFRMPEig 149
Cdd:PRK06369    8 RKMKQMMKQMGID-VEelDVEEVII-RLKDKEIVFENPQVtvMDAQGQKTYQIVGEPEEV------EKEAEKEVEIPE-- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1789585050 150 atsqraeastatveaqveedeeeidetgveaRDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:PRK06369   78 -------------------------------EDIELVAEQTGVSEEEARKALEEANGDLAEAILKLS 113
TIGR00264 TIGR00264
alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its ...
 182-215 5.77e-04

alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its C-terminal domain of about 40 amino acids is homologous to the C-termini of the nascent polypeptide-associated complex alpha chain (alpha-NAC) and its yeast ortholog Egd2p and to the huntingtin-interacting protein HYPK. It shows weaker similarity, possibly through shared structural constraints rather than through homology, with the amino-terminal domain of elongation factor Ts. Alpha-NAC plays a role in preventing nascent polypeptides from binding inappropriately to membrane-targeting apparatus during translation, but is also active as a transcription regulator. [Unknown function, General]


Pssm-ID: 272988 [Multi-domain]  Cd Length: 116  Bit Score: 38.39  E-value: 5.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1789585050 182 DIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMEL 215
Cdd:TIGR00264  81 DIELVMKQCNVSKEEARRALEECGGDLAEAIMKL 114
 
Name Accession Description Interval E-value
NAC_NACA cd22054
nascent polypeptide-associated complex (NAC), alpha subunit; The nascent ...
 84-131 2.62e-23

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 409233  Cd Length: 48  Bit Score: 88.00  E-value: 2.62e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1789585050  84 GMKPVTGVSRVTIKRTKNVLFFISKPDVFKSPHSETYVIFGEAKIEDL 131
Cdd:cd22054     1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDTYIVFGEAKIEDL 48
NAC pfam01849
NAC domain;
75-128 1.66e-19

NAC domain;


Pssm-ID: 426474  Cd Length: 54  Bit Score: 78.28  E-value: 1.66e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1789585050  75 KSRKAMLKLGMKPVTGVSRVTIKRTKNVLFFISKPDVFKSPHSETYVIFGEAKI 128
Cdd:pfam01849   1 KLQKALKKLGLKPIPGVEEVNIFKSDGKVLVFNNPKVQKSPGSNTYVVFGEAEE 54
UBA_NAC_euk cd14358
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its ...
 180-216 2.23e-17

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes; The subfamily contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. All family members contain an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 270541 [Multi-domain]  Cd Length: 37  Bit Score: 72.27  E-value: 2.23e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1789585050 180 ARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14358     1 PKDIELVMQQANVSRAKAVKALKENDNDIVNAIMELT 37
UBA_NACA_NACP1 cd14415
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and ...
 176-216 3.37e-14

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1); NACA, also called NAC-alpha or alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. Both NACA and BTF3 harbor an NAC domain that mediates the dimerization of the two subunits. By contrast, NACA has an extra ubiquitin-associated (UBA) domain in the C-terminus. In addition to NACA, the family includes NACP1, also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1. The biological function of NACP1 remains unclear.


Pssm-ID: 270598  Cd Length: 46  Bit Score: 64.20  E-value: 3.37e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1789585050 176 TGVEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14415     6 TGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELT 46
UBA_NACAD cd14416
UBA-like domain found in nascent polypeptide-associated complex subunit alpha ...
 176-216 3.59e-13

UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD); The subfamily includes a group of uncharacterized proteins mainly found in vertebrates. Their biological function remains unknown, but they show high sequence similarity to the nascent polypeptide-associated complex (NAC) subunit alpha (NACA) that exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. Like NACA, NACAD contains an NAC domain and a C-terminal ubiquitin-associated (UBA) domain.


Pssm-ID: 270599  Cd Length: 44  Bit Score: 61.63  E-value: 3.59e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1789585050 176 TGVEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14416     3 TGLEVRDIELVMAQANVSRAKAVRALRHNNNDIVNAIMELT 43
UBA_NAC_like cd14278
UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and ...
 182-216 5.10e-13

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins; The family contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins found in archaea and bacteria. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. The family also includes huntingtin-interacting protein K (HYPK), also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K. It is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It may be involved in regulating cell growth, cell cycle, unfolded protein response and cell death. All members in this family contain an ubiquitin-associated (UBA) domain.


Pssm-ID: 270464 [Multi-domain]  Cd Length: 37  Bit Score: 60.96  E-value: 5.10e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1789585050 182 DIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14278     3 DIELVMSQTGVSREEAIKALRENKGDVVDAILELT 37
EGD2 COG1308
Transcription factor homologous to NACalpha-BTF3 [Transcription];
74-216 3.27e-10

Transcription factor homologous to NACalpha-BTF3 [Transcription];


Pssm-ID: 440919 [Multi-domain]  Cd Length: 116  Bit Score: 55.62  E-value: 3.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789585050  74 KKSRKAMLKLGMKPVT-GVSRVTIkRTKNVLFFISKPDV--FKSPHSETYVIFGEAKIEDLSSQlqtqaaqqfrmpeiga 150
Cdd:COG1308     8 RKMKQMMKQMGIKVEEiDAEEVII-RTKDKEIVFENPQVtvMKAQGQETYQIVGEPEEVEKGAE---------------- 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1789585050 151 tsqraeastatveaqveedeeeIDETGVEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:COG1308    71 ----------------------EAEVEIPEEDVELVAEQTGVSEEEAREALEEANGDLAEAILKLE 114
HYPK_UBA pfam19026
HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK ...
 176-216 7.82e-10

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.


Pssm-ID: 436907  Cd Length: 41  Bit Score: 52.56  E-value: 7.82e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1789585050 176 TGVEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:pfam19026   1 VKVKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41
UBA_AeNAC cd14359
UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from ...
 182-216 4.29e-09

UBA-like domain found in archaeal nascent polypeptide-associated complex homolog from Methanothermobacter marburgensis (AeNAC) and similar proteins; AeNAC is a functional archaeal homolog of eukaryotic nascent polypeptide-associated complex (NAC). Both AeNAC and eukaryotic NAC function as the cytosolic chaperone that can bind to ribosomal RNA, interact with the nascent polypeptide chains as they emerge from the ribosome, and assist in post-translational processes. They all contain a NAC domain and an ubiquitin-associated (UBA) domain in the C-terminus. However, unlike eukaryotic NAC, AeNAC forms a ribosome associated homodimer, but not heterodimer. The NAC domain of AeNAC is responsible for the homodimer formation.


Pssm-ID: 270542 [Multi-domain]  Cd Length: 40  Bit Score: 50.68  E-value: 4.29e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1789585050 182 DIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14359     6 DIELVMEQTGVSREEARKALEESGGDLAEAILKLT 40
nac PRK06369
nascent polypeptide-associated complex protein; Reviewed
 74-216 1.94e-08

nascent polypeptide-associated complex protein; Reviewed


Pssm-ID: 235786 [Multi-domain]  Cd Length: 115  Bit Score: 50.63  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789585050  74 KKSRKAMLKLGMKpVT--GVSRVTIkRTKNVLFFISKPDV--FKSPHSETYVIFGEAKIEdlssqlQTQAAQQFRMPEig 149
Cdd:PRK06369    8 RKMKQMMKQMGID-VEelDVEEVII-RLKDKEIVFENPQVtvMDAQGQKTYQIVGEPEEV------EKEAEKEVEIPE-- 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1789585050 150 atsqraeastatveaqveedeeeidetgveaRDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:PRK06369   78 -------------------------------EDIELVAEQTGVSEEEARKALEEANGDLAEAILKLS 113
NAC cd21114
NAC domain; This family contains the NAC domain, named after the nascent ...
 88-130 1.23e-05

NAC domain; This family contains the NAC domain, named after the nascent polypeptide-associated complex (NAC) whose subunits contain NAC domains. In eukaryotes, the NAC complex, which plays an important role in co-translational targeting of nascent polypeptides to endoplasmic reticulum (ER), consists of 2 subunits: NAC alpha and a shortened splice variant of the basal transcription factor 3 (BTF3; also called BTF3b or NAC beta). The full length BTF3a protein excites transcription.


Pssm-ID: 409232  Cd Length: 43  Bit Score: 41.13  E-value: 1.23e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1789585050  88 VTGVSRVTIKRTKNVLFFISKPDVFKSPHSETYVIFGEAKIED 130
Cdd:cd21114     1 IPGIEEVTMVMEDGSVIVFTMPKVQASLASNVFVVTGEATREQ 43
UBA_HYPK cd14361
UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, ...
 178-216 2.57e-05

UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K, is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It is involved in regulating cell growth, cell cycle, unfolded protein response, and cell death. All members in this subfamily contain an N-terminal ubiquitin-associated (UBA) that shows high sequence similarity with that of eukaryotic nascent polypeptide-associated complex proteins (NAC) which is one of the cytosolic chaperones that contact the nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes.


Pssm-ID: 270544  Cd Length: 41  Bit Score: 40.18  E-value: 2.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1789585050 178 VEARDIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMELT 216
Cdd:cd14361     3 VKKEDVELIVNELEVSKAQAERALREHNGDVVKALRALI 41
TIGR00264 TIGR00264
alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its ...
 182-215 5.77e-04

alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its C-terminal domain of about 40 amino acids is homologous to the C-termini of the nascent polypeptide-associated complex alpha chain (alpha-NAC) and its yeast ortholog Egd2p and to the huntingtin-interacting protein HYPK. It shows weaker similarity, possibly through shared structural constraints rather than through homology, with the amino-terminal domain of elongation factor Ts. Alpha-NAC plays a role in preventing nascent polypeptides from binding inappropriately to membrane-targeting apparatus during translation, but is also active as a transcription regulator. [Unknown function, General]


Pssm-ID: 272988 [Multi-domain]  Cd Length: 116  Bit Score: 38.39  E-value: 5.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1789585050 182 DIDLVMTQAGVSRSKAVKALKSHDGDIVSAIMEL 215
Cdd:TIGR00264  81 DIELVMKQCNVSKEEARRALEECGGDLAEAIMKL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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