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Conserved domains on  [gi|1915337593|dbj|BBW73612|]
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deoxyguanosinetriphosphate triphosphohydrolase-like protein 2 (plasmid) [Escherichia coli]

Protein Classification

deoxyguanosinetriphosphate triphosphohydrolase family protein( domain architecture ID 11480718)

deoxyguanosinetriphosphate triphosphohydrolase family protein similar to deoxyguanosinetriphosphate (dGTP) triphosphohydrolase, which catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
antiphage_dGTPase NF041026
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
 9-440 0e+00

anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.


:

Pssm-ID: 468955 [Multi-domain]  Cd Length: 426  Bit Score: 666.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593   9 WYER-QGYNTTRPNEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDTDEG 87
Cdd:NF041026    1 WQERrRGEEKKRRNDHRSPFQRDRARIIHSAAFRRLQAKTQVLGLGESDFYRTRLTHSLEVAQIGTGIVAQLKAKQPEPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  88 GKFLPDPSLMQAICLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKYTETNGLDPTRRLILGVLKYPAS 167
Cdd:NF041026   81 RALLPDDSLIEAICLAHDIGHPPFGHGGEVALNYMMRDHGGFEGNGQTLRILTKLEPYTEHHGMNLTRRTLLGVLKYPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 168 YSEVVNERaysQLQPRSNEWLFKSSEFKPPKCYLDSEENTVRFALQPFDSDDVKLFKTVKTTALNKHKETIYKALDTTIM 247
Cdd:NF041026  161 YSQVQAPQ---LPPKVSNFRQLKASDWKPPKGYYDCDQDVVDWVLAPLSENDRALFTSLDEKPGKQHGKTRFKSLDCSIM 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 248 DLADEISYSLHDLEDAISLKMIDKKMWEEHFEDKshlFAACQCDSFNLKADDVAEKLF-GESYLRKECIGTLVHLMITSV 326
Cdd:NF041026  238 ELADDIAYGVHDLEDAIVLGLVTREQWQEAVAPK---LAALGDPWLSDNLDELSDKLFsGEHYERKDAIGALVNYFITSI 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 327 KLEVQNsDFKSKILRYKVALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPIRFLPTETRKKYN 406
Cdd:NF041026  315 EIKEVD-AFEEPLLRYNAVLPPEVAALLEVLKQFVYQYVIRSPEVQQLEYKGQQIVMELFEALASDPERLLPENTRERWQ 393

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1915337593 407 QEEAKGdDKKMRVICDYVSGMTDDYATRLYEKIF 440
Cdd:NF041026  394 EAEEDG-ENGKRVICDYIAGMTDEYALRLYQRLF 426
 
Name Accession Description Interval E-value
antiphage_dGTPase NF041026
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
 9-440 0e+00

anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.


Pssm-ID: 468955 [Multi-domain]  Cd Length: 426  Bit Score: 666.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593   9 WYER-QGYNTTRPNEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDTDEG 87
Cdd:NF041026    1 WQERrRGEEKKRRNDHRSPFQRDRARIIHSAAFRRLQAKTQVLGLGESDFYRTRLTHSLEVAQIGTGIVAQLKAKQPEPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  88 GKFLPDPSLMQAICLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKYTETNGLDPTRRLILGVLKYPAS 167
Cdd:NF041026   81 RALLPDDSLIEAICLAHDIGHPPFGHGGEVALNYMMRDHGGFEGNGQTLRILTKLEPYTEHHGMNLTRRTLLGVLKYPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 168 YSEVVNERaysQLQPRSNEWLFKSSEFKPPKCYLDSEENTVRFALQPFDSDDVKLFKTVKTTALNKHKETIYKALDTTIM 247
Cdd:NF041026  161 YSQVQAPQ---LPPKVSNFRQLKASDWKPPKGYYDCDQDVVDWVLAPLSENDRALFTSLDEKPGKQHGKTRFKSLDCSIM 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 248 DLADEISYSLHDLEDAISLKMIDKKMWEEHFEDKshlFAACQCDSFNLKADDVAEKLF-GESYLRKECIGTLVHLMITSV 326
Cdd:NF041026  238 ELADDIAYGVHDLEDAIVLGLVTREQWQEAVAPK---LAALGDPWLSDNLDELSDKLFsGEHYERKDAIGALVNYFITSI 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 327 KLEVQNsDFKSKILRYKVALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPIRFLPTETRKKYN 406
Cdd:NF041026  315 EIKEVD-AFEEPLLRYNAVLPPEVAALLEVLKQFVYQYVIRSPEVQQLEYKGQQIVMELFEALASDPERLLPENTRERWQ 393

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1915337593 407 QEEAKGdDKKMRVICDYVSGMTDDYATRLYEKIF 440
Cdd:NF041026  394 EAEEDG-ENGKRVICDYIAGMTDEYALRLYQRLF 426
PRK05318 PRK05318
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 6-440 0e+00

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235403 [Multi-domain]  Cd Length: 432  Bit Score: 615.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593   6 ENTWYERQ-GYNTTRPNEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDT 84
Cdd:PRK05318    3 SSVWQERRlGEDKQRRNDHRSPYQRDRARILHSAAFRRLQAKTQVLGVGENDFYRTRLTHSLEVAQIGTGIVAQLKKEKQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  85 DEGGKFLPDPSLMQAICLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKYTETNGLDPTRRLILGVLKY 164
Cdd:PRK05318   83 PELKPLLPSDSLIESLCLAHDIGHPPFGHGGEVALNYMMRDHGGFEGNGQTFRILTKLEPYTEHFGMNLTRRTLLGILKY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 165 PASYSEVVNEraySQLQPRSNEWLFKSSEFKPPKCYLDSEENTVRFALQPFDSDDVKLFKTVK--TTALNKHKETIYKAL 242
Cdd:PRK05318  163 PALYSELVAQ---YPPPDVANHRQLKASDWKPPKGIFDDDQDIFDWVLEPLSENDRALFQSLRpePDSPKEHLKTRYKSL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 243 DTTIMDLADEISYSLHDLEDAISLKMIDKKMWEEHFEDKshlFAACQCDSFNLKADDVAEKLF-GESYLRKECIGTLVHL 321
Cdd:PRK05318  240 DCSIMELADDIAYGVHDLEDAIVLGLVTRSQWQEDVAPQ---LAQCGDPWLEEEIETIGEKLFsGEHHLRKDAIGTLVNY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 322 MITSVKLEVqNSDFKSKILRYKVALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPIRFLPTET 401
Cdd:PRK05318  317 FITSIRIKE-NEEFEEPLLRYNAALEPEFAAALEVLKQFVYKYVIRKPEVQRLEYKGQQIVMELFEALSSDPERLLPRNT 395

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1915337593 402 RKKYNQeeAKGDDKKMRVICDYVSGMTDDYATRLYEKIF 440
Cdd:PRK05318  396 QERWRK--AEDEENSMRVICDYISGMTDEYAYRLYQQLF 432
Dgt COG0232
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
21-440 1.47e-130

dGTP triphosphohydrolase [Nucleotide transport and metabolism];


Pssm-ID: 440002 [Multi-domain]  Cd Length: 345  Bit Score: 380.65  E-value: 1.47e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  21 NEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGIlsqlskrdtdeGGKFLPDPSLMQAI 100
Cdd:COG0232     1 DDIRSPFQRDRDRIIHSAAFRRLQDKTQVFPLPEGDHYRTRLTHSLEVAQIARSI-----------ARALGLNEDLVEAA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 101 CLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKYTETNGLDPTRRLILGVLKYPASYSEVVNeraysql 180
Cdd:COG0232    70 ALAHDLGHPPFGHAGEDALNELFRDLGGFEGNAQSLRILTRLEKRYAFGGLNLTYATLDGILKYPGPSLAAPK------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 181 qprsnewlfkssefKPPKCYLDSEENTVRFALQPFDSDDVKLFKTvkttalnkhketiykaLDTTIMDLADEISYSLHDL 260
Cdd:COG0232   143 --------------PKPKGFYQSEKDVFDWVREELGLLALGRPRT----------------LEAQIVELADDIAYSVHDL 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 261 EDAISLKMIDKKMWEEHFEDKshlfaacqcdsfnlkaddvaeKLFGESYLRKECIGTLVHLMITSVKLEVQNSDFKSKIl 340
Cdd:COG0232   193 EDAIRAGLLSLEDLPELLEYL---------------------GPLDERRRLGELRSRLIGRLVTDVIEASRENLFDGPL- 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 341 rykVALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPIRFLPTETRKKYnqEEAKGDDKKMRVI 420
Cdd:COG0232   251 ---IAFSPEVAAALKELKKFLFERVYRHPEVLRLELKGRRIIRELFDAFLEDPLELLPEEFRERY--EAADDEYGRLRVV 325

                         410       420
                  ....*....|....*....|
gi 1915337593 421 CDYVSGMTDDYATRLYEKIF 440
Cdd:COG0232   326 ADYIAGMTDRYALRLYRRLF 345
dGTP_triPase TIGR01353
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
 23-440 5.40e-122

deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273571 [Multi-domain]  Cd Length: 381  Bit Score: 360.14  E-value: 5.40e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  23 IRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDTDEGGKFLPDPSLMQAICL 102
Cdd:TIGR01353   1 ERTPFERDYDRIIHSSAFRRLQDKTQVFPLAENDFVRTRLTHSLEVAQVGRSIANLIGLRYDLELEELGPFERLAETACL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 103 AHDIGHPPFGHGGEVALNYCMRSYG-GFEGNGQTLRILSKLDKYTET-NGLDPTRRLILGVLKYPASYSEVvneraysql 180
Cdd:TIGR01353  81 AHDIGNPPFGHAGERALNDWMREYGpGFEGNAQTFRILTTLEKRRRAkGGLNLTWRTLAGILKYPRPSSED--------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 181 qprsnewLFKSSEFKPPKCYLDSEENTvrfalqpfdsddvklFKTVKTTALnkhkETIYKALDTTIMDLADEISYSLHDL 260
Cdd:TIGR01353 152 -------AFKGGYLNKKKGIYDSELAV---------------FDRVAELLG----LTWYRSPLAQLMEAADDIAYTVHDL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 261 EDAISLKMIDKKMWEEHFEDKShLFAACQCDSFNLKADDVAEKLF-GESYLRKECIGTLVHLMITSVKLEVQNSDFKSKI 339
Cdd:TIGR01353 206 EDAIKLGLLTFDDLQHLLLIQA-GFEELGSEMTDLSISAENEQIRsLRGKLITDLIESVAKAEFSSHLVAILIGTFHHTL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 340 LRYKVALPAAVEELRKaifeLVRNKVIQHENVQLLEFKGQKLIVELFNVLAND-PIRFLPTETRKKYNQEEakGDDKKMR 418
Cdd:TIGR01353 285 VEFSPRLAELLEALKK----FLRKRVYRHPDVERIEYQGEQIITGLFDAFMPDlPPRLLPPELRSKLRKAE--DNYYKAR 358

                         410       420
                  ....*....|....*....|..
gi 1915337593 419 VICDYVSGMTDDYATRLYEKIF 440
Cdd:TIGR01353 359 VVCDYIAGMTDRYALEEYRRLF 380
HD_assoc pfam13286
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
 344-438 1.38e-23

Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.


Pssm-ID: 433087 [Multi-domain]  Cd Length: 91  Bit Score: 94.13  E-value: 1.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 344 VALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPiRFLPTETRKKYNQEEakgDDKKMRVICDY 423
Cdd:pfam13286   1 VAFSPEMAAELAELKRFLFEYVYRHPRVQREEEKARRIIRELFEALMADP-ELLPPEFRARWEAAG---DDARARVVCDY 76

                          90
                  ....*....|....*
gi 1915337593 424 VSGMTDDYATRLYEK 438
Cdd:pfam13286  77 IAGMTDRYALRLHRR 91
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 59-119 9.42e-07

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 47.68  E-value: 9.42e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1915337593   59 RTRLTHSMEVAQIGGGILSQLskrdtdeggkFLPDPSLMQAICLAHDIGHPPFGHGGEVAL 119
Cdd:smart00471   3 YHVFEHSLRVAQLAAALAEEL----------GLLDIELLLLAALLHDIGKPGTPDSFLVKT 53
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 59-125 1.24e-03

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 39.24  E-value: 1.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1915337593  59 RTRLTHSMEVAQIGGGILSQLSKRDtdeggkflPDPSLMQAICLAHDIGHPPFGHGGEVALNYCMRS 125
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELGLSE--------EDIELLRLAALLHDIGKPGTPDAITEEESELEKD 59
 
Name Accession Description Interval E-value
antiphage_dGTPase NF041026
anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of ...
 9-440 0e+00

anti-phage deoxyguanosine triphosphatase; Proteins of this family are distant homologues of human antiviral protein SAMHD1. It has been shown that proteins of this family protected bacteria from phage infection by degrading dGTP into phosphate-free deoxyguanosine. The anti-phage dGTPase may also be involved in other biological processes.


Pssm-ID: 468955 [Multi-domain]  Cd Length: 426  Bit Score: 666.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593   9 WYER-QGYNTTRPNEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDTDEG 87
Cdd:NF041026    1 WQERrRGEEKKRRNDHRSPFQRDRARIIHSAAFRRLQAKTQVLGLGESDFYRTRLTHSLEVAQIGTGIVAQLKAKQPEPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  88 GKFLPDPSLMQAICLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKYTETNGLDPTRRLILGVLKYPAS 167
Cdd:NF041026   81 RALLPDDSLIEAICLAHDIGHPPFGHGGEVALNYMMRDHGGFEGNGQTLRILTKLEPYTEHHGMNLTRRTLLGVLKYPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 168 YSEVVNERaysQLQPRSNEWLFKSSEFKPPKCYLDSEENTVRFALQPFDSDDVKLFKTVKTTALNKHKETIYKALDTTIM 247
Cdd:NF041026  161 YSQVQAPQ---LPPKVSNFRQLKASDWKPPKGYYDCDQDVVDWVLAPLSENDRALFTSLDEKPGKQHGKTRFKSLDCSIM 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 248 DLADEISYSLHDLEDAISLKMIDKKMWEEHFEDKshlFAACQCDSFNLKADDVAEKLF-GESYLRKECIGTLVHLMITSV 326
Cdd:NF041026  238 ELADDIAYGVHDLEDAIVLGLVTREQWQEAVAPK---LAALGDPWLSDNLDELSDKLFsGEHYERKDAIGALVNYFITSI 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 327 KLEVQNsDFKSKILRYKVALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPIRFLPTETRKKYN 406
Cdd:NF041026  315 EIKEVD-AFEEPLLRYNAVLPPEVAALLEVLKQFVYQYVIRSPEVQQLEYKGQQIVMELFEALASDPERLLPENTRERWQ 393

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1915337593 407 QEEAKGdDKKMRVICDYVSGMTDDYATRLYEKIF 440
Cdd:NF041026  394 EAEEDG-ENGKRVICDYIAGMTDEYALRLYQRLF 426
PRK05318 PRK05318
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 6-440 0e+00

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235403 [Multi-domain]  Cd Length: 432  Bit Score: 615.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593   6 ENTWYERQ-GYNTTRPNEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDT 84
Cdd:PRK05318    3 SSVWQERRlGEDKQRRNDHRSPYQRDRARILHSAAFRRLQAKTQVLGVGENDFYRTRLTHSLEVAQIGTGIVAQLKKEKQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  85 DEGGKFLPDPSLMQAICLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKYTETNGLDPTRRLILGVLKY 164
Cdd:PRK05318   83 PELKPLLPSDSLIESLCLAHDIGHPPFGHGGEVALNYMMRDHGGFEGNGQTFRILTKLEPYTEHFGMNLTRRTLLGILKY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 165 PASYSEVVNEraySQLQPRSNEWLFKSSEFKPPKCYLDSEENTVRFALQPFDSDDVKLFKTVK--TTALNKHKETIYKAL 242
Cdd:PRK05318  163 PALYSELVAQ---YPPPDVANHRQLKASDWKPPKGIFDDDQDIFDWVLEPLSENDRALFQSLRpePDSPKEHLKTRYKSL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 243 DTTIMDLADEISYSLHDLEDAISLKMIDKKMWEEHFEDKshlFAACQCDSFNLKADDVAEKLF-GESYLRKECIGTLVHL 321
Cdd:PRK05318  240 DCSIMELADDIAYGVHDLEDAIVLGLVTRSQWQEDVAPQ---LAQCGDPWLEEEIETIGEKLFsGEHHLRKDAIGTLVNY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 322 MITSVKLEVqNSDFKSKILRYKVALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPIRFLPTET 401
Cdd:PRK05318  317 FITSIRIKE-NEEFEEPLLRYNAALEPEFAAALEVLKQFVYKYVIRKPEVQRLEYKGQQIVMELFEALSSDPERLLPRNT 395

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1915337593 402 RKKYNQeeAKGDDKKMRVICDYVSGMTDDYATRLYEKIF 440
Cdd:PRK05318  396 QERWRK--AEDEENSMRVICDYISGMTDEYAYRLYQQLF 432
Dgt COG0232
dGTP triphosphohydrolase [Nucleotide transport and metabolism];
21-440 1.47e-130

dGTP triphosphohydrolase [Nucleotide transport and metabolism];


Pssm-ID: 440002 [Multi-domain]  Cd Length: 345  Bit Score: 380.65  E-value: 1.47e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  21 NEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGIlsqlskrdtdeGGKFLPDPSLMQAI 100
Cdd:COG0232     1 DDIRSPFQRDRDRIIHSAAFRRLQDKTQVFPLPEGDHYRTRLTHSLEVAQIARSI-----------ARALGLNEDLVEAA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 101 CLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKYTETNGLDPTRRLILGVLKYPASYSEVVNeraysql 180
Cdd:COG0232    70 ALAHDLGHPPFGHAGEDALNELFRDLGGFEGNAQSLRILTRLEKRYAFGGLNLTYATLDGILKYPGPSLAAPK------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 181 qprsnewlfkssefKPPKCYLDSEENTVRFALQPFDSDDVKLFKTvkttalnkhketiykaLDTTIMDLADEISYSLHDL 260
Cdd:COG0232   143 --------------PKPKGFYQSEKDVFDWVREELGLLALGRPRT----------------LEAQIVELADDIAYSVHDL 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 261 EDAISLKMIDKKMWEEHFEDKshlfaacqcdsfnlkaddvaeKLFGESYLRKECIGTLVHLMITSVKLEVQNSDFKSKIl 340
Cdd:COG0232   193 EDAIRAGLLSLEDLPELLEYL---------------------GPLDERRRLGELRSRLIGRLVTDVIEASRENLFDGPL- 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 341 rykVALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPIRFLPTETRKKYnqEEAKGDDKKMRVI 420
Cdd:COG0232   251 ---IAFSPEVAAALKELKKFLFERVYRHPEVLRLELKGRRIIRELFDAFLEDPLELLPEEFRERY--EAADDEYGRLRVV 325

                         410       420
                  ....*....|....*....|
gi 1915337593 421 CDYVSGMTDDYATRLYEKIF 440
Cdd:COG0232   326 ADYIAGMTDRYALRLYRRLF 345
dGTP_triPase TIGR01353
deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) ...
 23-440 5.40e-122

deoxyguanosinetriphosphate triphosphohydrolase, putative; dGTP triphosphohydrolase (dgt) releases inorganic triphosphate, an unusual activity reaction product, from GTP. Its activity has been called limited to the Enterobacteriaceae, although homologous sequences are detected elsewhere. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from E. coli was shown to bind coopertatively to single stranded DNA. The biological role of dgt is unknown. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273571 [Multi-domain]  Cd Length: 381  Bit Score: 360.14  E-value: 5.40e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  23 IRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDTDEGGKFLPDPSLMQAICL 102
Cdd:TIGR01353   1 ERTPFERDYDRIIHSSAFRRLQDKTQVFPLAENDFVRTRLTHSLEVAQVGRSIANLIGLRYDLELEELGPFERLAETACL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 103 AHDIGHPPFGHGGEVALNYCMRSYG-GFEGNGQTLRILSKLDKYTET-NGLDPTRRLILGVLKYPASYSEVvneraysql 180
Cdd:TIGR01353  81 AHDIGNPPFGHAGERALNDWMREYGpGFEGNAQTFRILTTLEKRRRAkGGLNLTWRTLAGILKYPRPSSED--------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 181 qprsnewLFKSSEFKPPKCYLDSEENTvrfalqpfdsddvklFKTVKTTALnkhkETIYKALDTTIMDLADEISYSLHDL 260
Cdd:TIGR01353 152 -------AFKGGYLNKKKGIYDSELAV---------------FDRVAELLG----LTWYRSPLAQLMEAADDIAYTVHDL 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 261 EDAISLKMIDKKMWEEHFEDKShLFAACQCDSFNLKADDVAEKLF-GESYLRKECIGTLVHLMITSVKLEVQNSDFKSKI 339
Cdd:TIGR01353 206 EDAIKLGLLTFDDLQHLLLIQA-GFEELGSEMTDLSISAENEQIRsLRGKLITDLIESVAKAEFSSHLVAILIGTFHHTL 284

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 340 LRYKVALPAAVEELRKaifeLVRNKVIQHENVQLLEFKGQKLIVELFNVLAND-PIRFLPTETRKKYNQEEakGDDKKMR 418
Cdd:TIGR01353 285 VEFSPRLAELLEALKK----FLRKRVYRHPDVERIEYQGEQIITGLFDAFMPDlPPRLLPPELRSKLRKAE--DNYYKAR 358

                         410       420
                  ....*....|....*....|..
gi 1915337593 419 VICDYVSGMTDDYATRLYEKIF 440
Cdd:TIGR01353 359 VVCDYIAGMTDRYALEEYRRLF 380
PRK01286 PRK01286
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 20-443 1.69e-66

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234934 [Multi-domain]  Cd Length: 336  Bit Score: 216.19  E-value: 1.69e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  20 PNEIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLskrdtdeggkFLpDPSLMQA 99
Cdd:PRK01286   22 PCPIRTEFQRDRDRIIHSKAFRRLKHKTQVFINPEGDHYRTRLTHTLEVAQIARTIARAL----------RL-NEDLTEA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 100 ICLAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKLDKytETNGLDPTRRLILGVLKYpasysevvneraysq 179
Cdd:PRK01286   91 IALGHDLGHTPFGHAGEDALNELMKEYGGFEHNEQSLRVVDKLEK--RYDGLNLTWEVREGILKH--------------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 180 lqprsnewlfkssefkppkcyldseentvrfalqpfdsddvklfktvkTTALNKHKETiYKALDTTIMDLADEISYSLHD 259
Cdd:PRK01286  154 ------------------------------------------------SGPRNAPLGT-AATLEGQIVRLADEIAYNNHD 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 260 LEDAISLKMIDKKMWEEHFedkshlfaacqcdsfnlkaddvaEKLFGESYLRKecIGTLVHLMITSVKLEVQNSDFKSKI 339
Cdd:PRK01286  185 IDDGIRAGLITLEDLPEDV-----------------------RRLLGETHRRR--INTLVVDLIKNTQRNLAEGAAAPPL 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 340 LRYKVALPAAVEELRKAIFElvrnKVIQHENVQLLEFKGQKLIVELFNVLANDPiRFLPTEtrkkYnQEEAKGDDKKmRV 419
Cdd:PRK01286  240 VSFSEEVAEAMKELRRFLFE----NVYRHPKVKREREKAKRIVQDLFEYYMEDP-ELLPPE----Y-QNIAEEEGLE-RA 308

                         410       420
                  ....*....|....*....|....
gi 1915337593 420 ICDYVSGMTDDYATRLYEKIFVPR 443
Cdd:PRK01286  309 VADYIAGMTDRYALREYRRLFVPK 332
PRK03007 PRK03007
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 22-437 3.27e-58

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 235098 [Multi-domain]  Cd Length: 428  Bit Score: 197.09  E-value: 3.27e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  22 EIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSkrdtdeggkflPDPSLMQAIC 101
Cdd:PRK03007   32 QHRTDFARDRARVLHSAALRRLADKTQVVGPREGDTPRTRLTHSLEVAQIGRGIAAGLG-----------CDPDLVDLAG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 102 LAHDIGHPPFGHGGEVALNYCMRSYGGFEGNGQTLRILSKL-----DKYTETNGLDPTRRLILGVLKYPasysevvnera 176
Cdd:PRK03007  101 LAHDIGHPPYGHNGERALDEVAADCGGFEGNAQTLRILTRLepkvlDPDGRSAGLNLTRASLDAACKYP----------- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 177 ysqlQPRSNEWLFKSSEFkppKCYldseentvrfalqpfdSDDVKLFKTVKTTALNKHketiyKALDTTIMDLADEISYS 256
Cdd:PRK03007  170 ----WTRGEADGSPRRKF---GFY----------------DDDREVFAWVRQGAPAGR-----PCLEAQVMDWADDVAYS 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 257 LHDLEDAISLKMID--------------KKMwEEHFEDKSH--LFAACQcdsfNLKADDV---AEKLFG--ESY-----L 310
Cdd:PRK03007  222 VHDVEDGVVSGRIDlrvladpvelaalaELG-AAWFSGVDAdeLLAAAD----RLSELPVvaaVGKFDGslRSSaalknL 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 311 RKECIGTLVHLMITSVKLEVQNSDFKskilRYKVALpaAVEELRKAifELVRNKVI---------QHENVQLLEfkgQKL 381
Cdd:PRK03007  297 TSELVGRFASAAITATRAAAGPGPLT----RYDADL--VVPELVRA--EVALLKTLalqfvmsdpRHLARQARQ---RER 365

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1915337593 382 IVELFNVL------ANDPIrFLPtetrkkyNQEEAKGDDKKMRVICDYVSGMTDDYATRLYE 437
Cdd:PRK03007  366 IHRVADALwagapgALDPQ-FRA-------AFNEAADDAARLRVVVDQIASLTESRLERLHA 419
PRK01096 PRK01096
deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional
 11-436 1.29e-52

deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional


Pssm-ID: 234897 [Multi-domain]  Cd Length: 440  Bit Score: 182.81  E-value: 1.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  11 ERQGYNTTRPN--EIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIGGGILSQLSKRDTDEGg 88
Cdd:PRK01096   10 ERLGKKGKTSKdeLGRSPFHKDYDRIIFSGSFRRLQRKTQVHPLAKNDHIHTRLTHSLEVSCVGRSLGMRVGETLKEEK- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  89 kfLPDPS-------LMQAICLAHDIGHPPFGHGGEVALNYCMRSYGG-----------------FEGNGQTLRILSKLDK 144
Cdd:PRK01096   89 --LPDWIspadigaIVQSACLAHDIGNPPFGHFGEDAIREWFQDAAGrgflddlspqeradflnFEGNAQGFRVLTKLEY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 145 YTETNGLDPTRRLILGVLKYPASySEVVNERAYsqlqprsnewlfKSSEFkppKCYLdSEEntvrfalqpfdsddvKLFK 224
Cdd:PRK01096  167 HQDDGGMRLTYATLGTYIKYPWS-SRHANKQQI------------KKKKF---GCYQ-SEL---------------PLFE 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 225 TVKT-TALNKHKETIYK--ALdTTIMDLADEISYSLHDLEDAISLKMIDKKMWEEHFE--------------DKSHlFAA 287
Cdd:PRK01096  215 QIAEaLGLPQLGEQRWCrhPL-TYLLEAADDICYALIDLEDGLEMGLLNYQEVEALFLeligdkekyrqlgpQDSR-RQK 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 288 CQcdSFNLKA-----DDVAEKlFGESY---LRKECIGTLVHLMITSVKLEVQNS-DF-KSKILRYKvalpaaveelRKAI 357
Cdd:PRK01096  293 LA--RLRGKAigrlvNAVAEA-FVENYdaiLAGTLPGDLIEHCDPDAKRCVQQAkDLaREKIFQHK----------RKVE 359

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 358 FELVRNKVIQ------------HENVQLLEFKgQKLIVELFNVLAndpirflPTETRKKYNqeeakgddKKMRVIcDYVS 425
Cdd:PRK01096  360 LEIGAYTILEilldafvpaalyYDSGTTPSFK-DKRLLDLLGDNA-------PDPTMKLYL--------RLLRVL-DFIS 422

                         490
                  ....*....|.
gi 1915337593 426 GMTDDYATRLY 436
Cdd:PRK01096  423 GMTDSYAKELA 433
dgt PRK04926
deoxyguanosinetriphosphate triphosphohydrolase; Provisional
 22-432 2.16e-36

deoxyguanosinetriphosphate triphosphohydrolase; Provisional


Pssm-ID: 235320 [Multi-domain]  Cd Length: 503  Bit Score: 140.06  E-value: 2.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  22 EIRSEYERDLSRLIHSSAFRRLQSKTQVLGLGESDFYRTRLTHSMEVAQIG----GGILSQLSKRDTDE--GGKFLPDP- 94
Cdd:PRK04926   27 EILRIFESDRGRIINSAAIRRLQQKTQVFPLERNAAVRSRLTHSLEVQQVGryiaKEILSRLKEQKLLEayGLDELTGPf 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593  95 -SLMQAICLAHDIGHPPFGHGGEVALN-----------------------YCMRSYGG-----------------FEGNG 133
Cdd:PRK04926  107 eSIVEMACLMHDIGNPPFGHFGEAAINdwfrqrldpdaesqpltddrcsvAALRLRDGeeplnelrrkirqdlchFEGNA 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 134 QTLRILSKLDKytetngLDPTRRLILGVLKYPAsysevvneRAY-SQLQPRSNEWLFKSSEFkppkcYLdSEENTVR--- 209
Cdd:PRK04926  187 QGIRLVHTLLR------LNLTYAQVACILKYTR--------PAWwRGPTPASHHYLMKKPGY-----YL-SEEAYVArlr 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 210 --FALQPFdsddvklfktvkttalNKHKETiYkaldttIMDLADEISYSLHDLEDAISLKMID--------KKMWEEHfE 279
Cdd:PRK04926  247 keLNLAPY----------------SRFPLT-Y------IMEAADDISYCIADLEDAVEKRIFSveqlyhhlHEAWGEH-E 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 280 DKshlfaacqcDSFNLKADDVAEKLFGESYLRKECIGTLVHLMITSVKLEVQNS-----DFKSKIlrYKVALPAAVEE-- 352
Cdd:PRK04926  303 KG---------DLFSLVVENAWEKSRANSLSRSSEDQFFMYLRVNTLNKLVPYAaqrfiDNLPAI--FAGTFNQALLEda 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 353 -----LRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNV---------------LAND-----PI-----RFLPTETR 402
Cdd:PRK04926  372 spasrLLKTFKNVARKHVFSHPEVEQLELQGYRVISGLLDIyspllalpledftelVEKErhkryPIetrlfHKLSTRHR 451

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1915337593 403 KKYNQ--EEAKGDDKKM---------RVICDYVSGMTDDYA 432
Cdd:PRK04926  452 LAYVEavSKLPSDSPEFplweyyyraRLIQDYISGMTDLYA 492
HD_assoc pfam13286
Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal ...
 344-438 1.38e-23

Phosphohydrolase-associated domain; This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.


Pssm-ID: 433087 [Multi-domain]  Cd Length: 91  Bit Score: 94.13  E-value: 1.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915337593 344 VALPAAVEELRKAIFELVRNKVIQHENVQLLEFKGQKLIVELFNVLANDPiRFLPTETRKKYNQEEakgDDKKMRVICDY 423
Cdd:pfam13286   1 VAFSPEMAAELAELKRFLFEYVYRHPRVQREEEKARRIIRELFEALMADP-ELLPPEFRARWEAAG---DDARARVVCDY 76

                          90
                  ....*....|....*
gi 1915337593 424 VSGMTDDYATRLYEK 438
Cdd:pfam13286  77 IAGMTDRYALRLHRR 91
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 59-119 9.42e-07

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 47.68  E-value: 9.42e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1915337593   59 RTRLTHSMEVAQIGGGILSQLskrdtdeggkFLPDPSLMQAICLAHDIGHPPFGHGGEVAL 119
Cdd:smart00471   3 YHVFEHSLRVAQLAAALAEEL----------GLLDIELLLLAALLHDIGKPGTPDSFLVKT 53
HD pfam01966
HD domain; HD domains are metal dependent phosphohydrolases.
 61-113 1.08e-04

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 460398 [Multi-domain]  Cd Length: 110  Bit Score: 41.45  E-value: 1.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1915337593  61 RLTHSMEVAQIGGGILSQLskrdtdeggkFLPDPSLMQAICLAHDIGHPPFGH 113
Cdd:pfam01966   1 RLEHSLRVALLARELAEEL----------GELDRELLLLAALLHDIGKGPFGD 43
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 59-125 1.24e-03

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 39.24  E-value: 1.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1915337593  59 RTRLTHSMEVAQIGGGILSQLSKRDtdeggkflPDPSLMQAICLAHDIGHPPFGHGGEVALNYCMRS 125
Cdd:cd00077     1 EHRFEHSLRVAQLARRLAEELGLSE--------EDIELLRLAALLHDIGKPGTPDAITEEESELEKD 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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