|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02427 |
PRK02427 |
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional |
22-449 |
0e+00 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 235037 [Multi-domain] Cd Length: 435 Bit Score: 572.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 22 QPPVGLSLKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNtelVRVKGIGLGNLLE 101
Cdd:PRK02427 6 LIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIEDDE---VVVEGVGGGGLKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 102 PVDVLNAGNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLaPLAITG-QALKPTHY 180
Cdd:PRK02427 83 PEDVLDCGNSGTTMRLLTGLLALQPG-EVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEGYL-PLTIRGgKKGGPIEY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 181 HSPIASAQVKSCILLAGLLTEG--KTTVTEPALSRDHSE---RMLRAFGADLTTDPETN--SVTIIGPAQLYGQKVVVPG 253
Cdd:PRK02427 161 DGPVSSQFVKSLLLLAPLFAEGdtETTVIEPLPSRPHTEitlRMLRAFGVEVENVEGWGyrRIVIKGGQRLRGQDITVPG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 254 DISSAAFWLVAGAIVPGSNLLIENVGVNPSRTG--ILEALSLMGADVQLENQREVaGEPVADLRVRYSRLKSCTIAgdiI 331
Cdd:PRK02427 241 DPSSAAFFLAAAAITGGSEVTITNVGLNSTQGGkaIIDVLEKMGADIEIENEREG-GEPVGDIRVRSSELKGIDID---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 332 PRLIDEIPILAVAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPlvGTDVDSHTDHRIA 411
Cdd:PRK02427 317 PDIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGGPL--AGVVDSYGDHRIA 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 1210235219 412 MSLAIAALVASGITSIHRAEAAAISYPNFTATLQQVCQ 449
Cdd:PRK02427 395 MAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLASLGA 432
|
|
| AroA |
COG0128 |
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ... |
28-447 |
0e+00 |
|
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439898 Cd Length: 421 Bit Score: 570.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 28 SLKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVKGIGlGNLLEPVDVLN 107
Cdd:COG0128 11 PLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIEELDGGTLRVTGVG-GGLKEPDAVLD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 108 AGNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLaPLAITGQALKPTHYHSP-IAS 186
Cdd:COG0128 90 CGNSGTTMRLLTGLLALQPG-EVVLTGDESLRKRPMGRLLDPLRQLGARIESRGGGYL-PLTIRGGPLKGGEYEIPgSAS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 187 AQVKSCILLAGLLTEGKTTVT-----EPALSRDHSERMLRAFGADLTTDpETNSVTIIGPAQLYGQKVVVPGDISSAAFW 261
Cdd:COG0128 168 SQFKSALLLAGPLAEGGLEITvtgelESKPYRDHTERMLRAFGVEVEVE-GYRRFTVPGGQRYRPGDYTVPGDISSAAFF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 262 LVAGAIVpGSNLLIENVGVNPS--RTGILEALSLMGADVQLENQRevagepvadLRVRYSRLKSCTIAGDIIPrliDEIP 339
Cdd:COG0128 247 LAAAAIT-GSEVTVEGVGLNSTqgDTGILDILKEMGADIEIENDG---------ITVRGSPLKGIDIDLSDIP---DEAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 340 ILAVAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPLVGTDVDSHTDHRIAMSLAIAAL 419
Cdd:COG0128 314 TLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRIAMAFAVAGL 393
|
410 420
....*....|....*....|....*...
gi 1210235219 420 VASGITSIHRAEAAAISYPNFTATLQQV 447
Cdd:COG0128 394 RAEGPVTIDDAECVAKSFPDFFELLESL 421
|
|
| EPSP_synthase |
cd01556 |
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ... |
29-447 |
6.51e-177 |
|
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.
Pssm-ID: 238797 Cd Length: 409 Bit Score: 500.93 E-value: 6.51e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 29 LKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVrVKGIGLGnLLEPVDVLNA 108
Cdd:cd01556 1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGTVE-IVGGGGL-GLPPEAVLDC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 109 GNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLaITGQALKPTHYHSPIA-SA 187
Cdd:cd01556 79 GNSGTTMRLLTGLLALQGG-DSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPL-IGGGGLKGGEVEIPGAvSS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 188 QVKSCILLAGLLTEGKTTVT----EPALSRDHSERMLRAFGADLTTDPEtNSVTIIGPAQLYGQKVVVPGDISSAAFWLV 263
Cdd:cd01556 157 QFKSALLLAAPLAEGPTTIIigelESKPYIDHTERMLRAFGAEVEVDGY-RTITVKGGQKYKGPEYTVEGDASSAAFFLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 264 AGAIVPgSNLLIENVGVNPSRTGILEALSLMGADVQLENQREVAGEPVAdlrvrysRLKSCTIAGDIIPrliDEIPILAV 343
Cdd:cd01556 236 AAAITG-SEIVIKNVGLNSGDTGIIDVLKEMGADIEIGNEDTVVVESGG-------KLKGIDIDGNDIP---DEAPTLAV 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 344 AAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGT-PLVGTDVDSHTDHRIAMSLAIAALVAS 422
Cdd:cd01556 305 LAAFAEGPTRIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPlKGAGVEVYTYGDHRIAMSFAIAGLVAE 384
|
410 420
....*....|....*....|....*
gi 1210235219 423 GITSIHRAEAAAISYPNFTATLQQV 447
Cdd:cd01556 385 GGVTIEDPECVAKSFPNFFEDLESL 409
|
|
| EPSP_synthase |
pfam00275 |
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); |
29-440 |
3.07e-153 |
|
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
Pssm-ID: 395213 Cd Length: 415 Bit Score: 440.97 E-value: 3.07e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 29 LKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVKGIGLGNLLEP--VDVL 106
Cdd:pfam00275 6 LSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIIKLDDEKSVVIVEGLGGSFEApeDLVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 107 NAGNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKPTHYHSPIAS 186
Cdd:pfam00275 86 DMGNSGTALRPLTGRLALQSG-EVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGLRLGGIHIDGDVSS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 187 AQVKSCILLAGLLTEGKTTVTEPA--LSRDHSERMLRAFGADLTTDPETNSVTIIGPAQLYGQKVVVPGDISSAAFWLVA 264
Cdd:pfam00275 165 QFVTSLLMLAALLAEGTTTIENLAsePYIDDTENMLKKFGAKIEGSGTELSITVKGGEKLPGQEYRVEGDRSSAAYFLVA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 265 GAIVPGsNLLIENVGVNPSRTG--ILEALSLMGADVQlenqrevaGEPVADLRVRYSrlkSCTIAGDIIPRLIDEIPILA 342
Cdd:pfam00275 245 AAITGG-TVTVENVGINSLQGDeaLLEILEKMGAEIT--------QEEDADIVVGPP---GLRGKAVDIRTAPDPAPTTA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 343 VAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTP-LVGTDVDSHTDHRIAMSLAIAALVA 421
Cdd:pfam00275 313 VLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIPAVKeLKGAEVDSYGDHRIAMALALAGLVA 392
|
410
....*....|....*....
gi 1210235219 422 SGITSIHRAEAAAISYPNF 440
Cdd:pfam00275 393 EGETIIDDIECTDRSFPDF 411
|
|
| aroA |
TIGR01356 |
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ... |
31-447 |
1.80e-144 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273574 Cd Length: 409 Bit Score: 418.60 E-value: 1.80e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 31 GSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVrVKGIGLgnlLEPVDVLNAGN 110
Cdd:TIGR01356 1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAV-IEGVGG---KEPQAELDLGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 111 SGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKPTHYHSPIASAQVK 190
Cdd:TIGR01356 77 SGTTARLLTGVLALADG-EVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 191 SCILLAG--LLTEGKTTVTEPALSRDHSERMLRAFGADLTTDPETNSVTI-IGPAQLY-GQKVVVPGDISSAAFWLVAGA 266
Cdd:TIGR01356 156 SALLLAApaLQAVGITIVGEPLKSRPYIEITLDLLGSFGVEVERSDGRKIvVPGGQKYgPQGYDVPGDYSSAAFFLAAAA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 267 IVPGsNLLIENVGVNPSRTG--ILEALSLMGADVQLENQrevagepvaDLRVRYSR-LKSCTIAgdiIPRLIDEIPILAV 343
Cdd:TIGR01356 236 ITGG-RVTLENLGINPTQGDkaIIIVLEEMGADIEVEED---------DLIVEGASgLKGIKID---MDDMIDELPTLAV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 344 AAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPLVGTDVDSHTDHRIAMSLAIAALVASG 423
Cdd:TIGR01356 303 LAAFAEGVTRITGAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELKGAVVDTFGDHRIAMAFAVAGLVAEG 382
|
410 420
....*....|....*....|....
gi 1210235219 424 ITSIHRAEAAAISYPNFTATLQQV 447
Cdd:TIGR01356 383 EVLIDDPECVAKSFPSFFDVLERL 406
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02427 |
PRK02427 |
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional |
22-449 |
0e+00 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 235037 [Multi-domain] Cd Length: 435 Bit Score: 572.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 22 QPPVGLSLKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNtelVRVKGIGLGNLLE 101
Cdd:PRK02427 6 LIIPPSPLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIEDDE---VVVEGVGGGGLKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 102 PVDVLNAGNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLaPLAITG-QALKPTHY 180
Cdd:PRK02427 83 PEDVLDCGNSGTTMRLLTGLLALQPG-EVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEGYL-PLTIRGgKKGGPIEY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 181 HSPIASAQVKSCILLAGLLTEG--KTTVTEPALSRDHSE---RMLRAFGADLTTDPETN--SVTIIGPAQLYGQKVVVPG 253
Cdd:PRK02427 161 DGPVSSQFVKSLLLLAPLFAEGdtETTVIEPLPSRPHTEitlRMLRAFGVEVENVEGWGyrRIVIKGGQRLRGQDITVPG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 254 DISSAAFWLVAGAIVPGSNLLIENVGVNPSRTG--ILEALSLMGADVQLENQREVaGEPVADLRVRYSRLKSCTIAgdiI 331
Cdd:PRK02427 241 DPSSAAFFLAAAAITGGSEVTITNVGLNSTQGGkaIIDVLEKMGADIEIENEREG-GEPVGDIRVRSSELKGIDID---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 332 PRLIDEIPILAVAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPlvGTDVDSHTDHRIA 411
Cdd:PRK02427 317 PDIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGGPL--AGVVDSYGDHRIA 394
|
410 420 430
....*....|....*....|....*....|....*...
gi 1210235219 412 MSLAIAALVASGITSIHRAEAAAISYPNFTATLQQVCQ 449
Cdd:PRK02427 395 MAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLASLGA 432
|
|
| AroA |
COG0128 |
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ... |
28-447 |
0e+00 |
|
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439898 Cd Length: 421 Bit Score: 570.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 28 SLKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVKGIGlGNLLEPVDVLN 107
Cdd:COG0128 11 PLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIEELDGGTLRVTGVG-GGLKEPDAVLD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 108 AGNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLaPLAITGQALKPTHYHSP-IAS 186
Cdd:COG0128 90 CGNSGTTMRLLTGLLALQPG-EVVLTGDESLRKRPMGRLLDPLRQLGARIESRGGGYL-PLTIRGGPLKGGEYEIPgSAS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 187 AQVKSCILLAGLLTEGKTTVT-----EPALSRDHSERMLRAFGADLTTDpETNSVTIIGPAQLYGQKVVVPGDISSAAFW 261
Cdd:COG0128 168 SQFKSALLLAGPLAEGGLEITvtgelESKPYRDHTERMLRAFGVEVEVE-GYRRFTVPGGQRYRPGDYTVPGDISSAAFF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 262 LVAGAIVpGSNLLIENVGVNPS--RTGILEALSLMGADVQLENQRevagepvadLRVRYSRLKSCTIAGDIIPrliDEIP 339
Cdd:COG0128 247 LAAAAIT-GSEVTVEGVGLNSTqgDTGILDILKEMGADIEIENDG---------ITVRGSPLKGIDIDLSDIP---DEAP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 340 ILAVAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPLVGTDVDSHTDHRIAMSLAIAAL 419
Cdd:COG0128 314 TLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRIAMAFAVAGL 393
|
410 420
....*....|....*....|....*...
gi 1210235219 420 VASGITSIHRAEAAAISYPNFTATLQQV 447
Cdd:COG0128 394 RAEGPVTIDDAECVAKSFPDFFELLESL 421
|
|
| EPSP_synthase |
cd01556 |
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ... |
29-447 |
6.51e-177 |
|
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.
Pssm-ID: 238797 Cd Length: 409 Bit Score: 500.93 E-value: 6.51e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 29 LKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVrVKGIGLGnLLEPVDVLNA 108
Cdd:cd01556 1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGTVE-IVGGGGL-GLPPEAVLDC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 109 GNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLaITGQALKPTHYHSPIA-SA 187
Cdd:cd01556 79 GNSGTTMRLLTGLLALQGG-DSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPL-IGGGGLKGGEVEIPGAvSS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 188 QVKSCILLAGLLTEGKTTVT----EPALSRDHSERMLRAFGADLTTDPEtNSVTIIGPAQLYGQKVVVPGDISSAAFWLV 263
Cdd:cd01556 157 QFKSALLLAAPLAEGPTTIIigelESKPYIDHTERMLRAFGAEVEVDGY-RTITVKGGQKYKGPEYTVEGDASSAAFFLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 264 AGAIVPgSNLLIENVGVNPSRTGILEALSLMGADVQLENQREVAGEPVAdlrvrysRLKSCTIAGDIIPrliDEIPILAV 343
Cdd:cd01556 236 AAAITG-SEIVIKNVGLNSGDTGIIDVLKEMGADIEIGNEDTVVVESGG-------KLKGIDIDGNDIP---DEAPTLAV 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 344 AAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGT-PLVGTDVDSHTDHRIAMSLAIAALVAS 422
Cdd:cd01556 305 LAAFAEGPTRIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPlKGAGVEVYTYGDHRIAMSFAIAGLVAE 384
|
410 420
....*....|....*....|....*
gi 1210235219 423 GITSIHRAEAAAISYPNFTATLQQV 447
Cdd:cd01556 385 GGVTIEDPECVAKSFPNFFEDLESL 409
|
|
| PRK14806 |
PRK14806 |
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; ... |
26-447 |
1.18e-169 |
|
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 237820 [Multi-domain] Cd Length: 735 Bit Score: 494.13 E-value: 1.18e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 26 GLSLKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVKGIGLGNLLEPVDV 105
Cdd:PRK14806 309 GGAVKGTIRVPGDKSISHRSIMLGSLAEGVTEVEGFLEGEDALATLQAFRDMGVVIEGPHNGRVTIHGVGLHGLKAPPGP 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 106 LNAGNSGTTLRLMLGILASHPgrfF--TVTGDGSLRSRPMSRVVKPLQQMGAQIwGRQNNSLAPLAITG-QALKPTHYHS 182
Cdd:PRK14806 389 LYMGNSGTSMRLLSGLLAAQS---FdsVLTGDASLSKRPMERVAKPLREMGAVI-ETGEEGRPPLSIRGgQRLKGIHYDL 464
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 183 PIASAQVKSCILLAGLLTEGKTTVTEPALSRDHSERMLRAFGADLTTDPETNSVTiiGPAQLYGQKVVVPGDISSAAFWL 262
Cdd:PRK14806 465 PMASAQVKSCLLLAGLYAEGETSVTEPAPTRDHTERMLRGFGYPVKVEGNTISVE--GGGKLTATDIEVPADISSAAFFL 542
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 263 VAGAIVPGSNLLIENVGVNPSRTGILEALSLMGADVQLENQREVAGEPVADLRVRYSRLKSCTIAGDIIPRLIDEIPILA 342
Cdd:PRK14806 543 VAASIAEGSELTLEHVGINPTRTGVIDILKLMGADITLENEREVGGEPVADIRVRGARLKGIDIPEDQVPLAIDEFPVLF 622
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 343 VAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPlVGTDVDSHTDHRIAMSLAIAALVAS 422
Cdd:PRK14806 623 VAAACAEGRTVLTGAEELRVKESDRIQVMADGLKTLGIDCEPTPDGIIIEGGIF-GGGEVESHGDHRIAMSFSVASLRAS 701
|
410 420
....*....|....*....|....*
gi 1210235219 423 GITSIHRAEAAAISYPNFTATLQQV 447
Cdd:PRK14806 702 GPITIHDCANVATSFPNFLELANQV 726
|
|
| EPSP_synthase |
pfam00275 |
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); |
29-440 |
3.07e-153 |
|
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
Pssm-ID: 395213 Cd Length: 415 Bit Score: 440.97 E-value: 3.07e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 29 LKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVKGIGLGNLLEP--VDVL 106
Cdd:pfam00275 6 LSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIIKLDDEKSVVIVEGLGGSFEApeDLVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 107 NAGNSGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKPTHYHSPIAS 186
Cdd:pfam00275 86 DMGNSGTALRPLTGRLALQSG-EVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGLRLGGIHIDGDVSS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 187 AQVKSCILLAGLLTEGKTTVTEPA--LSRDHSERMLRAFGADLTTDPETNSVTIIGPAQLYGQKVVVPGDISSAAFWLVA 264
Cdd:pfam00275 165 QFVTSLLMLAALLAEGTTTIENLAsePYIDDTENMLKKFGAKIEGSGTELSITVKGGEKLPGQEYRVEGDRSSAAYFLVA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 265 GAIVPGsNLLIENVGVNPSRTG--ILEALSLMGADVQlenqrevaGEPVADLRVRYSrlkSCTIAGDIIPRLIDEIPILA 342
Cdd:pfam00275 245 AAITGG-TVTVENVGINSLQGDeaLLEILEKMGAEIT--------QEEDADIVVGPP---GLRGKAVDIRTAPDPAPTTA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 343 VAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTP-LVGTDVDSHTDHRIAMSLAIAALVA 421
Cdd:pfam00275 313 VLAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIPAVKeLKGAEVDSYGDHRIAMALALAGLVA 392
|
410
....*....|....*....
gi 1210235219 422 SGITSIHRAEAAAISYPNF 440
Cdd:pfam00275 393 EGETIIDDIECTDRSFPDF 411
|
|
| aroA |
TIGR01356 |
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ... |
31-447 |
1.80e-144 |
|
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273574 Cd Length: 409 Bit Score: 418.60 E-value: 1.80e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 31 GSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVrVKGIGLgnlLEPVDVLNAGN 110
Cdd:TIGR01356 1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAV-IEGVGG---KEPQAELDLGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 111 SGTTLRLMLGILASHPGrFFTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKPTHYHSPIASAQVK 190
Cdd:TIGR01356 77 SGTTARLLTGVLALADG-EVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 191 SCILLAG--LLTEGKTTVTEPALSRDHSERMLRAFGADLTTDPETNSVTI-IGPAQLY-GQKVVVPGDISSAAFWLVAGA 266
Cdd:TIGR01356 156 SALLLAApaLQAVGITIVGEPLKSRPYIEITLDLLGSFGVEVERSDGRKIvVPGGQKYgPQGYDVPGDYSSAAFFLAAAA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 267 IVPGsNLLIENVGVNPSRTG--ILEALSLMGADVQLENQrevagepvaDLRVRYSR-LKSCTIAgdiIPRLIDEIPILAV 343
Cdd:TIGR01356 236 ITGG-RVTLENLGINPTQGDkaIIIVLEEMGADIEVEED---------DLIVEGASgLKGIKID---MDDMIDELPTLAV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 344 AAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPLVGTDVDSHTDHRIAMSLAIAALVASG 423
Cdd:TIGR01356 303 LAAFAEGVTRITGAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELKGAVVDTFGDHRIAMAFAVAGLVAEG 382
|
410 420
....*....|....*....|....
gi 1210235219 424 ITSIHRAEAAAISYPNFTATLQQV 447
Cdd:TIGR01356 383 EVLIDDPECVAKSFPSFFDVLERL 406
|
|
| EPT-like |
cd01554 |
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine ... |
29-447 |
9.04e-108 |
|
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer.
Pssm-ID: 238795 Cd Length: 408 Bit Score: 324.94 E-value: 9.04e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 29 LKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEIsELNTELVRVKGIGLGNLLEPVDVLNA 108
Cdd:cd01554 1 LHGIIRVPGDKSISHRSLIFASLAEGETKVYNILRGEDVLSTMQVLRDLGVEI-EDKDGVITIQGVGMAGLKAPQNALNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 109 GNSGTTLRLMLGILASHPGRFfTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKPTHYHSPIASAQ 188
Cdd:cd01554 80 GNSGTAIRLISGVLAGADFEV-ELFGDDSLSKRPMDRVTLPLKKMGASISGQEERDLPPLLKGGKNLGPIHYEDPIASAQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 189 VKSCILLAGLLTEGKTTVTEPA--LSRDHSERMLRAFGADLTTDpETNSVTIIGPAQLYGQKVVVPGDISSAAFWLVAGA 266
Cdd:cd01554 159 VKSALMFAALLAKGETVIIEAAkePTINHTENMLQTFGGHISVQ-GTKKIVVQGPQKLTGQKYVVPGDISSAAFFLVAAA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 267 IVPGSnLLIENVGVNPSRTGILEALSLMGADVQLenqrevaGEpvADLRVRYSRLKSCTIAGDIIPRLIDEIPILAVAAV 346
Cdd:cd01554 238 IAPGR-LVLQNVGINETRTGIIDVLRAMGAKIEI-------GE--DTISVESSDLKATEICGALIPRLIDELPIIALLAL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 347 FAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPLVGTDVDSHTDHRIAMSLAIAALVASGITS 426
Cdd:cd01554 308 QAQGTTVIKDAEELKVKETDRIFVVADELNSMGADIEPTADGMIIKGKEKLHGARVNTFGDHRIGMMTALAALVADGEVE 387
|
410 420
....*....|....*....|.
gi 1210235219 427 IHRAEAAAISYPNFTATLQQV 447
Cdd:cd01554 388 LDRAEAINTSYPSFFDDLESL 408
|
|
| PRK11860 |
PRK11860 |
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase; |
23-449 |
1.68e-54 |
|
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
Pssm-ID: 237003 [Multi-domain] Cd Length: 661 Bit Score: 192.18 E-value: 1.68e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 23 PPVgLSLKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTElVRVKGIGlGNLLEP 102
Cdd:PRK11860 10 PPL-LSAGGTVRLPGSKSISNRVLLLAALSEGTTTVRDLLDSDDTRVMLDALRALGCGVEQLGDT-YRITGLG-GQFPVK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 103 VDVLNAGNSGTTLRLMLGILASHPGRFfTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKPthyHS 182
Cdd:PRK11860 87 QADLFLGNAGTAMRPLTAALALLGGEY-ELSGVPRMHERPIGDLVDALRQLGCDIDYLGNEGFPPLRIGPAPLRL---DA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 183 PIA-----SAQVKSCILLAGLLTEGKTTVTE---PALSRDHSE---RMLRAFGADLTTDpETNSVTIIGPAQLYGQKVV- 250
Cdd:PRK11860 163 PIRvrgdvSSQFLTALLMALPLVARRDITIEvvgELISKPYIEitlNLLARFGIAVQRE-GWQRFTIPAGSRYRSPGEIh 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 251 VPGDISSAAFWLVAGAIVPGSNLLIENVGVNPSRTGI--LEALSLMGADVQLENQREVAGEPVADLRvrysrlksctiAG 328
Cdd:PRK11860 242 VEGDASSASYFIAAGAIAGGAPVRIEGVGRDSIQGDIrfAEAARAMGAQVTSGPNWLEVRRGAWPLK-----------AI 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 329 DI----IPrliDEIPILAVAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITggTPLVGTD--- 401
Cdd:PRK11860 311 DLdcnhIP---DAAMTLAVMALYADGTTTLRNIASWRVKETDRIAAMATELRKLGATVEEGADYIRVT--PPAQAADwka 385
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 1210235219 402 --VDSHTDHRIAMSLAIAALVASGI-TSIHRAEAAAISYPNFTATLQQVCQ 449
Cdd:PRK11860 386 aaIHTYDDHRMAMCFSLAAFNPAGLpVRINDPKCVAKTFPDYFEALFSVAQ 436
|
|
| PLN02338 |
PLN02338 |
3-phosphoshikimate 1-carboxyvinyltransferase |
28-449 |
7.46e-41 |
|
3-phosphoshikimate 1-carboxyvinyltransferase
Pssm-ID: 177972 [Multi-domain] Cd Length: 443 Bit Score: 151.05 E-value: 7.46e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 28 SLKGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISElNTELVRVKGIGLGNLL-----EP 102
Cdd:PLN02338 11 EISGTVKLPGSKSLSNRILLLAALSEGTTVVDNLLDSDDIRYMLGALKTLGLNVEE-DSENNRAVVEGCGGKFpvsgdSK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 103 VDV-LNAGNSGTTLRLMLGILASHPGRF-FTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKP--T 178
Cdd:PLN02338 90 EDVeLFLGNAGTAMRPLTAAVTAAGGNAsYVLDGVPRMRERPIGDLVDGLKQLGADVECTLGTNCPPVRVNAAGGLPggK 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 179 HYHSPIASAQVKSCILLAGLLTEGKTTV--TEPALSRDHSE---RMLRAFGADLTTDPETNSVTIIGpaqlyGQKVVVP- 252
Cdd:PLN02338 170 VKLSGSISSQYLTALLMAAPLALGDVEIeiVDKLISVPYVEmtlKLMERFGVSVEHSDSWDRFFIKG-----GQKYKSPg 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 253 -----GDISSAAFWLvAGAIVPGSNLLIENVGVNPSR--TGILEALSLMGADVQ-LENQREVAGEPVADLRVRysRLKSC 324
Cdd:PLN02338 245 nayveGDASSASYFL-AGAAITGGTVTVEGCGTTSLQgdVKFAEVLEKMGAKVEwTENSVTVTGPPRDAFGGK--HLKAI 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 325 TIAGDIIPrliDEIPILAVAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPLVGTDVDS 404
Cdd:PLN02338 322 DVNMNKMP---DVAMTLAVVALFADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCIITPPKKLKPAEIDT 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1210235219 405 HTDHRIAMSLAIAALVASGITsIHRAEAAAISYPNFTATLQQVCQ 449
Cdd:PLN02338 399 YDDHRMAMAFSLAACGDVPVT-INDPGCTRKTFPTYFDVLESIAK 442
|
|
| PRK11861 |
PRK11861 |
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional |
30-419 |
2.61e-35 |
|
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
Pssm-ID: 183343 [Multi-domain] Cd Length: 673 Bit Score: 138.69 E-value: 2.61e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 30 KGSIRVPGDKSISHRALMLGALAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVrvKGIGLGNLLEPVDVLNAG 109
Cdd:PRK11861 252 QGTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGVKLSRDGGTCV--VGGTRGAFTAKTADLFLG 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 110 NSGTTLRLMLGILASHPGRFfTVTGDGSLRSRPMSRVVKPLQQMGAQIWGRQNNSLAPLAITGQALKpthYHSPI----- 184
Cdd:PRK11861 330 NAGTAVRPLTAALAVNGGEY-RIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPATIS---VDAPIrvrgd 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 185 ASAQVKSCILLAGLLTEGK--TTVTE---PALSRDHSE---RMLRAFGADLTTDPETNSVTIIGPAQLYGQKVVVPGDIS 256
Cdd:PRK11861 406 VSSQFLTALLMTLPLVKAKdgASVVEidgELISKPYIEitiKLMARFGVTVERDGWQRFTVPAGVRYRSPGTIMVEGDAS 485
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 257 SAAFWLVAGAIvPGSNLLIENVGVNPSR--TGILEALSLMGADVQL-ENQREVAGepvadLRVRYSRLKSCTIAGDIIPr 333
Cdd:PRK11861 486 SASYFLAAGAL-GGGPLRVEGVGRASIQgdVGFANALMQMGANVTMgDDWIEVRG-----IGHDHGRLAPIDMDFNLIP- 558
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 334 liDEIPILAVAAVFAEGTTVIKDAEELRVKESDRIAVMAQQLNKMGAKVTELPDGMEITGGTPLV-GTDVDSHTDHRIAM 412
Cdd:PRK11861 559 --DAAMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTpNASIDTYDDHRMAM 636
|
....*..
gi 1210235219 413 SLAIAAL 419
Cdd:PRK11861 637 CFSLVSL 643
|
|
| UdpNAET |
cd01555 |
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ... |
29-447 |
1.05e-25 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.
Pssm-ID: 238796 Cd Length: 400 Bit Score: 107.94 E-value: 1.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 29 LKGSIRVPGDKSiSHRALMLGA-LAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVKGIGLGNLLEPVDVLN 107
Cdd:cd01555 1 LSGEVRISGAKN-AALPILAAAlLTDEPVTLRNVPDLLDVETMIELLRSLGAKVEFEGENTLVIDASNINSTEAPYELVR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 108 agnsgtTLR---LMLGILASHPGRFFtVTGDG--SLRSRPMSRVVKPLQQMGAQIWGRQNNSLAplaITGQALKPTHYHS 182
Cdd:cd01555 80 ------KMRasiLVLGPLLARFGEAR-VSLPGgcAIGARPVDLHLKGLEALGAKIEIEDGYVEA---KAAGRLKGARIYL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 183 PIASAQVKSCILLAGLLTEGKTTVTEPALsrdhsE-------RMLRAFGADLTTDpETNSVTIIGPAQLYGQKVVVPGDI 255
Cdd:cd01555 150 DFPSVGATENIMMAAVLAEGTTVIENAAR-----EpeivdlaNFLNKMGAKIEGA-GTDTIRIEGVERLHGAEHTVIPDR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 256 SSAAFWLVAGAIVpGSNLLIENVGVNPSRTgILEALSLMGADVQL-ENQREVAGEPVadlrvrysRLKSCTIAGDIIPRL 334
Cdd:cd01555 224 IEAGTFLVAAAIT-GGDITVENVIPEHLEA-VLAKLREMGAKIEIgEDGIRVDGDGG--------RLKAVDIETAPYPGF 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 335 I-DEIPILAVAAVFAEGTTVIKDaeelRVKESdRIAvMAQQLNKMGAKVTELPDGMEITGGTPLVGTDVDShTDHRIAMS 413
Cdd:cd01555 294 PtDLQAQFMALLTQAEGTSVITE----TIFEN-RFM-HVDELNRMGADIKVEGNTAIIRGVTKLSGAPVMA-TDLRAGAA 366
|
410 420 430
....*....|....*....|....*....|....
gi 1210235219 414 LAIAALVASGITSIHRAEAAAISYPNFTATLQQV 447
Cdd:cd01555 367 LVLAGLAAEGETIISNIYHIDRGYERIEEKLRAL 400
|
|
| MurA |
COG0766 |
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ... |
17-431 |
7.53e-20 |
|
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440529 Cd Length: 416 Bit Score: 91.20 E-value: 7.53e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 17 KLIIQQppvGLSLKGSIRVPGDK-SishrAL-MLGA--LAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVK 92
Cdd:COG0766 3 KLIIEG---GKPLSGEVRISGAKnA----ALpILAAalLTDGPVTLRNVPDLSDVRTMLELLESLGVKVERDDGGTLTID 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 93 GIGLgNLLEPVDVLnagnsGTTLR---LMLG-ILA-------SHPGrfftvtGDgSLRSRPMSRVVKPLQQMGAQIWGRQ 161
Cdd:COG0766 76 ASNI-NSTEAPYEL-----VRKMRasiLVLGpLLArfgearvSLPG------GC-AIGARPIDLHLKGLEALGAEIEIEH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 162 NNslaplaITGQA--LKPTHYHSPIAS----AQvkscILLAGLLTEGKTTVTEPAlsrdhSE-------RMLRAFGADLT 228
Cdd:COG0766 143 GY------IEARAgrLKGARIYLDFPSvgatEN----IMMAAVLAEGTTVIENAA-----REpeivdlaNFLNAMGAKIE 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 229 TDPeTNSVTIIGPAQLYGQKVVVPGDISSAAFWLVAGAIVpGSNLLIENVgvNPSR-TGILEALSLMGADVQLENQreva 307
Cdd:COG0766 208 GAG-TDTITIEGVEKLHGAEHTVIPDRIEAGTFLVAAAIT-GGDVTVKNV--IPEHlEAVLAKLREAGVEIEEGDD---- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 308 gepvaDLRVRYS-RLKSCTIAGDIIPRL-IDEIPILAVAAVFAEGTTVIKDaeelRVKESdRIavM-AQQLNKMGAKVTE 384
Cdd:COG0766 280 -----GIRVRGPgRLKAVDIKTAPYPGFpTDLQAQFMALLTQAEGTSVITE----TVFEN-RF--MhVDELNRMGADIKL 347
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1210235219 385 LPDGMEITGGTPLVGTDVDShTDHRIAMSLAIAALVASGITSIHRAE 431
Cdd:COG0766 348 DGHTAIVRGVTKLSGAPVMA-TDLRAGAALVLAGLAAEGETVIDNIY 393
|
|
| PRK09369 |
PRK09369 |
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated |
16-431 |
7.22e-17 |
|
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
Pssm-ID: 236486 Cd Length: 417 Bit Score: 82.00 E-value: 7.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 16 HKLIIQQppvGLSLKGSIRVPGDKSiSHRALMLGA-LAQGETEIEGLLLGEDPRSTASCFQALGAEISELNTELVRVKGI 94
Cdd:PRK09369 2 DKLVIEG---GKPLSGEVTISGAKN-AALPILAASlLAEEPVTLTNVPDLSDVRTMIELLRSLGAKVEFDGNGTVTIDAS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 95 GLGNLLEPVDVLNagnsgtTLR---LMLG-ILA-------SHPGrfftvtGD--GSlrsRPMSRVVKPLQQMGAQIWGRQ 161
Cdd:PRK09369 78 NINNTEAPYELVK------KMRasiLVLGpLLArfgeakvSLPG------GCaiGA---RPVDLHLKGLEALGAEIEIEH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 162 NNSLAPlaiTGQALKPTHYHSPIAS----AQvkscILLAGLLTEGKTTVT----EPalsrdhsE-----RMLRAFGADLT 228
Cdd:PRK09369 143 GYVEAK---ADGRLKGAHIVLDFPSvgatEN----ILMAAVLAEGTTVIEnaarEP-------EivdlaNFLNKMGAKIS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 229 TDPeTNSVTIIGPAQLYGQKVVVPGDISSAAFWLVAGAIVpGSNLLIENVGVNPSRTgILEALSLMGADVQLENQrevag 308
Cdd:PRK09369 209 GAG-TDTITIEGVERLHGAEHTVIPDRIEAGTFLVAAAIT-GGDVTIRGARPEHLEA-VLAKLREAGAEIEEGED----- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210235219 309 epvaDLRVRYS-RLKSCTIAGDIIPRLI-DEIPILAVAAVFAEGTTVIKDaeelRVKESdRIavM-AQQLNKMGAKVTEL 385
Cdd:PRK09369 281 ----GIRVDMPgRLKAVDIKTAPYPGFPtDMQAQFMALLTQAEGTSVITE----TIFEN-RF--MhVPELIRMGADIEVD 349
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1210235219 386 PDGMEITGGTPLVGTDVDShTDHRIAMSLAIAALVASGITSIHRAE 431
Cdd:PRK09369 350 GHTAVVRGVEKLSGAPVMA-TDLRASASLVLAGLVAEGTTIVDRIY 394
|
|
| |
