nodulin-like protein [Arabidopsis thaliana]
MFS transporter( domain architecture ID 13024088)
major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides
List of domain hits
Name | Accession | Description | Interval | E-value | ||||||||
MFS_Mch1p_like | cd17354 | Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
7-500 | 8.25e-104 | ||||||||
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. : Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 316.50 E-value: 8.25e-104
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Name | Accession | Description | Interval | E-value | ||||||||
MFS_Mch1p_like | cd17354 | Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
7-500 | 8.25e-104 | ||||||||
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 316.50 E-value: 8.25e-104
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Nodulin-like | pfam06813 | Nodulin-like; This family represents a conserved region within plant nodulin-like proteins. |
7-240 | 9.14e-59 | ||||||||
Nodulin-like; This family represents a conserved region within plant nodulin-like proteins. Pssm-ID: 284279 Cd Length: 250 Bit Score: 195.25 E-value: 9.14e-59
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NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
308-513 | 9.64e-12 | ||||||||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 66.83 E-value: 9.64e-12
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Name | Accession | Description | Interval | E-value | ||||||||
MFS_Mch1p_like | cd17354 | Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
7-500 | 8.25e-104 | ||||||||
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 316.50 E-value: 8.25e-104
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Nodulin-like | pfam06813 | Nodulin-like; This family represents a conserved region within plant nodulin-like proteins. |
7-240 | 9.14e-59 | ||||||||
Nodulin-like; This family represents a conserved region within plant nodulin-like proteins. Pssm-ID: 284279 Cd Length: 250 Bit Score: 195.25 E-value: 9.14e-59
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MFS_OFA_like | cd17353 | Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
303-507 | 2.41e-14 | ||||||||
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 74.57 E-value: 2.41e-14
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NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
308-513 | 9.64e-12 | ||||||||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 66.83 E-value: 9.64e-12
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UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
316-513 | 7.75e-08 | ||||||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 7.75e-08
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MFS_YcxA_like | cd17355 | MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
289-507 | 5.00e-06 | ||||||||
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.81 E-value: 5.00e-06
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MFS_MCT_SLC16 | cd17352 | Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
342-507 | 3.47e-05 | ||||||||
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 46.01 E-value: 3.47e-05
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CynX | COG2807 | Cyanate permease [Inorganic ion transport and metabolism]; |
317-507 | 8.21e-05 | ||||||||
Cyanate permease [Inorganic ion transport and metabolism]; Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.86 E-value: 8.21e-05
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MFS_1 | pfam07690 | Major Facilitator Superfamily; |
319-513 | 1.04e-03 | ||||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.04e-03
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UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
317-508 | 1.14e-03 | ||||||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.39 E-value: 1.14e-03
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AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
307-446 | 2.29e-03 | ||||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 2.29e-03
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MFS_ExuT_GudP_like | cd17319 | Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
364-507 | 3.05e-03 | ||||||||
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.86 E-value: 3.05e-03
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AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
306-524 | 4.11e-03 | ||||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 4.11e-03
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MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
319-513 | 9.72e-03 | ||||||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 9.72e-03
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Blast search parameters | ||||
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