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Conserved domains on  [gi|194382218|dbj|BAG58864|]
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unnamed protein product [Homo sapiens]

Protein Classification

pre-mRNA-splicing factor CWC25 family protein( domain architecture ID 10576129)

pre-mRNA-splicing factor CWC25 family protein is involved in pre-mRNA splicing as a component of the spliceosome

Gene Ontology:  GO:0000398
PubMed:  19704000

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CWC25 pfam12542
Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 ...
 4-94 2.34e-17

Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.


:

Pssm-ID: 463626 [Multi-domain]  Cd Length: 97  Bit Score: 76.33  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194382218    4 EEKLDWMYQGPGGMVNR--DEYLLGRP-IDKYVFEK---MEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLF 77
Cdd:pfam12542   1 LERLDWMYDGPSGGVEEemEEYLLGKKrVDKLLEGGddaEKKKAAKASFSAASVPGALFLEKAINSARDTARKLREDPLL 80

                          90
                  ....*....|....*..
gi 194382218   78 IIRKKEEEKKREVLNNP 94
Cdd:pfam12542  81 AIKKQEQEARQALLNNP 97
 
Name Accession Description Interval E-value
CWC25 pfam12542
Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 ...
 4-94 2.34e-17

Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.


Pssm-ID: 463626 [Multi-domain]  Cd Length: 97  Bit Score: 76.33  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194382218    4 EEKLDWMYQGPGGMVNR--DEYLLGRP-IDKYVFEK---MEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLF 77
Cdd:pfam12542   1 LERLDWMYDGPSGGVEEemEEYLLGKKrVDKLLEGGddaEKKKAAKASFSAASVPGALFLEKAINSARDTARKLREDPLL 80

                          90
                  ....*....|....*..
gi 194382218   78 IIRKKEEEKKREVLNNP 94
Cdd:pfam12542  81 AIKKQEQEARQALLNNP 97
 
Name Accession Description Interval E-value
CWC25 pfam12542
Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 ...
 4-94 2.34e-17

Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.


Pssm-ID: 463626 [Multi-domain]  Cd Length: 97  Bit Score: 76.33  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194382218    4 EEKLDWMYQGPGGMVNR--DEYLLGRP-IDKYVFEK---MEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLF 77
Cdd:pfam12542   1 LERLDWMYDGPSGGVEEemEEYLLGKKrVDKLLEGGddaEKKKAAKASFSAASVPGALFLEKAINSARDTARKLREDPLL 80

                          90
                  ....*....|....*..
gi 194382218   78 IIRKKEEEKKREVLNNP 94
Cdd:pfam12542  81 AIKKQEQEARQALLNNP 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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