|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
67-501 |
1.61e-165 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 475.91 E-value: 1.61e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 67 ESRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIAGFSFGIMLGMGSALETLCGQAFGAGKVSMLG 146
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 147 VYLQRSWVILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISGV 226
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 227 VLVIHSFFTWLVMSRLHWGLPGLALVLNTSWWVIVVAQLVYI-FNCTCGEAWSGFTWEAFHNLWGFVKLSLASAAMLCLE 305
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIfFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 306 IWYFMALVLFAGYLKnAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILSTAIGMFIA 385
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 386 AGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLFGVPFGLLLGFKL 465
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 1789591981 466 EYGVMGIWWGMVTGTFVQSIVLTWMICKTNWEKEAS 501
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAE 435
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
77-417 |
1.68e-54 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 186.68 E-value: 1.68e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 77 PAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIaGFSFGIMLGMGSALETLCGQAFGAGKVSMLGVYLQRSWVIL 156
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVF-MFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 157 SVTALFLSLIYIFAAPILTFIGQTA-AISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISGVVLVIHSFFT 235
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADgEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 236 W-LVMSRL-HWGLPGLALVLNTSWWVIVVAQLVYIFNC-TCGEAWSGFTWEAFHNLWGFVKLSLASAAMLCLEIWYFMAL 312
Cdd:TIGR00797 160 YiLIFGKFgFLGIVGAALATVISYWLMFLLLLYYIKKAkKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 313 VLFAGYLKnaEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILSTAIGMFIAAGLLFFR 392
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
330 340
....*....|....*....|....*
gi 1789591981 393 NEYPVLFVEDEEVRNVVRELTPMLA 417
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
69-490 |
4.54e-53 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 185.35 E-value: 4.54e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVI-AGFSFGIMLGMGSAleTLCGQAFGAGKVSMLGV 147
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFfLLIALGIGLGVGGT--ALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 148 YLQRS-WVILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISGV 226
Cdd:COG0534 86 VLGQAlLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 227 VLVIHSFFTWLVMSRLHWGLPGLALVLNTSWWVIVVAQLVYIFNCTCGEAWSGFTWEA-FHNLWGFVKLSLASAAMLCLE 305
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPdRKILKRILRIGLPAGLQQLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 306 IWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILSTAIGMFIA 385
Cdd:COG0534 246 SLGFLVLNALVARL--GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 386 AGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLFGVPFGLLLGFkL 465
Cdd:COG0534 324 LLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-L 402
|
410 420
....*....|....*....|....*
gi 1789591981 466 EYGVMGIWWGMVTGTFVQSIVLTWM 490
Cdd:COG0534 403 GLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
67-489 |
5.53e-44 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 161.13 E-value: 5.53e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 67 ESRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIAGFSFGIMlGMGSALETLCGQAFGAGKVSMLG 146
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGM-GLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 147 VYLQRSWVILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISGV 226
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 227 VLVIHSFFTWLVMSRlHWGLP-----GLALVLNTSWWVIVVAQLVYIFN------CTCGEAWSGFTWEAFHNLWgfvKLS 295
Cdd:cd13131 160 ALVLNIPLNYVLIFG-KFGLPalggaGAGLATAIVYWLMFLALAFYIRRhkrfrrYRLFARFWRPDWARLKELL---RLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 296 LASAAMLCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVI 375
Cdd:cd13131 236 LPIGLTIFFEVSLFAAVALLMGRL--GTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 376 LSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLFGV 455
Cdd:cd13131 314 LGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGL 393
|
410 420 430
....*....|....*....|....*....|....
gi 1789591981 456 PFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTW 489
Cdd:cd13131 394 PLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
69-496 |
5.54e-37 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 141.50 E-value: 5.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIaGFSFGIMLGMGSALETLCGQAFGAGKVSMLGVY 148
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVL-WLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 149 LQRSWVILSVTALFLSLI-YIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISGVV 227
Cdd:cd13137 80 LGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 228 LVIHSFFTWLVM----SRLHWGLPGLALVLNTSWWVIVVAQLVYIFNCTCG--EAWSGFTWEaFHNLWGFVKLSLASAAM 301
Cdd:cd13137 160 NVLNIVLDYVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPikISFKGFRLD-RKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 302 LCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILSTAIG 381
Cdd:cd13137 239 QLLRSLGFLVLLAIVASY--GTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFM 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 382 MFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLFGVPFGLLL 461
Cdd:cd13137 317 GLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLL 396
|
410 420 430
....*....|....*....|....*....|....*
gi 1789591981 462 GFKLEYGVMGIWWGMVTGTFVQSIVLTWMICKTNW 496
Cdd:cd13137 397 GFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
69-496 |
1.06e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 121.09 E-value: 1.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAvsienSVIAG--FSFGIMLGMGSA--LETLCGQAFGAGKVSM 144
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAA-----SGPAGvlYFAILMLFFGLSsgVQVFVAQYNGAGRYSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 145 LGVYLQRSWVILSVTALFLSLIYIFAAP-ILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFL--QSQSKIMVMA 221
Cdd:cd13133 80 IGRVLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFsgIGRTRVVMVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 222 GISGVVLVIhsFFTWLvmsrL---HWGLPGL-----ALVLNTSWWVIVVAQLVYIF---NCTCGEAWSGFTWEaFHNLWG 290
Cdd:cd13133 160 NLVMVVVNI--VLDYA----LifgKLGFPAMgiagaAIATVIAEAVSLLFFLLLLFrrkNRRRFGLRRAWRFD-RELLRR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 291 FVKLSLASAAMLCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSL 370
Cdd:cd13133 233 ILRLGLPSGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVT 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 371 VVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPML---AFCIVINNVQPVLSGVAVGAGWQAVVAYVNI 447
Cdd:cd13133 311 RRGLKLALAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLLrfvAAYILFDALALVFAGALRGAGDTRFVMLAEL 390
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1789591981 448 ACYYLFGVPfGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTWMICKTNW 496
Cdd:cd13133 391 IVAWLYLLP-PAYLLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
77-237 |
2.38e-28 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 110.35 E-value: 2.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 77 PAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSvIAGFSFGIMLGMGSALETLCGQAFGAGKVSMLGVYLQRSWVIL 156
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANS-IASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 157 SVTALFLSLI-YIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISGVVLVIHSFFT 235
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 1789591981 236 WL 237
Cdd:pfam01554 160 YL 161
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
75-488 |
5.82e-27 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 112.80 E-value: 5.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 75 AGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIAGFSFGIMlGMGSALETLCGQAFGAGKVSMLGVYLQRS-W 153
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGV-GLSVGTSALISQAIGAGDEEKARRVLVQSiV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 154 VILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISGVVLVIHSF 233
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 234 FTWLV---MSRLHWGLPGLALVLNTSWWVIVVAQLVYIFnctCGEAWSGFTWEAFH----NLWGFVKLSLASAAMLCLEI 306
Cdd:cd12082 160 LDPLLifgLGPPELGIAGAALATVISYVIGALLLLIYLR---KGKKILKFKLSLLKpdleLLRRLLRIGLPSAIQNSLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 307 WYFMALVLFAGYLKNAEVsVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILSTAIGMFIAA 386
Cdd:cd12082 237 LGLLIIVAIVAAFGGAAA-LAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 387 GLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLFGVPFGLLLGFkLE 466
Cdd:cd12082 316 LILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LG 394
|
410 420
....*....|....*....|..
gi 1789591981 467 YGVMGIWWGMVTGTFVQSIVLT 488
Cdd:cd12082 395 LGLYGIWLALVISLILAALVLL 416
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
69-476 |
8.74e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 109.52 E-value: 8.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGH-ISTLALAAVSIENSVIAG-FSFGIMLGMGSAleTLCGQAFGAGKVSMLG 146
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLVFPIIMLlMALGLMIGVGGA--SLISRRLGAGDREKAN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 147 VYLQRS-WVILSVTALFLSLIYIFAAPILTFIGQTAAISAMA----GIFSIYMIPQIFAYAINFptakFLQSQSKIMVMA 221
Cdd:cd13143 82 RIFSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAvdylRIILLGAPFTILSSVLNN----LLRAEGKPKLAM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 222 GISGVVLVIHSFFTWLVMSRLHWGLPGLALVLNTSWWVIVVAQLVYIF--NCTCGEAWSGFTWEaFHNLWGFVKLSLASA 299
Cdd:cd13143 158 LGMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFrgKSLLKLSLLRFKLS-LKIIKEILALGFPSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 300 AM-LCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILST 378
Cdd:cd13143 237 LMqLSSSVVTIVLNLTLLGYG--GDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVAL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 379 AIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSG--VAVGAGWQAVVayVNIACYYLFGVP 456
Cdd:cd13143 315 IYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGyfQAIGKAKRAAL--LSLLRQGLFLIP 392
|
410 420
....*....|....*....|
gi 1789591981 457 FGLLLGFKleYGVMGIWWGM 476
Cdd:cd13143 393 LLLILPRL--FGLDGIWLAF 410
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
298-460 |
3.15e-25 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 101.87 E-value: 3.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 298 SAAMLCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILS 377
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 378 TAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACyYLFGVPF 457
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPL 158
|
...
gi 1789591981 458 GLL 460
Cdd:pfam01554 159 NYL 161
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
68-498 |
7.64e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 104.12 E-value: 7.64e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 68 SRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVI-AGFSFGIMLGMGSALetLCGQAFGAGKVSMLG 146
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILfLLILIFSFISTGTSI--LIAQYLGAKDKKKAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 147 VYLQRSWVILSVTALFLSLI-YIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQS--QSKIMVMAGI 223
Cdd:cd13134 80 QIAGVALLFNLLLGLVFSLLlLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRShgRTKIPMYVSL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 224 SGVVL-------VIHSFFTWLVMsrlhwGLPGLALVLNTSWWVIVVAQLVYIFnctCGEAWSGFTWEAFHNLWGFVKLSL 296
Cdd:cd13134 160 IMNILnivgnylLIFGWFGLPKL-----GVAGVAISTVISRAVGLVLLFILLF---RKLKIRFRLKDLRPFPKKLLKKIL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 297 ASAAMLCLE--IWYFMALVLFAGYLKNAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAV 374
Cdd:cd13134 232 KIGLPSAGEelSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 375 ILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLFG 454
Cdd:cd13134 312 KIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGIS 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1789591981 455 VPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTWMICKTNWEK 498
Cdd:cd13134 392 VPLAYLLGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKWIK 435
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
69-497 |
1.14e-23 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 103.31 E-value: 1.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHI-STLALAAVSIeNSVIAGFSFGIMLGMGSALETLCGQAFGAGKVSMLGV 147
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFlGVAALAAVSN-GSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 148 YLQRSWVILSVTALFLSLI-YIFAAPILTFIGQTAAISAMAGIF-SIYMIPQIFAYAINFPTAkFLQSQ--SKIMVMagI 223
Cdd:cd13138 82 AVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYlRICFLGIPFIFGYNAYSA-ILRGLgdSKTPLY--F 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 224 SGVVLVIHSFFTWLVMSRLHWGLPGLALVLNTSWWVIVVAQLVYIFNctcGEAWSGFTWEAFH----NLWGFVKLSLASA 299
Cdd:cd13138 159 VIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRK---KKLPFKLSLKDFRfdkeILKEILKIGLPSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 300 AMlcleiwyfMALVLFAGYLKNAEVS------VAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVA 373
Cdd:cd13138 236 LQ--------QSLVSISFLIINSIVNsygvvaSAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 374 VILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLF 453
Cdd:cd13138 308 IIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLV 387
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1789591981 454 GVPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTWMICKTNWE 497
Cdd:cd13138 388 RIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
62-489 |
6.88e-20 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 92.18 E-value: 6.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 62 REFRIESRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENS----VIAGFSfGIMLgmgsALETLCGQAF 137
Cdd:PRK01766 5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiwlpVILFGH-GLLL----ALTPIVAQLN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 138 GAGKVSMLG-VYLQRSWVILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSK 216
Cdd:PRK01766 80 GAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 217 ---IMVMAGISgvvLVIHSFFTWLVMSRlHWGLP-----GLALVLNTSWWVIVVAQLVYIF------NCTCGEAWSGFTW 282
Cdd:PRK01766 160 tkpTMVIGFLG---LLINIPLNYIFIYG-KFGFPelggvGCGVATAIVYWVMFLAMLIYIKrarrfrDFRLFKGLYKPDW 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 283 EAFHNLWgfvKLSLASAAMLCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASH 362
Cdd:PRK01766 236 AVIKRLL---KLGLPIGLAIFFEVSLFAVVTLLVSPL--GTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGR 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 363 PRTAKFSLVVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVV 442
Cdd:PRK01766 311 TLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVI 390
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1789591981 443 AYVNIACYYLFGVPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTW 489
Cdd:PRK01766 391 FFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
69-498 |
1.59e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 88.02 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIaGFSFGIMLGMGSALETLCGQAFGAGKVSMLGVY 148
Cdd:cd13142 11 RTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANKV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 149 LQRSWVILSVTALFLSLI-YIFAAPILT-FIGQTAAISAMAGIFS-IYMIPQIFAYAINFPTAKFL---QSQSKIMVMAG 222
Cdd:cd13142 90 AGQTFSFVIILSLILAVLgYILSRPLLLlLIGAPEEVYPLALAYLrIIFLGLPFMFIFFVFNSLLRgigDTKTPMKIMFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 223 ISGVVLVIHSFFTWLVMSRLHWGLPGLALVLNTSWWVIVVAQLVYIFNctcGEAWSGFTWEAFHNLWGFVKL-------S 295
Cdd:cd13142 170 SVLLNVILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFK---GRVGLKISLRDLKPDWEWLKKifriglpS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 296 LASAAMLCLEIWYFMALVLFAGylknaEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVI 375
Cdd:cd13142 247 SIEQSARALGFTVMTALVAGFG-----TVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAAL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 376 LSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLFGV 455
Cdd:cd13142 322 LIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRI 401
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1789591981 456 PFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTWMICKTNWEK 498
Cdd:cd13142 402 PLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
69-493 |
2.42e-16 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 81.07 E-value: 2.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLA-LAAVSIENSVIAGFSFGIM-LGMGSAleTLCGQAFGAG-KVSML 145
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTLFWLFGfLRMGTT--GLVAQALGAGdREEAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 146 GVYLQRSWVILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAGISG 225
Cdd:cd13136 81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 226 VVLVIHSFFTWLVMSRLHWGLPGLALVLNTSWWVIVVAQLVYIFnctcgEAWSGFTWEAFHNLWGFVKL-SLASAA---- 300
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLR-----RRVRLLGKSLSRRLPSKAALkRLFKLNrdif 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 301 --MLCLEIWYFMALVLFAGYlknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVILST 378
Cdd:cd13136 236 irTLALLAAFLFFTALAARL---GDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 379 AIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACyylFGVPFG 458
Cdd:cd13136 313 GLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS---LAVFLP 389
|
410 420 430
....*....|....*....|....*....|....*
gi 1789591981 459 LLLGFKLEYGVMGIWWGMVTGTFVQSIVLTWMICK 493
Cdd:cd13136 390 LLFLLVPLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
69-498 |
3.54e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 80.73 E-value: 3.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIAgFSFGIMLGMGSALETLCGQAFGAGKVSMLGV- 147
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLT-IVYSIAIGLSMAATALVARRIGEKDPEGAGFa 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 148 YLQRSWVILSVTALFLSLIYIFAAPILTFIGQTAAISA---------MAGIFSIYM---IPQIFAYAINFPTAKflqsqs 215
Cdd:cd13139 93 AVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAegygytrimFGGNGFIMLlflINGIFRGAGDAAIAM------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 216 KIMVMAGISGVVLVIHSFFTWLVMSRlhWGLPGLALVLNTSWWVIVVAQLVYIFNctcGEAWSGFTWEAFHNLWGFVK-- 293
Cdd:cd13139 167 RSLWLANGLNIILDPLFIFGLGPIPA--MGVTGAAIATTIGRSIGVLYQLYHLFK---GKGRIQIRRRHLKLDWAIIKki 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 294 LSLASAAMLCLEI----WYFMALVLfagyLKNAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFS 369
Cdd:cd13139 242 IKIAVGGILQFLIasssWIFLVRII----AEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKS 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 370 LVVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIAC 449
Cdd:cd13139 318 VWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVG 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1789591981 450 YYLFGVPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTWMICKTNWEK 498
Cdd:cd13139 398 FWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKWKT 446
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
69-487 |
3.37e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 74.64 E-value: 3.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAV-SIENSVIAGFSFGIMLGMGSALetLCGQAFGAGKVSMLGV 147
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVgNVTTPFNTITGFLGSISIGFTI--LGSQSVGAKDIKRIND 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 148 YLQRSWVILSVTALFLSLIYIFAAPIL-TFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQ--SQSKIMVMAGIS 224
Cdd:cd13135 79 YAISSIVYNSIIGVILFLLWLFGARIIfVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQgiGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 225 GVVLVIhsFFTWlVMSRLHWGLPGL-----------ALVLNTSWWVIVVAQLVYIFNCTCGEAWSGFTWEAFHNLwgfVK 293
Cdd:cd13135 159 KNLLNV--ILDY-VLIFGNFGFPRLgiigaaiattiANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFT---IK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 294 LSLASAAMLCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVA 373
Cdd:cd13135 233 LGLPLGGEEFLWNIGNLAVIRILNRI--GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNIC 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 374 VILSTAIGMFIAAGLLFFRNEYPVLFVEDEEvrnVVRELTPMLAFCIVINNVQPVlsGVAVGAGWQAVVAYVNIACYYLF 453
Cdd:cd13135 311 LGLGLLIYIAAAIVFLAFPYKILSLFTNDPE---LINYSIPYLIFIIIILFFKSI--NIVYGFAIRAIGDTKWMLYTQII 385
|
410 420 430
....*....|....*....|....*....|....*...
gi 1789591981 454 G----VPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVL 487
Cdd:cd13135 386 GtiivVSVALLLIFVFKLGLAGVYITLFIDEIIRAIIN 423
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
65-489 |
5.90e-12 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 67.85 E-value: 5.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 65 RIESRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIAGFSFgIMLGMGSALETLCGQAFGAGKVSM 144
Cdd:PRK00187 6 TTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSI-FCVGVIAAVGTLVAIRHGAGDIEG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 145 LGVYLQRSWVILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSI---YMIPQIFAYAI--NFPTAkfLQSQSKIMV 219
Cdd:PRK00187 85 ATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHllpFALPGYLSFMAlrGFTSA--LGRAGPVMV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 220 --MAGISGVVLVIHSFFT-WLVMSRLhwGLPGLALVLNTSWWVIVVAQLVYIFNCTCGEAWSGFT------WEAFHNLWg 290
Cdd:PRK00187 163 isLAGAVANLLLNYALIEgWFGLPKL--GLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRKglsrpsRAALRELW- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 291 fvKLSLASAAMLCLEIWYFMALVLFAGYLKNaeVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSL 370
Cdd:PRK00187 240 --RLGLPIGGTYAVEVGLFTFAALCMGALGS--TQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 371 VVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDE-----EVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYV 445
Cdd:PRK00187 316 RVGIGFGAVVMLLFAGLFWLLPEAIIGLFLDRNdpafaEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLI 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1789591981 446 NIACYYLFGVPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTW 489
Cdd:PRK00187 396 GLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
68-497 |
6.07e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 61.39 E-value: 6.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 68 SRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIeNSVIAGFSFGIMLGMGSALETLCGQAFGAGKVSMLGV 147
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGT-AGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 148 YLQRS-WVILSVTALFLSLIYIFAAPILTFIG-QTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQ--SKIMVMAGI 223
Cdd:cd13140 83 YARNAlQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALgdSKTPFIINA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 224 SGVVL-------VIHSFFTWLVMsrlhwGLPGLALVLNTSWWVIVVAQLVYIFNCT-CGEAWSGFTWEAFHNLWGFVKLS 295
Cdd:cd13140 163 IGLVLniildplLIFGFGPFPAL-----GVAGAALATVLAQAIVFLLFLYALKKKKgLFLKIRILKRPDRKYIKEILKLG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 296 LASAAMLCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVVAVI 375
Cdd:cd13140 238 LPVALQSILFALISMILARIIASF--GPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 376 LSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYLfGV 455
Cdd:cd13140 316 IASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVFNGL-RI 394
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1789591981 456 PFGLLLGfKLEYGVMGIWWGMVTGTFVQSIVLTWMICKTNWE 497
Cdd:cd13140 395 PLALLLS-PTGLGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
71-491 |
8.62e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 60.69 E-value: 8.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 71 LWKLAGPA----IFTTMsqYSLgaVTQVFAGHISTLALAAVSIENSV---IAGFSFGImlgmGSALETLCGQAFGAGKVS 143
Cdd:cd13145 11 IRKLAIPAsvgfFFNTM--FNV--VDTFFAGKISTEALAALSLSFPIffiIIAIGVGI----GTGTTALIGNALGAGDRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 144 MLGVYLQRSWVILSVTALFLSLIYIFAAP-ILTFIGQTAAISAMAgifSIYMIPqIFAYAINFPTAKF----LQSQ--SK 216
Cdd:cd13145 83 KARRYAAQGLSFGIILAILLTVIGLFAAPpLFRLLGAEGDYLDLA---LEYMDV-IFAGSIFFLLNFGlngiLNAQgdTK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 217 IMVMAGISGVVL--VIHSFFTWLVMSRLHWGLPGLAlvlntswWVIVVAQ---LVYIF------NCTCGEAWSGFT--WE 283
Cdd:cd13145 159 SYRNFLIIGFFLniILDPLFIFGGGGIPAMGVSGIA-------LATIISQfigMFYLLykvrksGIISGCRLRDFIprLD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 284 AFHNLwgFVKLSLASAAMLCLEIWYFMALVLFAGYLKNAevsVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASH- 362
Cdd:cd13145 232 VYKEI--LKQGFPASLNMMTIGLGIFVITYFVGQFGDEA---VAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKy 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 363 ---PRTAKFSLVVAVILSTA--IGMFIAAGLLFFrneypvLFVEDEEVRNV----VRELTPMLAFCIVINNVQPVLSGVA 433
Cdd:cd13145 307 drvRETYKKALKYGFVIMVVatVFLLFFAEPLMS------LFTNDPAVIAIgagyLRIDALIFYAYVVLFISVSVLQGLK 380
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1789591981 434 vgagwQAVVA-YVNIACYYLFGVPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVLTWMI 491
Cdd:cd13145 381 -----RPIFAlWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYT 434
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
59-269 |
2.89e-09 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 59.26 E-value: 2.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 59 DFVREFRIESRKLWKLAGP-AIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSvIAGFSFGIMLGMGSALETLCGQAF 137
Cdd:cd12082 209 SLLKPDLELLRRLLRIGLPsAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFR-IASLAFMPALGLAQAALPVVGQNL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 138 GAGKVSMLGVYLQRSWVILSVTALFLS-LIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQSK 216
Cdd:cd12082 288 GAGNFDRARRITWVALLIGLLIGAVLGlLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGR 367
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1789591981 217 IMVMAGISGVVLVIHSFFTWLVMSRLHWGLPGLALVLNTSWWVIVVAQLVYIF 269
Cdd:cd12082 368 TLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
118-482 |
3.02e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 55.87 E-value: 3.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 118 SFGIMLGMGSaletLCGQAFGAGKVSMLGVYLQRSWVI-LSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIP 196
Cdd:cd13146 63 GNGIQVGVSS----LLARAIGAQRAKELDQAADSGLALaLLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLP 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 197 QIFAYAINFPTAKFLQSQSKIMVMAGISGVVLVIHSFFTWLVMSRLHWGLPGLALVLNTSWwVIVVAQLVYIF-----NC 271
Cdd:cd13146 139 GVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQ-AISLLYLLYVFligksNV 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 272 TCGEAWSGFTWEAFHNLwgfvkLSLASAAMLCLEIWYFMALVLFAGYLKNAEVSVAALSICMNILGWAAMVAFGTNAAVS 351
Cdd:cd13146 218 TIHIKLSNISSSVIVEI-----LRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALL 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 352 VRVSNELGASHPRTAKFSLVVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVInnVQPVLSG 431
Cdd:cd13146 293 TIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPF--VAISILV 370
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1789591981 432 V----AVGAGWQAVVayVNIACYYLFGVPFGLLLGFKLEYGVMGIWWGMVTGTFV 482
Cdd:cd13146 371 TeffqAIGKAWPSLL--LTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSANFF 423
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
292-507 |
7.69e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 51.36 E-value: 7.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 292 VKLSLASAAMLCLEIWYFMALVLFAGYLknAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLV 371
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRL--GAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 372 VAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAG-------WQAVVAY 444
Cdd:cd13137 82 QSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGdtktpmyIMIIVNV 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1789591981 445 VNIACYYLFGvpFGLLLGFKLeyGVMGIWWGMVTGTFVQSIVLTWMICKTNWEKEASMAEERI 507
Cdd:cd13137 162 LNIVLDYVLI--FGLWGFPGL--GVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRL 220
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
68-491 |
2.27e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 46.84 E-value: 2.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 68 SRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVS----IENSVIAgfsfgIMLGMGSALETLCGQAFGAGKVS 143
Cdd:cd13144 7 LRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSlafpIQNLMIA-----VAVGTGVGVNALLSRSLGEKDQK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 144 MLGVYLQRSWVILSVTALFLSLIYIFAA-PILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFLQSQS------K 216
Cdd:cd13144 82 EANKAANNGLLLALLSYLLFLLLGLFGVkPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGntitpmI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 217 IMVMAGISGVVLVIHSFFTWLVMSRlhWGLPGLALVLNTSWwvIVVAQLVYIFNCTCGEAwSGFTWEAFHNLWGFVK--- 293
Cdd:cd13144 162 AQLIGAIINIILDPILIFGLFGFPA--MGIAGAAIATVIGQ--ILAMFLAFFFLLRKNKD-VQPDLRLFRPSLRIIKeiy 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 294 -LSLASAAMLCleIWYFMALVLFAGYLKNAEVSVAALSICMNILGWAAMVAFGTNAAVSVRVSNELGASHPRTAKFSLVV 372
Cdd:cd13144 237 aVGLPSIIMQA--ISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKY 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 373 AVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYL 452
Cdd:cd13144 315 AILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLV 394
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1789591981 453 FGVPFGLLLGfkLEYGVMGIWWGMV---TGTFVQSIVLTWMI 491
Cdd:cd13144 395 VLLPLAWLLA--KMFGLNGVWWSFPiaeIVSFLLSLLFLKRL 434
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
71-486 |
2.23e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 43.68 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 71 LWKLAGPAIFTT--MSQYSLgaVTQVFAGHISTLALAAVSIEN---SVIAGFSFGIMLGMGSALETLCGQA--FGAGKVS 143
Cdd:cd13147 11 IIKLSIPMIIAMllQTLYNL--VDAIWVAGLGADALAAIGFVFplfMIIIGLGNGLGAGASSAISRRIGAKdkEGADNAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 144 MLGVYLqrswvILSVTALFLSLIYIFAAPILTFIGQTAAI------SAMAGIFSIYMIPQIFAYAInfptakfLQSQ--S 215
Cdd:cd13147 89 VHSILL-----GLIISIILTIVLLPFLEPILVLMGAGEVLdlavdyGRIIFLGSIFLIFNNVAYGI-------LRGEgdT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 216 KIMVMAGISGVVLVIhsFFTWLVMSRLHWGLPGLALVLNTSwwvIVVAQLVYIFNCTCG-EAWSGFTWEAFHNLWGFVKL 294
Cdd:cd13147 157 KRAMYAMVAGSILNI--ILDPIFIYTLGLGIAGAAWATVIS---MLISSLVLLYWFFVKkDTYVSLSLKNFKFDKKIVKD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 295 SL-----ASAAMLCLEIWYFMALVLFAGYLKNAEVSV--AALSICMniLGWAAMVAFGTnAAVSVrVSNELGASHPRTAK 367
Cdd:cd13147 232 ILkvgipASLEQLIMSVLMIILNLILVIVAGTDGVAVytAGWRIVS--FAIIPLIGIAT-AVTSV-TGAAYGARNYEKLK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 368 FSLVVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLA-FCIVINNVQPVLSGVAV--GAGWQAVVAY 444
Cdd:cd13147 308 TAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVAFLRiMCLFLPFVPFGMMSSSMfqGIGKGLTSLI 387
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1789591981 445 VNIACYYLFGVPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIV 486
Cdd:cd13147 388 ITILRELIFQVLFAYLFAIVLGLGLFGVWWGIVLGNAIGSIV 429
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
69-177 |
3.35e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 43.00 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIAgFSFGIMLGMGSALETLCGQAFGAGKVSMLGVY 148
Cdd:TIGR00797 216 KRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVES-LLFMPAFGFGIAVSILVGQALGAGDPKRAKEV 294
|
90 100
....*....|....*....|....*....
gi 1789591981 149 LQRSWVILSVTALFLSLIYIFAAPILTFI 177
Cdd:TIGR00797 295 ARVALKLSLLLGLVLAIILILFREFIARL 323
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
112-487 |
3.48e-04 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 43.01 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 112 SVIAGFSFGIMLGMGSALetlcGQAFGAGKVSMLGVYLQRSWVILSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFS 191
Cdd:COG2244 46 SIVALLSVLADLGLSTAL----VRFIAEYREEELRRLLSTALLLRLLLSLLLALLLLLLAPFIAALLGEPELALLLLLLA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 192 IYmipqIFAYAINFPTAKFLQSQSKIMVMAGISGVVLVIHSFFTWLVmsrLHWGLPGLALVLNTSWWVIVVAQLVYIFNc 271
Cdd:COG2244 122 LA----LLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLALLL---ALLGLGLWGLVLKYSLPLLLSGLLGLLLT- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 272 tcgeawsgftweafhnlwgfvklslasaamlcleiwyfMALVLFAGYLKNAEvSVAALSICMNILGWAAMVAFGTNAAVS 351
Cdd:COG2244 194 --------------------------------------NLDRLLLGALLGPA-AVGIYSAAYRLASLLLLLITALSQVLF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 352 VRVSNELGASHPRTAKFSLVVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVrnVVRELTPMLAFCIVINNVQPVLSG 431
Cdd:COG2244 235 PRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYA--EAAPVLPILALGALFLALSGVLSN 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1789591981 432 VAVGAGWQAVVAYVNIACyylFGVPFGLLLGFKLEYGVMGIWWGMVTGTFVQSIVL 487
Cdd:COG2244 313 LLLALGRTRLLLIISLIG---AVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLL 365
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
291-490 |
2.88e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 40.19 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 291 FVKLSLASAAMLCLEIWYFMALVLFAGYLKNAEvSVAALSICMNILGwaAMVAFGTNAAV--SVRVSNELGASHPRTAKF 368
Cdd:cd13143 6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGVGAL-ALAAVNLVFPIIM--LLMALGLMIGVggASLISRRLGAGDREKANR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 369 SLVVAVILSTAIGMFIAAGLLFFRNEYPVLFVEDEEVRNVVRELTPMLAFCIVINNVQPVLSGVAVGAGW-------QAV 441
Cdd:cd13143 83 IFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKpklamlgMLI 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1789591981 442 VAYVNIACYYLFGVPFGLllgfkleyGVMGIWWGMVTGTFVQSIVLTWM 490
Cdd:cd13143 163 GAVLNIILDPLFIFVLGL--------GIAGAALATVIAQLISLLLLLLY 203
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
67-251 |
3.73e-03 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 39.72 E-value: 3.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 67 ESRKLWKLAGPAIFTTMSQYSLGAVTQVFAGHI-STLALAAVSIeNSVIAGFSFGIMLGMGSALETLCGQAFGAGKVSML 145
Cdd:PRK10367 7 SDKALWRLALPMIFSNITVPLLGLVDTAVIGHLdSPVYLGGVAV-GATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 146 GVYLQRSWVI-LSVTALFLSLIYIFAAPILTFIGQTAAISAMAGIFSIYMIPQIFAYAINFPTAKFL------QSQSKIM 218
Cdd:PRK10367 86 ARALVQPLLLaLGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLlgvqyaRAPVILL 165
|
170 180 190
....*....|....*....|....*....|...
gi 1789591981 219 VMAGISGVVLVIhsfftWLVMSrLHWGLPGLAL 251
Cdd:PRK10367 166 VVGNILNIVLDL-----WLVMG-LHMNVQGAAL 192
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
69-345 |
4.26e-03 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 39.75 E-value: 4.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 69 RKLWKLAGPAIFTTMSQYSLGAVTQVFAGHISTLALAAVSIENSVIaGFSFGI-MLGMGSALETLCGQAFGAGKVSMLGV 147
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLY-QLPLGLfGVAIGTALLPRLSRAAAAGDLEEFRR 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 148 YLQRSWVILSVTALFLSL-IYIFAAPILTFIGQ-----TAAISAMAGIFSIYMIpQIFAYAINFPTAKFLQSQSKIMVMA 221
Cdd:COG0728 301 TLSRGLRLVLLLTLPAAVgLIVLAEPIVRLLFErgaftAEDTALTALALAAYAL-GLPAFALVKVLARAFYARQDTRTPV 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1789591981 222 GISGVVLVIHSFFTWLVMSRLhwGLPGLALVLNTSWWVIVVAQLVYIFNCTCGEAWSGFtweafhnLWGFVKLSLASAAM 301
Cdd:COG0728 380 RIAVIAVVVNIVLNLLLVPPL--GHAGLALATSLSALVNALLLLVLLRRRLGGLPLRGI-------LRTLLKLLLASLVM 450
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1789591981 302 LCLeIWYFMALV--LFAGYLKNAEVSVAALSICMNILGWAAMVAFG 345
Cdd:COG0728 451 GAV-LWLLLRLLgdWLGGGLLGRLLALALLILVGAAVYFALLLLLG 495
|
|
| |
