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Conserved domains on  [gi|74194602|dbj|BAE37328|]
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unnamed protein product [Mus musculus]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.110
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
157-248 4.00e-05

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 4.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602 157 ACGAFVHGLEDEMYEVRIAAVEALCMLAqsspsfAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNnitlrEDQLDTVLA 236
Cdd:COG1413  48 AVPALLEALKDPDPEVRAAAAEALGRIG------DPEAVPALIAALKDEDPEVRRAAAEALGRLGD-----PAAVPALLE 116

                        90
                ....*....|..
gi 74194602 237 VLEDSSRDIREA 248
Cdd:COG1413 117 ALKDPDWEVRRA 128
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
157-248 4.00e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 4.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602 157 ACGAFVHGLEDEMYEVRIAAVEALCMLAqsspsfAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNnitlrEDQLDTVLA 236
Cdd:COG1413  48 AVPALLEALKDPDPEVRAAAAEALGRIG------DPEAVPALIAALKDEDPEVRRAAAEALGRLGD-----PAAVPALLE 116

                        90
                ....*....|..
gi 74194602 237 VLEDSSRDIREA 248
Cdd:COG1413 117 ALKDPDWEVRRA 128
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 165-253 7.12e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.70  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602   165 LEDEMYEVRIAAVEALCMLAqsspsfAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNnitlrEDQLDTVLAVL-EDSSR 243
Cdd:pfam13646   9 LRDPDPEVRAAAIRALGRIG------DPEAVPALLELLKDEDPAVRRAAAEALGKIGD-----PEALPALLELLrDDDDD 77

                          90
                  ....*....|
gi 74194602   244 DIREALHELL 253
Cdd:pfam13646  78 VVRAAAAEAL 87
PDS5 cd19953
Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. ...
 171-249 3.70e-03

Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. Together with WapI and Scc3, it is involved in the release of the cohesin complex from chromosomes during S phase. The core of the cohesin complex consists of a coiled-coiled heterodimer of Smc1 and Smc30, together with Scc1 (also called kleisin). Pds5 interacts with Scc1 via a conserved patch on the surface of its heat repeats. Pds5 also promotes the acetylation of Smc3 that protects cohesin from releasing activity in G2 phase.


Pssm-ID: 410996 [Multi-domain]  Cd Length: 630  Bit Score: 38.66  E-value: 3.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602 171 EVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKIS-NNITLR--EDQLDTVLAVLEDSSRDIR- 246
Cdd:cd19953 302 EVRLAWVESAKHILLNHPDLAEDILEALKKRLLDPDEKVRLAAVKAICDLAyEDLLHKvpEELLSTLAERLRDKKASVRk 381


                ...
gi 74194602 247 EAL 249
Cdd:cd19953 382 EAL 384
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
157-248 4.00e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 4.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602 157 ACGAFVHGLEDEMYEVRIAAVEALCMLAqsspsfAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNnitlrEDQLDTVLA 236
Cdd:COG1413  48 AVPALLEALKDPDPEVRAAAAEALGRIG------DPEAVPALIAALKDEDPEVRRAAAEALGRLGD-----PAAVPALLE 116

                        90
                ....*....|..
gi 74194602 237 VLEDSSRDIREA 248
Cdd:COG1413 117 ALKDPDWEVRRA 128
HEAT COG1413
HEAT repeat [General function prediction only];
160-248 7.85e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 7.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602 160 AFVHGLEDEMYEVRIAAVEALCMLAqsspsfAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNnitlrEDQLDTVLAVLE 239
Cdd:COG1413  20 ALIAALADEDPDVRAAAARALGRLG------DPRAVPALLEALKDPDPEVRAAAAEALGRIGD-----PEAVPALIAALK 88


                ....*....
gi 74194602 240 DSSRDIREA 248
Cdd:COG1413  89 DEDPEVRRA 97
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 165-253 7.12e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.70  E-value: 7.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602   165 LEDEMYEVRIAAVEALCMLAqsspsfAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNnitlrEDQLDTVLAVL-EDSSR 243
Cdd:pfam13646   9 LRDPDPEVRAAAIRALGRIG------DPEAVPALLELLKDEDPAVRRAAAEALGKIGD-----PEALPALLELLrDDDDD 77

                          90
                  ....*....|
gi 74194602   244 DIREALHELL 253
Cdd:pfam13646  78 VVRAAAAEAL 87
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 161-242 1.12e-03

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 40.30  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602   161 FVHGLEDEmyEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRK-ISNNITLREDQLDTVLAVLE 239
Cdd:pfam01602 344 YVHEIADP--DFKIELVRAIGRLAEKFPTDAEWYLDVLLDLLSLAGSYVVDEIVEVIRDiIQNVPELREYILEHLCELLE 421


                  ...
gi 74194602   240 DSS 242
Cdd:pfam01602 422 DIE 424
PDS5 cd19953
Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. ...
 171-249 3.70e-03

Sister chromatid cohesion protein PDS5; Pds5 plays a crucial role in sister chromatid cohesion. Together with WapI and Scc3, it is involved in the release of the cohesin complex from chromosomes during S phase. The core of the cohesin complex consists of a coiled-coiled heterodimer of Smc1 and Smc30, together with Scc1 (also called kleisin). Pds5 interacts with Scc1 via a conserved patch on the surface of its heat repeats. Pds5 also promotes the acetylation of Smc3 that protects cohesin from releasing activity in G2 phase.


Pssm-ID: 410996 [Multi-domain]  Cd Length: 630  Bit Score: 38.66  E-value: 3.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74194602 171 EVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKIS-NNITLR--EDQLDTVLAVLEDSSRDIR- 246
Cdd:cd19953 302 EVRLAWVESAKHILLNHPDLAEDILEALKKRLLDPDEKVRLAAVKAICDLAyEDLLHKvpEELLSTLAERLRDKKASVRk 381


                ...
gi 74194602 247 EAL 249
Cdd:cd19953 382 EAL 384
HEAT COG1413
HEAT repeat [General function prediction only];
157-220 8.03e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 35.76  E-value: 8.03e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74194602 157 ACGAFVHGLEDEMYEVRIAAVEALCMLAqsspsfAEKCLDFLVDMFNDEIEEVRLQSIHTMRKI 220
Cdd:COG1413  79 AVPALIAALKDEDPEVRRAAAEALGRLG------DPAAVPALLEALKDPDWEVRRAAARALGRL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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