|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-362 |
4.79e-45 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 160.46 E-value: 4.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 40 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 116
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 117 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 195
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 196 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 275
Cdd:COG2319 249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 276 ykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQILALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 354
Cdd:COG2319 319 -----TGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389
|
....*....
gi 194379292 355 CG-DRAVRL 362
Cdd:COG2319 390 GSaDGTVRL 398
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
46-363 |
9.87e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 130.15 E-value: 9.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 46 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 124
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 125 LRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSP 203
Cdd:cd00200 75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 204 CGRFVASCGFTPDVKVWEVcfgKKGEFQEVvrafeLKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKKQdpy 283
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 284 lLKTGRFEEaagAAPCRLALSPNAQILALASG-SSIHLYNTRRGEKEECFERVHGECIAnLSFDITGRFLASCG-DRAVR 361
Cdd:cd00200 212 -LGTLRGHE---NGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIR 286
|
..
gi 194379292 362 LF 363
Cdd:cd00200 287 IW 288
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
50-82 |
3.00e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 52.31 E-value: 3.00e-09
10 20 30
....*....|....*....|....*....|...
gi 194379292 50 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 82
Cdd:smart00320 8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
50-82 |
8.28e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.81 E-value: 8.28e-09
10 20 30
....*....|....*....|....*....|...
gi 194379292 50 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 82
Cdd:pfam00400 7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-362 |
4.79e-45 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 160.46 E-value: 4.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 40 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFI 116
Cdd:COG2319 106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LL 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 117 VWLANGDTLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMN 195
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKL-LRTLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 196 NTHAAVSPCGRFVASCGFTPDVKVWEVcfgKKGEfqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDve 275
Cdd:COG2319 249 VRSVAFSPDGRLLASGSADGTVRLWDL---ATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 276 ykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQILALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLAS 354
Cdd:COG2319 319 -----TGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDdGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRTLAS 389
|
....*....
gi 194379292 355 CG-DRAVRL 362
Cdd:COG2319 390 GSaDGTVRL 398
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
44-379 |
6.00e-39 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 144.28 E-value: 6.00e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 44 RLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWStkdfLQREHRSMRANVELDHATLVRFSPDCRaFIVWLANGD 123
Cdd:COG2319 68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD----LATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 124 TLRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVS 202
Cdd:COG2319 143 TVRLWDLATGKL-LRTLTG--------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 203 PCGRFVASCGFTPDVKVWEVcfgKKGEFQevvraFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkkqdp 282
Cdd:COG2319 214 PDGKLLASGSADGTVRLWDL---ATGKLL-----RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA--------- 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 283 yllkTG---RFEEAAGAAPCRLALSPNAQILALASG-SSIHLYNTRRGEKEECFERvHGECIANLSFDITGRFLASCG-D 357
Cdd:COG2319 277 ----TGellRTLTGHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSdD 351
|
330 340
....*....|....*....|..
gi 194379292 358 RAVRLFHNTPGHRamVEEMQGH 379
Cdd:COG2319 352 GTVRLWDLATGEL--LRTLTGH 371
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
46-273 |
2.47e-36 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 136.96 E-value: 2.47e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 46 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRANVELDHAtlVRFSPDCRafivWLANGD-- 123
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRS--VAFSPDGR----LLASGSad 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 124 -TLRVFKMTkredggytfTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAV 201
Cdd:COG2319 268 gTVRLWDLA---------TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAF 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194379292 202 SPCGRFVASCGFTPDVKVWEVCFGKKGEfqevvrafELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTD 273
Cdd:COG2319 339 SPDGKTLASGSDDGTVRLWDLATGELLR--------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
46-363 |
9.87e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 130.15 E-value: 9.87e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 46 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDT 124
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 125 LRVFKMTKREDgGYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSP 203
Cdd:cd00200 75 IRLWDLETGEC-VRTLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 204 CGRFVASCGFTPDVKVWEVcfgKKGEFQEVvrafeLKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKKQdpy 283
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDL---RTGKCVAT-----LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 284 lLKTGRFEEaagAAPCRLALSPNAQILALASG-SSIHLYNTRRGEKEECFERVHGECIAnLSFDITGRFLASCG-DRAVR 361
Cdd:cd00200 212 -LGTLRGHE---NGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIR 286
|
..
gi 194379292 362 LF 363
Cdd:cd00200 287 IW 288
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
151-373 |
1.24e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 89.97 E-value: 1.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 151 HKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKkge 229
Cdd:COG2319 35 LAAAVASLAASPDGARLAAGAGDLTLLLLdAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 230 fqevvRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDtdveykkkqdpylLKTGR----FEEAAGAAPCrLALSP 305
Cdd:COG2319 112 -----LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------------LATGKllrtLTGHSGAVTS-VAFSP 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194379292 306 NAQILALASG-SSIHLYNTRRGEKEECFeRVHGECIANLSFDITGRFLASCG-DRAVRLF--------HNTPGHRAMV 373
Cdd:COG2319 173 DGKLLASGSDdGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSaDGTVRLWdlatgkllRTLTGHSGSV 249
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-183 |
2.63e-15 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 76.87 E-value: 2.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 40 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDflQREHRSMRANVelDHATLVRFSPDCRaFIVWL 119
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHT--GAVRSVAFSPDGK-TLASG 348
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194379292 120 ANGDTLRVFKMTKREDGgYTFTAtpedfpkkHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKG 183
Cdd:COG2319 349 SDDGTVRLWDLATGELL-RTLTG--------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
170-379 |
1.06e-12 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 69.17 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 170 ASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVcfgkkgefQEVVRAFELKGHSAAVHSF 249
Cdd:COG2319 13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--------AAGALLATLLGHTAAVLSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194379292 250 AFSNDSRRMASVSKDGTWKLWDTDveykkkqDPYLLKTGRFEEAAGAApcrLALSPNAQILALASG-SSIHLYNTRRGEK 328
Cdd:COG2319 85 AFSPDGRLLASASADGTVRLWDLA-------TGLLLRTLTGHTGAVRS---VAFSPDGKTLASGSAdGTVRLWDLATGKL 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 194379292 329 EECFERvHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRamVEEMQGH 379
Cdd:COG2319 155 LRTLTG-HSGAVTSVAFSPDGKLLASGSdDGTVRLWDLATGKL--LRTLTGH 203
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
50-82 |
3.00e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 52.31 E-value: 3.00e-09
10 20 30
....*....|....*....|....*....|...
gi 194379292 50 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 82
Cdd:smart00320 8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
50-82 |
8.28e-09 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.81 E-value: 8.28e-09
10 20 30
....*....|....*....|....*....|...
gi 194379292 50 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 82
Cdd:pfam00400 7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
237-271 |
3.18e-08 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 49.23 E-value: 3.18e-08
10 20 30
....*....|....*....|....*....|....*
gi 194379292 237 FELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 271
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
238-271 |
8.11e-07 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 45.41 E-value: 8.11e-07
10 20 30
....*....|....*....|....*....|....
gi 194379292 238 ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 271
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
50-82 |
3.80e-06 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 48.10 E-value: 3.80e-06
10 20 30
....*....|....*....|....*....|...
gi 194379292 50 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS 82
Cdd:cd00200 257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| |
