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Conserved domains on  [gi|74186194|dbj|BAE42893|]
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unnamed protein product [Mus musculus]

Protein Classification

PAZ domain-containing protein( domain architecture ID 13328984)

PAZ (Piwi Argonaut and Zwille) domain-containing protein similar to PAZ domain region of argonaute proteins which play central roles in RNA silencing processes, as essential components of the RNA-induced silencing complex (RISC) that is responsible for the gene silencing phenomenon known as RNA interference (RNAi)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgoL1 pfam08699
Argonaute linker 1 domain; ArgoL1 is a region found in argonaute proteins. It normally ...
 177-227 1.63e-22

Argonaute linker 1 domain; ArgoL1 is a region found in argonaute proteins. It normally co-occurs with pfam02179 and pfam02171. It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold.


:

Pssm-ID: 462567  Cd Length: 52  Bit Score: 87.58  E-value: 1.63e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 74186194   177 PVGRSFFSAPEGYDHPL-GGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYK 227
Cdd:pfam08699   1 GVGRSFFSPPGENRVDLgGGGLEAWRGFFQSVRPTQGGLLLNVDVSHTAFYK 52
PLN03202 super family cl33661
protein argonaute; Provisional
 20-235 1.58e-20

protein argonaute; Provisional


The actual alignment was detected with superfamily member PLN03202:

Pssm-ID: 215631 [Multi-domain]  Cd Length: 900  Bit Score: 90.93  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194   20 RPGYGTMGKPIKLLANCFQVEIPKIDVYL--YEVDIK-PDKCP---RRVNREVVDSMVQHFKvTIFGDRRPVYDGKRSLY 93
Cdd:PLN03202  36 RRGFGSKGQKIQLLTNHFKVSVNNPDGHFfhYSVSLTyEDGRPvdgKGIGRKVIDKVQETYS-SDLAGKDFAYDGEKSLF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194   94 TANPLPvaTTGVDLDVTL-------------------PGEGGKDRP--------FKVSVKFVSRVSWHLLHEALAGgtlp 146
Cdd:PLN03202 115 TVGALP--QNKLEFTVVLedvssnrnngngspvgngsPNGGDRKRSrrpyqsktFKVEISFAAKIPMQAIANALRG---- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194  147 eplELDKPvSTNPVHAVDVVLR-HLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAF 225
Cdd:PLN03202 189 ---QESEN-SQDALRVLDIILRqHAAKQGCLLVRQSFFHNDPKNFVDLGGGVLGCRGFHSSFRTTQGGLSLNIDVSTTMI 264

                        250
                 ....*....|
gi 74186194  226 YKAQPVIQFM 235
Cdd:PLN03202 265 VQPGPVVDFL 274
 
Name Accession Description Interval E-value
ArgoL1 pfam08699
Argonaute linker 1 domain; ArgoL1 is a region found in argonaute proteins. It normally ...
 177-227 1.63e-22

Argonaute linker 1 domain; ArgoL1 is a region found in argonaute proteins. It normally co-occurs with pfam02179 and pfam02171. It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold.


Pssm-ID: 462567  Cd Length: 52  Bit Score: 87.58  E-value: 1.63e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 74186194   177 PVGRSFFSAPEGYDHPL-GGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYK 227
Cdd:pfam08699   1 GVGRSFFSPPGENRVDLgGGGLEAWRGFFQSVRPTQGGLLLNVDVSHTAFYK 52
PLN03202 PLN03202
protein argonaute; Provisional
 20-235 1.58e-20

protein argonaute; Provisional


Pssm-ID: 215631 [Multi-domain]  Cd Length: 900  Bit Score: 90.93  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194   20 RPGYGTMGKPIKLLANCFQVEIPKIDVYL--YEVDIK-PDKCP---RRVNREVVDSMVQHFKvTIFGDRRPVYDGKRSLY 93
Cdd:PLN03202  36 RRGFGSKGQKIQLLTNHFKVSVNNPDGHFfhYSVSLTyEDGRPvdgKGIGRKVIDKVQETYS-SDLAGKDFAYDGEKSLF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194   94 TANPLPvaTTGVDLDVTL-------------------PGEGGKDRP--------FKVSVKFVSRVSWHLLHEALAGgtlp 146
Cdd:PLN03202 115 TVGALP--QNKLEFTVVLedvssnrnngngspvgngsPNGGDRKRSrrpyqsktFKVEISFAAKIPMQAIANALRG---- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194  147 eplELDKPvSTNPVHAVDVVLR-HLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAF 225
Cdd:PLN03202 189 ---QESEN-SQDALRVLDIILRqHAAKQGCLLVRQSFFHNDPKNFVDLGGGVLGCRGFHSSFRTTQGGLSLNIDVSTTMI 264

                        250
                 ....*....|
gi 74186194  226 YKAQPVIQFM 235
Cdd:PLN03202 265 VQPGPVVDFL 274
ArgoN pfam16486
N-terminal domain of argonaute; ArgoN is the N-terminal domain of argonaute proteins in ...
 73-167 3.21e-13

N-terminal domain of argonaute; ArgoN is the N-terminal domain of argonaute proteins in eukaryotes. ArgoN is composed of an antiparallel four-stranded beta sheet core that has two alpha helices positioned along one face of the sheet and an extended beta strand towards its N-terminus. The core fold of the N domain most closely resembles the catalytic domain of replication-initiator protein Rep. The N domain is linked to the PAZ domain via linker 1 region, and together these three regions are designated the PAZ-containing lobe of argonaute.


Pssm-ID: 465134  Cd Length: 93  Bit Score: 63.85  E-value: 3.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194    73 HFKVTifgdrrpvyDGKRSLYTANPLPVATTGVDLDVTLPGEGGK-------DRPFKVSVKFVSRVSWHLLHEALAGGTL 145
Cdd:pfam16486   9 YFPVT---------DGRKNLYSAKKLPFGEEEFVVLDEEPGRGARkrpgvrrPRTFKVTIKFTKTINLQDLLEYLRGKQD 79

                          90       100
                  ....*....|....*....|..
gi 74186194   146 PEPLELdkpvstnpVHAVDVVL 167
Cdd:pfam16486  80 NTPLEA--------IQALDIVL 93
 
Name Accession Description Interval E-value
ArgoL1 pfam08699
Argonaute linker 1 domain; ArgoL1 is a region found in argonaute proteins. It normally ...
 177-227 1.63e-22

Argonaute linker 1 domain; ArgoL1 is a region found in argonaute proteins. It normally co-occurs with pfam02179 and pfam02171. It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold.


Pssm-ID: 462567  Cd Length: 52  Bit Score: 87.58  E-value: 1.63e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 74186194   177 PVGRSFFSAPEGYDHPL-GGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYK 227
Cdd:pfam08699   1 GVGRSFFSPPGENRVDLgGGGLEAWRGFFQSVRPTQGGLLLNVDVSHTAFYK 52
PLN03202 PLN03202
protein argonaute; Provisional
 20-235 1.58e-20

protein argonaute; Provisional


Pssm-ID: 215631 [Multi-domain]  Cd Length: 900  Bit Score: 90.93  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194   20 RPGYGTMGKPIKLLANCFQVEIPKIDVYL--YEVDIK-PDKCP---RRVNREVVDSMVQHFKvTIFGDRRPVYDGKRSLY 93
Cdd:PLN03202  36 RRGFGSKGQKIQLLTNHFKVSVNNPDGHFfhYSVSLTyEDGRPvdgKGIGRKVIDKVQETYS-SDLAGKDFAYDGEKSLF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194   94 TANPLPvaTTGVDLDVTL-------------------PGEGGKDRP--------FKVSVKFVSRVSWHLLHEALAGgtlp 146
Cdd:PLN03202 115 TVGALP--QNKLEFTVVLedvssnrnngngspvgngsPNGGDRKRSrrpyqsktFKVEISFAAKIPMQAIANALRG---- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194  147 eplELDKPvSTNPVHAVDVVLR-HLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAF 225
Cdd:PLN03202 189 ---QESEN-SQDALRVLDIILRqHAAKQGCLLVRQSFFHNDPKNFVDLGGGVLGCRGFHSSFRTTQGGLSLNIDVSTTMI 264

                        250
                 ....*....|
gi 74186194  226 YKAQPVIQFM 235
Cdd:PLN03202 265 VQPGPVVDFL 274
ArgoN pfam16486
N-terminal domain of argonaute; ArgoN is the N-terminal domain of argonaute proteins in ...
 73-167 3.21e-13

N-terminal domain of argonaute; ArgoN is the N-terminal domain of argonaute proteins in eukaryotes. ArgoN is composed of an antiparallel four-stranded beta sheet core that has two alpha helices positioned along one face of the sheet and an extended beta strand towards its N-terminus. The core fold of the N domain most closely resembles the catalytic domain of replication-initiator protein Rep. The N domain is linked to the PAZ domain via linker 1 region, and together these three regions are designated the PAZ-containing lobe of argonaute.


Pssm-ID: 465134  Cd Length: 93  Bit Score: 63.85  E-value: 3.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74186194    73 HFKVTifgdrrpvyDGKRSLYTANPLPVATTGVDLDVTLPGEGGK-------DRPFKVSVKFVSRVSWHLLHEALAGGTL 145
Cdd:pfam16486   9 YFPVT---------DGRKNLYSAKKLPFGEEEFVVLDEEPGRGARkrpgvrrPRTFKVTIKFTKTINLQDLLEYLRGKQD 79

                          90       100
                  ....*....|....*....|..
gi 74186194   146 PEPLELdkpvstnpVHAVDVVL 167
Cdd:pfam16486  80 NTPLEA--------IQALDIVL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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