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Conserved domains on  [gi|1915266001|dbj|BBW14525|]
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hypothetical protein STN0717CIT27_P30240 (plasmid) [Citrobacter portucalensis]

Protein Classification

ParA family protein( domain architecture ID 11439703)

ParA (plasmid partition protein A) family protein similar to ParA, which is essential for plasmid partition, ensuring the proper distribution of newly replicated plasmids to daughter cells during cell division

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  17161598|2149583|26339031|11522360
SCOP:  4003982

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParA COG1192
ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein ...
 1-176 2.73e-26

ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ [Cell cycle control, cell division, chromosome partitioning, Cell motility];


:

Pssm-ID: 440805 [Multi-domain]  Cd Length: 253  Bit Score: 101.47  E-value: 2.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   1 MLTISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFAGYAKQNG------------------------- 55
Cdd:COG1192     1 MKVIAVANQKGGVGKTTTAVNLAAALARRGKRVLLIDLDPQGNLTSGLGLDPDDLdptlydlllddapledaivpteipg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  56 --------------RELPFHVGR--------KPAPDS-DYIIFDHSPGVNSG--GALGS--FVIVPTI---LDAASFSVT 105
Cdd:COG1192    81 ldlipanidlagaeIELVSRPGRelrlkralAPLADDyDYILIDCPPSLGLLtlNALAAadSVLIPVQpeyLSLEGLAQL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001 106 LKSIDELK---NEMKKPYLLLPNRVEIQNREQSELLERIQEKARAHGYEqPFIRKRVAYPRAYGMGITVFE--PKS 176
Cdd:COG1192   161 LETIEEVRedlNPKLEILGILLTMVDPRTRLSREVLEELREEFGDKVLD-TVIPRSVALAEAPSAGKPVFEydPKS 235
 
Name Accession Description Interval E-value
ParA COG1192
ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein ...
 1-176 2.73e-26

ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440805 [Multi-domain]  Cd Length: 253  Bit Score: 101.47  E-value: 2.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   1 MLTISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFAGYAKQNG------------------------- 55
Cdd:COG1192     1 MKVIAVANQKGGVGKTTTAVNLAAALARRGKRVLLIDLDPQGNLTSGLGLDPDDLdptlydlllddapledaivpteipg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  56 --------------RELPFHVGR--------KPAPDS-DYIIFDHSPGVNSG--GALGS--FVIVPTI---LDAASFSVT 105
Cdd:COG1192    81 ldlipanidlagaeIELVSRPGRelrlkralAPLADDyDYILIDCPPSLGLLtlNALAAadSVLIPVQpeyLSLEGLAQL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001 106 LKSIDELK---NEMKKPYLLLPNRVEIQNREQSELLERIQEKARAHGYEqPFIRKRVAYPRAYGMGITVFE--PKS 176
Cdd:COG1192   161 LETIEEVRedlNPKLEILGILLTMVDPRTRLSREVLEELREEFGDKVLD-TVIPRSVALAEAPSAGKPVFEydPKS 235
ParAB_family cd02042
partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved ...
 3-142 1.58e-24

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.


Pssm-ID: 349760 [Multi-domain]  Cd Length: 130  Bit Score: 93.37  E-value: 1.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   3 TISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFAgYakqngrelpfhvgrkpapdsDYIIFDhspgvn 82
Cdd:cd02042     2 VIAVANQKGGVGKTTLAVNLAAALALRGKRVLLIDLDPQGSLTSWL-Y--------------------DYILID------ 54

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001  83 SGGALGS----------FVIVPTILDAASFSVTLKSIDELK------NEMKKPYLLLPNRVEIQNREQSELLERIQ 142
Cdd:cd02042    55 TPPSLGLltrnalaaadLVLIPVQPSPFDLDGLAKLLDTLEelkkqlNPPLLILGILLTRVDPRTKLAREVLEELK 130
ParA_partition NF041546
ParA family partition ATPase;
3-193 2.89e-21

ParA family partition ATPase;


Pssm-ID: 469431 [Multi-domain]  Cd Length: 202  Bit Score: 86.84  E-value: 2.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   3 TISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMifaGYAKQNGRELPFHVGRKPAP-----------DSD 71
Cdd:NF041546    1 IIAVLNQKGGVGKTTLATHLAAALARRGYRVLLVDADPQGSAL---DWAAAREDERPFPVVGLARPtlhrelpslarDYD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  72 YIIFDHSPGVNSGGALG----SFVIVP---TILDAASFSVTLKSIDElKNEMK---KPYLLLpNRVEIQNREQSELLERI 141
Cdd:NF041546   78 FVVIDGPPRAEDLARSAikaaDLVLIPvqpSPYDLWASADTVDLIKE-AREYTpglKAAFVL-NRAIARTALGREVAEAL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001 142 QEkarahgYEQPF----IRKRVAYPRAYGMGITVFEpksgLPSANDAQAEFEHLLA 193
Cdd:NF041546  156 AE------YGLPVlktrIGQRVAFAESAAEGLTVFE----AEPDGKAAREIRALAK 201
PHA02518 PHA02518
ParA-like protein; Provisional
 4-192 1.93e-16

ParA-like protein; Provisional


Pssm-ID: 222854 [Multi-domain]  Cd Length: 211  Bit Score: 74.50  E-value: 1.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFA-------------GYAKQNGRELPfhvgrKPAPDS 70
Cdd:PHA02518    3 IAVLNQKGGAGKTTVATNLASWLHADGHKVLLVDLDPQGSSTDWAeareegeplipvvRMGKSIRADLP-----KVASGY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  71 DYIIFDHSPGVN----SGGALGSFVIVPT------ILDAASFSVTLKSIDELKNEMKKPYLLlpNRVEIQNREqselLER 140
Cdd:PHA02518   78 DYVVVDGAPQDSelarAALRIADMVLIPVqpspfdIWAAPDLVELIKARQEVTDGLPKFAFI--ISRAIKNTQ----LYR 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001 141 IQEKARAhGYEQP----FIRKRVAYPRAYGMGITVFEPKSGLPSANDAQAEFEHLL 192
Cdd:PHA02518  152 EARKALA-GYGLPilrnGTTQRVAYADAAEAGGSVLELPEDDKAAEEIIQLVKELF 206
AAA_31 pfam13614
AAA domain; This family includes a wide variety of AAA domains including some that have lost ...
 1-118 2.54e-15

AAA domain; This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.


Pssm-ID: 433350 [Multi-domain]  Cd Length: 177  Bit Score: 70.69  E-value: 2.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   1 MLTISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFAGYAKQNGRELPFHVGRKPAPDSDYIIFDHSPG 80
Cdd:pfam13614   1 GKVIAIANQKGGVGKTTTSVNLAAALAKKGKKVLLIDLDPQGNATSGLGIDKNNVEKTIYELLIGECNIEEAIIKTVIEN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1915266001  81 VNsggalgsfvIVPTILDAASFSVTLKSIDE----LKNEMKK 118
Cdd:pfam13614  81 LD---------LIPSNIDLAGAEIELIGIENreniLKEALEP 113
partition_RepA TIGR03453
plasmid partitioning protein RepA; Members of this family are the RepA (or ParA) protein ...
 4-41 5.95e-05

plasmid partitioning protein RepA; Members of this family are the RepA (or ParA) protein involved in replicon partitioning. All known examples occur in bacterial species with two or more replicons, on a plasmid or the smaller chromosome. Note that an apparent exception may be seen as a pseudomolecule from assembly of an incompletely sequenced genome. Members of this family belong to a larger family that also includes the enzyme cobyrinic acid a,c-diamide synthase, but assignment of that name to members of this family would be in error. [Mobile and extrachromosomal element functions, Plasmid functions]


Pssm-ID: 274585 [Multi-domain]  Cd Length: 387  Bit Score: 43.04  E-value: 5.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQ 41
Cdd:TIGR03453 107 IAVTNFKGGSGKTTTAAHLAQYLALRGYRVLAIDLDPQ 144
ArsA_halo NF041417
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
 10-40 8.43e-03

arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.


Pssm-ID: 469308 [Multi-domain]  Cd Length: 617  Bit Score: 36.78  E-value: 8.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDP 40
Cdd:NF041417   20 KGGVGKSTVSCATAQWLARNGYDTLLVTTDP 50
 
Name Accession Description Interval E-value
ParA COG1192
ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein ...
 1-176 2.73e-26

ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440805 [Multi-domain]  Cd Length: 253  Bit Score: 101.47  E-value: 2.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   1 MLTISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFAGYAKQNG------------------------- 55
Cdd:COG1192     1 MKVIAVANQKGGVGKTTTAVNLAAALARRGKRVLLIDLDPQGNLTSGLGLDPDDLdptlydlllddapledaivpteipg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  56 --------------RELPFHVGR--------KPAPDS-DYIIFDHSPGVNSG--GALGS--FVIVPTI---LDAASFSVT 105
Cdd:COG1192    81 ldlipanidlagaeIELVSRPGRelrlkralAPLADDyDYILIDCPPSLGLLtlNALAAadSVLIPVQpeyLSLEGLAQL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001 106 LKSIDELK---NEMKKPYLLLPNRVEIQNREQSELLERIQEKARAHGYEqPFIRKRVAYPRAYGMGITVFE--PKS 176
Cdd:COG1192   161 LETIEEVRedlNPKLEILGILLTMVDPRTRLSREVLEELREEFGDKVLD-TVIPRSVALAEAPSAGKPVFEydPKS 235
ParAB_family cd02042
partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved ...
 3-142 1.58e-24

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.


Pssm-ID: 349760 [Multi-domain]  Cd Length: 130  Bit Score: 93.37  E-value: 1.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   3 TISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFAgYakqngrelpfhvgrkpapdsDYIIFDhspgvn 82
Cdd:cd02042     2 VIAVANQKGGVGKTTLAVNLAAALALRGKRVLLIDLDPQGSLTSWL-Y--------------------DYILID------ 54

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001  83 SGGALGS----------FVIVPTILDAASFSVTLKSIDELK------NEMKKPYLLLPNRVEIQNREQSELLERIQ 142
Cdd:cd02042    55 TPPSLGLltrnalaaadLVLIPVQPSPFDLDGLAKLLDTLEelkkqlNPPLLILGILLTRVDPRTKLAREVLEELK 130
ParA_partition NF041546
ParA family partition ATPase;
3-193 2.89e-21

ParA family partition ATPase;


Pssm-ID: 469431 [Multi-domain]  Cd Length: 202  Bit Score: 86.84  E-value: 2.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   3 TISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMifaGYAKQNGRELPFHVGRKPAP-----------DSD 71
Cdd:NF041546    1 IIAVLNQKGGVGKTTLATHLAAALARRGYRVLLVDADPQGSAL---DWAAAREDERPFPVVGLARPtlhrelpslarDYD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  72 YIIFDHSPGVNSGGALG----SFVIVP---TILDAASFSVTLKSIDElKNEMK---KPYLLLpNRVEIQNREQSELLERI 141
Cdd:NF041546   78 FVVIDGPPRAEDLARSAikaaDLVLIPvqpSPYDLWASADTVDLIKE-AREYTpglKAAFVL-NRAIARTALGREVAEAL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001 142 QEkarahgYEQPF----IRKRVAYPRAYGMGITVFEpksgLPSANDAQAEFEHLLA 193
Cdd:NF041546  156 AE------YGLPVlktrIGQRVAFAESAAEGLTVFE----AEPDGKAAREIRALAK 201
PHA02518 PHA02518
ParA-like protein; Provisional
 4-192 1.93e-16

ParA-like protein; Provisional


Pssm-ID: 222854 [Multi-domain]  Cd Length: 211  Bit Score: 74.50  E-value: 1.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFA-------------GYAKQNGRELPfhvgrKPAPDS 70
Cdd:PHA02518    3 IAVLNQKGGAGKTTVATNLASWLHADGHKVLLVDLDPQGSSTDWAeareegeplipvvRMGKSIRADLP-----KVASGY 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  71 DYIIFDHSPGVN----SGGALGSFVIVPT------ILDAASFSVTLKSIDELKNEMKKPYLLlpNRVEIQNREqselLER 140
Cdd:PHA02518   78 DYVVVDGAPQDSelarAALRIADMVLIPVqpspfdIWAAPDLVELIKARQEVTDGLPKFAFI--ISRAIKNTQ----LYR 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1915266001 141 IQEKARAhGYEQP----FIRKRVAYPRAYGMGITVFEPKSGLPSANDAQAEFEHLL 192
Cdd:PHA02518  152 EARKALA-GYGLPilrnGTTQRVAYADAAEAGGSVLELPEDDKAAEEIIQLVKELF 206
AAA_31 pfam13614
AAA domain; This family includes a wide variety of AAA domains including some that have lost ...
 1-118 2.54e-15

AAA domain; This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.


Pssm-ID: 433350 [Multi-domain]  Cd Length: 177  Bit Score: 70.69  E-value: 2.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   1 MLTISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMIFAGYAKQNGRELPFHVGRKPAPDSDYIIFDHSPG 80
Cdd:pfam13614   1 GKVIAIANQKGGVGKTTTSVNLAAALAKKGKKVLLIDLDPQGNATSGLGIDKNNVEKTIYELLIGECNIEEAIIKTVIEN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1915266001  81 VNsggalgsfvIVPTILDAASFSVTLKSIDE----LKNEMKK 118
Cdd:pfam13614  81 LD---------LIPSNIDLAGAEIELIGIENreniLKEALEP 113
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 4-171 3.34e-08

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 51.96  E-value: 3.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQG---------GAMIFAGYAKQNGRE----------------- 57
Cdd:pfam01656   1 IAIAGTKGGVGKTTLAANLARALARRGLRVLLIDLDPQSnnssvegleGDIAPALQALAEGLKgrvnldpillkeksdeg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  58 --------LPFHVGRKPAPDS-----------------DYIIFD--HSPGVNSGGALGS--FVIVPT------ILDAASF 102
Cdd:pfam01656  81 gldlipgnIDLEKFEKELLGPrkeerlrealealkedyDYVIIDgaPGLGELLRNALIAadYVIIPLepevilVEDAKRL 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1915266001 103 SVTLKSIDELKNEMKKPYL-LLPNRVEIQNREQS--ELLERIQEKARAHGyeqpFIRKRVAYPRAYGMGITV 171
Cdd:pfam01656 161 GGVIAALVGGYALLGLKIIgVVLNKVDGDNHGKLlkEALEELLRGLPVLG----VIPRDEAVAEAPARGLPV 228
PHA02519 PHA02519
plasmid partition protein SopA; Reviewed
 4-74 2.53e-07

plasmid partition protein SopA; Reviewed


Pssm-ID: 107201 [Multi-domain]  Cd Length: 387  Bit Score: 50.01  E-value: 2.53e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVD-LDPQGGAMIFAGYA-----KQNGRELPFHVGRKpaPDSDYII 74
Cdd:PHA02519  109 LAVMSHKGGVYKTSSAVHTAQWLALQGHRVLLIEgNDPQGTASMYHGYVpdlhiHADDTLLPFYLGER--DNAEYAI 183
PRK13705 PRK13705
plasmid-partitioning protein SopA; Provisional
 4-74 1.09e-06

plasmid-partitioning protein SopA; Provisional


Pssm-ID: 184261 [Multi-domain]  Cd Length: 388  Bit Score: 48.05  E-value: 1.09e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVD-LDPQGGAMIFAGYA-----KQNGRELPFHVGRKpaPDSDYII 74
Cdd:PRK13705  109 IGVAAHKGGVYKTSVSVHLAQDLALKGLRVLLVEgNDPQGTASMYHGWVpdlhiHAEDTLLPFYLGEK--DDATYAI 183
CpaE COG4963
Flp pilus assembly ATPase CpaE/TadZ, contains N-terminal REC/TadZ_N domain [Intracellular ...
 3-43 2.70e-06

Flp pilus assembly ATPase CpaE/TadZ, contains N-terminal REC/TadZ_N domain [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443989 [Multi-domain]  Cd Length: 358  Bit Score: 47.03  E-value: 2.70e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1915266001   3 TISVWNRKGGIGKSNTAINVAGWFAAQ-GRKTSLVDLDPQGG 43
Cdd:COG4963   104 VIAVVGAKGGVGATTLAVNLAWALAREsGRRVLLVDLDLQFG 145
partition_RepA TIGR03453
plasmid partitioning protein RepA; Members of this family are the RepA (or ParA) protein ...
 4-41 5.95e-05

plasmid partitioning protein RepA; Members of this family are the RepA (or ParA) protein involved in replicon partitioning. All known examples occur in bacterial species with two or more replicons, on a plasmid or the smaller chromosome. Note that an apparent exception may be seen as a pseudomolecule from assembly of an incompletely sequenced genome. Members of this family belong to a larger family that also includes the enzyme cobyrinic acid a,c-diamide synthase, but assignment of that name to members of this family would be in error. [Mobile and extrachromosomal element functions, Plasmid functions]


Pssm-ID: 274585 [Multi-domain]  Cd Length: 387  Bit Score: 43.04  E-value: 5.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQ 41
Cdd:TIGR03453 107 IAVTNFKGGSGKTTTAAHLAQYLALRGYRVLAIDLDPQ 144
PRK13869 PRK13869
plasmid-partitioning protein RepA; Provisional
 4-42 8.37e-05

plasmid-partitioning protein RepA; Provisional


Pssm-ID: 139929 [Multi-domain]  Cd Length: 405  Bit Score: 42.74  E-value: 8.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQG 42
Cdd:PRK13869  124 IAVTNFKGGSGKTTTSAHLAQYLALQGYRVLAVDLDPQA 162
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 10-39 1.18e-04

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 41.71  E-value: 1.18e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLD 39
Cdd:COG0489   101 KGGEGKSTVAANLALALAQSGKRVLLIDAD 130
NifH-like cd02117
NifH family; This family contains the NifH (iron protein) of nitrogenase, L subunit (BchL/ChlL) ...
 10-42 1.39e-04

NifH family; This family contains the NifH (iron protein) of nitrogenase, L subunit (BchL/ChlL) of the protochlorophyllide reductase, and the BchX subunit of the Chlorophyllide reductase. Members of this family use energy from ATP hydrolysis and transfer electrons through a Fe4-S4 cluster to other subunit for substrate reduction


Pssm-ID: 349761  Cd Length: 266  Bit Score: 41.58  E-value: 1.39e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQG 42
Cdd:cd02117     8 KGGIGKSTTASNLSAALAEGGKKVLHVGCDPKH 40
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 10-39 1.91e-04

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 40.90  E-value: 1.91e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLD 39
Cdd:pfam10609  12 KGGVGKSTVAVNLALALARLGYKVGLLDAD 41
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
4-87 1.98e-04

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 41.18  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLD---PQGGAMIfaGYAKQngrelpfhvgRKPAPDSDYI--IFDHS 78
Cdd:PRK11670  110 IAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADiygPSIPTML--GAEDQ----------RPTSPDGTHMapIMAHG 177


                  ....*....
gi 1915266001  79 PGVNSGGAL 87
Cdd:PRK11670  178 LATNSIGYL 186
NifH cd02040
nitrogenase component II NifH; NifH gene encodes component II (iron protein) of nitrogenase. ...
 10-40 5.51e-04

nitrogenase component II NifH; NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the mollybdenum-iron (alternatively, vanadium-iron or iron-iron) protein (commonly referred to as component 1), and the iron protein (commonly referred to as component 2). The iron protein is a homodimer, with an Fe4S4 cluster bound between the subunits and two ATP-binding domains. It supplies energy by ATP hydrolysis, and transfers electrons from reduced ferredoxin or flavodoxin to component 1 for the reduction of molecular nitrogen to ammonia.


Pssm-ID: 349759  Cd Length: 265  Bit Score: 39.80  E-value: 5.51e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDP 40
Cdd:cd02040     8 KGGIGKSTTASNLSAALAEMGKKVLHVGCDP 38
FlhG-like cd02038
MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) ...
 3-39 7.03e-04

MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.


Pssm-ID: 349758 [Multi-domain]  Cd Length: 230  Bit Score: 39.47  E-value: 7.03e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1915266001   3 TISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLD 39
Cdd:cd02038     2 IIAVTSGKGGVGKTNVSANLALALSKLGKRVLLLDAD 38
MipZ pfam09140
ATPase MipZ; MipZ is an ATPase that forms a complex with the chromosome partitioning protein ...
 4-39 8.74e-04

ATPase MipZ; MipZ is an ATPase that forms a complex with the chromosome partitioning protein ParB near the chromosomal origin of replication. It is responsible for the temporal and spatial regulation of FtsZ ring formation.


Pssm-ID: 401181 [Multi-domain]  Cd Length: 262  Bit Score: 39.36  E-value: 8.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLD 39
Cdd:pfam09140   3 IVVGNEKGGSGKSTTAVHVAVALLYKGARVAAIDLD 38
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 10-39 9.20e-04

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 39.02  E-value: 9.20e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLD 39
Cdd:cd02037     9 KGGVGKSTVAVNLALALAKKGYKVGLLDAD 38
CpaE-like cd03111
pilus assembly ATPase CpaE; This protein family consists of proteins similar to the cpaE ...
 4-43 2.07e-03

pilus assembly ATPase CpaE; This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains 7 genes: pilA, cpaA, cpaB, cpaC, cpaD, cpaE and cpaF. These genes are clustered together on chromosome.


Pssm-ID: 349765 [Multi-domain]  Cd Length: 235  Bit Score: 38.03  E-value: 2.07e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1915266001   4 ISVWNRKGGIGKSNTAINVAGWFAAQ-GRKTSLVDLDPQGG 43
Cdd:cd03111     3 VAVVGAKGGVGASTLAVNLAQELAQRaKDKVLLIDLDLPFG 43
arsen_driv_ArsA TIGR04291
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
 10-40 3.19e-03

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


Pssm-ID: 275109 [Multi-domain]  Cd Length: 566  Bit Score: 37.76  E-value: 3.19e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDP 40
Cdd:TIGR04291  11 KGGVGKTSIACATAINLADQGKRVLLVSTDP 41
TraL cd05386
transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI ...
 10-54 3.37e-03

transfer origin protein TraL; The transfer origin protein TraL is member of the SIMIBI superfamily which contains a ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion. The specific function of TraL protein is unknown.


Pssm-ID: 349771  Cd Length: 155  Bit Score: 36.55  E-value: 3.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAmiFAGYAKQN 54
Cdd:cd05386     9 KGGVGKSVIASLLAQYLIDKGQPVSCIDTDPVNKT--FAGYKALN 51
MinD cd02036
septum site-determining protein MinD; Septum site-determining protein MinD is part of the ...
 3-39 4.16e-03

septum site-determining protein MinD; Septum site-determining protein MinD is part of the operon MinCDE that determines the site of the formation of a septum at mid-cell, an important part of bacterial cell division. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal role, selecting the mid-cell over other sites through the activation and regulation of MinC and MinE. MinD is a membrane-associated ATPase, related to nitrogenase iron protein.


Pssm-ID: 349756 [Multi-domain]  Cd Length: 236  Bit Score: 37.18  E-value: 4.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1915266001   3 TISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLD 39
Cdd:cd02036     2 VIVITSGKGGVGKTTTTANLGVALAKLGKKVLLIDAD 38
cellulose_yhjQ TIGR03371
cellulose synthase operon protein YhjQ; Members of this family are the YhjQ protein, found ...
 1-42 4.34e-03

cellulose synthase operon protein YhjQ; Members of this family are the YhjQ protein, found immediately upsteam of bacterial cellulose synthase (bcs) genes in a broad range of bacteria, including both copies of the bcs locus in Klebsiella pneumoniae. In several species it is seen clearly as part of the bcs operon. It is identified as a probable component of the bacterial cellulose metabolic process not only by gene location, but also by partial phylogenetic profiling, or Haft-Selengut algorithm (), based on a bacterial cellulose biosynthesis genome property profile. Cellulose plays an important role in biofilm formation and structural integrity in some bacteria. Mutants in yhjQ in Escherichia coli, show altered morphology an growth, but the function of YhjQ has not yet been determined. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274549 [Multi-domain]  Cd Length: 246  Bit Score: 36.94  E-value: 4.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1915266001   1 MLTISVWNRKGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQG 42
Cdd:TIGR03371   1 MKVIAIVSVRGGVGKTTLTANLASALKLLGEPVLAIDLDPQN 42
PRK13230 PRK13230
nitrogenase reductase-like protein; Reviewed
 10-85 5.22e-03

nitrogenase reductase-like protein; Reviewed


Pssm-ID: 183903  Cd Length: 279  Bit Score: 37.06  E-value: 5.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDPQGGAMifagyAKQNGRELP--FHVGRKPAPDS---DYIIFDHSPG---V 81
Cdd:PRK13230    9 KGGIGKSTTVCNIAAALAESGKKVLVVGCDPKADCT-----RNLVGEKIPtvLDVLREKGIDNlglEDIIYEGFNGiycV 83


                  ....
gi 1915266001  82 NSGG 85
Cdd:PRK13230   84 ESGG 87
ArsA cd02035
Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the ...
 10-40 7.09e-03

Arsenical pump-driving ATPase ArsA; ArsA ATPase functions as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes, respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.


Pssm-ID: 349755 [Multi-domain]  Cd Length: 250  Bit Score: 36.33  E-value: 7.09e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDP 40
Cdd:cd02035     8 KGGVGKTTIAAATAVRLAEQGKRVLLVSTDP 38
BY-kinase cd05387
bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on ...
 12-39 7.34e-03

bacterial tyrosine-kinase; Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.


Pssm-ID: 349772 [Multi-domain]  Cd Length: 190  Bit Score: 36.01  E-value: 7.34e-03
                          10        20
                  ....*....|....*....|....*...
gi 1915266001  12 GIGKSNTAINVAGWFAAQGRKTSLVDLD 39
Cdd:cd05387    30 GEGKSTVAANLAVALAQSGKRVLLIDAD 57
ArsA COG0003
Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];
10-40 7.37e-03

Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];


Pssm-ID: 439774  Cd Length: 299  Bit Score: 36.34  E-value: 7.37e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDP 40
Cdd:COG0003    11 KGGVGKTTVAAATALALAERGKRTLLVSTDP 41
ArsA_halo NF041417
arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical ...
 10-40 8.43e-03

arsenical pump-driving ATPase, halobacterial type; Members of this family of arsenical pump-driving ATPase (ArsA) occur typically in Halobacteria (a branch of the archaea), accompanied by homologs of ArsD and by HcsL and HcsS (halo-CC-Star proteins, long and short), two proteins that both end with Cys-Cys-COOH motifs indicative of interaction with heavy metal atoms.


Pssm-ID: 469308 [Multi-domain]  Cd Length: 617  Bit Score: 36.78  E-value: 8.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1915266001  10 KGGIGKSNTAINVAGWFAAQGRKTSLVDLDP 40
Cdd:NF041417   20 KGGVGKSTVSCATAQWLARNGYDTLLVTTDP 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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