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Conserved domains on  [gi|74178329|dbj|BAE32436|]
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unnamed protein product [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
3-396 1.21e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329   3 QTKELSLEGNTMSVRTVGKPSSGRTQLTEHQRihtgekPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSL--CGKAFQ 80
Cdd:COG5048   1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPR------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329  81 RSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLTQHEVTHSGE-KPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSIC 159
Cdd:COG5048  75 RPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 160 GRAFGQSP-SLYKHMRIHKRSKPYQSNNFSLAFVPNTPLPqgeglltEVKSYHCNDCGKDFGHITDFSEHQRLH------ 232
Cdd:COG5048 155 NSSSVNTPqSNSLHPPLPANSLSKDPSSNLSLLISSNVST-------SIPSSSENSPLSSSYSIPSSSSDQNLEnssssl 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 233 -AGENSYGSEQTLLGQQ------SLSHPREKPYQCNVCGKAFKRSTSFIEHH-RIHTG-EKPYECNECGEAFSRLSSLTQ 303
Cdd:COG5048 228 pLTTNSQLSPKSLLSQSpsslssSDSSSSASESPRSSLPTASSQSSSPNESDsSSEKGfSLPIKSKQCNISFSRSSPLTR 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 304 HERT--HAGE--KPYEC--IDCGKAFSQSSSLIQHERTHTGEKPYEC--NECGRAFRKKTN-----LHDHQRTHTGEKPY 370
Cdd:COG5048 308 HLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKS 387

                       410       420
                ....*....|....*....|....*...
gi 74178329 371 AC--KECGRNFSRSSALTKHHRVHARNK 396
Cdd:COG5048 388 ETlsNSCIRNFKRDSNLSLHIITHLSFR 415
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
3-396 1.21e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329   3 QTKELSLEGNTMSVRTVGKPSSGRTQLTEHQRihtgekPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSL--CGKAFQ 80
Cdd:COG5048   1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPR------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329  81 RSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLTQHEVTHSGE-KPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSIC 159
Cdd:COG5048  75 RPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 160 GRAFGQSP-SLYKHMRIHKRSKPYQSNNFSLAFVPNTPLPqgeglltEVKSYHCNDCGKDFGHITDFSEHQRLH------ 232
Cdd:COG5048 155 NSSSVNTPqSNSLHPPLPANSLSKDPSSNLSLLISSNVST-------SIPSSSENSPLSSSYSIPSSSSDQNLEnssssl 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 233 -AGENSYGSEQTLLGQQ------SLSHPREKPYQCNVCGKAFKRSTSFIEHH-RIHTG-EKPYECNECGEAFSRLSSLTQ 303
Cdd:COG5048 228 pLTTNSQLSPKSLLSQSpsslssSDSSSSASESPRSSLPTASSQSSSPNESDsSSEKGfSLPIKSKQCNISFSRSSPLTR 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 304 HERT--HAGE--KPYEC--IDCGKAFSQSSSLIQHERTHTGEKPYEC--NECGRAFRKKTN-----LHDHQRTHTGEKPY 370
Cdd:COG5048 308 HLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKS 387

                       410       420
                ....*....|....*....|....*...
gi 74178329 371 AC--KECGRNFSRSSALTKHHRVHARNK 396
Cdd:COG5048 388 ETlsNSCIRNFKRDSNLSLHIITHLSFR 415
zf-H2C2_2 pfam13465
Zinc-finger double domain;
29-53 7.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.71e-04
                          10        20
                  ....*....|....*....|....*
gi 74178329    29 LTEHQRIHTGEKPFECNVCGKAFRH 53
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 124-179 8.67e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 8.67e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74178329 124 KPFqCKECGKAFSRCSSLVQHERTHTgekpFECSICGRAFGQSPSLYKH-MRIHKRS 179
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKET 52
PHA00733 PHA00733
hypothetical protein
 69-116 9.80e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 74178329   69 PYQCSLCGKAFQRSSSLVQHQRIHTGEKpyRCNLCGRSFRHSTSLTQH 116
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
3-396 1.21e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329   3 QTKELSLEGNTMSVRTVGKPSSGRTQLTEHQRihtgekPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSL--CGKAFQ 80
Cdd:COG5048   1 ATLTSSQSSSSNNSVLSSTPKSTLKSLSNAPR------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFS 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329  81 RSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLTQHEVTHSGE-KPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSIC 159
Cdd:COG5048  75 RPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 160 GRAFGQSP-SLYKHMRIHKRSKPYQSNNFSLAFVPNTPLPqgeglltEVKSYHCNDCGKDFGHITDFSEHQRLH------ 232
Cdd:COG5048 155 NSSSVNTPqSNSLHPPLPANSLSKDPSSNLSLLISSNVST-------SIPSSSENSPLSSSYSIPSSSSDQNLEnssssl 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 233 -AGENSYGSEQTLLGQQ------SLSHPREKPYQCNVCGKAFKRSTSFIEHH-RIHTG-EKPYECNECGEAFSRLSSLTQ 303
Cdd:COG5048 228 pLTTNSQLSPKSLLSQSpsslssSDSSSSASESPRSSLPTASSQSSSPNESDsSSEKGfSLPIKSKQCNISFSRSSPLTR 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 304 HERT--HAGE--KPYEC--IDCGKAFSQSSSLIQHERTHTGEKPYEC--NECGRAFRKKTN-----LHDHQRTHTGEKPY 370
Cdd:COG5048 308 HLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKS 387

                       410       420
                ....*....|....*....|....*...
gi 74178329 371 AC--KECGRNFSRSSALTKHHRVHARNK 396
Cdd:COG5048 388 ETlsNSCIRNFKRDSNLSLHIITHLSFR 415
zf-H2C2_2 pfam13465
Zinc-finger double domain;
29-53 7.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.71e-04
                          10        20
                  ....*....|....*....|....*
gi 74178329    29 LTEHQRIHTGEKPFECNVCGKAFRH 53
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 124-179 8.67e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 8.67e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74178329 124 KPFqCKECGKAFSRCSSLVQHERTHTgekpFECSICGRAFGQSPSLYKH-MRIHKRS 179
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKET 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
84-109 1.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 74178329    84 SLVQHQRIHTGEKPYRCNLCGRSFRH 109
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 38-121 1.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329  38 GEKPFECNV--CGKAFRHSSSLGQHE-NAHtgekpyqcslCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLT 114
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....*..
gi 74178329 115 QHeVTHS 121
Cdd:COG5189 416 YH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-351 1.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....
gi 74178329   328 SLIQHERTHTGEKPYECNECGRAF 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-325 1.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 74178329   300 SLTQHERTHAGEKPYECIDCGKAFSQ 325
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
140-163 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....
gi 74178329   140 SLVQHERTHTGEKPFECSICGRAF 163
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
112-137 2.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 74178329   112 SLTQHEVTHSGEKPFQCKECGKAFSR 137
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
324-400 4.91e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 4.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74178329 324 SQSSSLIQHERTHTGE----KPYECNECGRAFRKKTNLHDHQRTHTGEKPYACKECGR--NFSRSSALTKHHRVHARNKL 397
Cdd:COG5048  12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPS 91


                ...
gi 74178329 398 QES 400
Cdd:COG5048  92 DLN 94
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 68-116 6.10e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 6.10e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 74178329  68 KPYqCSLCGKAFQRSSSLVQHQRIHTgekpYRCNLCGRSFRHSTSLTQH 116
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-297 6.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.56e-03
                          10        20
                  ....*....|....*....|...
gi 74178329   275 EHHRIHTGEKPYECNECGEAFSR 297
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 69-116 9.80e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 74178329   69 PYQCSLCGKAFQRSSSLVQHQRIHTGEKpyRCNLCGRSFRHSTSLTQH 116
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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