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Conserved domains on  [gi|74191864|dbj|BAE32882|]
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unnamed protein product [Mus musculus]

Protein Classification

sodium/hydrogen exchanger( domain architecture ID 11489762)

sodium/hydrogen exchanger is a solute carrier family 9 member involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
99-664 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 834.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864    99 DYPHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGV-GETPPFLQSDVFFLFLLPPIILDA 177
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASpHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   178 GYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINE 257
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   258 LLHILVFGESLLNDAVTVVLYHLFEEFA--SYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEP 335
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHktADEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   336 LFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNW 415
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   416 TFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFT 495
Cdd:TIGR00840 321 AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFFT 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   496 VFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEP 575
Cdd:TIGR00840 401 VIFQGGTIKPLVEVLKVKKGCISKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPKSS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   576 QLIAFYHKMEMKRAIELVESGgmgkIPSAVSTVsmqnihPKAVTSDRILPALSKDKEEEIRKILRSNLQKTRQRLRSYNR 655
Cdd:TIGR00840 481 DIVAVYHKLNLKQAISLVEGG----SLSFVGTN------PEPSNSEPIIPALSSEDKEEIRDILGTNLYKPRQRFQSYSR 550

                  ....*....
gi 74191864   656 HTLVADPYE 664
Cdd:TIGR00840 551 HVLKPVPLE 559
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
99-664 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 834.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864    99 DYPHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGV-GETPPFLQSDVFFLFLLPPIILDA 177
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASpHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   178 GYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINE 257
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   258 LLHILVFGESLLNDAVTVVLYHLFEEFA--SYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEP 335
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHktADEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   336 LFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNW 415
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   416 TFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFT 495
Cdd:TIGR00840 321 AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFFT 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   496 VFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEP 575
Cdd:TIGR00840 401 VIFQGGTIKPLVEVLKVKKGCISKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPKSS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   576 QLIAFYHKMEMKRAIELVESGgmgkIPSAVSTVsmqnihPKAVTSDRILPALSKDKEEEIRKILRSNLQKTRQRLRSYNR 655
Cdd:TIGR00840 481 DIVAVYHKLNLKQAISLVEGG----SLSFVGTN------PEPSNSEPIIPALSSEDKEEIRDILGTNLYKPRQRFQSYSR 550

                  ....*....
gi 74191864   656 HTLVADPYE 664
Cdd:TIGR00840 551 HVLKPVPLE 559
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
109-507 5.16e-82

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 267.58  E-value: 5.16e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   109 ISLWILLACLMKIGFHVIPtissiVPESCLLIVVGLLVGGLIKGVGETPPFlQSDVFFLFLLPPIILDAGYFLPLRQFTE 188
Cdd:pfam00999   1 IVLLILLALLAPLLARRLK-----LPPIVGLIIAGILLGPSGLGLISEVDE-DLEVLSNLGLPPLLFLAGLELDLRELRK 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   189 NLGTILIFAVVGTLWNAFFLGGLLYAVclvggeqINNIGLLDTLLFGSIISAVDPVAVLAVF-EEIHINELLHILVFGES 267
Cdd:pfam00999  75 NGGSILLLALLGVLIPFVLIGLLLYLL-------GLGIPLLEALLFGAILSATSPVVVLAILkELGRVPERLGTLLLGES 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   268 LLNDAVTVVLYHLFEEFASYDSvGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYL 347
Cdd:pfam00999 148 VLNDGVAVVLLAVLLALAQGVG-GGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAAL 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   348 SAELFHLSGIMALIASGVVMRPYVEAN-ISHKSHttikyflKMWSSVSETLIFIFLGVSTVAGS-HQWNWTFVISTLLFC 425
Cdd:pfam00999 227 LAEALGVSGILGAFLAGLVLSEYPFANkLSEKLE-------PFGYGLFNPLFFVLVGLSLDLSSlLLSVWILVLLALVAI 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   426 LIARVLGVLVLTWFInkfrivKLTPKDQFIIAYGGL-RGAIAFSLGYLLDKKHFPMCDLFlTAIITVIFFTVFVQGMTIR 504
Cdd:pfam00999 300 LLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIARELY-PLLIVVVLFTVLVQGITLK 372

                  ...
gi 74191864   505 PLV 507
Cdd:pfam00999 373 PLL 375
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
133-536 8.53e-56

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 200.19  E-value: 8.53e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 133 VPESCLLIVVGLLVGGLIkGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLL 212
Cdd:COG0025  26 LPAPLLLLLAGILLGPGL-GLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAA 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 213 YAVClvggeqinNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINE-LLHILVfGESLLNDAVTVVLYHLFEEFASYDSVG 291
Cdd:COG0025 105 HWLL--------GLPLAAALLLGAILAPTDPVAVSPILRRLGVPKrLRTILE-GESLLNDATALVLFVLALAAALGGGFS 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 292 ISDIFLGFLSFFvvalggVFVGVVYGVIAAFTSRFTSHIR--VIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRP 369
Cdd:COG0025 176 LGEALLDFLLAI------LGGILVGLLLGWLLGRLLRRLPdpLLEILLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGN 249
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 370 YVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGS-HQWNWTFVISTLLFCLIARVLGVLVLTWfinkFRIVKL 448
Cdd:COG0025 250 AGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQLPLILlGALGLGGILLVLLALLVVRPLWVFLSLA----LRGSRL 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 449 TPKDQFIIAYGGLRGAIAFSLGYLL---DKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEE 525
Cdd:COG0025 326 SWRERLFLSWGGPRGIVSLALALSLplhGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELEAA 405
                       410
                ....*....|.
gi 74191864 526 IHTQFLDHLLT 536
Cdd:COG0025 406 LARAALLELLA 416
PRK05326 PRK05326
potassium/proton antiporter;
225-531 4.19e-06

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 50.20  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  225 NIGLLDTLLFGSIISAVDPVAVLAVFEE--IHINE----LLHIlvfgESLLNDAVTVVLYHLFEEFASYDSVGISDIFLG 298
Cdd:PRK05326 114 GLDWLEGLLLGAIVGSTDAAAVFSLLRGkgLNLKErvasTLEI----ESGSNDPMAVFLTITLIELITGGETGLSWGFLL 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  299 flSFFVVALGGVFVGVVYGVIAAFTSRftsHIRVIE----PLFVFLYSYMAYLSAELFHLSGIMALIASGVVMrpyveAN 374
Cdd:PRK05326 190 --LFLQQFGLGALIGLLGGWLLVQLLN---RIALPAeglyPILVLAGALLIFALTAALGGSGFLAVYLAGLVL-----GN 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  375 ISHKSHTTIKYFLKMWSSVSETLIFIFLG-------VSTVAGshqwnWTFVISTLLFcLIARVLGV-LVLTWFinkfriv 446
Cdd:PRK05326 260 RPIRHRHSILRFFDGLAWLAQIGMFLVLGllvtpsrLLDIAL-----PALLLALFLI-LVARPLAVfLSLLPF------- 326
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  447 KLTPKDQFIIAYGGLRGA--IAFSLgylldkkhFPMC-------DLFLTAIITVIFFTVfVQGMTIRPLVDLLAVKKKQE 517
Cdd:PRK05326 327 RFNLREKLFISWVGLRGAvpIVLAT--------FPMMaglpnaqLIFNVVFFVVLVSLL-LQGTTLPWAARKLGVVVPPE 397
                        330       340
                 ....*....|....*....|
gi 74191864  518 TKR------SINEEIHTQFL 531
Cdd:PRK05326 398 ARPvsrvelDPLEESDAELL 417
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
99-664 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 834.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864    99 DYPHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGV-GETPPFLQSDVFFLFLLPPIILDA 177
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASpHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   178 GYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINE 257
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   258 LLHILVFGESLLNDAVTVVLYHLFEEFA--SYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEP 335
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHktADEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   336 LFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNW 415
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENHEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   416 TFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFT 495
Cdd:TIGR00840 321 AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVFFT 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   496 VFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEP 575
Cdd:TIGR00840 401 VIFQGGTIKPLVEVLKVKKGCISKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPKSS 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   576 QLIAFYHKMEMKRAIELVESGgmgkIPSAVSTVsmqnihPKAVTSDRILPALSKDKEEEIRKILRSNLQKTRQRLRSYNR 655
Cdd:TIGR00840 481 DIVAVYHKLNLKQAISLVEGG----SLSFVGTN------PEPSNSEPIIPALSSEDKEEIRDILGTNLYKPRQRFQSYSR 550

                  ....*....
gi 74191864   656 HTLVADPYE 664
Cdd:TIGR00840 551 HVLKPVPLE 559
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
109-507 5.16e-82

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 267.58  E-value: 5.16e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   109 ISLWILLACLMKIGFHVIPtissiVPESCLLIVVGLLVGGLIKGVGETPPFlQSDVFFLFLLPPIILDAGYFLPLRQFTE 188
Cdd:pfam00999   1 IVLLILLALLAPLLARRLK-----LPPIVGLIIAGILLGPSGLGLISEVDE-DLEVLSNLGLPPLLFLAGLELDLRELRK 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   189 NLGTILIFAVVGTLWNAFFLGGLLYAVclvggeqINNIGLLDTLLFGSIISAVDPVAVLAVF-EEIHINELLHILVFGES 267
Cdd:pfam00999  75 NGGSILLLALLGVLIPFVLIGLLLYLL-------GLGIPLLEALLFGAILSATSPVVVLAILkELGRVPERLGTLLLGES 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   268 LLNDAVTVVLYHLFEEFASYDSvGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYL 347
Cdd:pfam00999 148 VLNDGVAVVLLAVLLALAQGVG-GGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAAL 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   348 SAELFHLSGIMALIASGVVMRPYVEAN-ISHKSHttikyflKMWSSVSETLIFIFLGVSTVAGS-HQWNWTFVISTLLFC 425
Cdd:pfam00999 227 LAEALGVSGILGAFLAGLVLSEYPFANkLSEKLE-------PFGYGLFNPLFFVLVGLSLDLSSlLLSVWILVLLALVAI 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   426 LIARVLGVLVLTWFInkfrivKLTPKDQFIIAYGGL-RGAIAFSLGYLLDKKHFPMCDLFlTAIITVIFFTVFVQGMTIR 504
Cdd:pfam00999 300 LLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSLALAAIGPLLGIIARELY-PLLIVVVLFTVLVQGITLK 372

                  ...
gi 74191864   505 PLV 507
Cdd:pfam00999 373 PLL 375
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
133-536 8.53e-56

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 200.19  E-value: 8.53e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 133 VPESCLLIVVGLLVGGLIkGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLL 212
Cdd:COG0025  26 LPAPLLLLLAGILLGPGL-GLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAA 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 213 YAVClvggeqinNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINE-LLHILVfGESLLNDAVTVVLYHLFEEFASYDSVG 291
Cdd:COG0025 105 HWLL--------GLPLAAALLLGAILAPTDPVAVSPILRRLGVPKrLRTILE-GESLLNDATALVLFVLALAAALGGGFS 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 292 ISDIFLGFLSFFvvalggVFVGVVYGVIAAFTSRFTSHIR--VIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRP 369
Cdd:COG0025 176 LGEALLDFLLAI------LGGILVGLLLGWLLGRLLRRLPdpLLEILLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGN 249
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 370 YVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGS-HQWNWTFVISTLLFCLIARVLGVLVLTWfinkFRIVKL 448
Cdd:COG0025 250 AGRRSLSPETRLQLLEFWETLEFLLNSLLFVLLGAQLPLILlGALGLGGILLVLLALLVVRPLWVFLSLA----LRGSRL 325
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 449 TPKDQFIIAYGGLRGAIAFSLGYLL---DKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEE 525
Cdd:COG0025 326 SWRERLFLSWGGPRGIVSLALALSLplhGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELEAA 405
                       410
                ....*....|.
gi 74191864 526 IHTQFLDHLLT 536
Cdd:COG0025 406 LARAALLELLA 416
NEXCaM_BD pfam16644
Regulatory region of Na+/H+ exchanger NHE binds to calmodulin; NEXCaM_BD is a coiled-coil ...
603-704 8.50e-33

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin; NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD.


Pssm-ID: 465214  Cd Length: 109  Bit Score: 122.51  E-value: 8.50e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   603 SAVSTVSMQNIHPKAVtsDRILPAlskdKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQ 682
Cdd:pfam16644   1 AVPSTVSLQNIRKEST--KRLSPA----DVEEMRDILSKNLYQIRQRTLSYNRHNLVADTSEKQAKEILIRRQHSLRESL 74
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 74191864   683 KITN-------------YLTVPAHKLDSPTLSRAR 704
Cdd:pfam16644  75 RKGSslpgrpagtktqrYLSLPKNTSLPSKLDKRR 109
a_cpa1 TIGR00831
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ...
133-507 2.81e-29

Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129911 [Multi-domain]  Cd Length: 525  Bit Score: 123.07  E-value: 2.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   133 VPESCLLIVVGLLVGgLIKGVGETPpfLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLL 212
Cdd:TIGR00831  22 LPYPIALILAGLLLG-LAGLLPEVP--LDREIVLFLFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVGFSL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   213 YAVClvggeqinNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFAsyDSVGI 292
Cdd:TIGR00831  99 NWIL--------GIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVVFAIAVAVA--LGKGV 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   293 SDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPY-V 371
Cdd:TIGR00831 169 FDPLNAALDFAVVCVGGIAAGLAVGYLAYRLLRAKIDDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYgR 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864   372 EANISHKSHTTIKYFLKMWSSVSETLIFIFLGVST-VAGSHQW-------NWTFVISTLLFCLIARVLGVLVLTWFINKF 443
Cdd:TIGR00831 249 DFSMSPTTRLIALDFWSVIVFLVNGIIFILIGVQTpGTIFSAWkeilvapAAVILALFTNAFVIYPVMTYVRFLWTMKPF 328
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74191864   444 --RIVKLTPKD-----QFIIAYGGLRGAIAFSLGY-----LLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLV 507
Cdd:TIGR00831 329 snRFLKKKPMEfgtrwKHVVSWAGLRGAIPLALALsfpnqLLSGMAFPARYELVFLAAGVILFSLLVQGISLPIFV 404
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
107-499 4.40e-09

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 59.39  E-value: 4.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 107 FEISLWILLACLMKIGFHVIPtISSIVpescLLIVVGLLVGGLIKGVGETPPFLQ--SD---VFFLFLlppiildAGYFL 181
Cdd:COG0475   7 LQLGLLLLAAVLAGLLARRLG-LPSVL----GYILAGILLGPSGLGLIEDSEALEllAElgvVLLLFL-------IGLEL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 182 PLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVclvggeqinNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLH- 260
Cdd:COG0475  75 DLKRLRKMGRRALGIGLLQVLLPFLLGFLLALLL---------GLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLg 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 261 ILVFGESLLNDAVTVVLYHLFEEFASYDSVGISDIFLGFLSFFVVALGGVFVGVVYGVIAAFTSRFTShiRVIEPLFVFL 340
Cdd:COG0475 146 QLILGVALFDDIAAILLLALVPALAGGGSVAGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRS--RELFLLFALL 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 341 YSYMAYLSAELFHLSGIMALIASGVVM-----RPYVEANIShkshtTIKYFLkmwssvsETLIFIFLGVSTVAGSHQWNW 415
Cdd:COG0475 224 LVLLAAALAELLGLSAALGAFLAGLVLaeseyRHELEEKIE-----PFGDLF-------LPLFFVSVGLSLDLSALLSNP 291
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864 416 TFVISTLLFCLIARVLGVLVLtwfinkFRIVKLTPKDQFIIAyGGL--RGAIAF---SLGY---LLDKKHFPMcdLFLTA 487
Cdd:COG0475 292 LLALLLVLAAIVGKLLGAYLA------ARLFGLSRREALRIG-LLLapRGEFALvlaSLGLsagLISPELFAA--LVLVV 362
                       410
                ....*....|..
gi 74191864 488 IITVIFFTVFVQ 499
Cdd:COG0475 363 LLTTLLTPLLLR 374
PRK05326 PRK05326
potassium/proton antiporter;
225-531 4.19e-06

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 50.20  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  225 NIGLLDTLLFGSIISAVDPVAVLAVFEE--IHINE----LLHIlvfgESLLNDAVTVVLYHLFEEFASYDSVGISDIFLG 298
Cdd:PRK05326 114 GLDWLEGLLLGAIVGSTDAAAVFSLLRGkgLNLKErvasTLEI----ESGSNDPMAVFLTITLIELITGGETGLSWGFLL 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  299 flSFFVVALGGVFVGVVYGVIAAFTSRftsHIRVIE----PLFVFLYSYMAYLSAELFHLSGIMALIASGVVMrpyveAN 374
Cdd:PRK05326 190 --LFLQQFGLGALIGLLGGWLLVQLLN---RIALPAeglyPILVLAGALLIFALTAALGGSGFLAVYLAGLVL-----GN 259
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  375 ISHKSHTTIKYFLKMWSSVSETLIFIFLG-------VSTVAGshqwnWTFVISTLLFcLIARVLGV-LVLTWFinkfriv 446
Cdd:PRK05326 260 RPIRHRHSILRFFDGLAWLAQIGMFLVLGllvtpsrLLDIAL-----PALLLALFLI-LVARPLAVfLSLLPF------- 326
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74191864  447 KLTPKDQFIIAYGGLRGA--IAFSLgylldkkhFPMC-------DLFLTAIITVIFFTVfVQGMTIRPLVDLLAVKKKQE 517
Cdd:PRK05326 327 RFNLREKLFISWVGLRGAvpIVLAT--------FPMMaglpnaqLIFNVVFFVVLVSLL-LQGTTLPWAARKLGVVVPPE 397
                        330       340
                 ....*....|....*....|
gi 74191864  518 TKR------SINEEIHTQFL 531
Cdd:PRK05326 398 ARPvsrvelDPLEESDAELL 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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