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Conserved domains on  [gi|1210219922|dbj|BAZ38951|]
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uroporphyrinogen III methylase [Calothrix sp. NIES-4101]

Protein Classification

uroporphyrinogen-III synthase( domain architecture ID 10003986)

uroporphyrinogen-III synthase catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III

CATH:  3.40.50.10090
EC:  4.2.1.75
Gene Ontology:  GO:0006782|GO:0006780|GO:0004852|GO:0033014
PubMed:  12196144
SCOP:  4003361

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HemD COG1587
Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III ...
 11-249 5.78e-78

Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III synthase is part of the Pathway/BioSystem: Heme biosynthesis


:

Pssm-ID: 441195  Cd Length: 229  Bit Score: 235.57  E-value: 5.78e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  11 LAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGkd 90
Cdd:COG1587     1 LAGKRVLVTRPAPQAEELAALLEALGAEVVELPLIEIEPLPDPAALRAALERLGDYDWVIFTSANAVRAFFEALEELG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  91 aRALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVDNFPeELVNLKILFPRVEsGGREVLVKELTQKGAEVIEVA 170
Cdd:COG1587    79 -LRLAGLKIAAVGPKTAAALRAAGLKVDLVPEGFTSEGLLELLQ-ALAGKRVLIPRGD-GGREDLAETLRAAGAEVDEVE 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1210219922 171 AYQSCCPSHIPPSAELALQSGNIDIITFASSKTVKFFCQLATRVFPEnvlgsCLEGICIASIGPQTSKSCQDLIGRVDV 249
Cdd:COG1587   156 VYRTVPPDDLPEELLEALAAGEIDAVLFTSPSTVRNLLELAPDAGLA-----ALARVRIAAIGPRTAEAARELGLKVVI 229
 
Name Accession Description Interval E-value
HemD COG1587
Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III ...
 11-249 5.78e-78

Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III synthase is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 441195  Cd Length: 229  Bit Score: 235.57  E-value: 5.78e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  11 LAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGkd 90
Cdd:COG1587     1 LAGKRVLVTRPAPQAEELAALLEALGAEVVELPLIEIEPLPDPAALRAALERLGDYDWVIFTSANAVRAFFEALEELG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  91 aRALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVDNFPeELVNLKILFPRVEsGGREVLVKELTQKGAEVIEVA 170
Cdd:COG1587    79 -LRLAGLKIAAVGPKTAAALRAAGLKVDLVPEGFTSEGLLELLQ-ALAGKRVLIPRGD-GGREDLAETLRAAGAEVDEVE 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1210219922 171 AYQSCCPSHIPPSAELALQSGNIDIITFASSKTVKFFCQLATRVFPEnvlgsCLEGICIASIGPQTSKSCQDLIGRVDV 249
Cdd:COG1587   156 VYRTVPPDDLPEELLEALAAGEIDAVLFTSPSTVRNLLELAPDAGLA-----ALARVRIAAIGPRTAEAARELGLKVVI 229
HemD cd06578
Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole ...
 16-263 2.78e-71

Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease.


Pssm-ID: 119440 [Multi-domain]  Cd Length: 239  Bit Score: 218.72  E-value: 2.78e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  16 VLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSsWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGKdaRALT 95
Cdd:cd06578     1 VLVTRPRPQADELAALLEALGAEVLELPLIEIEPLD-DAELDAALADLDEYDWLIFTSPNAVEAFFEALEELGL--RALA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  96 GVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVDNFPEELV-NLKILFPRVEsGGREVLVKELTQKGAEVIEVAAYQS 174
Cdd:cd06578    78 GLKIAAVGPKTAEALREAGLTADFVPEEGDSEGLLELLELQDGkGKRILRPRGG-RAREDLAEALRERGAEVDEVEVYRT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922 175 CCPSHIPPSAELaLQSGNIDIITFASSKTVKFFCQLAtrvfpENVLGSCLEGICIASIGPQTSKSCQDLIGRVDVEAEEY 254
Cdd:cd06578   157 VPPDLDAELLEL-LEEGAIDAVLFTSPSTVRNLLELL-----GKEGRALLKNVKIAAIGPRTAEALRELGLKVVIVAESP 230


                  ....*....
gi 1210219922 255 TLPGLTQAL 263
Cdd:cd06578   231 TLEALLEAL 239
HEM4 pfam02602
Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD ...
 28-261 7.33e-65

Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as Swiss:Q59294 with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.


Pssm-ID: 426866 [Multi-domain]  Cd Length: 230  Bit Score: 202.16  E-value: 7.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  28 FSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGKDARALTGVKIAVVGEKTA 107
Cdd:pfam02602   2 LAELLEALGAEPLELPLIEIVPPEDRAELDEALKDLGEYDWLIFTSANAVRAFFEALKLEGEDLRALANIKIAAVGPKTA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922 108 QSLQKHSIQADFIPPN-FVADSLVDNFPEELVNLKILFPRvESGGREVLVKELTQKGAEVIEVAAYQSCCPSHIPPSAEL 186
Cdd:pfam02602  82 RALREAGLTPDFVPSEeGTAEGLAEELAELLAGKRVLLLR-GNIGRDDLAEALRERGAEVTEVVVYRTVPPEELPEELRE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1210219922 187 ALQSGNIDIITFASSKTVKFFCQLATRVFPEnvlgsCLEGICIASIGPQTSKSCQDLIGRVDVEAEEYTLPGLTQ 261
Cdd:pfam02602 161 ALKDGEIDAVTFTSPSTVRNLLELLKDEGLD-----WLKSVKAAAIGPTTAEALKELGLKVDVVAERPTMEALVA 230
hemD PRK05928
uroporphyrinogen-III synthase; Reviewed
 13-266 7.75e-51

uroporphyrinogen-III synthase; Reviewed


Pssm-ID: 235647  Cd Length: 249  Bit Score: 167.07  E-value: 7.75e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  13 GKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIgPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGKdaR 92
Cdd:PRK05928    1 MMKILVTRPSPKAEELVELLRELGFVALHFPLIEI-EPGRQLPQLAAQLAALGADWVIFTSKNAVEFLLSALKKKKL--K 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  93 ALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVDNFPEELV-NLKILFPRvESGGREVLVKELTQKGAEVIEVAA 171
Cdd:PRK05928   78 WPKNKKYAAIGEKTALALKKLGGKVVFVPEDGESSELLLELPELLLkGKRVLYLR-GNGGREVLGDTLEERGAEVDECEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922 172 YQSCCPSHIPPSAELALQSGNIDIITFASSKTVKFFCQLATRVFPENVLGSCLegicIASIGPQTSKSCQDLIGRVDVEA 251
Cdd:PRK05928  157 YERVPPKLDGAELLARLQSGEVDAVIFTSPSTVRAFFSLAPELGRREWLLSCK----AVVIGERTAEALRELGIKVIIVP 232

                         250
                  ....*....|....*
gi 1210219922 252 EEYTLPGLTQALIKW 266
Cdd:PRK05928  233 DSADNEALLRALKEL 247
 
Name Accession Description Interval E-value
HemD COG1587
Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III ...
 11-249 5.78e-78

Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III synthase is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 441195  Cd Length: 229  Bit Score: 235.57  E-value: 5.78e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  11 LAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGkd 90
Cdd:COG1587     1 LAGKRVLVTRPAPQAEELAALLEALGAEVVELPLIEIEPLPDPAALRAALERLGDYDWVIFTSANAVRAFFEALEELG-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  91 aRALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVDNFPeELVNLKILFPRVEsGGREVLVKELTQKGAEVIEVA 170
Cdd:COG1587    79 -LRLAGLKIAAVGPKTAAALRAAGLKVDLVPEGFTSEGLLELLQ-ALAGKRVLIPRGD-GGREDLAETLRAAGAEVDEVE 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1210219922 171 AYQSCCPSHIPPSAELALQSGNIDIITFASSKTVKFFCQLATRVFPEnvlgsCLEGICIASIGPQTSKSCQDLIGRVDV 249
Cdd:COG1587   156 VYRTVPPDDLPEELLEALAAGEIDAVLFTSPSTVRNLLELAPDAGLA-----ALARVRIAAIGPRTAEAARELGLKVVI 229
HemD cd06578
Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole ...
 16-263 2.78e-71

Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease.


Pssm-ID: 119440 [Multi-domain]  Cd Length: 239  Bit Score: 218.72  E-value: 2.78e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  16 VLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSsWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGKdaRALT 95
Cdd:cd06578     1 VLVTRPRPQADELAALLEALGAEVLELPLIEIEPLD-DAELDAALADLDEYDWLIFTSPNAVEAFFEALEELGL--RALA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  96 GVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVDNFPEELV-NLKILFPRVEsGGREVLVKELTQKGAEVIEVAAYQS 174
Cdd:cd06578    78 GLKIAAVGPKTAEALREAGLTADFVPEEGDSEGLLELLELQDGkGKRILRPRGG-RAREDLAEALRERGAEVDEVEVYRT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922 175 CCPSHIPPSAELaLQSGNIDIITFASSKTVKFFCQLAtrvfpENVLGSCLEGICIASIGPQTSKSCQDLIGRVDVEAEEY 254
Cdd:cd06578   157 VPPDLDAELLEL-LEEGAIDAVLFTSPSTVRNLLELL-----GKEGRALLKNVKIAAIGPRTAEALRELGLKVVIVAESP 230


                  ....*....
gi 1210219922 255 TLPGLTQAL 263
Cdd:cd06578   231 TLEALLEAL 239
HEM4 pfam02602
Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD ...
 28-261 7.33e-65

Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as Swiss:Q59294 with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.


Pssm-ID: 426866 [Multi-domain]  Cd Length: 230  Bit Score: 202.16  E-value: 7.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  28 FSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGKDARALTGVKIAVVGEKTA 107
Cdd:pfam02602   2 LAELLEALGAEPLELPLIEIVPPEDRAELDEALKDLGEYDWLIFTSANAVRAFFEALKLEGEDLRALANIKIAAVGPKTA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922 108 QSLQKHSIQADFIPPN-FVADSLVDNFPEELVNLKILFPRvESGGREVLVKELTQKGAEVIEVAAYQSCCPSHIPPSAEL 186
Cdd:pfam02602  82 RALREAGLTPDFVPSEeGTAEGLAEELAELLAGKRVLLLR-GNIGRDDLAEALRERGAEVTEVVVYRTVPPEELPEELRE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1210219922 187 ALQSGNIDIITFASSKTVKFFCQLATRVFPEnvlgsCLEGICIASIGPQTSKSCQDLIGRVDVEAEEYTLPGLTQ 261
Cdd:pfam02602 161 ALKDGEIDAVTFTSPSTVRNLLELLKDEGLD-----WLKSVKAAAIGPTTAEALKELGLKVDVVAERPTMEALVA 230
hemD PRK05928
uroporphyrinogen-III synthase; Reviewed
 13-266 7.75e-51

uroporphyrinogen-III synthase; Reviewed


Pssm-ID: 235647  Cd Length: 249  Bit Score: 167.07  E-value: 7.75e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  13 GKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIgPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQGKdaR 92
Cdd:PRK05928    1 MMKILVTRPSPKAEELVELLRELGFVALHFPLIEI-EPGRQLPQLAAQLAALGADWVIFTSKNAVEFLLSALKKKKL--K 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  93 ALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVDNFPEELV-NLKILFPRvESGGREVLVKELTQKGAEVIEVAA 171
Cdd:PRK05928   78 WPKNKKYAAIGEKTALALKKLGGKVVFVPEDGESSELLLELPELLLkGKRVLYLR-GNGGREVLGDTLEERGAEVDECEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922 172 YQSCCPSHIPPSAELALQSGNIDIITFASSKTVKFFCQLATRVFPENVLGSCLegicIASIGPQTSKSCQDLIGRVDVEA 251
Cdd:PRK05928  157 YERVPPKLDGAELLARLQSGEVDAVIFTSPSTVRAFFSLAPELGRREWLLSCK----AVVIGERTAEALRELGIKVIIVP 232

                         250
                  ....*....|....*
gi 1210219922 252 EEYTLPGLTQALIKW 266
Cdd:PRK05928  233 DSADNEALLRALKEL 247
PRK06975 PRK06975
bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed
 15-177 2.58e-21

bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed


Pssm-ID: 235899 [Multi-domain]  Cd Length: 656  Bit Score: 92.86  E-value: 2.58e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  15 TVLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLfaqgkDARAL 94
Cdd:PRK06975    5 TVVVTRPDGQSAALAAQLAAAGLDVLDFPLLDIAPVADDAPLRAALARLSDYALVVFVSPNAVDRALARL-----DAIWP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  95 TGVKIAVVGEKTAQSLQKHSIQAD---FIPPNFVADSLVDNFPEE------------LVNLKILFPRVEsGGREVLVKEL 159
Cdd:PRK06975   80 HALPVAVVGPGSVAALARHGIAAPahrVIAPDAPADGGEARYDSEalfaeidaafgaLAGKRVLIVRGD-GGREWLAERL 158

                         170
                  ....*....|....*...
gi 1210219922 160 TQKGAEVIEVAAYQSCCP 177
Cdd:PRK06975  159 REAGAEVELVEAYRRVVP 176
HEM4 pfam02602
Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD ...
 8-131 5.90e-14

Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as Swiss:Q59294 with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.


Pssm-ID: 426866 [Multi-domain]  Cd Length: 230  Bit Score: 69.27  E-value: 5.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922   8 QQPLAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSS-WDKLDNAIANlSSFNWLVLTSSNGVEYFFErlFA 86
Cdd:pfam02602 109 AELLAGKRVLLLRGNIGRDDLAEALRERGAEVTEVVVYRTVPPEElPEELREALKD-GEIDAVTFTSPSTVRNLLE--LL 185

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1210219922  87 QGKDARALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVD 131
Cdd:pfam02602 186 KDEGLDWLKSVKAAAIGPTTAEALKELGLKVDVVAERPTMEALVA 230
HemD cd06578
Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole ...
 8-131 4.91e-13

Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease.


Pssm-ID: 119440 [Multi-domain]  Cd Length: 239  Bit Score: 66.95  E-value: 4.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922   8 QQPLAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANlSSFNWLVLTSSNGVEYFFErlFAQ 87
Cdd:cd06578   117 LQDGKGKRILRPRGGRAREDLAEALRERGAEVDEVEVYRTVPPDLDAELLELLEE-GAIDAVLFTSPSTVRNLLE--LLG 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1210219922  88 GKDARALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVD 131
Cdd:cd06578   194 KEGRALLKNVKIAAIGPRTAEALRELGLKVVIVAESPTLEALLE 237
HemD COG1587
Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III ...
 9-118 4.01e-12

Uroporphyrinogen-III synthase [Coenzyme transport and metabolism]; Uroporphyrinogen-III synthase is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 441195  Cd Length: 229  Bit Score: 64.15  E-value: 4.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922   9 QPLAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALE-IGPPSSWDKLDNAIANlSSFNWLVLTSSNGVEYFFERLFAQ 87
Cdd:COG1587   121 QALAGKRVLIPRGDGGREDLAETLRAAGAEVDEVEVYRtVPPDDLPEELLEALAA-GEIDAVLFTSPSTVRNLLELAPDA 199

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1210219922  88 GKDarALTGVKIAVVGEKTAQSLQKHSIQAD 118
Cdd:COG1587   200 GLA--ALARVRIAAIGPRTAEAARELGLKVV 228
hemD PRK05928
uroporphyrinogen-III synthase; Reviewed
 11-131 1.49e-10

uroporphyrinogen-III synthase; Reviewed


Pssm-ID: 235647  Cd Length: 249  Bit Score: 59.98  E-value: 1.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  11 LAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPP--------SSWDKLDNAIanlssfnwLVLTSSNGVEYFFe 82
Cdd:PRK05928  123 LKGKRVLYLRGNGGREVLGDTLEERGAEVDECEVYERVPPkldgaellARLQSGEVDA--------VIFTSPSTVRAFF- 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1210219922  83 RLFAQGKDARALTGVKIAVVGEKTAQSLQKHSIQADFIPPNFVADSLVD 131
Cdd:PRK05928  194 SLAPELGRREWLLSCKAVVIGERTAEALRELGIKVIIVPDSADNEALLR 242
HEM4 pfam02602
Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD ...
 154-268 3.74e-05

Uroporphyrinogen-III synthase HemD; This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea. This enzyme catalyzes the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O. Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as Swiss:Q59294 with pfam00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease.


Pssm-ID: 426866 [Multi-domain]  Cd Length: 230  Bit Score: 43.85  E-value: 3.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922 154 VLVKELTQKGAEVIEVAAYQsccpsHIPPSAELALQS-----GNIDIITFASSKTVKFFCQLATRVFPenvLGSCLEGIC 228
Cdd:pfam02602   1 ELAELLEALGAEPLELPLIE-----IVPPEDRAELDEalkdlGEYDWLIFTSANAVRAFFEALKLEGE---DLRALANIK 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1210219922 229 IASIGPQTSKSCQDLIGRVD-VEAEEYTLPGLTQALIKWAS 268
Cdd:pfam02602  73 IAAVGPKTARALREAGLTPDfVPSEEGTAEGLAEELAELLA 113
PRK07168 PRK07168
uroporphyrin-III C-methyltransferase;
8-130 6.58e-05

uroporphyrin-III C-methyltransferase;


Pssm-ID: 180864 [Multi-domain]  Cd Length: 474  Bit Score: 43.83  E-value: 6.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922   8 QQPLAGKTVLVTRSAGQSSHFSELLIQSGANVVEMPALEigpPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERLFAQ 87
Cdd:PRK07168  246 RKPLHGKKVLFTSATNKTSVMKQKLQEAGAEIYQIPTFK---KEEYTLTLEQINEIFNVNRLVFCSAESVEILMQSCSKY 322

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1210219922  88 GKDARALTGvKIAVVGEKTAQSLQKHSIQADfiPPNFVADSLV 130
Cdd:PRK07168  323 KKDIRSLQA-ELQHMNVATQEKLMQYGLLSK--EAKFSSDTTV 362
PRK07239 PRK07239
bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated
 9-157 1.57e-04

bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated


Pssm-ID: 235981 [Multi-domain]  Cd Length: 381  Bit Score: 42.66  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922   9 QPLAGKTVLV-----TRSAGQSSHFSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSS--FNWLVLTSSNGVEYFF 81
Cdd:PRK07239  138 EGVAGKRIAVqlhgaTDEWEPLPEFLEALRAAGAEVVPVPVYRWVPPPDPGPLDRLVDAIASrgLDAVTFTSAPAVAALL 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  82 ERLFAQGKDARAL----TGVKIAVVGEKTAQSLQKHSIqADFIPPNFVADSLVDNFPEELVNLKILfpRVESGGREVLVK 157
Cdd:PRK07239  218 ERAREMGLLDQLLaalrTDVLAACVGPVTAAPLVRAGV-PTSAPERMRLGALARHITEELPLRRAR--TLRAAGHVLEIR 294
PRK05752 PRK05752
uroporphyrinogen-III synthase; Validated
 16-181 3.19e-04

uroporphyrinogen-III synthase; Validated


Pssm-ID: 235590  Cd Length: 255  Bit Score: 41.24  E-value: 3.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  16 VLVTRSAGQSSHFSELLIQSGANVVEMPALEIGPPSSWDKLDNAIANLSSFNWLVLTSSNGVEYFFERL---FAQGKDAR 92
Cdd:PRK05752    6 LLLTRPAEECAALAASLAEAGIFSSSLPLLAIEPLPETPEQRALLLELDRYCAVIVVSKPAARLGLELLdryWPQPPQQP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1210219922  93 ALTgvkiavVGEKTAQSLQKHSIQADFIPPNFVADSLVDnFPEELVNLKILFPRV----ESGGREVLVKELTQKGAEVIE 168
Cdd:PRK05752   86 WFS------VGAATAAILQDYGLDVSYPEQGDDSEALLA-LPALRQALAVPDPRVlimrGEGGRELLAERLREQGASVDY 158

                         170
                  ....*....|...
gi 1210219922 169 VAAYQSCCPSHIP 181
Cdd:PRK05752  159 LELYRRCLPDYPA 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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