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Conserved domains on  [gi|194379310|dbj|BAG63621|]
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unnamed protein product [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-269 5.80e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 5.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  13 VRFSPDCRaFIVWLANGDTLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQ 91
Cdd:COG2319  168 VAFSPDGK-LLASGSDDGTVRLWDLATGKLL-RTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGK 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  92 VLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKD 171
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 172 GTWKLWDTDveykkkqDPYLLKTGRfeeAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANL 250
Cdd:COG2319  310 GTVRLWDLA-------TGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSV 378

                        250       260
                 ....*....|....*....|
gi 194379310 251 SFDITGRFLASCG-DRAVRL 269
Cdd:COG2319  379 AFSPDGRTLASGSaDGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-269 5.80e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 5.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  13 VRFSPDCRaFIVWLANGDTLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQ 91
Cdd:COG2319  168 VAFSPDGK-LLASGSDDGTVRLWDLATGKLL-RTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGK 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  92 VLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKD 171
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 172 GTWKLWDTDveykkkqDPYLLKTGRfeeAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANL 250
Cdd:COG2319  310 GTVRLWDLA-------TGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSV 378

                        250       260
                 ....*....|....*....|
gi 194379310 251 SFDITGRFLASCG-DRAVRL 269
Cdd:COG2319  379 AFSPDGRTLASGSaDGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-289 1.78e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  56 KKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgkk 134
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 135 gEFQEVVRafELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKqdpyllktgRFEEAAGAAPCrLALSPNA 214
Cdd:cd00200   81 -ETGECVR--TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNS-VAFSPDG 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194379310 215 QVLALASG-SSIHLYNTRRGEKEECFERvHGECIANLSFDITG-RFLASCGDRAVRLFHNTPGHraMVEEMQGHLKR 289
Cdd:cd00200  148 TFVASSSQdGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGK--CLGTLRGHENG 221
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 144-178 1.99e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 1.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 194379310   144 FELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 178
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
145-178 5.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 5.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 194379310  145 ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 178
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-269 5.80e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 5.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  13 VRFSPDCRaFIVWLANGDTLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQ 91
Cdd:COG2319  168 VAFSPDGK-LLASGSDDGTVRLWDLATGKLL-RTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGK 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  92 VLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKD 171
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 172 GTWKLWDTDveykkkqDPYLLKTGRfeeAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANL 250
Cdd:COG2319  310 GTVRLWDLA-------TGKLLRTLT---GHTGAVRSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSV 378

                        250       260
                 ....*....|....*....|
gi 194379310 251 SFDITGRFLASCG-DRAVRL 269
Cdd:COG2319  379 AFSPDGRTLASGSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
10-286 1.67e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 1.67e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  10 ATLVRFSPDcRAFIVWLANGDTLRVFKMTkredggytfTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK 89
Cdd:COG2319   81 VLSVAFSPD-GRLLASASADGTVRLWDLA---------TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  90 -GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKkgefqevvRAFELKGHSAAVHSFAFSNDSRRMASV 168
Cdd:COG2319  151 tGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK--------LLRTLTGHTGAVRSVAFSPDGKLLASG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 169 SKDGTWKLWDTDVEykkkqdpyllKTGRFEEAAGAAPCRLALSPNAQVLALASGS-SIHLYNTRRGEKEECFERvHGECI 247
Cdd:COG2319  223 SADGTVRLWDLATG----------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADgTVRLWDLATGELLRTLTG-HSGGV 291

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 194379310 248 ANLSFDITGRFLASCG-DRAVRLFHNTPGHRamVEEMQGH 286
Cdd:COG2319  292 NSVAFSPDGKLLASGSdDGTVRLWDLATGKL--LRTLTGH 329
WD40 COG2319
WD40 repeat [General function prediction only];
58-286 1.07e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  58 HKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKkge 136
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLAtGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK--- 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 137 fqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDtdveykkkqdpylLKTGRFE---EAAGAAPCRLALSPN 213
Cdd:COG2319  154 -----LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD-------------LATGKLLrtlTGHTGAVRSVAFSPD 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194379310 214 AQVLALASG-SSIHLYNTRRGeKEECFERVHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRamVEEMQGH 286
Cdd:COG2319  216 GKLLASGSAdGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSPDGRLLASGSaDGTVRLWDLATGEL--LRTLTGH 287
WD40 COG2319
WD40 repeat [General function prediction only];
13-180 1.78e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 1.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  13 VRFSPDCRafivWLANGD---TLRVFKMTkredggytfTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK 89
Cdd:COG2319  252 VAFSPDGR----LLASGSadgTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  90 -GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEfqevvrafELKGHSAAVHSFAFSNDSRRMASV 168
Cdd:COG2319  319 tGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR--------TLTGHTGAVTSVAFSPDGRTLASG 390

                        170
                 ....*....|..
gi 194379310 169 SKDGTWKLWDTD 180
Cdd:COG2319  391 SADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-289 1.78e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  56 KKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgkk 134
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLEtGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 135 gEFQEVVRafELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKqdpyllktgRFEEAAGAAPCrLALSPNA 214
Cdd:cd00200   81 -ETGECVR--TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNS-VAFSPDG 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194379310 215 QVLALASG-SSIHLYNTRRGEKEECFERvHGECIANLSFDITG-RFLASCGDRAVRLFHNTPGHraMVEEMQGHLKR 289
Cdd:cd00200  148 TFVASSSQdGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGK--CLGTLRGHENG 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 21-270 4.67e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 4.67e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  21 AFIVWLANGD---------TLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KG 90
Cdd:cd00200   55 RDVAASADGTylasgssdkTIRLWDLETGECV-RTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  91 QVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEFQEVvrafeLKGHSAAVHSFAFSNDSRRMASVSK 170
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 171 DGTWKLWDTDveyKKKQdpylLKTGRFEEaagAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERVHGECIAn 249
Cdd:cd00200  198 DGTIKLWDLS---TGKC----LGTLRGHE---NGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTS- 266

                        250       260
                 ....*....|....*....|..
gi 194379310 250 LSFDITGRFLASCG-DRAVRLF 270
Cdd:cd00200  267 LAWSPDGKRLASGSaDGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
58-280 2.36e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.66  E-value: 2.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  58 HKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKkge 136
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLdAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 137 fqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDtdveykkkqdpylLKTGR----FEEAAGAAPCrLALSP 212
Cdd:COG2319  112 -----LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------------LATGKllrtLTGHSGAVTS-VAFSP 172

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194379310 213 NAQVLALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLASCG-DRAVRLF--------HNTPGHRAMV 280
Cdd:COG2319  173 DGKLLASGSDdGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSaDGTVRLWdlatgkllRTLTGHSGSV 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-178 1.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  58 HKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKkge 136
Cdd:cd00200  176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE--- 252

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 194379310 137 fqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 178
Cdd:cd00200  253 -----CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
77-286 2.30e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310  77 ASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgkkgefQEVVRAFELKGHSAAVHSF 156
Cdd:COG2319   13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--------AAGALLATLLGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 157 AFSNDSRRMASVSKDGTWKLWDTDveykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQVLALASG-SSIHLYNTRRGEK 235
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLA-------TGLLLRTLTGHTGAVRS---VAFSPDGKTLASGSAdGTVRLWDLATGKL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194379310 236 EECFERvHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRamVEEMQGH 286
Cdd:COG2319  155 LRTLTG-HSGAVTSVAFSPDGKLLASGSdDGTVRLWDLATGKL--LRTLTGH 203
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-286 1.25e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379310 144 FELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKqdpyllktgRFEEAAGAAPCrLALSPNAQVLALASG- 222
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR---------TLKGHTGPVRD-VAASADGTYLASGSSd 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194379310 223 SSIHLYNTrrgEKEECFERVHGEC--IANLSFDITGRFLASCG-DRAVRLFHNTPGHRAMVeeMQGH 286
Cdd:cd00200   73 KTIRLWDL---ETGECVRTLTGHTsyVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT--LRGH 134
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 144-178 1.99e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 1.99e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 194379310   144 FELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 178
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
145-178 5.04e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 5.04e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 194379310  145 ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 178
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
13-90 1.04e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 1.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194379310  13 VRFSPDCRaFIVWLANGDTLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKG 90
Cdd:COG2319  336 VAFSPDGK-TLASGSDDGTVRLWDLATGELL-RTLTG--------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 56-87 6.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.82e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 194379310    56 KKHKAPVIDIGIANTGKFIMTASSDTTVLIWS 87
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
58-87 8.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 8.35e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 194379310   58 HKAPVIDIGIANTGKFIMTASSDTTVLIWS 87
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-87 8.82e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 37.31  E-value: 8.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194379310  13 VRFSPDCRafivWLANGD---TLRVFKMTKREdGGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWS 87
Cdd:cd00200  225 VAFSPDGY----LLASGSedgTIRVWDLRTGE-CVQTLSG--------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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