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Conserved domains on  [gi|74181667|dbj|BAE32552|]
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unnamed protein product [Mus musculus]

Protein Classification

major facilitator superfamily domain-containing protein 12( domain architecture ID 13024796)

major facilitator superfamily domain-containing protein 12 (MFSD12) acts as a transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation

CATH:  1.20.1250.20
Gene Symbol:  MFSD12
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 21-465 0e+00

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341044  Cd Length: 438  Bit Score: 636.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRA-SCVRCGPRKAWHLAGTV 99
Cdd:cd17491   1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTnGCGKYGRRKSWHLIGTI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 100 CVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVY 179
Cdd:cd17491  81 CVLLSFPFIFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANITVY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 180 GAAWLLLHlQGSAHGEQDISvgdqlgVQDVPVFRNLALLVVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPLVAPaAQ 259
Cdd:cd17491 161 LIAWLLLQ-QSSGDSVNPTS------AQDLPIFRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTNEGEEVTAP-EE 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 260 PLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMT 339
Cdd:cd17491 233 PRLTWKEWLREPQFYQVALLYMCTRLIVNLSQVYIPLYLTETLQLPKESIAIVPLVMYVSGFLTSLVMKPINKKIGRKIT 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 340 YFTGLLVILAFAAWVALADNL--GVAVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVM 417
Cdd:cd17491 313 YLLGLLFVLGFCIWVWFQSGSsrTYEIYGAAVLLGVGSATLLVTSLSMTADLIGTNTESGAFVYGAMSFTDKLSNGIAVL 392

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 74181667 418 AVQSLHPCPSELCcgACISFYHWVMTAVTGGVGVAAALALCSLLIWPI 465
Cdd:cd17491 393 IIQSLHPCNTELD--ECISYYYRVMVVVAGGVAILAGLLLLAFLLLPK 438
 
Name Accession Description Interval E-value
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 21-465 0e+00

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 636.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRA-SCVRCGPRKAWHLAGTV 99
Cdd:cd17491   1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTnGCGKYGRRKSWHLIGTI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 100 CVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVY 179
Cdd:cd17491  81 CVLLSFPFIFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANITVY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 180 GAAWLLLHlQGSAHGEQDISvgdqlgVQDVPVFRNLALLVVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPLVAPaAQ 259
Cdd:cd17491 161 LIAWLLLQ-QSSGDSVNPTS------AQDLPIFRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTNEGEEVTAP-EE 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 260 PLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMT 339
Cdd:cd17491 233 PRLTWKEWLREPQFYQVALLYMCTRLIVNLSQVYIPLYLTETLQLPKESIAIVPLVMYVSGFLTSLVMKPINKKIGRKIT 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 340 YFTGLLVILAFAAWVALADNL--GVAVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVM 417
Cdd:cd17491 313 YLLGLLFVLGFCIWVWFQSGSsrTYEIYGAAVLLGVGSATLLVTSLSMTADLIGTNTESGAFVYGAMSFTDKLSNGIAVL 392

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 74181667 418 AVQSLHPCPSELCcgACISFYHWVMTAVTGGVGVAAALALCSLLIWPI 465
Cdd:cd17491 393 IIQSLHPCNTELD--ECISYYYRVMVVVAGGVAILAGLLLLAFLLLPK 438
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-419 5.14e-35

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 135.80  E-value: 5.14e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  12 PPRTLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRASCvRCGPRK 91
Cdd:COG2211   3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRT-RWGRRR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  92 AWHLAGTVCVLLSFPFIFSPclgcgEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFT 171
Cdd:COG2211  82 PWILIGAIPLALSFVLLFTA-----PDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 172 VVANITVYGAAWLLLHLQGSAHGEQdisvgdqlgvqdvpvFRNLALLVVGVGAIFSLLFHLGTKEGHRsqhwgnEPNEHT 251
Cdd:COG2211 157 GLGGLLASVLPPPLVAAFGGDAALG---------------YRLTALIFAVLGLLAFLLTFFGTKERPV------PEEEKV 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 252 PLVApaaqpllLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVN 331
Cdd:COG2211 216 SLKE-------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 332 RRIGRNMTYFTGLLVILAFAAWVALADNLGVA-VYGAAVLLGAGCATILVTSLAMTADLIGPH-----THSGAFVYGAMS 405
Cdd:COG2211 289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWlLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGLYFGIFT 368

                       410
                ....*....|....
gi 74181667 406 FSDKVANGLAVMAV 419
Cdd:COG2211 369 FAIKLGQALAGALA 382
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 40-419 6.99e-14

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 73.11  E-value: 6.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667    40 TYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAScVRCGPRKAWHLAGTVCVLLSFPFIFSPCLGCGEAT 119
Cdd:pfam13347  18 TYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILAVSFILLFTPPELGRAPL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   120 PEWAALLYygpfiVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFtvvANITVYGAAwlLLHLQgsahgeqdIS 199
Cdd:pfam13347  97 FIWLLATY-----ILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFF---SVGGGLLAA--ALAFP--------LV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   200 VGDQLGVQDVPVFRNLALLVVGVGAIFSLLFHLGTKEGHrsqhwgNEPNEHTPLVAPAAQPLLLWKHWLREPAFYQVGML 279
Cdd:pfam13347 159 LILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERV------SMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLAS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   280 YMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAA--WVALA 357
Cdd:pfam13347 233 FLLAALAMGVLNGLLLYYFRYVLGNGFAA-SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFAlaLLLGP 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74181667   358 DNLgVAVYGAAVLLGAGCATILVTSLAMTADLI-------GphTHSGAFVYGAMSFSDKVANGLAVMAV 419
Cdd:pfam13347 312 NNT-LLFLVLYIIIGFGYGSSFFLPWSMLADVVdygelrtG--KRREGTFFAMWSFISKLATGVGLGVS 377
PRK10429 PRK10429
melibiose:sodium transporter MelB;
14-390 2.68e-04

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 43.16  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   14 RTLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADrASCVRCGPRKAW 93
Cdd:PRK10429   1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVN-NTRSRWGKFKPW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   94 HLAGTVCVLLSFPFIFSPCLGCGEATPEWAALLYygpfiVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVV 173
Cdd:PRK10429  80 ILIGTLANSVVLFLLFSAHLFEGTAQYVFVCVTY-----ILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  174 ANITVYGAAWLLLhlqgSAHGEQDISVGdqlgvqdvpvFRNLALLVVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPL 253
Cdd:PRK10429 155 AGFVTAGFTLPFV----NYVGGGDRGFG----------FQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQVSAEGSHLTL 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  254 VAPAAqplLLWKHwlrEPAFYQVGML--YMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVN 331
Cdd:PRK10429 221 KDIVA---LIYKN---DQLSCLLGMAlaYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLS 294

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74181667  332 RRIGRNMTYFTGLL--VILAFAAWVALADNLGVAVygAAVLLGAGCATILVTSLAMTADLI 390
Cdd:PRK10429 295 RRILWAGASIFPVLscGVLLLMGLAAPHNALLIVI--AGILLNIGTALFWVLQVIMVADTV 353
 
Name Accession Description Interval E-value
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 21-465 0e+00

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 636.99  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRA-SCVRCGPRKAWHLAGTV 99
Cdd:cd17491   1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTnGCGKYGRRKSWHLIGTI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 100 CVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVY 179
Cdd:cd17491  81 CVLLSFPFIFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANITVY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 180 GAAWLLLHlQGSAHGEQDISvgdqlgVQDVPVFRNLALLVVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPLVAPaAQ 259
Cdd:cd17491 161 LIAWLLLQ-QSSGDSVNPTS------AQDLPIFRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTNEGEEVTAP-EE 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 260 PLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMT 339
Cdd:cd17491 233 PRLTWKEWLREPQFYQVALLYMCTRLIVNLSQVYIPLYLTETLQLPKESIAIVPLVMYVSGFLTSLVMKPINKKIGRKIT 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 340 YFTGLLVILAFAAWVALADNL--GVAVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVM 417
Cdd:cd17491 313 YLLGLLFVLGFCIWVWFQSGSsrTYEIYGAAVLLGVGSATLLVTSLSMTADLIGTNTESGAFVYGAMSFTDKLSNGIAVL 392

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*...
gi 74181667 418 AVQSLHPCPSELCcgACISFYHWVMTAVTGGVGVAAALALCSLLIWPI 465
Cdd:cd17491 393 IIQSLHPCNTELD--ECISYYYRVMVVVAGGVAILAGLLLLAFLLLPK 438
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 21-451 1.33e-64

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 214.78  E-value: 1.33e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAScVRCGPRKAWHLAGTVC 100
Cdd:cd17332   1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTR-SRWGRFRPWLLWGAIP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 101 VLLSFPFIFSPCLGCGeatpeWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVANITVYG 180
Cdd:cd17332  80 LALLFVLLFTTPDGSG-----TGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 181 AAWLLLHLQGSAHGEqdisvgdqlgvqdvPVFRNLALLVVGVGAIFSLLFHLGTKEGHRSqhwgnEPNEHTPLvapaaQP 260
Cdd:cd17332 155 LPPPLVAYFGGGNAS--------------RGYFLTALIIGIIGIILLLICFFGTRERVVP-----PEEEKSKL-----PL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 261 LLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYslSLPKKFIATIPLVMYLSG-FFSSFLMKPVNRRIGRNMT 339
Cdd:cd17332 211 LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKY--VLGGRAELVLLLLLILSGaLLALLPWPPLKKRFGKKKA 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 340 YFTGLLV-ILAFAAWVALADNLGVAVYGAAVLLGAGCATILVTSLAMTADLIGPHT-HSG----AFVYGAMSFSDKVANG 413
Cdd:cd17332 289 FFIGLLLaILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGElKTGkrreGIFYSVMTFFRKLGLA 368

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 74181667 414 LAVMAVQSLHPC----PSELCCGACISFYHWVMTAVTGGVGV 451
Cdd:cd17332 369 LAGALVGLILSLagyvANAAAQSASALNGIRLLIAVLPAVLL 410
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-419 5.14e-35

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 135.80  E-value: 5.14e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  12 PPRTLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRASCvRCGPRK 91
Cdd:COG2211   3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRT-RWGRRR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  92 AWHLAGTVCVLLSFPFIFSPclgcgEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFT 171
Cdd:COG2211  82 PWILIGAIPLALSFVLLFTA-----PDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 172 VVANITVYGAAWLLLHLQGSAHGEQdisvgdqlgvqdvpvFRNLALLVVGVGAIFSLLFHLGTKEGHRsqhwgnEPNEHT 251
Cdd:COG2211 157 GLGGLLASVLPPPLVAAFGGDAALG---------------YRLTALIFAVLGLLAFLLTFFGTKERPV------PEEEKV 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 252 PLVApaaqpllLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVN 331
Cdd:COG2211 216 SLKE-------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 332 RRIGRNMTYFTGLLVILAFAAWVALADNLGVA-VYGAAVLLGAGCATILVTSLAMTADLIGPH-----THSGAFVYGAMS 405
Cdd:COG2211 289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWlLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGLYFGIFT 368

                       410
                ....*....|....
gi 74181667 406 FSDKVANGLAVMAV 419
Cdd:COG2211 369 FAIKLGQALAGALA 382
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 40-419 6.99e-14

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 73.11  E-value: 6.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667    40 TYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAScVRCGPRKAWHLAGTVCVLLSFPFIFSPCLGCGEAT 119
Cdd:pfam13347  18 TYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILAVSFILLFTPPELGRAPL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   120 PEWAALLYygpfiVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFtvvANITVYGAAwlLLHLQgsahgeqdIS 199
Cdd:pfam13347  97 FIWLLATY-----ILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFF---SVGGGLLAA--ALAFP--------LV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   200 VGDQLGVQDVPVFRNLALLVVGVGAIFSLLFHLGTKEGHrsqhwgNEPNEHTPLVAPAAQPLLLWKHWLREPAFYQVGML 279
Cdd:pfam13347 159 LILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERV------SMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLAS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   280 YMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAA--WVALA 357
Cdd:pfam13347 233 FLLAALAMGVLNGLLLYYFRYVLGNGFAA-SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFAlaLLLGP 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74181667   358 DNLgVAVYGAAVLLGAGCATILVTSLAMTADLI-------GphTHSGAFVYGAMSFSDKVANGLAVMAV 419
Cdd:pfam13347 312 NNT-LLFLVLYIIIGFGYGSSFFLPWSMLADVVdygelrtG--KRREGTFFAMWSFISKLATGVGLGVS 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 218-392 2.17e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.88  E-value: 2.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 218 LVVGVGAIFSLLFHLGTKEGHRSQHWGNEPnehtplvaPAAQPLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMY 297
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAV--------SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLY 225

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 298 LTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLgVAVYGAAVLLGAGCAT 377
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF-WLLLLLLALLGLGLGL 304

                       170
                ....*....|....*
gi 74181667 378 ILVTSLAMTADLIGP 392
Cdd:cd17325 305 VFPATLALLADIVPP 319
MFS_MFSD2 cd17392
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ...
 21-423 3.40e-06

Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340950  Cd Length: 446  Bit Score: 49.39  E-value: 3.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRASCVRCGPRKAWHLAGTVC 100
Cdd:cd17392   1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 101 VLLSFPFIFspclgcgeATPEWAAL--LYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTAlrYAFTVVANITV 178
Cdd:cd17392  81 IILAYFFLW--------FLPPFTSLsgLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATA--YRMTVEVFGTL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 179 YGAAwllLHLQ--GSAHGEQDISVGDQLGVQDVPV---------FRNLALLVVGVGAIFSLLFHLGTKEghrsqhwgnEP 247
Cdd:cd17392 151 MGAT---IQGQivGVAHRPRRQDCTATPGTSDHPVtvlpntrraYLIAALVVVVLYFVCCSILFLGVKE---------QP 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 248 NEHTPLVAPAAQPLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSFLM 327
Cdd:cd17392 219 DPLSPASGPGLSYLAGLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHF-QHLVLAILVSATLSIPLW 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 328 KPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGAAVLLGAGCATILVTSLAMTADLI------GPHTHS-GAFV 400
Cdd:cd17392 298 QWVLQRRGKKTTSFIGISAMVPFLILLALVPSNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVddfqlkNPHCPGlEPIF 377

                       410       420
                ....*....|....*....|....
gi 74181667 401 YGAMSFSDKVANGLAV-MAVQSLH 423
Cdd:cd17392 378 YSCYVFFTKLGGGLSLgISTLSLH 401
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 276-407 5.00e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.50  E-value: 5.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 276 VGMLYMTTRLIVNLSQTYIAMYLTySLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVA 355
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 74181667 356 LADNLGVaVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:cd06174  80 FAPSFWL-LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGS 130
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
252-406 6.43e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 6.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 252 PLVAPAAQPLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVN 331
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74181667 332 RRIGRNMTYFTGLLVILAFAAWVALADNLgVAVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAF-VYGAMSF 406
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLALAGSL-WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASgLYNSAFF 342
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 24-415 8.55e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.72  E-value: 8.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  24 FAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRgAGLLLLLGQVADGLCTPLVGYEADrascvRCGPRKAWHLAGTVCVLL 103
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQ-LGLLFALFSLGYALLQPLAGLLAD-----RFGRRPVLLLGLLLFALG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 104 SFPFIFSPCLgcgeatpeWAALLYYgpfiVVFQFGWAATQIAHLSLIPELVtSDHEKVELTALRYAFTVVANITVYGAA- 182
Cdd:cd06174  75 ALLFAFAPSF--------WLLLLGR----FLLGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGg 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 183 WLLLHLQGSahgeqdisvgdqlgvqdvpvFRNLALLVVGVGAIFSLLFHLGTKEGHRSQhwgnepnEHTPLVAPAAQPLL 262
Cdd:cd06174 142 ILASSLGFG--------------------WRAVFLIAAALALLAAILLLLVVPDPPESA-------RAKNEEASSKSVLK 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 263 LWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRR-IGRNMTYF 341
Cdd:cd06174 195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLL 274

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74181667 342 TGLLVILAFAAWVALADNLGVAVyGAAVLLGAGCATILVTSLAMTADLIGPhtHSGAFVYGAMSFSDKVANGLA 415
Cdd:cd06174 275 IGLLLMALGLALLLLAPSLLLLL-LLLLLLGFGLGGLLPLSFALIAELFPP--EIRGTAFGLLNTFGFLGGAIG 345
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
 21-390 9.41e-05

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 44.81  E-value: 9.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRASCVRCGPRKAWHLAGTVC 100
Cdd:cd17452   1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 101 VLLSFPFI-FSPCLGCGEatpewaaLLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVVAniTVY 179
Cdd:cd17452  81 IVVSYFFLwFVPPFTTGR-------FLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLG--TLV 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 180 GAAwllLHLQGSAHGeqdisvgdqlgvqdvpvFRNLALLVVGVGAIFSLLFHLGTKEghrsqhwgnEPNEHTPLVAPAAQ 259
Cdd:cd17452 152 GAA---VQGQIVASA-----------------YMIAAGVIGGLYLLCISVLFLGVKE---------RDDPYAPKSGKAIP 202

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 260 PLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSFLMKPVNRRIGRNMT 339
Cdd:cd17452 203 FFKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHF-QNLVLTILVSAVVSIPFWQWFLQRFGKKAA 281

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 74181667 340 YFtGLLVILAFAAWVALADNLGVAvYGAAVLLGAGCATILVTSLAMTADLI 390
Cdd:cd17452 282 AC-GISWMIPFAIMLVTIPNLIVA-YVVAFVSGLSIAASLLLPWSMLPDVV 330
PRK10429 PRK10429
melibiose:sodium transporter MelB;
14-390 2.68e-04

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 43.16  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   14 RTLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADrASCVRCGPRKAW 93
Cdd:PRK10429   1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVN-NTRSRWGKFKPW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   94 HLAGTVCVLLSFPFIFSPCLGCGEATPEWAALLYygpfiVVFQFGWAATQIAHLSLIPELVTSDHEKVELTALRYAFTVV 173
Cdd:PRK10429  80 ILIGTLANSVVLFLLFSAHLFEGTAQYVFVCVTY-----ILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  174 ANITVYGAAWLLLhlqgSAHGEQDISVGdqlgvqdvpvFRNLALLVVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPL 253
Cdd:PRK10429 155 AGFVTAGFTLPFV----NYVGGGDRGFG----------FQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQVSAEGSHLTL 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  254 VAPAAqplLLWKHwlrEPAFYQVGML--YMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVN 331
Cdd:PRK10429 221 KDIVA---LIYKN---DQLSCLLGMAlaYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLS 294

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74181667  332 RRIGRNMTYFTGLL--VILAFAAWVALADNLGVAVygAAVLLGAGCATILVTSLAMTADLI 390
Cdd:PRK10429 295 RRILWAGASIFPVLscGVLLLMGLAAPHNALLIVI--AGILLNIGTALFWVLQVIMVADTV 353
MFS_1 pfam07690
Major Facilitator Superfamily;
276-407 4.11e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667   276 VGMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVA 355
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 74181667   356 LADNLgVAVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:pfam07690  81 FASSL-WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFG 131
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 310-405 5.51e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.18  E-value: 5.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 310 ATIPLVMYLSGF-FSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGvAVYGAAVLLGAGCATILVTSLAMTAD 388
Cdd:cd17323  36 ANLGVSLFVLGFgLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA-MLIILRFLQGFFGSSPLAIGAGTIAD 114

                        90
                ....*....|....*..
gi 74181667 389 LIGPHTHSGAFVYGAMS 405
Cdd:cd17323 115 LFTPEERGKAMGVYSLG 131
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
292-398 7.05e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 7.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 292 TYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGaAVLL 371
Cdd:COG0738 231 DWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIG-LALV 309

                        90       100
                ....*....|....*....|....*..
gi 74181667 372 GAGCATILVTSLAMTADLIGPHTHSGA 398
Cdd:COG0738 310 GLGLSLMFPTIFSLALDGLGKRTAAAV 336
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 306-407 2.88e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 39.87  E-value: 2.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 306 KKFIATIPLVMYLSGFFS-SFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNlgVAVY-GAAVLLGAGCATILVTSL 383
Cdd:cd17317  23 RDWLVALVQTIFFLGVLIgSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS--YELFlVLRFLVGVTSAGIFTVGF 100

                        90       100
                ....*....|....*....|....
gi 74181667 384 AMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:cd17317 101 VLGMEIVGPKYRSFVGILFGLFWA 124
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
213-406 3.23e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.86  E-value: 3.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 213 RNLALLVVGVGAIFSLLFHLGTKeghrsqhwgnepNEHTPLVAPAAQPLLLWKHWLREPAFYQVGMLYMTTRLIVNLSQT 292
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLR------------DPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSS 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 293 YIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGAAVLLG 372
Cdd:COG2223 227 WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLG 306

                       170       180       190
                ....*....|....*....|....*....|....
gi 74181667 373 AGCATILVTSLAMTADLIGPHtHSGAfVYGAMSF 406
Cdd:COG2223 307 LALGGGNGAVFALVPDIFPTK-NAGA-VYGLVGA 338
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
276-407 3.29e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 276 VGMLYMTTRLIVNLSQTYIAMYLTYSLSLpkkfIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVA 355
Cdd:COG2814  18 GAFLSGLGIGIVLPALPLIAADLGASPAQ----AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 74181667 356 LADNLGVaVYGAAVLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:COG2814  94 LAPSLWL-LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLG 144
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 70-396 6.55e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 38.76  E-value: 6.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667  70 LCTPLVGYEADRaSCVRCGPRKAWHLAGTVCVLLSF---PFIFSPCLGCGEATPEWAALLYYGpFIVVFQFGWAATQIAH 146
Cdd:cd17313  49 FVQPLVGSLSDR-CNSRIGRRRPFILVGAPLAALGLiliPNAADIGLALGDGPRTWALVLFVL-GIVLLDFAMNVCQGPV 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 147 LSLIPELVTSDHEkveltalRYAFTVVANITVYGAAwlLLHLQGSAHGEQDISvGDQLGVQDVPVFrnlallvvGVGAIF 226
Cdd:cd17313 127 RALLPDLVPPEQR-------SKANGIINFMGGLGGV--LGYLLGAILWDHNWF-GFALGGNLKVPF--------YIGAII 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 227 SLLFHLGTKEGHRSQHWGNEPNEHTPLVAPAAQPLLLWKHWLREP----------AFYQVG----MLYMTTRLIVNLSQT 292
Cdd:cd17313 189 LLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPrsllrlllviFFWWIAffpfELFFTDYMGEEVYHG 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 293 YIAMYLTYSLSlpkKFIATIPLVMY-LSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVyGAAVLL 371
Cdd:cd17313 269 TSAASSHYGAG---VRMGAWGLLIFsLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVAL-VLFALG 344

                       330       340
                ....*....|....*....|....*
gi 74181667 372 GAGCATILVTSLAMTADLIGPHTHS 396
Cdd:cd17313 345 GIGWATININPYPLVSDYHSESGRG 369
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 292-406 7.22e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74181667 292 TYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVyGAAVLL 371
Cdd:cd17473 218 IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVL-LGAILA 296

                        90       100       110
                ....*....|....*....|....*....|....*
gi 74181667 372 GAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSF 406
Cdd:cd17473 297 GLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF 331
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 316-374 9.53e-03

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 38.39  E-value: 9.53e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74181667 316 MYLSGFFSSFLMKPVNRRIGRNMTYFTGLLVILAFAAWVALADNLGvAVYGAAVLLGAG 374
Cdd:cd17361  60 LYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIA-MLIVGRILLGFG 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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