S24/S26 family peptidase similar to human signal peptidase complex catalytic subunit SEC11C, a component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum
The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal ...
1-177
4.99e-86
The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The S26 type I signal peptidase (SPase) family also includes mitochondrial inner membrane protease (IMP)-like members. SPases are essential membrane-bound proteases which function to cleave away the amino-terminal signal peptide from the translocated pre-protein, thus playing a crucial role in the transport of proteins across membranes in all living organisms. All members in this superfamily are unique serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases.
The actual alignment was detected with superfamily member PRK13884:
Pssm-ID: 447902 Cd Length: 178 Bit Score: 250.33 E-value: 4.99e-86
conjugative transfer signal peptidase TraF; This protein is found in apparent operons encoding ...
10-177
6.30e-64
conjugative transfer signal peptidase TraF; This protein is found in apparent operons encoding elements of conjugative transfer systems. This family is homologous to a broader family of signal (leader) peptidases such as lepB. This family is present in both Ti-type and I-type conjugative systems.
Pssm-ID: 131818 [Multi-domain] Cd Length: 171 Bit Score: 194.24 E-value: 6.30e-64
Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, ...
53-177
9.66e-35
Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones, Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443985 [Multi-domain] Cd Length: 114 Bit Score: 118.09 E-value: 9.66e-35
Signal peptidase, peptidase S26; This is a family of membrane signal serine endopeptidases ...
4-168
9.21e-30
Signal peptidase, peptidase S26; This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesized secreted proteins. Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.
Pssm-ID: 431321 [Multi-domain] Cd Length: 162 Bit Score: 106.91 E-value: 9.21e-30
conjugative transfer signal peptidase TraF; This protein is found in apparent operons encoding ...
10-177
6.30e-64
conjugative transfer signal peptidase TraF; This protein is found in apparent operons encoding elements of conjugative transfer systems. This family is homologous to a broader family of signal (leader) peptidases such as lepB. This family is present in both Ti-type and I-type conjugative systems.
Pssm-ID: 131818 [Multi-domain] Cd Length: 171 Bit Score: 194.24 E-value: 6.30e-64
Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, ...
53-177
9.66e-35
Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones, Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443985 [Multi-domain] Cd Length: 114 Bit Score: 118.09 E-value: 9.66e-35
Signal peptidase, peptidase S26; This is a family of membrane signal serine endopeptidases ...
4-168
9.21e-30
Signal peptidase, peptidase S26; This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesized secreted proteins. Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.
Pssm-ID: 431321 [Multi-domain] Cd Length: 162 Bit Score: 106.91 E-value: 9.21e-30
signal peptidase I, bacterial type; This model represents signal peptidase I from most ...
49-168
3.92e-08
signal peptidase I, bacterial type; This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274044 [Multi-domain] Cd Length: 142 Bit Score: 49.92 E-value: 3.92e-08
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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