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Conserved domains on  [gi|194379470|dbj|BAG63701|]
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unnamed protein product [Homo sapiens]

Protein Classification

vacuolar protein sorting family 37 protein( domain architecture ID 12073684)

vacuolar protein sorting family 37 protein similar to vacuolar protein sorting-associated protein 37 (Vps37), which is a component of the ESCRT-I complex, a regulator of vesicular trafficking process

CATH:  1.10.287.660
Gene Ontology:  GO:0000813|GO:0043162|GO:0006623|GO:0006612|GO:0048306
SCOP:  4001064

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 5-149 2.05e-51

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


:

Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 166.64  E-value: 2.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470    5 KDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQ 84
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLQELLEELKALKSEYEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194379470   85 KAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVR 149
Cdd:pfam07200  81 EQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREK 145
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 187-318 1.87e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470  187 PPVVEEQPQPPSAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGP-----RGAAGYSWS 261
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpprrlTRPAVASLS 2792

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 194379470  262 PQRSMPPRPGYPG-TPMGASGPGYPLRGGRAPSPGY-PQQSPYPATGGKPPYPIQPQLP 318
Cdd:PHA03247 2793 ESRESLPSPWDPAdPPAAVLAPAAALPPAASPAGPLpPPTSAQPTAPPPPPGPPPPSLP 2851
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 5-149 2.05e-51

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 166.64  E-value: 2.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470    5 KDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQ 84
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLQELLEELKALKSEYEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194379470   85 KAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVR 149
Cdd:pfam07200  81 EQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREK 145
PHA03247 PHA03247
large tegument protein UL36; Provisional
 187-318 1.87e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470  187 PPVVEEQPQPPSAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGP-----RGAAGYSWS 261
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpprrlTRPAVASLS 2792

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 194379470  262 PQRSMPPRPGYPG-TPMGASGPGYPLRGGRAPSPGY-PQQSPYPATGGKPPYPIQPQLP 318
Cdd:PHA03247 2793 ESRESLPSPWDPAdPPAAVLAPAAALPPAASPAGPLpPPTSAQPTAPPPPPGPPPPSLP 2851
 
Name Accession Description Interval E-value
Mod_r pfam07200
Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region ...
 5-149 2.05e-51

Modifier of rudimentary (Mod(r)) protein; This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homolog of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors.


Pssm-ID: 462117 [Multi-domain]  Cd Length: 146  Bit Score: 166.64  E-value: 2.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470    5 KDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQ 84
Cdd:pfam07200   1 EDLSTEELQELLNDEDKLDAFVHSLPQVKALQAEKEELLAENESLAEENLSLEPELEELRSQLQELLEELKALKSEYEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194379470   85 KAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVR 149
Cdd:pfam07200  81 EQELDELLSKFSPDALLARLQAAAAEAEEESEALAESFLEGEIDLDEFLKQFKEKRKLYHLRREK 145
PHA03247 PHA03247
large tegument protein UL36; Provisional
 187-318 1.87e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470  187 PPVVEEQPQPPSAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGP-----RGAAGYSWS 261
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpprrlTRPAVASLS 2792

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 194379470  262 PQRSMPPRPGYPG-TPMGASGPGYPLRGGRAPSPGY-PQQSPYPATGGKPPYPIQPQLP 318
Cdd:PHA03247 2793 ESRESLPSPWDPAdPPAAVLAPAAALPPAASPAGPLpPPTSAQPTAPPPPPGPPPPSLP 2851
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
187-315 4.28e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 4.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470 187 PPVVEEQPQPPSAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSwSPQRSM 266
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP-APAPAP 454

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 194379470 267 PPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQP 315
Cdd:PRK12323 455 AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELP 503
PHA03247 PHA03247
large tegument protein UL36; Provisional
 158-318 4.30e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470  158 RKPRASQELAGDAPPPRPPPPVRPVPQGT----PPVVEEQPQPPSAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQ 233
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEP 2710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379470  234 PSFYSGPLGPTYPAAQlgprgaagyswSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPI 313
Cdd:PHA03247 2711 APHALVSATPLPPGPA-----------AARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779


                  ....*
gi 194379470  314 QPQLP 318
Cdd:PHA03247 2780 PRRLT 2784
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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