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Conserved domains on  [gi|110739263|dbj|BAF01545|]
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nodulin-like protein [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 13024088)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
7-500 8.25e-104

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 316.50  E-value: 8.25e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263   7 KWVAAAASIWIQSFSGASYTFGIYSSVLKSSQSYDQSTLDTVSVYKDIGANVGILSGLFYTavasrksgnggfFSGPWLV 86
Cdd:cd17354    2 RWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLLSVAKDLGYLVGPLLGLLSD------------RLGPWLL 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263  87 IFVGLLQWFVGYGFIWMATSGVIPRPPVAMMCLFMFFAGHCQPFFNTAIVVTAVRNFSDYGGTAVGIMKGYLGLSGAILV 166
Cdd:cd17354   70 LLIGAILFFPGYGVLWLVVTGLISDLSFWLMCLCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 167 QMYHIFCGGDPRNYILLLAVVPSLLILTLMPFVRTYDtviagdkkhlnglsaisliivtylmvvilveniigmsmpmkic 246
Cdd:cd17354  150 QLYKALFFHDSARVFLFLAVLPAVVGLLAWFSVRIVS------------------------------------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 247 sftflllllaspllvavraqrEEEHRFLSldfpvterttlldspklnsssdvkdvmtndmnvleaicTTNFWLLFVAMIC 326
Cdd:cd17354  187 ---------------------IEEGEFLK--------------------------------------DIDFWLLFISLFL 207
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 327 GMGSGLATINNIRQMGESLRYSTVQlNSLVSLWSIWNFLGRFGSGYISDTYLHSHGWPRPVFMAITLGLMAIGHIVMASG 406
Cdd:cd17354  208 GVGPGEMFINNLGQIGQSLTGPSNT-STLVSLFSIFSFLGRLLSGLLSDLFVRKFRLPRPSRMVLLLLILSLGHLLQAFG 286
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 407 L-LGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSYFFSVKVIGYLYDKV---ASEDDHSCYG 482
Cdd:cd17354  287 LpSGALYVASALIGFGYGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYYDNGgegAGSDDLSCIG 366
                        490
                 ....*....|....*...
gi 110739263 483 NHCFRTSFLIMAAMALLG 500
Cdd:cd17354  367 PHCFSLTFLIMAAVCLLA 384
 
Name Accession Description Interval E-value
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
7-500 8.25e-104

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 316.50  E-value: 8.25e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263   7 KWVAAAASIWIQSFSGASYTFGIYSSVLKSSQSYDQSTLDTVSVYKDIGANVGILSGLFYTavasrksgnggfFSGPWLV 86
Cdd:cd17354    2 RWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLLSVAKDLGYLVGPLLGLLSD------------RLGPWLL 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263  87 IFVGLLQWFVGYGFIWMATSGVIPRPPVAMMCLFMFFAGHCQPFFNTAIVVTAVRNFSDYGGTAVGIMKGYLGLSGAILV 166
Cdd:cd17354   70 LLIGAILFFPGYGVLWLVVTGLISDLSFWLMCLCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 167 QMYHIFCGGDPRNYILLLAVVPSLLILTLMPFVRTYDtviagdkkhlnglsaisliivtylmvvilveniigmsmpmkic 246
Cdd:cd17354  150 QLYKALFFHDSARVFLFLAVLPAVVGLLAWFSVRIVS------------------------------------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 247 sftflllllaspllvavraqrEEEHRFLSldfpvterttlldspklnsssdvkdvmtndmnvleaicTTNFWLLFVAMIC 326
Cdd:cd17354  187 ---------------------IEEGEFLK--------------------------------------DIDFWLLFISLFL 207
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 327 GMGSGLATINNIRQMGESLRYSTVQlNSLVSLWSIWNFLGRFGSGYISDTYLHSHGWPRPVFMAITLGLMAIGHIVMASG 406
Cdd:cd17354  208 GVGPGEMFINNLGQIGQSLTGPSNT-STLVSLFSIFSFLGRLLSGLLSDLFVRKFRLPRPSRMVLLLLILSLGHLLQAFG 286
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 407 L-LGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSYFFSVKVIGYLYDKV---ASEDDHSCYG 482
Cdd:cd17354  287 LpSGALYVASALIGFGYGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYYDNGgegAGSDDLSCIG 366
                        490
                 ....*....|....*...
gi 110739263 483 NHCFRTSFLIMAAMALLG 500
Cdd:cd17354  367 PHCFSLTFLIMAAVCLLA 384
Nodulin-like pfam06813
Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.
7-240 9.14e-59

Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.


Pssm-ID: 284279  Cd Length: 250  Bit Score: 195.25  E-value: 9.14e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263    7 KWVAAAASIWIQSFSGASYTFGIYSSVLKSSQSYDQSTLDTVSVYKDIGANVGILSGLfytavASRKSGnggffsgPWLV 86
Cdd:pfam06813   1 RWLVLVAAIWIQSIAGANYDFSAYSSALKSSLGYSQVQLNLLGVAKDLGKNFGWLSGL-----ASEYLP-------PWVV 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263   87 IFVGLLQWFVGYGFIWMATSGVIPRPPVAMMCLFMFFAGHCQPFFNTAIVVTAVRNFSDYGGTAVGIMKGYLGLSGAILV 166
Cdd:pfam06813  69 LLVGAAMGLVGYGVQWLVVTGRIPGLPYWLMFLCICLAGNSICWFNTASLVTCIRNFPESRGVVLGLLKGYAGLSGAIYT 148
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110739263  167 QMYHIFCGGDPRNYILLLAVVPSLLILTLMPFVRTYD-----TVIAGDKKHLNGLSAISLIIVTYLMVVILVENIIGMS 240
Cdd:pfam06813 149 QLYTAIYGSDAKSLLLLNALVPLVVSLVALYFVRPCPpspsvGERRSEDRVFLVLNVISVLLAVYLLVMSILSKFSDLS 227
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
308-513 9.64e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.83  E-value: 9.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 308 VLEAICTTNFWLLFVAMICGMGSGLATINNIRQMG-ESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTylhshgWPRP 386
Cdd:COG2223  198 QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR------IGGR 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 387 VFMAITLGLMAIGHIVMASGL--LGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSyFFSVKV 464
Cdd:COG2223  272 RVLLIVFALMALGLLLLALALgsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG-FLGPLL 350
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 110739263 465 IGYLYDKVASeddhscygnhcFRTSFLIMAAMALLGSLVALVLLLRTKK 513
Cdd:COG2223  351 FGALLDATGS-----------YTAAFLVFAVLALVALVLTLLLYRRPRR 388
 
Name Accession Description Interval E-value
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
7-500 8.25e-104

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 316.50  E-value: 8.25e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263   7 KWVAAAASIWIQSFSGASYTFGIYSSVLKSSQSYDQSTLDTVSVYKDIGANVGILSGLFYTavasrksgnggfFSGPWLV 86
Cdd:cd17354    2 RWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLLSVAKDLGYLVGPLLGLLSD------------RLGPWLL 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263  87 IFVGLLQWFVGYGFIWMATSGVIPRPPVAMMCLFMFFAGHCQPFFNTAIVVTAVRNFSDYGGTAVGIMKGYLGLSGAILV 166
Cdd:cd17354   70 LLIGAILFFPGYGVLWLVVTGLISDLSFWLMCLCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 167 QMYHIFCGGDPRNYILLLAVVPSLLILTLMPFVRTYDtviagdkkhlnglsaisliivtylmvvilveniigmsmpmkic 246
Cdd:cd17354  150 QLYKALFFHDSARVFLFLAVLPAVVGLLAWFSVRIVS------------------------------------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 247 sftflllllaspllvavraqrEEEHRFLSldfpvterttlldspklnsssdvkdvmtndmnvleaicTTNFWLLFVAMIC 326
Cdd:cd17354  187 ---------------------IEEGEFLK--------------------------------------DIDFWLLFISLFL 207
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 327 GMGSGLATINNIRQMGESLRYSTVQlNSLVSLWSIWNFLGRFGSGYISDTYLHSHGWPRPVFMAITLGLMAIGHIVMASG 406
Cdd:cd17354  208 GVGPGEMFINNLGQIGQSLTGPSNT-STLVSLFSIFSFLGRLLSGLLSDLFVRKFRLPRPSRMVLLLLILSLGHLLQAFG 286
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 407 L-LGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSYFFSVKVIGYLYDKV---ASEDDHSCYG 482
Cdd:cd17354  287 LpSGALYVASALIGFGYGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYYDNGgegAGSDDLSCIG 366
                        490
                 ....*....|....*...
gi 110739263 483 NHCFRTSFLIMAAMALLG 500
Cdd:cd17354  367 PHCFSLTFLIMAAVCLLA 384
Nodulin-like pfam06813
Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.
7-240 9.14e-59

Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.


Pssm-ID: 284279  Cd Length: 250  Bit Score: 195.25  E-value: 9.14e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263    7 KWVAAAASIWIQSFSGASYTFGIYSSVLKSSQSYDQSTLDTVSVYKDIGANVGILSGLfytavASRKSGnggffsgPWLV 86
Cdd:pfam06813   1 RWLVLVAAIWIQSIAGANYDFSAYSSALKSSLGYSQVQLNLLGVAKDLGKNFGWLSGL-----ASEYLP-------PWVV 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263   87 IFVGLLQWFVGYGFIWMATSGVIPRPPVAMMCLFMFFAGHCQPFFNTAIVVTAVRNFSDYGGTAVGIMKGYLGLSGAILV 166
Cdd:pfam06813  69 LLVGAAMGLVGYGVQWLVVTGRIPGLPYWLMFLCICLAGNSICWFNTASLVTCIRNFPESRGVVLGLLKGYAGLSGAIYT 148
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110739263  167 QMYHIFCGGDPRNYILLLAVVPSLLILTLMPFVRTYD-----TVIAGDKKHLNGLSAISLIIVTYLMVVILVENIIGMS 240
Cdd:pfam06813 149 QLYTAIYGSDAKSLLLLNALVPLVVSLVALYFVRPCPpspsvGERRSEDRVFLVLNVISVLLAVYLLVMSILSKFSDLS 227
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
303-507 2.41e-14

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 74.57  E-value: 2.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 303 TNDMNVLEAICTTNFWLLFVAMICGMGSGLATINNIRQMGESLRYSTVQLNSL-VSLWSIWNFLGRFGSGYISDTYlhsh 381
Cdd:cd17353  201 PRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALaVSILSIFNGGGRPFWGWLSDKI---- 276
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 382 GWPRPVFMAITLGLMAIGHIVMASGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGT---IFYT-ISIASPVGS 457
Cdd:cd17353  277 GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTnygLLYTaKGVGGLIGP 356
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 110739263 458 YFFSVKVIGYLYdkvaseddhscygnhcfRTSFLIMAAMALLGSLVALVL 507
Cdd:cd17353  357 IIAAYVLYTGGY-----------------NAAFIIAAALSLVALALALLL 389
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
308-513 9.64e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.83  E-value: 9.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 308 VLEAICTTNFWLLFVAMICGMGSGLATINNIRQMG-ESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTylhshgWPRP 386
Cdd:COG2223  198 QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR------IGGR 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 387 VFMAITLGLMAIGHIVMASGL--LGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSyFFSVKV 464
Cdd:COG2223  272 RVLLIVFALMALGLLLLALALgsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGG-FLGPLL 350
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 110739263 465 IGYLYDKVASeddhscygnhcFRTSFLIMAAMALLGSLVALVLLLRTKK 513
Cdd:COG2223  351 FGALLDATGS-----------YTAAFLVFAVLALVALVLTLLLYRRPRR 388
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
316-513 7.75e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.49  E-value: 7.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 316 NFWLLFVAMICGMGSGLATINNI-RQMGESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTYlhshGWPRPVFMAITLG 394
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLpTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL----GRRRKLVLAIGLL 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 395 LMAIGHIVMA-SGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSYFFSVkVIGYLYDKVA 473
Cdd:COG2271  257 LAALALLLLAlLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL-LVGYLLDATG 335
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 110739263 474 seddhscygnhcFRTSFLIMAAMALLGSLVALVLLLRTKK 513
Cdd:COG2271  336 ------------YQAAFLLLAALALLAALLALLLLRETRK 363
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
289-507 5.00e-06

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 48.81  E-value: 5.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 289 SPKLNSSSDVKDVMTNDMNVLEAICTTNFWLLFVAM-ICGMGSGLATINNIRQMGEsLRYSTVQLNSLVSLWSIWNFLGR 367
Cdd:cd17355  184 ADLALRAYDDASPASPGSTLKEALRSASFWLLALAFfLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGR 262
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 368 FGSGYISDTYlhshGWPRPVFMAITLGLMAIGHIVMASGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFY 447
Cdd:cd17355  263 LLSGWLGDRY----SPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFG 338
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 448 TISIASPVGSyFFSVKVIGYLYDKVASeddhscygnhcFRTSFLIMAAMALLGSLVALVL 507
Cdd:cd17355  339 LVFAPHQLGS-ALGPWLGGLLYDRTGS-----------YTAAWALAVALGLIAALLVLPI 386
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
342-507 3.47e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 46.01  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 342 GESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTYLHshgwPRPVFMAITLGLMAIGHIVMA-SGLLGSLYIGSLLVGL 420
Cdd:cd17352  210 AKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI----GRLYLYIFTLLILGLSLLAFPlATTYVGLIVFSVLFGF 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 421 AYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSyFFSVKVIGYLYDKVASeddhscygnhcFRTSFLIMAAMALLG 500
Cdd:cd17352  286 CSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAA-LVGPPIAGLLRDYTGD-----------YDAAFYFCGACLLLS 353

                 ....*..
gi 110739263 501 SLVALVL 507
Cdd:cd17352  354 GVLLFLL 360
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
317-507 8.21e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 8.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 317 FWLLFVAMICGMGSGLATINNIRQMGESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDtylhsHGWPRPVFMAITLGLM 396
Cdd:COG2807  217 AWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD-----RLGDRRPLLLLLGLLG 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 397 AIGHIVMASGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLH--------MGTIFYTISIASPVgsyffsvkVIGYL 468
Cdd:COG2807  292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeaaalsgmAQSVGYLLAALGPL--------LVGAL 363
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 110739263 469 YDKVASeddhscygnhcFRTSFLIMAAMALLGSLVALVL 507
Cdd:COG2807  364 HDATGS-----------WTAALLLLAALAVLMLVAGLLA 391
MFS_1 pfam07690
Major Facilitator Superfamily;
319-513 1.04e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.25  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263  319 LLFVAMICGMGSGLATINNIRQMGESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTYlhshgwPRPVFMAITLGLMAI 398
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF------GRRRVLLIGLLLFAL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263  399 GHIVMA-SGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSYFFSVkVIGYLYDKVAsedd 477
Cdd:pfam07690  75 GLLLLLfASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPL-LGGLLASLFG---- 149
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 110739263  478 hscygnhcFRTSFLIMAAMALLGSLVALVLLLRTKK 513
Cdd:pfam07690 150 --------WRAAFLILAILSLLAAVLLLLPRPPPES 177
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
317-508 1.14e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.39  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 317 FWLLFVAMICGMGSGLATINN---IRQMGESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTYlhshgwPRPVFMAITL 393
Cdd:COG2271    9 WRILALLFLAYFLNYLDRSNLsvaAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF------GRRRVLAIGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 394 GLMAIGHIVMA-SGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSYFFSVkVIGYLYDKV 472
Cdd:COG2271   83 LLWGLATLLFGfATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP-LLGWLLAAF 161
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 110739263 473 AseddhscygnhcFRTSFLIMAAMALLGSLVALVLL 508
Cdd:COG2271  162 G------------WRAAFLILGLPGLLLALLRFWLL 185
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
307-446 2.29e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 2.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 307 NVLEAICTTNFWLLFVAMICGMGSGLATINNIRQMG-ESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTylhshgWPR 385
Cdd:COG2814  199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR------FGR 272
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110739263 386 PVFMAITLGLMAIGHIVMA-SGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIF 446
Cdd:COG2814  273 RRLLLIGLLLLALGLLLLAlAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRAS 334
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
364-507 3.05e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.86  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 364 FLGRFGSGYISDTYLHshgWPRPVFMAITLGLMAIGhiVMASGLLGSLYIGSLLVGLA---YGSQWSLMPTITSEIFGVL 440
Cdd:cd17319  229 AIGMILGGRLSDRLLR---GARRLVIIIGLLLAAVG--LLLAYLTTSPVVAVILLSLAgfgIGAASPVFWSLPADLLPGE 303
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110739263 441 HMGTIFYTISIASPVGSyFFSVKVIGYLYDKVASeddhscygnhcFRTSFLIMAAMALLGSLVALVL 507
Cdd:cd17319  304 AAATAGGLINSGGNLGG-FVAPLLIGYLVDATGS-----------YTAAFLFLAAVALLAALLVLLL 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
306-524 4.11e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 306 MNVLEAICTTNFWLLFVAMICGMGSGLATINNIRQMGESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTYlhshgwPR 385
Cdd:COG2814    1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF------GR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 386 PVFMAITLGLMAIGHIVMA-SGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSyFFSVKV 464
Cdd:COG2814   75 RRVLLLGLLLFALGSLLCAlAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP-ALGPLL 153
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 465 IGYLYDKVAseddhscygnhcFRTSFLIMAAMALLGSLVALVLLLRTKKFYATLVAKRIL 524
Cdd:COG2814  154 GGLLADLFG------------WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR 201
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
319-513 9.72e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 9.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 319 LLFVAMICGMGSGLATINNIrQMGESLRYSTVQLNSLVSLWSIWNFLGRFGSGYISDTYlhshgwPRPVFMAITLGLMAI 398
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLP-ALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF------GRRPVLLLGLLLFAL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110739263 399 GHIVMA-SGLLGSLYIGSLLVGLAYGSQWSLMPTITSEIFGVLHMGTIFYTISIASPVGSYFFSVkVIGYLYDKVASEdd 477
Cdd:cd06174   74 GALLFAfAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPL-LGGILASSLGFG-- 150
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 110739263 478 hscygnhcFRTSFLIMAAMALLGSLVALVLLLRTKK 513
Cdd:cd06174  151 --------WRAVFLIAAALALLAAILLLLVVPDPPE 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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