NCBI Conserved Domain Search

Kelch domain;

471-517

5.97e-17

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 74.90 E-value: 5.97e-17

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 74219668    471 LLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHN 517
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-175

8.80e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 76.90 E-value: 8.80e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18326   7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPT-----HRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18326  82 DFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

66-175

9.74e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 76.22 E-value: 9.74e-17

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  66 VMNELRLSQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSI--EGIHPKVMERLIEFAYTA 143
Cdd:cd18245   4 ALNSFREEPHLCDATLVVGGEEIPV-----QKNVLAAASPYFRAKLNYNPPKDDGSTYKIelEGISVEVMEEILDYIYTG 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 74219668 144 SISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18245  79 QIKLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-175

1.04e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 76.13 E-value: 1.04e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVKYEDIPaaqFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISVGEKC 151
Cdd:cd18294  11 NPEFSDVKFLVGPERQE---IFAHKCILAARCEVFRAMFLTGPQKEStQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHT 87

                        90       100
                ....*....|....*....|....
gi 74219668 152 VLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18294  88 VIEVLAAAVEYGLDELRKLCERFI 111

Kelch

Kelch domain;

565-611

2.48e-16

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 72.98 E-value: 2.48e-16

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 74219668    565 KIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTME 611
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

177-277

7.26e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 73.64 E-value: 7.26e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 177 QQLDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYD 256
Cdd:cd18469   1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                        90       100
                ....*....|....*....|.
gi 74219668 257 CPQRRFYVQALLRAVRCHALT 277
Cdd:cd18469  81 PQARAAHLPELLSLVHLSLLT 101

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-174

1.09e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 73.68 E-value: 1.09e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVkyEDIpaaQFMAHKVVLASSSPVFKAMFTNGlREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18212   6 HKDTVLTNFEEQRKKDFLCDITLIV--ENV---QFRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLE 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 74219668 139 FAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18212  80 FIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115

Kelch

Kelch domain;

518-564

1.60e-15

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 70.67 E-value: 1.60e-15

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 74219668    518 CIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQG 564
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

73-171

1.96e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 71.99 E-value: 1.96e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCV 152
Cdd:cd18314   3 DSEFSDVVLCVG-----DRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENV 77

                        90
                ....*....|....*....
gi 74219668 153 LHVMNGAVMYQIDSVVRAC 171
Cdd:cd18314  78 LDLLMLASKYQVPDLEKLC 96

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-185

2.17e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 73.11 E-value: 2.17e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRL---SQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18270   6 NTEYAVSLLEQLKFfyeQQLLTDIVLIVE-----GTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQI 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 74219668 136 LIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18270  81 IITYAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

179-278

2.42e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 71.80 E-value: 2.42e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18514   1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                        90       100
                ....*....|....*....|
gi 74219668 259 QRRFYVQALLRAVRChALTP 278
Cdd:cd18514  81 KRKDYLPELLRNVRL-ALLP 99

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-175

7.79e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 71.07 E-value: 7.79e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18328   7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQ-----EYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAIL 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18328  82 EFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

507-551

1.11e-14

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 68.41 E-value: 1.11e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 74219668   507 RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMR 551
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-145

1.78e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 70.05 E-value: 1.78e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  62 QAFGVMNElrlSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAY 141
Cdd:cd18280   3 QHFGALLE---SEEGADVTFNVDGE-----KFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIY 74


                ....
gi 74219668 142 TASI 145
Cdd:cd18280  75 KDEL 78

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-175

2.21e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 70.26 E-value: 2.21e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGM-------EVVSIEGIHP 130
Cdd:cd18327   7 EHSSELLSCLNEQRRAGLLCDLTIKTR-----GLEYRTHRAVLAACSLYFRKLFTGGGGGSGDlgagggqDVCELDFVGP 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 74219668 131 KVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18327  82 EALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

180-234

2.37e-14

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 67.69 E-value: 2.37e-14

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 74219668 180 DPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISR 234
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

179-278

2.61e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 69.00 E-value: 2.61e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLnVRCESEVFHACIDWVKYDCP 258
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                        90       100
                ....*....|....*....|
gi 74219668 259 QRRFYVQALLRAVRCHALTP 278
Cdd:cd18476  80 ARKGYIHDLFKKVRLQYVHP 99

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-187

2.83e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 69.83 E-value: 2.83e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18276  12 LNRMKELAELTDVVLVAEGEKFPC-----HRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLH 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 74219668 147 VGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18276  87 LTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

Kelch

Kelch domain;

424-469

3.73e-14

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 66.81 E-value: 3.73e-14

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 74219668    424 HIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLN 469
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

179-272

3.96e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 68.61 E-value: 3.96e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18462   1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                        90
                ....*....|....
gi 74219668 259 QRRFYVQALLRAVR 272
Cdd:cd18462  81 KRIECAYDLLSSIK 94

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-175

4.71e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 69.12 E-value: 4.71e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQ-------GMEVVSIEGIHPK 131
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRVQ-----DKIFRAHKVVLAACSDFFRSKLVGQASPRlvlvspaGKCVLDLHHVTVT 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 74219668 132 VMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18228  77 GFAPLLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

553-598

6.96e-14

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 66.10 E-value: 6.96e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 74219668   553 HRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMT 598
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

76-183

7.58e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 68.07 E-value: 7.58e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  76 LCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS---VGEKCV 152
Cdd:cd18297  12 MSDVTFLVE-----GRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDA 86

                        90       100       110
                ....*....|....*....|....*....|.
gi 74219668 153 LHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18297  87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

PLN02193

nitrile-specifier protein

461-594

7.90e-14

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 74.22 E-value: 7.90e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  461 IGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMN---TIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERY 537
Cdd:PLN02193 220 LGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSY 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74219668  538 DVETETW--------TFVApmrhhRSALGITVHQGKIYVLGGYDGHTfLDSVECYDPDSDTWSEV 594
Cdd:PLN02193 300 NIVDKKWfhcstpgdSFSI-----RGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQV 358

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

57-183

8.40e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 68.45 E-value: 8.40e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  57 EDHTKQAFGVMNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERL 136
Cdd:cd18261   9 KSHKDAVLAALNQQRNDGILCDITLVAEEQ-----KFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 74219668 137 IEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18261  84 LDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-183

9.68e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 68.31 E-value: 9.68e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  54 YTLEDHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVM 133
Cdd:cd18251   1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEA-----HRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAM 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 74219668 134 ERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18251  76 CKILDFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

66-185

1.04e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 67.92 E-value: 1.04e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  66 VMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTnglREQGMEVVSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18260   8 GLNRMRQERFLCDLTIATK-----TKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTGKL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 74219668 146 SVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18260  80 TLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-183

1.29e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 67.99 E-value: 1.29e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  54 YTLEDHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVM 133
Cdd:cd18266   3 YRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPA-----HRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGL 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 74219668 134 ERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18266  78 KAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

179-272

1.58e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 66.62 E-value: 1.58e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18479   1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                        90
                ....*....|....
gi 74219668 259 QRRFYVQALLRAVR 272
Cdd:cd18479  81 SRSQYLSSVLSQIR 94

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

181-278

2.37e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 66.37 E-value: 2.37e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 181 PSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQR 260
Cdd:cd18464   2 PSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRR 81

                        90
                ....*....|....*...
gi 74219668 261 RFYVQALLRAVRChALTP 278
Cdd:cd18464  82 HEVLPELLRSVRL-ALLP 98

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

179-272

6.01e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 65.20 E-value: 6.01e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                        90
                ....*....|....
gi 74219668 259 QRRFYVQALLRAVR 272
Cdd:cd18460  81 HRQHFWPELLQHVR 94

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-181

1.10e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 65.07 E-value: 1.10e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI--EGIHPKVMERL 136
Cdd:cd18196   4 HFEQIFQQLNYQRLHGQLCDCVIVVG-----NRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLdsEVVTAEAFAAL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 74219668 137 IEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18196  79 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

459-504

1.80e-12

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 61.86 E-value: 1.80e-12

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 74219668   459 RRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMN 504
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

179-256

1.86e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 63.11 E-value: 1.86e-12

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYD 256
Cdd:cd18480   1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHD 78

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

182-273

1.91e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 63.62 E-value: 1.91e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 182 SNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRR 261
Cdd:cd18516   4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                        90
                ....*....|..
gi 74219668 262 FYVQALLRAVRC 273
Cdd:cd18516  84 KALPVLLESIRF 95

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

179-277

2.38e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 63.32 E-value: 2.38e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                        90
                ....*....|....*....
gi 74219668 259 QRRFYVQALLRAVRCHALT 277
Cdd:cd18477  81 NRQKALPTVFESIRFRLLP 99

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-187

2.78e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 64.10 E-value: 2.78e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18341  18 LKELLDENKFVDCTLKAGDKSLPC-----HRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEID 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 74219668 147 VGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18341  93 LNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-175

2.93e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 63.91 E-value: 2.93e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  56 LEDHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTngLREqgMEVVSIEGI-HPKVME 134
Cdd:cd18222   5 IPDFSNSVLSHLNQLRMQGRLCDIVVNVQ-----GQSFRAHKVVLAASSPYFRDHMS--LNE--MSTVSISVIkNPTVFE 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 74219668 135 RLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18222  76 QLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQIL 116

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-183

3.35e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 63.99 E-value: 3.35e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVKYED----IPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEvVSIEGIHPKVMERLIEFAYTASISVG 148
Cdd:cd18281  19 NETLSDVHFIVGKGDneqrIPA-----HKFVLSIGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIG 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 74219668 149 EKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18281  93 PETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

4.26e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 63.34 E-value: 4.26e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLReQGMEVVSIE-GIHPKVMERLIEFAYTASI 145
Cdd:cd18331  15 LNRLRSRDILTDVVIVVSRE-----QFRAHKTVLMACSGLFYSIFTDQLK-CNLSVINLDpEINPEGFNILLDFMYTSRL 88

                        90       100       110
                ....*....|....*....|....*....|
gi 74219668 146 SVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18331  89 NLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

179-268

4.50e-12

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 62.64 E-value: 4.50e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLaTLI--SRDDLNVRCESEVFHACIDWVKYD 256
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQI-EVIleSNQELESINERKLCQLVLEWVQRS 79

                        90
                ....*....|..
gi 74219668 257 CPQRRFYVQALL 268
Cdd:cd18502  80 IEEGGLDLDDLT 91

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-175

4.69e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 63.02 E-value: 4.69e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVkyEDipaAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18287   4 DHVHFLSEDIGALFLNEEYSDVTFVV--EE---KRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 74219668 138 EFAYTASISVG---EKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18287  79 KYIYTGRLTLTdlkEDVLLDVLGLAHQYGFEELEAAISDYL 119

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-179

4.92e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 63.33 E-value: 4.92e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKYEDIpAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18211  16 MHKLRLLGHLCDVTVQVEHQGS-KEEFSAHKAVLAASSKYFKEVFLNEKISDGkNTNVMLNEIYTADFASFLEFVYTAKV 94

                        90       100       110
                ....*....|....*....|....*....|....
gi 74219668 146 SVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18211  95 EVEEDRVQRMLEIAEKLKCLDLSETCFQLKKQML 128

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-182

9.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 62.77 E-value: 9.02e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLR-EQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18230   4 HYRHLLRELNEQRQHGILCDVCIIVE-----GKIFKAHKNVLLGSSRYFKTLYCQVQKtSDQATVTHLDIVTAQGFKAII 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPS 182
Cdd:cd18230  79 DFMYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

1.13e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 61.86 E-value: 1.13e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQ-QLCDVTLQVKYEdipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVvSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18231   4 LNEQRLFQpDLCDVDIVLVRQ---RSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVEL-SLEALTSQGLQQILNFIYTSKL 79

                        90       100       110
                ....*....|....*....|....*....|
gi 74219668 146 SVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18231  80 LVNSCNVQDVLNAAAVLQMNDIAASCQELI 109

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

78-180

1.24e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 61.93 E-value: 1.24e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  78 DVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLRE-----QGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCV 152
Cdd:cd18296  19 DVCFQVEGH-----RFPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENA 93

                        90       100
                ....*....|....*....|....*...
gi 74219668 153 LHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Cdd:cd18296  94 YDVLYVADMYLLPGLKRLCGTVLAQSLD 121

Kelch

Kelch domain;

373-423

1.62e-11

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 59.11 E-value: 1.62e-11

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 74219668    373 LLYAVGGRNnspdGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDG 423
Cdd:smart00612   1 KIYVVGGFD----GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-175

1.75e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 61.41 E-value: 1.75e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGT-----PLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLD 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 74219668 139 FAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18332  77 FMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

179-281

1.95e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 60.94 E-value: 1.95e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18446   1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                        90       100
                ....*....|....*....|...
gi 74219668 259 QRRFYVQALLRAVRCHALTPRFL 281
Cdd:cd18446  81 ERLPLLPRVLENVRLPLLDPWYF 103

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

179-253

2.86e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 59.32 E-value: 2.86e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWV 253
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-175

2.91e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 60.81 E-value: 2.91e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  54 YTLEDHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLreqgMEVVSIEGI-HPKV 132
Cdd:cd18220   3 FDVPEYSNTVLSQLNELRLQGKLCDIIVHIQ-----GQPFRAHKAVLAASSPYFRDHSALST----MSGLSISVIkNPNV 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 74219668 133 MERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18220  74 FEQLLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

76-179

3.15e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 61.51 E-value: 3.15e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  76 LCDVTLQVkyEDipaAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHV 155
Cdd:cd18244  30 LLDVTLVI--ED---HQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEI 104

                        90       100
                ....*....|....*....|....
gi 74219668 156 MNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18244 105 LQAAMYVQLTEVVKFCCSFLLAKI 128

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

74-179

3.71e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 60.33 E-value: 3.71e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  74 QQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGE--KC 151
Cdd:cd18300   7 GLFSDVTFIVEDGTIPA-----HKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEdgDC 81

                        90       100
                ....*....|....*....|....*...
gi 74219668 152 VlHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18300  82 V-GLIVLANRLCLPRLVALCEQYIVKEL 108

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

76-179

4.16e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 60.18 E-value: 4.16e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  76 LCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHV 155
Cdd:cd18352  13 LSDVTFLVE-----GRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDL 87

                        90       100
                ....*....|....*....|....
gi 74219668 156 MNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18352  88 LRAADQYLLEGLKRLCEYTIAQDL 111

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

181-278

4.42e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 59.60 E-value: 4.42e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 181 PSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQR 260
Cdd:cd18515   2 PTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKR 81

                        90
                ....*....|....*...
gi 74219668 261 RFYVQALLRAVRChALTP 278
Cdd:cd18515  82 HCYLSELLQTVRL-ALLP 98

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

51-177

7.48e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 59.98 E-value: 7.48e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  51 TFSYTLEDHTKQAFGVMNELRLSQ-QLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLrEQGMEVVSIE--G 127
Cdd:cd18207   1 SYTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPA-----HRAVLAACSEYFESVFSAQE-GDGGTPRELEmhT 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 74219668 128 IHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18207  75 ISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

95-179

8.07e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 59.33 E-value: 8.07e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  95 AHKVVLASSSPVFKAMFTNGLREQGMEVVsIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18282  25 AHKYVLATGSSVFYAMFYGGLAENKNEIE-IPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQF 103


                ....*
gi 74219668 175 LVQQL 179
Cdd:cd18282 104 LETSL 108

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

179-273

9.47e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 58.63 E-value: 9.47e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                        90
                ....*....|....*
gi 74219668 259 QRrfyVQALLRAVRC 273
Cdd:cd18517  81 NR---VKSLGEIFDC 92

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-174

9.60e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 59.12 E-value: 9.60e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLReQGMEVVSIEG-IHPKVMERLI 137
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGRE-----QFRAHKTVLMACSGLFYSIFTDQLK-NNVSVINLDPeIEPEGFRILL 75

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18215  76 DFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-184

9.80e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 59.48 E-value: 9.80e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKCV 152
Cdd:cd18345  15 RSAFSDVTLCVG-----GREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMA 89

                        90       100       110
                ....*....|....*....|....*....|..
gi 74219668 153 LHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
Cdd:cd18345  90 DDLLAAADKYALERLKVMCEEALCSNLSVENV 121

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

412-456

1.29e-10

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 56.85 E-value: 1.29e-10

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 74219668   412 PRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPM 456
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

76-176

1.30e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 57.94 E-value: 1.30e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  76 LCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNgLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEKcvlhv 155
Cdd:cd18315   1 LVDVTLACEGGSLKA-----HKLVLAAASPYFAALLKE-TPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQE----- 69

                        90       100
                ....*....|....*....|.
gi 74219668 156 mngavmyQIDSVVRACSDFLV 176
Cdd:cd18315  70 -------QLESLLKLAELLQI 83

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-174

1.39e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 58.79 E-value: 1.39e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKYEDipaaqFMAHKVVLASSSPVFKAMFTNGlreqgMEVVSIEGIHPKVMERLIE 138
Cdd:cd18206   5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVD-----FKAHKAVLAACSEYFRMLFVDQ-----KDVVHLDISNAAGLGQVLE 74

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 74219668 139 FAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18206  75 FMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-170

1.65e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 58.47 E-value: 1.65e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREqgmEVVSIEGIHPKVMERLIE 138
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVD-----GHQFKAHKAVLAACSQFFYKFFQDFTQE---PLVEIEGVSNMAFRHLIE 72

                        90       100       110
                ....*....|....*....|....*....|...
gi 74219668 139 FAYTASISV-GEKCVLHVMNGAVMYQIDSVVRA 170
Cdd:cd18221  73 FTYTAKLMVqGEEEANDVWKAAEYLQMQEAIKA 105

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-183

1.67e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 58.86 E-value: 1.67e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  69 ELRLSQQLCDVTLQVKYED----IPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTAS 144
Cdd:cd18343   5 ECRLAEDLGNLWENSRFTDcslfVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 84

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 74219668 145 ISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18343  85 APNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

53-187

2.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 59.14 E-value: 2.21e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  53 SYTLEDHT---KQAFGVMNELRLSQQLCDVTLQVKYEDipaaqFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIH 129
Cdd:cd18272   6 SYTFTDRShssRVAQSIMDLCLEDGLFADVTISVEGKE-----FQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 74219668 130 PKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGI 187
Cdd:cd18272  81 ESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

361-410

2.63e-10

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 55.70 E-value: 2.63e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 74219668   361 PRSGLAGCVVGGLLYAVGGRnnspDGNTDSSALDCYNPMTNQWSPCASMS 410
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF----DGNQSLNSVEVYDPETNTWSKLPSMP 46

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

179-256

3.09e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 56.75 E-value: 3.09e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYD 256
Cdd:cd18474   1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

92-184

3.22e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 58.04 E-value: 3.22e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  92 QFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTasisvGEKCVLH-------VMNGAVMYQI 164
Cdd:cd18344  34 EFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYT-----GKAPHLHshsmacdVLAAADKYGL 108

                        90       100
                ....*....|....*....|
gi 74219668 165 DSVVRACSDFLVQQLDPSNA 184
Cdd:cd18344 109 EGLKVLCEDALCRNLSVENA 128

PHA02713

hypothetical protein; Provisional

396-569

4.30e-10

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 62.72 E-value: 4.30e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  396 YNPMTNQWSPCASmsVPRNRIGV--GVIDGHIYAVGG-SHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
Cdd:PHA02713 277 YNINTMEYSVIST--IPNHIINYasAIVDNEIIIAGGyNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTI 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  473 YAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGG------YDGQDQLNSVE----------- 535
Cdd:PHA02713 355 YAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidYTSVHHMNSIDmeedthssnkv 434

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 74219668  536 -RYDVETETWTFVAPMRHHRSALGITVHQGKIYVL 569
Cdd:PHA02713 435 iRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-184

5.54e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 57.42 E-value: 5.54e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  69 ELRLSQQLCDVTLQVKYED----IPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTAS 144
Cdd:cd18342   6 ECRLADELGGLWENSRFTDcclcVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGK 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 74219668 145 ISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
Cdd:cd18342  86 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-181

6.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 57.35 E-value: 6.45e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  64 FGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFtNGLREQGMEVVSieGIHPKVMERLIEFAYTA 143
Cdd:cd18289  17 LGCLNEQRLMGLYCDVSIVVK-----GQAFKAHRAVLAASSLYFRDLF-SGNSKSAFELPA--TVPPACFQQILSFCYTG 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 74219668 144 SISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18289  89 KLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-177

6.72e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 56.79 E-value: 6.72e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQvkyedIPAAQFMAHKVVLASSSPVFKAMFTNGLREqgMEVVSIegIHPKVMERLIEFAYTASIS 146
Cdd:cd18229   9 LNAQRLGGHFCDVTVR-----IHDASLRAHRCVLAAGSPFFHDKLLLGHSE--IEVPPV--VPAQTVRQLVEFMYSGSLV 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 74219668 147 VGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18229  80 VAQSEALQILTAASILQIKTVIDECTQIISQ 110

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-171

7.55e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 57.14 E-value: 7.55e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18323   5 DHSRHLLQSLREQRHQGFLCDCTVLVG-----STQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLL 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18323  80 EFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC 113

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-174

7.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 56.53 E-value: 7.79e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNG--LREQGMEVVSIEgihP----KVMERLIEFA 140
Cdd:cd18292   8 IAQLYNNEELSDIVLRVGGK-----VFHAHRLILAKSSDVFRVMLSNDwwSESKQSEIELVE---DpecaAVFEKFLRYL 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 74219668 141 YTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18292  80 YTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-179

1.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 56.00 E-value: 1.46e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18279   9 LGNLWENSRFTDCCLCVG-----GQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAP 83

                        90       100       110
                ....*....|....*....|....*....|...
gi 74219668 147 VGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18279  84 NLDKMADDLLAAADKYALERLKVMCEDALCSNL 116

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

61-186

1.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 56.13 E-value: 1.64e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  61 KQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEV---VSIEGIHPKVMERLI 137
Cdd:cd18258   2 KEMLKELNQQRRAKEFTDLKIIVE-----GKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEkleLTMSNINADVLELLL 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIG 186
Cdd:cd18258  77 EFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-177

1.65e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 56.20 E-value: 1.65e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGlREQGMEVVSieGIHPKVMERLIEFAYTA--S 144
Cdd:cd18290  18 LNEQRLQGLYCDVSVVVK-----GHAFKAHRAVLAASSSYFRDLFNSS-RSAVVELPA--AVQPQSFQQILSFCYTGrlS 89

                        90       100       110
                ....*....|....*....|....*....|...
gi 74219668 145 ISVGEKCVLhvMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18290  90 MNVGDQFLL--MYTAGFLQIQEIMEKGTEFFLK 120

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

77-174

2.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 54.81 E-value: 2.13e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  77 CDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEV---VSIEGIHPKVMERLIEFAYTASISVGEKCVL 153
Cdd:cd18307   2 CDVVISVD-----NHSFAAHRNVLAAVSPFVKSLISSNDMKATDELsitIDCDYLSPETVEQLLDYFYTGKIVISEKNVE 76

                        90       100
                ....*....|....*....|.
gi 74219668 154 HVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18307  77 DLLKGAKYFNIPRLKDHCVDF 97

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-147

2.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 55.26 E-value: 2.57e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLREQgMEVVSIEGIHPKVMERLIE 138
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQ-----KFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLN 74


                ....*....
gi 74219668 139 FAYTASISV 147
Cdd:cd18209  75 YIYSSSLFV 83

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-172

3.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 54.66 E-value: 3.52e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVkyEDIpaaQFMAHKVVLASSSPVFKAMFTNgLREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVV--EDV---KFRAHRCVLAACSTYFKKLFKK-LEVDSSSVIEIDFLRSDIFEEVLN 74

                        90       100       110
                ....*....|....*....|....*....|....
gi 74219668 139 FAYTASISVGEKCVLHVMNGAVMYQIDSVVRACS 172
Cdd:cd18204  75 YMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCS 108

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

4.36e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 54.95 E-value: 4.36e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVF--KAMFTNGLReqgmeVVSIEGIHPKVMERLIEFAYTAS 144
Cdd:cd18227  16 LNQQRQQGQLCDISVVVQ-----GHLFRAHKAVLAASSPYFcdQVLLKNSRR-----IVLPDVMNPRVFENILLSCYTGR 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 74219668 145 ISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18227  86 LVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

Kelch

Kelch domain;

327-372

5.68e-09

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 52.18 E-value: 5.68e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 74219668    327 LIYTAGGY-FRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGG 372
Cdd:smart00612   1 KIYVVGGFdGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

179-274

6.13e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 53.66 E-value: 6.13e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGE-VAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDC 257
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                        90
                ....*....|....*..
gi 74219668 258 PQRRFYVQALLRAVRCH 274
Cdd:cd18482  81 KERAASAAEVLKCVRWQ 97

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

78-144

8.08e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 53.45 E-value: 8.08e-09

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74219668  78 DVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGM----EVVSIEGIHPKVMERLIEFAYTAS 144
Cdd:cd18301  20 DVVFQVGGKTFPA-----HKFILASRSDYFRKLFLSSLLTSEDavgcDVVHIEKVPPEIFEQLLQFIYTDT 85

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

95-183

8.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 54.29 E-value: 8.57e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  95 AHKVVLASSSPVFKAMFTNGLREQGMEvVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18346  46 AHRFVLAAGSAVFDAMFNGGMATTSAE-IELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 124


                ....*....
gi 74219668 175 LVQQLDPSN 183
Cdd:cd18346 125 LTKHLRADN 133

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

69-167

1.00e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 53.80 E-value: 1.00e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  69 ELRLSQQLC--DVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18286   8 LLQLFLNGEdsDITIKVD-----GKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLD 82

                        90       100
                ....*....|....*....|..
gi 74219668 147 VGEKCVL-HVMNGAVMYQIDSV 167
Cdd:cd18286  83 LPDDVNLgELLSLADMYGLDGL 104

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-146

2.02e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 52.93 E-value: 2.02e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFT-NGLREQGMEVVSIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18202  10 LNQQRLNNQFCDVTLLIEGE-----EYKAHKSVLAANSEYFRELFIeKGAVSSHEAVVDLSGFCKSSFLPLLEFAYTSEL 84


                .
gi 74219668 146 S 146
Cdd:cd18202  85 T 85

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-177

2.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 52.76 E-value: 2.17e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  56 LEDHTKQAFGVMNELRLSQQLCDVTLQvkyedIPAAQFMAHKVVLASSSPVFKAMFTNGLREqgMEVVSIEGIHPkvMER 135
Cdd:cd18208   5 LHNFSNSVLETLNEQRNRGHFCDVTVR-----IHGSMLRAHRCVLAAGSPFFQDKLLLGYSD--IEIPSVVSVQS--VQK 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 74219668 136 LIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
Cdd:cd18208  76 LIDFMYSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

67-175

2.33e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 52.21 E-value: 2.33e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKYEdipaAQFMAHKVVLASSSPVFKAMFTNglreqgMEVVSIEG-IHPKVMERLIEFAYTASI 145
Cdd:cd18299   3 LRNLLHSPSCADVVFILQGG----VRIFAHRIVLAAASSVFADLFLM------MTVVTLDSdITPEAFRRVLEFLYTGVL 72

                        90       100       110
                ....*....|....*....|....*....|
gi 74219668 146 SVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18299  73 DENEDDLKELKDAAELLELFDLVMMCTNVL 102

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

53-181

3.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 52.19 E-value: 3.14e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  53 SYTLEDHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTngLREQGMEVVSIegIH-PK 131
Cdd:cd18203   2 RFQLPGHEAATLRNMNQLRSEERFCDVTIVAD-----SLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSL--MHsSR 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 74219668 132 VMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18203  73 VVADLLLSCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-183

6.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 51.78 E-value: 6.50e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  68 NELRLSQQLCDVTLqvKYEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE------GIHPKVMERLIEFAY 141
Cdd:cd18241  15 NEQRKQGLFCDITL--AFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPDPDTVEAVIQYMY 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 74219668 142 TASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18241  93 TGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

7.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 50.98 E-value: 7.41e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVV-SIEGIHPKVMERLIEFAYTASI 145
Cdd:cd18329  12 LDEQRKQELFCDCSILVE-----GQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVaTFDVFSPDTFTIILDFVYSGKL 86

                        90       100       110
                ....*....|....*....|....*....|
gi 74219668 146 SVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18329  87 SLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-175

8.93e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 50.83 E-value: 8.93e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  52 FSYTLEDHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTnGLREQGMEVVSIEGIHPK 131
Cdd:cd18277   3 FAYESSVHSTNVLLSLNDQRKKDVLCDVTILVE-----GQRFRAHRSVLAACSSYFHSRIV-GQADAELNITLPEEVTVK 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 74219668 132 VMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18277  77 GFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB_POZ_ABTB2_BPOZ2

cd18350

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-185

9.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349659 [Multi-domain] Cd Length: 134 Bit Score: 51.39 E-value: 9.89e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTN--GLREQGMEVVSIEGIHPKVMERLIEFAY---TASISV 147
Cdd:cd18350  21 NKEMSDVTFLVE-----GKLFYAHKVLLVTASNRFKSLLTNksEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEI 95

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 74219668 148 GEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18350  96 PIADVLELLSAASLFQLDALQRHCEILCSQTINLENAV 133

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

69-171

1.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 50.71 E-value: 1.02e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  69 ELRLSQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQgmeVVSIEGIHPKVMERLIEFAYTASISVG 148
Cdd:cd18218  11 RLRPAGALCDTLITVGSQEFPA-----HSLVLAGASQQLGRQLTNPNPGQ---WCLGEGISPSTFKQLLDFVYGESVEVQ 82

                        90       100
                ....*....|....*....|...
gi 74219668 149 EKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18218  83 PGELRPLLEAARALEVESLEEAC 105

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-183

1.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 50.84 E-value: 1.06e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVKyEDIPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVvSIEGIHPKVMERLIEFAYTASISVGEKCV 152
Cdd:cd18347  19 NEVLSDVHFLVG-KGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAAFLALLKFLYSDEVQIGPETV 96

                        90       100       110
                ....*....|....*....|....*....|.
gi 74219668 153 LHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18347  97 MTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

76-175

1.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 49.77 E-value: 1.17e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  76 LCDVTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLREQGM----EVVSIEGIHPkvmerLIEFAYTASISVGEKC 151
Cdd:cd18955   1 LCDVTIVVEDQ-----RFRAHRAVLAACSDYFLSRVVGQTDGDLVitlpEEVTVKGFEP-----LLQFAYTAKLLLSKEN 70

                        90       100
                ....*....|....*....|....
gi 74219668 152 VLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18955  71 VLEVCRCAEFLGVHNIEKACFDFL 94

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-171

1.54e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 50.14 E-value: 1.54e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQvkyedIPAAQFMAHKVVLASSSPVFKAMFtnglREQGMEVVSI--EGIHPKVMERL 136
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIV-----IGQFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVFLdqSQVSADGFQKL 71

                        90       100       110
                ....*....|....*....|....*....|....*
gi 74219668 137 IEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18217  72 LEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-175

3.02e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 49.44 E-value: 3.02e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  56 LEDHTKQAFGVMNELRLSQQLCDVTLQvkyedIPAAQFMAHKVVLASSSPVFKAMFtnglreQGMEVVSIEG--IHPKVM 133
Cdd:cd18225   3 LPNYSRQLLQQLHTLRKEQQFCDCTIF-----IGTFHFRAHKLVLAASSLLFKSLL------DSTDTISIDAsvVSPEEF 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 74219668 134 ERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18225  72 ALLLEMVYTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

3.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 49.07 E-value: 3.13e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKamftNGLREQGMEVVSIEGI-HPKVMERLIEFAYTASI 145
Cdd:cd18210  12 LNQQRMEGKLCDISIHVQ-----GRVFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGVmDPGAFESVLASAYTGKL 82

                        90       100       110
                ....*....|....*....|....*....|
gi 74219668 146 SVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18210  83 TMLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

179-255

3.21e-07

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 48.11 E-value: 3.21e-07

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKY 255
Cdd:cd18503   1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

95-179

3.71e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 48.83 E-value: 3.71e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  95 AHKVVLASSSPVFKAMFTNGLREQGMEvVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18349  26 AHKYVLAVGSSVFYAMFYGDLAEVKSE-IHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNF 104


                ....*
gi 74219668 175 LVQQL 179
Cdd:cd18349 105 LETSL 109

PHA02713

hypothetical protein; Provisional

76-555

3.72e-07

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 53.09 E-value: 3.72e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668   76 LCDVTLQVKyediPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEV-VSIEGIHPKVMERLIEFAYTASISvgEKCVLH 154
Cdd:PHA02713  25 LCDVIITIG----DGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTrVNLQMFDKDAVKNIVQYLYNRHIS--SMNVID 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  155 VMNGAVMYQIDSVVRACSDFlvqqldpsnaigIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLShcqlaTLISR 234
Cdd:PHA02713  99 VLKCADYLLIDDLVTDCESY------------IKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIP-----TLITT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  235 DDLnvrcESEVFHACIDWVKYD----CPQRRFYVQALLRAVRCHALTPRFLQTQLQKCEILQADAR-------------- 296
Cdd:PHA02713 162 DAF----KKTVFEILFDIISTNdnvyLYREGYKVTILLKWLEYNYITEEQLLCILSCIDIQNLDKKsrlllysnktinmy 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  297 --CKDYLVQIFQE---------LTLHKPTQAV--PC------------------------RAPKVGRLIYTAGGYFRQSL 339
Cdd:PHA02713 238 psCIQFLLDNKQNrniiprqlcLVCHDTKYNVcnPCilvynintmeysvistipnhiinyASAIVDNEIIIAGGYNFNNP 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  340 SYLEAY--NPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNnspdGNTDSSALDCYNPMTNQWSPCASMSVPRNRIG 417
Cdd:PHA02713 318 SLNKVYkiNIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQN----GTNVERTIECYTMGDDKWKMLPDMPIALSSYG 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  418 VGVIDGHIYAVGGSHGCIHHSSVE------------------RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVggFD 479
Cdd:PHA02713 394 MCVLDQYIYIIGGRTEHIDYTSVHhmnsidmeedthssnkviRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV--CD 471

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  480 GTNRLNSAECYY----PERNEWRMITPMNTiRSGAGVCVLH-NCIYAAGGYDG---QDQLNsverydVETETWTFVApmr 551
Cdd:PHA02713 472 IKDEKNVKTCIFryntNTYNGWELITTTES-RLSALHTILHdNTIMMLHCYESymlQDTFN------VYTYEWNHIC--- 541


                 ....
gi 74219668  552 HHRS 555
Cdd:PHA02713 542 HQHS 545

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

68-175

7.89e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 48.11 E-value: 7.89e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  68 NELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSiegihPKVMERLIEFAYTASISV 147
Cdd:cd18205  10 NQMRLAGTLCDVVIMVD-----SQEFHAHRTVLACTSKMFEILFHRNSQHYTLDFLS-----PKTFQQILEYAYTATLQA 79

                        90       100
                ....*....|....*....|....*...
gi 74219668 148 GEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18205  80 KVEDLDDLLYAAEILEIEYLEEQCLKIL 107

PHA02713

hypothetical protein; Provisional

514-608

7.90e-07

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 51.93 E-value: 7.90e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  514 VLHNCIYAAGGYDGQD-QLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWS 592
Cdd:PHA02713 301 IVDNEIIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWK 380

                         90
                 ....*....|....*.
gi 74219668  593 EVTRMTSGRSGVGVAV 608
Cdd:PHA02713 381 MLPDMPIALSSYGMCV 396

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-175

9.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 47.80 E-value: 9.12e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVV-SIEGIHPKVMERLI 137
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVE-----GRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTaSFDVFSSDAFSIIL 75

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18199  76 DFVYSGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-183

9.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 48.50 E-value: 9.21e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  45 SQDGNRTFSYTlEDHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFT-NGLREQGMEVV 123
Cdd:cd18243   2 SRSGDRTSTFD-PSHSDNLLHGLNLLWRKQLFCDVTLTAQ-----GQQFHCHKAVLASCSQYFRSLFSiNNLVLQGCSSI 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 124 SIEGIhpkvmerlIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSN 183
Cdd:cd18243  76 GLRLV--------LEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-171

1.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 47.89 E-value: 1.17e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNglREQGMEVVSIEG--IHPKVMER 135
Cdd:cd18194   5 EHSRQLLQCLREQRSQGFLCDCTVLVG-----SAQFPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNSdiVTAPAFGL 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 74219668 136 LIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18194  78 LLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

183-272

1.20e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 47.18 E-value: 1.20e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 183 NAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDcpQRRF 262
Cdd:cd18470   5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD--QKRV 82

                        90
                ....*....|.
gi 74219668 263 -YVQALLRAVR 272
Cdd:cd18470  83 kYAADLLSNIR 93

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-147

1.22e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 47.97 E-value: 1.22e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVkyEDipaAQFMAHKVVLASSSPVFK-------------AMFTNGLREQGMEVVSIEGIHPKVM 133
Cdd:cd18195   9 LNEQRLRGLFCDVTLIA--GD---TKFRAHRSVLAASSPYFRellssplplgaaaVAAAPGATQSPERVLELPGVKAGVF 83

                        90
                ....*....|....
gi 74219668 134 ERLIEFAYTASISV 147
Cdd:cd18195  84 SDVLNFIYSSRVAL 97

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-173

1.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 47.48 E-value: 1.30e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  62 QAFGVMNELRLSQQLCDVTLQVKYEDIPaaqfmAHKVVLASSSPVFKAMFTNGLREQGMEVV-SIEGIHPKVMERLIEFA 140
Cdd:cd18293   1 TAFLQLHRQQNSGVFCDVLLQAEGESVP-----AHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFL 75

                        90       100       110
                ....*....|....*....|....*....|...
gi 74219668 141 YTASISVGEKCVLHVMNGAVMYQIDSVVRACSD 173
Cdd:cd18293  76 YTSELEVSSEEAQDVLAAARRLQISELESLCLE 108

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-150

1.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 47.48 E-value: 1.33e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVkyEDIpaaQFMAHKVVLASSSPVFKAMFTN-GLREQGmEVVSIEGIHPKVMERLI 137
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVV--EDT---KFKAHKNVLAASSLYFKNAFSSqEIWISS-HVLELPDLKAEVFAEIL 74

                        90
                ....*....|...
gi 74219668 138 EFAYTASISVGEK 150
Cdd:cd18223  75 NFIYSSKVVVKRQ 87

PLN02193

nitrile-specifier protein

323-500

2.26e-06

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 50.34 E-value: 2.26e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  323 KVGRLIYTAGGYF--RQSL-SYLEAYNPSNGSW-LRLADLQVPR-SGLAGCVV--GGLLYAVGGRNNSPDGNTDSSaldc 395
Cdd:PLN02193 173 QVGNKIYSFGGEFtpNQPIdKHLYVFDLETRTWsISPATGDVPHlSCLGVRMVsiGSTLYVFGGRDASRQYNGFYS---- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  396 YNPMTNQW---SPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEW-HLVAPM--LTRRIGVGVAVLN 469
Cdd:PLN02193 249 FDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfHCSTPGdsFSIRGGAGLEVVQ 328

                        170       180       190
                 ....*....|....*....|....*....|.
gi 74219668  470 RLLYAVGGFDGTnRLNSAECYYPERNEWRMI 500
Cdd:PLN02193 329 GKVWVVYGFNGC-EVDDVHYYDPVQDKWTQV 358

Kelch_3

Galactose oxidase, central domain;

564-608

2.54e-06

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 44.59 E-value: 2.54e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 74219668   564 GKIYVLGGYD--GHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAV 608
Cdd:pfam13415   2 DKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48

Kelch_6

Kelch motif;

553-601

2.81e-06

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 44.63 E-value: 2.81e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 74219668   553 HRSALGITVHQGKIYVLGGY-DGHTFLDSVECYDPDSDTWSEVTRMTSGR 601
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-145

3.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 46.75 E-value: 3.01e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNglreQGMEVV---SIEGIHPKVME 134
Cdd:cd18224   8 DHPNNLLKELNKCRLSETMCDVTIVVG-----NRSFAAHKAVLACAAGYFQKLFLS----TELDVArtyVVDFITPANFE 78

                        90
                ....*....|.
gi 74219668 135 RLIEFAYTASI 145
Cdd:cd18224  79 KVLSFIYTSEL 89

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

95-184

3.90e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 46.55 E-value: 3.90e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  95 AHKVVLASSSPVFKAMFTNGLREQGMEVvSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18348  39 GHKYVLAVGSSVFHAMFYGELAEDKDEI-RIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNF 117

                        90
                ....*....|
gi 74219668 175 LVQQLDPSNA 184
Cdd:cd18348 118 LETSLSAKNA 127

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-180

5.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 46.10 E-value: 5.43e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAM--FTNG-LREQG----MEVVSIEGihpkvMERLIEF 139
Cdd:cd18201  12 LNEQRKKGILCDVNIVVS-----GKVFRAHKNILVAGSRFFKTLycFTNKeSCDQTtvthLDVVAVQG-----FSVILDF 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 74219668 140 AYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Cdd:cd18201  82 MYSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

Kelch_6

Kelch motif;

506-552

5.59e-06

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 43.86 E-value: 5.59e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 74219668   506 IRSGAGVCVLHNCIYAAGGYDGQDQ-LNSVERYDVETETWTFVAPMRH 552
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPaLNKLEVYNPLTKSWEELPPLPT 48

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

95-183

6.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 45.17 E-value: 6.64e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  95 AHKVVLASSSPVFKAMFTNglreqgmEVVSIEGIHPKVMERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18275  18 AHKSVLAAKSDYFRARLSR-------DILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPCAAQCAVDA 90


                ....*....
gi 74219668 175 LVQQLDPSN 183
Cdd:cd18275  91 VRAQLCLGN 99

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-149

7.81e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 45.18 E-value: 7.81e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQ-QLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTnglREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18226   4 YNKNLLKYLNDDRQKQsSFCDLVITVE-----GKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLL 75

                        90
                ....*....|..
gi 74219668 138 EFAYTASISVGE 149
Cdd:cd18226  76 EFLYTSEFFVYE 87

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

79-142

7.89e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 44.19 E-value: 7.89e-06

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74219668  79 VTLQVKYEdipaaQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYT 142
Cdd:cd01165   1 VVLVVEGE-----KFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYG 59

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-178

8.36e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 46.18 E-value: 8.36e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18324   5 DHSRHLLQCLSEQRHQGFLCDCTVLVG-----DAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Cdd:cd18324  80 EFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-175

9.45e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 44.92 E-value: 9.45e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  64 FGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGM-EVVSIEGIHPKVMERLIEFAYT 142
Cdd:cd18330   6 LGELNEQRKRDFFCDCSIIVE-----GRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDIVTSEAFSIILDFLYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 74219668 143 ASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18330  81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-145

9.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 44.96 E-value: 9.88e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  56 LEDHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMftngLREQGMEVVSIEGIHPKVMER 135
Cdd:cd18334   1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVE-----NALFRAHKNILAASSMYFKSL----VLHDNLINLDTDMVNPTVFRQ 71

                        90
                ....*....|
gi 74219668 136 LIEFAYTASI 145
Cdd:cd18334  72 ILDFIYTGKL 81

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-181

1.19e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 44.82 E-value: 1.19e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  54 YTLEDHTKQAFGVMNELRLSQQLCDVTLQVKYEDIPaaqfmAHKVVLASSSPVFKAMFTngLREQGMEVVSIEGiHPKVM 133
Cdd:cd18214   3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVP-----GHKVVFAAGSPFLRDQFL--LNDSREVQISILQ-NSEVG 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 74219668 134 ERLIEFAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDP 181
Cdd:cd18214  75 RQLLLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

58-171

1.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 45.03 E-value: 1.43e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  58 DHTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLI 137
Cdd:cd18325   5 DHSRQLLQCLSQQRHQGFLCDCTVLVG-----EAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLL 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 74219668 138 EFAYTASISVGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18325  80 EFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

1.44e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 44.94 E-value: 1.44e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTnGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18278  22 LNDQRKQDILCDVTLIVE-----GKEFRAHRAVLAACSEYFLQALV-GQTENDLVVSLPEEVTARGFGPLLQFAYTAKLL 95

                        90       100
                ....*....|....*....|....*....
gi 74219668 147 VGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18278  96 LSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

PLN02153

epithiospecifier protein

412-594

1.77e-05

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 47.29 E-value: 1.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  412 PRNRIGVGVIDGHIYAVGGSHGCIHHSSVERY--EPERDEWHLV-----APMLTRrIGVGVAVLNRLLYAVGGFDGTNRL 484
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGELKPNEHIDKDLYvfDFNTHTWSIApangdVPRISC-LGVRMVAVGTKLYIFGGRDEKREF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  485 NSAECYYPERNEWRMITPMNTI-----RSGAGVCVLHNCIYAAGG------YDGQDQLNSVERYDVETETWTFVA-PMRH 552
Cdd:PLN02153 101 SDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYNIADGKWVQLPdPGEN 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74219668  553 --HRSALGITVHQGKIYVL---------GGYDGHTFlDSVECYDPDSDTWSEV 594
Cdd:PLN02153 181 feKRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEV 232

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

183-272

2.04e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 43.57 E-value: 2.04e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 183 NAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDcPQRRF 262
Cdd:cd18449   5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                        90
                ....*....|
gi 74219668 263 YVQALLRAVR 272
Cdd:cd18449  84 FAAKLMENIR 93

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

2.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 44.09 E-value: 2.09e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQvkyedIPAAQFMAHKVVLASSSPVFKAMFtngLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18197  16 MNLLRQQNLFCDVSIY-----INDTEFHGHKVILAACSTFMRDQF---LLNQSKQVRITILQSAEVGRKLLLSCYTGALE 87

                        90       100
                ....*....|....*....|....*....
gi 74219668 147 VGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18197  88 VKKKELLKYLTAASYLQMVHIVEKCTEAL 116

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

554-597

2.16e-05

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 41.94 E-value: 2.16e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 74219668   554 RSALGITVHQGKIYVLGGYDGH--TFLDSVECYDPDSDTWSEVTRM 597
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPRL 47

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-174

2.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 43.59 E-value: 2.23e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLqvkyeDIPAAQFMAHKVVLASSSPVFKAMFTNGLreqGMEVVSIEGIhPKVMERLIE 138
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATL-----DVGGRVFKAHWSVLACCSHFFQSLYGDGT---SGSVVLPESF-AEVFGLLLD 71

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 74219668 139 FAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Cdd:cd18232  72 FFYTGELALTRENRDRVLLAAKELRVPEAVELCQRF 107

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-175

2.97e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 43.73 E-value: 2.97e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNGlREQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVK-----GVCFKAHKNVLAAFSQYFRSLFQNS-SSQKNDVFHLDIKNVGGIGQILD 74

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 74219668 139 FAYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFL 175
Cdd:cd18233  75 FMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111

Kelch_6

Kelch motif;

361-413

3.68e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 41.55 E-value: 3.68e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 74219668   361 PRSGLAGCVVGGLLYAVGGRNNspdGNTDSSALDCYNPMTNQWSPCASMSVPR 413
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTN---ASPALNKLEVYNPLTKSWEELPPLPTPR 50

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

185-278

4.19e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 42.59 E-value: 4.19e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 185 IGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDcPQRRFYV 264
Cdd:cd18465   7 LNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRASA 85

                        90
                ....*....|....
gi 74219668 265 QALLravrCHALTP 278
Cdd:cd18465  86 SHVL----CHIRFP 95

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

67-175

5.35e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 42.92 E-value: 5.35e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  67 MNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFtngLREQGMEVVSIEGIHPKVMERLIEFAYTASIS 146
Cdd:cd18200   9 LNKHRLEGKFCDLSVHVQ-----GRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 74219668 147 VGEKCV---LHVMNGAVMYQidsVVRACSDFL 175
Cdd:cd18200  81 LCMDALpshLLVASGLQMWQ---VVDRCSELL 109

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

59-159

5.73e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 42.58 E-value: 5.73e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNglREQGMEVVSIEgIHPKVMERLIE 138
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVG-----GRSYGVHSVILAAVSSLFRERLLG--SNGPLPPLSLE-VTPVGWEAVLT 72

                        90       100
                ....*....|....*....|.
gi 74219668 139 FAYTASISVGEKCVLHVMNGA 159
Cdd:cd18262  73 FAYTGVLGRNPATVGDILVAA 93

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-185

6.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 43.04 E-value: 6.68e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVkyEDIPaaqFMAHKVVLASSSPVFKAMFTNGLREQGmEVVSIEGIHPKVMERLIEFAY---TASISVGE 149
Cdd:cd18351  21 NKEMSDVTFLV--EGRP---FYAHKVLLFTASPRFKALLSNKPSAEN-TCIEISYVKYHIFQLVMQYLYcggTESLLIKN 94

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 74219668 150 KCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18351  95 NEIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130

BTB_POZ_BT

cd18313

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

93-179

6.79e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349622 [Multi-domain] Cd Length: 102 Bit Score: 42.08 E-value: 6.79e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  93 FMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGE--KCVLHVMNGAVMYQIDSVVRA 170
Cdd:cd18313  14 IPAHSNVLASASPVIAGMLKQPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEEmeKFGIHLLVLSHVYVVPQLKRV 93


                ....*....
gi 74219668 171 CSDFLVQQL 179
Cdd:cd18313  94 CEKGLEQGL 102

BACK_BTBD17

cd18493

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...

190-253

9.95e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

Pssm-ID: 350568 Cd Length: 74 Bit Score: 41.02 E-value: 9.95e-05

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74219668 190 FAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWV 253
Cdd:cd18493  11 YAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

PHA02713

hypothetical protein; Provisional

449-596

1.09e-04

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 45.39 E-value: 1.09e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  449 EWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDG 527
Cdd:PHA02713 283 EYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNG 362

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74219668  528 QDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVEC-----YDPDSDTWSEVTR 596
Cdd:PHA02713 363 TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVHHmnsidMEEDTHSSNKVIR 436

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

73-185

1.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 41.93 E-value: 1.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  73 SQQLCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKamFTNGLREQGMEvvsIEGIHPKVMERLIEFAYT--ASISVGEK 150
Cdd:cd18303  15 KELYSDITIKLADKSIPA-----HKFVLAARSEKWS--NENLASTNELD---LSDISYEVVLALLRWLYTdeLDLTLDDE 84

                        90       100       110
                ....*....|....*....|....*....|....*
gi 74219668 151 CVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
Cdd:cd18303  85 FLLELMKAAKRFQLTDLVERCERALMSSVNVDNCI 119

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-171

1.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 41.81 E-value: 1.25e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFT-NGLREQGMEVVSiegihPKVMERLI 137
Cdd:cd18333   4 HSRQLLLQLNTQRTKGFLCDVIIVVQ-----NALFRAHKNILAASSVYLKSLVVhDNLINLDHEMVS-----PGIFRLIL 73

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 74219668 138 EFAYTASISVG----EKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18333  74 DYIYTGRLSEGdpgsEQNLGAVLAAASYLQIPDLVALC 111

BACK_BTBD3_like

cd18488

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...

198-261

1.52e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

Pssm-ID: 350563 Cd Length: 95 Bit Score: 41.20 E-value: 1.52e-04

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74219668 198 ELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRcESEVFHACIDWVKYDCpQRR 261
Cdd:cd18488  20 ELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWAEAEC-QRR 81

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

179-265

1.90e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 40.71 E-value: 1.90e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCP 258
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                ....*..
gi 74219668 259 QRRFYVQ 265
Cdd:cd18451  81 ERERYFE 87

Kelch_6

Kelch motif;

420-460

2.34e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 39.24 E-value: 2.34e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 74219668   420 VIDGHIYAVGG-SHGCIHHSSVERYEPERDEWHLVAPMLTRR 460
Cdd:pfam13964   9 SVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50

PRK14131

N-acetylneuraminate epimerase;

323-431

2.36e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 43.85 E-value: 2.36e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  323 KVGRLIYTAGGYFRQSLSYLEAYNPSNGsWLRLADLQ-VPRSGLAGCVVGGLLYAVGGRNNSPDgNTDSSALD---CYNP 398
Cdd:PRK14131  36 IDNNTVYVGLGSAGTSWYKLDLNAPSKG-WTKIAAFPgGPREQAVAAFIDGKLYVFGGIGKTNS-EGSPQVFDdvyKYDP 113

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 74219668  399 MTNQWSPCASMSvPRNRIG-VGVI--DGHIYAVGGS 431
Cdd:PRK14131 114 KTNSWQKLDTRS-PVGLAGhVAVSlhNGKAYITGGV 148

Kelch_3

Galactose oxidase, central domain;

469-515

2.60e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 38.81 E-value: 2.60e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 74219668   469 NRLLYAVGG--FDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVL 515
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

PRK14131

N-acetylneuraminate epimerase;

507-577

4.63e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 42.69 E-value: 4.63e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  507 RSGAGVCVLHNCIYAAGGY-----DGQDQL-NSVERYDVETETWTFVaPMRHHRSALG---ITVHQGKIYVLGGYDGHTF 577
Cdd:PRK14131  75 REQAVAAFIDGKLYVFGGIgktnsEGSPQVfDDVYKYDPKTNSWQKL-DTRSPVGLAGhvaVSLHNGKAYITGGVNKNIF 153

Kelch_3

Galactose oxidase, central domain;

371-413

7.99e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 37.65 E-value: 7.99e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 74219668   371 GGLLYAVGGRNnsPDGNTDSSALDCYNPMTNQWSPCASMSVPR 413
Cdd:pfam13415   1 GDKLYIFGGLG--FDGQTRLNDLYVYDLDTNTWTQIGDLPPPR 41

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

324-359

1.35e-03

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 36.82 E-value: 1.35e-03

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 74219668   324 VGRLIYTAGGY-FRQSLSYLEAYNPSNGSWLRLADLQ 359
Cdd:pfam01344  10 VGGKIYVIGGFdGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

361-409

1.36e-03

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 36.93 E-value: 1.36e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 74219668   361 PRSGLAGCVVGGLLYAVGGRNNSPDgnTDSSALDCYNPMTNQWSPCASM 409
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGD--LSSSDVLVYDPETNVWTEVPRL 47

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

96-177

1.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 38.80 E-value: 1.49e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  96 HKVVLaSSSPVFKAMFTNGLREQGMEVVSIEGIHPKV-MERL-IEFA--YTASISVGEKCVLHVMNGAVMYQIDSVVRAC 171
Cdd:cd18305  30 HKIYL-CQSGYFASMFSGSWKESKETVINLEIPDDNItVEALnVVFGslYRDEIEIKPSRVVSILAAATLLQLDGLIQQC 108


                ....*.
gi 74219668 172 SDFLVQ 177
Cdd:cd18305 109 SEVMKE 114

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

507-550

1.51e-03

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 36.93 E-value: 1.51e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 74219668   507 RSGAGVCVLHNCIYAAGGYDGQDQL--NSVERYDVETETWTFVAPM 550
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLssSDVLVYDPETNVWTEVPRL 47

BTB_POZ_KLHL42

cd18319

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

100-149

1.68e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349628 [Multi-domain] Cd Length: 93 Bit Score: 37.93 E-value: 1.68e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 74219668 100 LASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGE 149
Cdd:cd18319  20 LIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQ 69

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-172

2.07e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 38.28 E-value: 2.07e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  59 HTKQAFGVMNELRLSQQLCDVTLQVKyedipAAQFMAHKVVLASSSPVFKAMFTNglreQGMEVVSIEGIHPKVMERLIE 138
Cdd:cd18216   3 HATQLLLQLNNQRTKGFLCDVIIVVE-----NSLFRAHKNVLAASSGYFKSLVLH----DNLIHLDQDMVSPTVFQQILD 73

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 74219668 139 FAYTASISVGEKCVLH---VMNGAVMYQIDSVVRACS 172
Cdd:cd18216  74 FIYTGKLLDSLFEEPNlseVLAAANYLQLPDLAALCR 110

BTB2_POZ_RHOBTB3

cd18360

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

76-179

2.07e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349669 [Multi-domain] Cd Length: 110 Bit Score: 38.29 E-value: 2.07e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668  76 LCDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISVGEkcVLHV 155
Cdd:cd18360  10 LADVVFKIQGTTVPA-----HRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPAS--ILQA 82

                        90       100
                ....*....|....*....|....*..
gi 74219668 156 MN---GAVMYQIDSVVRACSDFLVQQL 179
Cdd:cd18360  83 MAlliCAEMYQVSRLQHICELYIITQL 109

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

179-272

2.28e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 37.96 E-value: 2.28e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74219668 179 LDPSNAIGIANFAEQIGCTELHQRAREYIYMHFGEVAK--QEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYD 256
Cdd:cd18471   1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKshPEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                        90
                ....*....|....*.
gi 74219668 257 CpqRRFYVQALLRAVR 272
Cdd:cd18471  81 C--RYQYMDELLQYVR 94

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

197-272

2.32e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 37.98 E-value: 2.32e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74219668 197 TELHQRAREYIYMHFGEVAKQEEFFNLSHCQLATLISRDDLnvrC--ESEVFHACIDWVKYDcPQRRFYVQALLRAVR 272
Cdd:cd14822  19 DDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSF---CapEVDIFNAVRRWCEHN-PDSKEDAKEILEAVR 92

Kelch_6

Kelch motif;

324-362

3.15e-03

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 36.16 E-value: 3.15e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 74219668   324 VGRLIYTAGGYFRQS--LSYLEAYNPSNGSWLRLADLQVPR 362
Cdd:pfam13964  10 VGGYIYVFGGYTNASpaLNKLEVYNPLTKSWEELPPLPTPR 50

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

77-146

4.28e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 37.75 E-value: 4.28e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74219668  77 CDVTLQVKYEDIPAaqfmaHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHP--KVMERLIEFAYTASIS 146
Cdd:cd18309  21 CDITLLLDGHPIPA-----HKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPsrQAFDSLLRYIYYGDVT 87

Kelch_3