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Conserved domains on  [gi|62087448|dbj|BAD92171|]
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plexin C1 variant, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
655-1173 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 768.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    655 TVPFLDYKHFALRTFFPESGgfTHIFTEDM-----HNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCL 729
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVE--DHPLLVLLdvpvtNDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCN 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    730 FASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQ-PKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLN 808
Cdd:pfam08337   79 VASLLMVALHGKLEYATEILKTLLRDLIDKSVESKnPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    809 QKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVVFEKIPENESadvcrnISVNVLDCDTIGQAKEKIFQAFLSKN 888
Cdd:pfam08337  159 QQVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSES------VPVKVLDCDTITQVKEKILDAIYKNT 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    889 GSPYGLQLNEIGLELQMG-TRQKELLDIDSSSVIlEDGITKLNTIGHYEISNGSTIKVFKKianftsdveysddHCHLIL 967
Cdd:pfam08337  233 PYSQRPSIDEVDLEWRHGrGGRLTLQDEDSTSKV-EGGWKKLNTLAHYKVPDGATLALIPK-------------YWHLVK 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    968 PDSEAfqdvQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPD 1047
Cdd:pfam08337  299 PSDEG----DQRKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPNSALPLAVKYLFDFLDEQAEKHGITDPE 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448   1048 VVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKS 1127
Cdd:pfam08337  375 VLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPRYKQMVER 454
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 62087448   1128 YYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVK 1173
Cdd:pfam08337  455 YYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
Sema super family cl15693
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
1-96 1.84e-55

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


The actual alignment was detected with superfamily member cd11246:

Pssm-ID: 472829  Cd Length: 401  Bit Score: 198.59  E-value: 1.84e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    1 DQPERVQ-PIASS----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPD 75
Cdd:cd11246  301 DFPERVQvPIAPSnnltTLIHSDLVSVYGTVVLNRTVLFLGTGDGQLLKVILGENMTSNCPEVLYEIKEETPVFYKLVPD 380
                         90       100
                 ....*....|....*....|.
gi 62087448   76 PVKNIYIYLTAGKEVRRIRVA 96
Cdd:cd11246  381 PVNNIYIYLTSGNKVRRIPVA 401
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
97-150 6.73e-16

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 72.74  E-value: 6.73e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 62087448     97 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE-NLENWLDISSgakKCP 150
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEgNCEEWEQASS---KCP 52
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
397-483 1.27e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.00  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    397 PHCSLIFPATTWISGGQNITMMGRNFDVID---NLIISHELKGNINVSEYCVAtycgFLAPSLKSSKVRTNVTVKLrvQD 473
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIV----CTTPPGTSGLVNVSVTVGG--GG 74
                           90
                   ....*....|
gi 62087448    474 TYLDCGTLQY 483
Cdd:pfam01833   75 ISSSPLTFTY 84
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
234-278 6.08e-06

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 44.46  E-value: 6.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 62087448     234 NCSSLKECPACVETG---CAWCKSARRCIHPfTACDPSDYERNQEQCP 278
Cdd:smart00423    1 RCSKYTSCSECLLARdpyCAWCSSQGRCTSG-ERCDSRRQNWLSGGCP 47
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
307-393 5.46e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.82  E-value: 5.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    307 IKSIEPQRVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGN-C 385
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPC------TVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiS 76

                   ....*...
gi 62087448    386 SSVGSLSY 393
Cdd:pfam01833   77 SSPLTFTY 84
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
655-1173 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 768.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    655 TVPFLDYKHFALRTFFPESGgfTHIFTEDM-----HNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCL 729
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVE--DHPLLVLLdvpvtNDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCN 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    730 FASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQ-PKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLN 808
Cdd:pfam08337   79 VASLLMVALHGKLEYATEILKTLLRDLIDKSVESKnPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    809 QKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVVFEKIPENESadvcrnISVNVLDCDTIGQAKEKIFQAFLSKN 888
Cdd:pfam08337  159 QQVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSES------VPVKVLDCDTITQVKEKILDAIYKNT 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    889 GSPYGLQLNEIGLELQMG-TRQKELLDIDSSSVIlEDGITKLNTIGHYEISNGSTIKVFKKianftsdveysddHCHLIL 967
Cdd:pfam08337  233 PYSQRPSIDEVDLEWRHGrGGRLTLQDEDSTSKV-EGGWKKLNTLAHYKVPDGATLALIPK-------------YWHLVK 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    968 PDSEAfqdvQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPD 1047
Cdd:pfam08337  299 PSDEG----DQRKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPNSALPLAVKYLFDFLDEQAEKHGITDPE 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448   1048 VVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKS 1127
Cdd:pfam08337  375 VLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPRYKQMVER 454
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 62087448   1128 YYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVK 1173
Cdd:pfam08337  455 YYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
653-1210 0e+00

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 747.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  653 FGTVPFLDYKHFALRTFFPESGGFTHIFT-EDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFA 731
Cdd:cd12789    1 FGTVPFLDYKHFALRTFFPESGGFTHIFTrDDPHDRDQTDKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  732 SFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKI 811
Cdd:cd12789   81 SFLTIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  812 NKGPVDVItckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflskngsp 891
Cdd:cd12789  161 NKGPVDVI------------------------------------------------------------------------ 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  892 yglqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpdse 971
Cdd:cd12789      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  972 afqdvqgkrhrgkhKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHI 1051
Cdd:cd12789  169 --------------KFKVKEMYLTKLLSTKVAIHSVVEKLFRSIWSLPNNKAPVAIKYFFDFLDAQAENKKITDPDVLHI 234
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1052 WKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKA 1131
Cdd:cd12789  235 WKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTNKLLYAKDIPQYKEEVKSYYKA 314
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62087448 1132 IRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFDEKKKCKW 1210
Cdd:cd12789  315 IRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLERERGLEEVQKQLLHVKALFDEKKKCKW 393
Sema_plexin_C1 cd11246
The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin ...
1-96 1.84e-55

The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin receptors. Plexin C1 has been identified as the receptor of semaphorin 7A, which plays regulation roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A-Plexin C1 signaling. Cofilin is not phosphorylated when Plexin C1 expression is silenced. Thus, melanoma invasion and metastasis may be promoted through the loss of Plexin C1 inhibitory signaling on cofilin activation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200507  Cd Length: 401  Bit Score: 198.59  E-value: 1.84e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    1 DQPERVQ-PIASS----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPD 75
Cdd:cd11246  301 DFPERVQvPIAPSnnltTLIHSDLVSVYGTVVLNRTVLFLGTGDGQLLKVILGENMTSNCPEVLYEIKEETPVFYKLVPD 380
                         90       100
                 ....*....|....*....|.
gi 62087448   76 PVKNIYIYLTAGKEVRRIRVA 96
Cdd:cd11246  381 PVNNIYIYLTSGNKVRRIPVA 401
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
97-150 6.73e-16

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 72.74  E-value: 6.73e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 62087448     97 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE-NLENWLDISSgakKCP 150
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEgNCEEWEQASS---KCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
97-150 5.49e-14

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 67.18  E-value: 5.49e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 62087448      97 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCvhSENLENWLDISsgakkCP 150
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERC--DSRRQNWLSGG-----CP 47
Sema smart00630
semaphorin domain;
2-78 1.30e-13

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 74.33  E-value: 1.30e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448       2 QPERVQPIASSTLIHSDLTSVYGTVVM---NRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKeetpVFYKlvPDPVK 78
Cdd:smart00630  317 QPLTGRPLFVKTDSNYLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSESVVLEEIS----VFPD--GSPIS 390
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
397-483 1.27e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.00  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    397 PHCSLIFPATTWISGGQNITMMGRNFDVID---NLIISHELKGNINVSEYCVAtycgFLAPSLKSSKVRTNVTVKLrvQD 473
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIV----CTTPPGTSGLVNVSVTVGG--GG 74
                           90
                   ....*....|
gi 62087448    474 TYLDCGTLQY 483
Cdd:pfam01833   75 ISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
396-484 2.35e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.42  E-value: 2.35e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448     396 LPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGN----INVSEycVATYCgfLAPSLKSSKVRTNV-TVKLR 470
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEApctfSPSSS--TAIVC--KTPPYHNIPGSVPVrTVGLR 76
                            90
                    ....*....|....
gi 62087448     471 VQDTYLDCGTLQYR 484
Cdd:smart00429   77 NGGVPSSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
397-485 5.91e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 48.61  E-value: 5.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  397 PHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHelKGNINVS-EYCVATYCGFLAPSLKSS-KVRTNVTVKLRVQDT 474
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTF--GGGVPCSvLSVSSTAIVCTTPPYANPgPGPVEVTVDRGNGGI 78
                         90
                 ....*....|.
gi 62087448  475 YLDCGTLQYRE 485
Cdd:cd00102   79 TSSPLTFTYVP 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
234-278 6.08e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 44.46  E-value: 6.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 62087448     234 NCSSLKECPACVETG---CAWCKSARRCIHPfTACDPSDYERNQEQCP 278
Cdd:smart00423    1 RCSKYTSCSECLLARdpyCAWCSSQGRCTSG-ERCDSRRQNWLSGGCP 47
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
234-278 6.40e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 44.62  E-value: 6.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 62087448    234 NCSSLKECPACVE---TGCAWCKSARRCIHP----FTACDPSDYERNQEQCP 278
Cdd:pfam01437    1 RCSQYTSCSSCLAardPYCGWCSSEGRCVRRsacgAPEGNCEEWEQASSKCP 52
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
1-80 1.82e-05

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 46.49  E-value: 1.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448      1 DQPERVQPIASST----LIHSD--LTSVYGTVVM----NRTVLFLGTGDGQLLKVIlgeNLTSNCPEVIyeikEETPVFy 70
Cdd:pfam01403   96 DHPLMDEAVQPVGgrplLVRTGvrLTSIAVDRVQaldgNYTVLFLGTDDGRLHKVV---LVGSEESHII----EEIQVF- 167
                           90
                   ....*....|
gi 62087448     71 kLVPDPVKNI 80
Cdd:pfam01403  168 -PEPQPVLNL 176
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
307-393 5.46e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.82  E-value: 5.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    307 IKSIEPQRVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGN-C 385
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPC------TVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiS 76

                   ....*...
gi 62087448    386 SSVGSLSY 393
Cdd:pfam01833   77 SSPLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
307-390 4.30e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 37.44  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  307 IKSIEPQRVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMK-DVCIQFDGGNC 385
Cdd:cd00102    3 ITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPC------SVLSVSSTAIVCTTPPYANPGPgPVEVTVDRGNG 76

                 ....*
gi 62087448  386 SSVGS 390
Cdd:cd00102   77 GITSS 81
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
655-1173 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 768.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    655 TVPFLDYKHFALRTFFPESGgfTHIFTEDM-----HNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCL 729
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVE--DHPLLVLLdvpvtNDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCN 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    730 FASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQ-PKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLN 808
Cdd:pfam08337   79 VASLLMVALHGKLEYATEILKTLLRDLIDKSVESKnPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIK 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    809 QKINKGPVDVITCKALYTLNEDWLLWQVPEFSTVALNVVFEKIPENESadvcrnISVNVLDCDTIGQAKEKIFQAFLSKN 888
Cdd:pfam08337  159 QQVEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENSES------VPVKVLDCDTITQVKEKILDAIYKNT 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    889 GSPYGLQLNEIGLELQMG-TRQKELLDIDSSSVIlEDGITKLNTIGHYEISNGSTIKVFKKianftsdveysddHCHLIL 967
Cdd:pfam08337  233 PYSQRPSIDEVDLEWRHGrGGRLTLQDEDSTSKV-EGGWKKLNTLAHYKVPDGATLALIPK-------------YWHLVK 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    968 PDSEAfqdvQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPD 1047
Cdd:pfam08337  299 PSDEG----DQRKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVPNSALPLAVKYLFDFLDEQAEKHGITDPE 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448   1048 VVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKS 1127
Cdd:pfam08337  375 VLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPRYKQMVER 454
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 62087448   1128 YYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVK 1173
Cdd:pfam08337  455 YYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
653-1210 0e+00

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 747.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  653 FGTVPFLDYKHFALRTFFPESGGFTHIFT-EDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFA 731
Cdd:cd12789    1 FGTVPFLDYKHFALRTFFPESGGFTHIFTrDDPHDRDQTDKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  732 SFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKI 811
Cdd:cd12789   81 SFLTIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  812 NKGPVDVItckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflskngsp 891
Cdd:cd12789  161 NKGPVDVI------------------------------------------------------------------------ 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  892 yglqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpdse 971
Cdd:cd12789      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  972 afqdvqgkrhrgkhKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHI 1051
Cdd:cd12789  169 --------------KFKVKEMYLTKLLSTKVAIHSVVEKLFRSIWSLPNNKAPVAIKYFFDFLDAQAENKKITDPDVLHI 234
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1052 WKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKA 1131
Cdd:cd12789  235 WKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTNKLLYAKDIPQYKEEVKSYYKA 314
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62087448 1132 IRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQKQLLHVKVLFDEKKKCKW 1210
Cdd:cd12789  315 IRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLERERGLEEVQKQLLHVKALFDEKKKCKW 393
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
655-1200 2.77e-170

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 508.30  E-value: 2.77e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  655 TVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFL 734
Cdd:cd12205    1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  735 TIALQTKLVYLTSILEVLTRDLMEQCSNM-QPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINK 813
Cdd:cd12205   81 MVALQGKMEYATEILFDLLTDLIEKSVSKkHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIEK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  814 GPVDVITckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflskngspyg 893
Cdd:cd12205  161 GPVDAIK------------------------------------------------------------------------- 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  894 lqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpdseaf 973
Cdd:cd12205      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  974 qdvqgkrhrgkhkfKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWK 1053
Cdd:cd12205  168 --------------LIPEIFLTRLLSTKGTLQKFVDDLFESILSVPQRSLPPAIKYLFDFLDEQARKHGISDPDVLHAWK 233
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1054 TNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIR 1133
Cdd:cd12205  234 TNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGKDSPSNKLLFAKDIPRYREMVANFYRDIS 313
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62087448 1134 DLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQ--KQLLHVKV 1200
Cdd:cd12205  314 NLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDDREARVQQlaDKLSQVAR 382
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
656-1194 3.88e-137

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 423.25  E-value: 3.88e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  656 VPFLDYKHFALRTFFPESGGF----------------------THIFTEDMHNRDANDKN--ESLTALDALICNKSFLVT 711
Cdd:cd12788    3 IPFLEYKHFVTRTFFPKCSSLyeeryvlpsqennsqgprqvpeTHPLLQEWKIPESCRPNmeEGITLFSTLLNNKHFLVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  712 VIHTLEKQKNFSVKDRCLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGF 791
Cdd:cd12788   83 FVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYSY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  792 LRETVGEPFYLLVTTLNQKINKGPVDVItckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcd 871
Cdd:cd12788  163 LRETVGEPFFLLLCAIKQQINKGSIDAI---------------------------------------------------- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  872 tigqakekifqaflskngspyglqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfKKIan 951
Cdd:cd12788  191 ---------------------------------------------------------------------------KKV-- 193
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  952 ftsdveysddhchliLPdseafqdvqgkrhrgkhkfkvkEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNSRAPFAIKYFF 1031
Cdd:cd12788  194 ---------------LP----------------------EIYLTRLLSTKGTLQKFLDDLFQAILSIPEDRPPLAVKYFF 236
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1032 DFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNK 1111
Cdd:cd12788  237 DFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMDACLSVIAQAFIDACSISDLQLGKDSPTNK 316
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1112 LLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEA 1191
Cdd:cd12788  317 LLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNVAMAEIYKYAKRYRAQIVSALESNPTARRT 396

                 ...
gi 62087448 1192 QKQ 1194
Cdd:cd12788  397 QLQ 399
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
655-1200 2.20e-123

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 385.62  E-value: 2.20e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  655 TVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASFL 734
Cdd:cd12790    1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  735 TIALQTKLVYLTSILEVLTRDLMEQC--SNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKIN 812
Cdd:cd12790   81 MVVLQSKMEYATDILKQLLADLIEKNleSKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  813 KGPVDVItckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflskngspy 892
Cdd:cd12790  161 KGPIDAI------------------------------------------------------------------------- 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  893 glqlneiglelQMgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpdsea 972
Cdd:cd12790  168 -----------KM------------------------------------------------------------------- 169
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  973 fqdvqgkrhrgkhkfkVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPN--SRAPFAIKYFFDFLDAQAENKKITDPDVVH 1050
Cdd:cd12790  170 ----------------VSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgSALPLAIKYMFDFLDEQADQHGITDPEVVH 233
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1051 IWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYK 1130
Cdd:cd12790  234 TWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYA 313
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1131 AIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERErglEEAQKQLLHVKV 1200
Cdd:cd12790  314 DIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEED---EFARKQRLAYKL 380
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
656-1192 1.83e-115

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 365.02  E-value: 1.83e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  656 VPFLDYKHFALRTFFPESGGfthiftEDMHNRDANDKNES--------LTALDALICNKSFLVTVIHTLEKQKNFSVKDR 727
Cdd:cd12787    2 IPFLDYKTYAERVFFPGHKD------GPLDVMIKLDIPEPrrptveqgLYQLSNLLNSKLFLINFIHTLENQREFSARDR 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  728 CLFASFLTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTL 807
Cdd:cd12787   76 VYVASLLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  808 NQKINKGPVDVitckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflsk 887
Cdd:cd12787  156 KHQVDKGPVDA--------------------------------------------------------------------- 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  888 ngspyglqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlil 967
Cdd:cd12787      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  968 pdseafqdVQGKRHRGkhkfkVKEMYLTKLLSTKVAIHSVLEKLFRSIWSlPNSRAPFAIKYFFDFLDAQAENKKITDPD 1047
Cdd:cd12787  167 --------VTGKRAKA-----IPEIYLTRLLSMKGTLQKFVDDFFQSILS-PGRPVPPAVKYFFDLLDEQAEKHGIQDED 232
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1048 VVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKS 1127
Cdd:cd12787  233 TIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLGRDSPSNKLLYAREIPRYKKMVER 312
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62087448 1128 YYKAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQ 1192
Cdd:cd12787  313 YYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEEDPAAQKMQ 377
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
656-1185 2.84e-110

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 351.07  E-value: 2.84e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  656 VPFLDYKHFALRTFFPESGG--FTHIFTEDMHNRDANDKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASF 733
Cdd:cd12791    2 IPFLDYRTYAERVFFPGHGGcpLQPSLEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  734 LTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINK 813
Cdd:cd12791   82 LSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVDK 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  814 GPVDVITckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflskngspyg 893
Cdd:cd12791  162 GPVDAVT------------------------------------------------------------------------- 168
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  894 lqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpdseaf 973
Cdd:cd12791      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  974 qdvqGKRHRGKhkfKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLpNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWK 1053
Cdd:cd12791  169 ----GKRERAK---AIPEIYLTRLLSMKGTLQKFVDDTFQAILSV-NRPVPIAVKYLFDFLDELAEKHGIEDPETLHIWK 240
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1054 TNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIR 1133
Cdd:cd12791  241 TNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIR 320
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 62087448 1134 DLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERE 1185
Cdd:cd12791  321 QSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEED 372
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
656-1192 2.35e-107

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 343.17  E-value: 2.35e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  656 VPFLDYKHFALRTFFPesGGFTHIFTEDMHNRDANDKN--ESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLFASF 733
Cdd:cd12793    2 IPFLDYRMYAERIFFP--GHRESPLRRDLDVPECRRQTveQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  734 LTIALQTKLVYLTSILEVLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINK 813
Cdd:cd12793   80 LTVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  814 GPVDVITckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflskngspyg 893
Cdd:cd12793  160 GPVDAVT------------------------------------------------------------------------- 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  894 lqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpdseaf 973
Cdd:cd12793      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  974 qdvqgkrhrGKHKFK-VKEMYLTKLLSTKVAIHSVLEKLFRSIwsLPNSR-APFAIKYFFDFLDAQAENKKITDPDVVHI 1051
Cdd:cd12793  167 ---------GKERAKaIPEIYLTRLLSMKGTLQKFVDDLFTVI--LSTSRpVPLAVKYFFDLLDEQALQHGISDPETIHI 235
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1052 WKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKA 1131
Cdd:cd12793  236 WKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYARDIPRYKQMVERYYAD 315
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62087448 1132 IRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQ 1192
Cdd:cd12793  316 IRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQ 376
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
656-1192 6.13e-104

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 334.29  E-value: 6.13e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  656 VPFLDYKHFALRTFF-PESGGFTHIFT----EDMHNRDANdKNESLTALDALICNKSFLVTVIHTLEKQKNFSVKDRCLF 730
Cdd:cd12792    2 IPFLDYKTYTDRVFFlPSKDGANDVMItgklDIPEARRAT-VEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  731 ASFLTIALQTKLVYLTSILEVLTRDLMEQ-CSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQ 809
Cdd:cd12792   81 ASLLTVALHGKLEYYTDIMRTLLLELMEQyVHSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  810 KINKGPVDVitckalytlnedwllwqvpefstvalnvvfekipenesadvcrnisvnvldcdtigqakekifqaflskng 889
Cdd:cd12792  161 QVEKGPVDA----------------------------------------------------------------------- 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  890 spyglqlneiglelqmgtrqkelldidsssviledgitklntighyeisngstikvfkkianftsdveysddhchlilpd 969
Cdd:cd12792      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  970 seafqdVQGKRHRGKhkfKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSlPNSRAPFAIKYFFDFLDAQAENKKITDPDVV 1049
Cdd:cd12792  170 ------VQKKKERTK---AITEIYLTRLLSVKGTLQQFVDNFFRSVLC-SGAVVPPAVKYFFDFLDEQAEKHDIVDEETI 239
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448 1050 HIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYY 1129
Cdd:cd12792  240 HIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNKLLYAKEISTYKKMVDDYY 319
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62087448 1130 KAIRDLPPLSSSEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERERGLEEAQ 1192
Cdd:cd12792  320 KGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSKQ 382
Sema_plexin_C1 cd11246
The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin ...
1-96 1.84e-55

The Sema domain, a protein interacting module, of Plexin C1; Plexins serve as semaphorin receptors. Plexin C1 has been identified as the receptor of semaphorin 7A, which plays regulation roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A-Plexin C1 signaling. Cofilin is not phosphorylated when Plexin C1 expression is silenced. Thus, melanoma invasion and metastasis may be promoted through the loss of Plexin C1 inhibitory signaling on cofilin activation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200507  Cd Length: 401  Bit Score: 198.59  E-value: 1.84e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    1 DQPERVQ-PIASS----TLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKEETPVFYKLVPD 75
Cdd:cd11246  301 DFPERVQvPIAPSnnltTLIHSDLVSVYGTVVLNRTVLFLGTGDGQLLKVILGENMTSNCPEVLYEIKEETPVFYKLVPD 380
                         90       100
                 ....*....|....*....|.
gi 62087448   76 PVKNIYIYLTAGKEVRRIRVA 96
Cdd:cd11246  381 PVNNIYIYLTSGNKVRRIPVA 401
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
827-945 1.89e-38

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 139.25  E-value: 1.89e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    827 LNEDWLLWQVPEFSTVALNVVFEKIPENESadvcrnISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQLNEIGLELQMG 906
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEGEVSES------VPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHG 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 62087448    907 TR-QKELLDIDSSSVIlEDGITKLNTIGHYEISNGSTIKV 945
Cdd:pfam20170   75 RGgRLILQDEDSTSKV-EGGWKKLNTLAHYKVPDGATLAL 113
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
7-96 8.92e-18

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 87.00  E-value: 8.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    7 QPIASSTLIH-SDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGenltSNCPEVIYEIKEET---PVFYKLVPDPvKNIYI 82
Cdd:cd11236  313 VPITTSAVLSdSLLTSVAVTTTRNHTVAFLGTSDGQLKKVVLE----SSSSATQYETLLVDsgsPILPDMVFDP-DGEHL 387
                         90
                 ....*....|....
gi 62087448   83 YLTAGKEVRRIRVA 96
Cdd:cd11236  388 YVMTPKKVTKVPVE 401
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
97-150 6.73e-16

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 72.74  E-value: 6.73e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 62087448     97 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE-NLENWLDISSgakKCP 150
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPEgNCEEWEQASS---KCP 52
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
7-134 1.86e-14

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 77.66  E-value: 1.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    7 QPIASSTLI---------HSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCP-EVIYEIKEETPVFYKLVPDp 76
Cdd:cd11272  374 QPLGGSTPVegvtlytssRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQyEMVSVFKDGSPILRDMAFS- 452
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 62087448   77 VKNIYIYLTAGKEVRRIRVANCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCVHSE 134
Cdd:cd11272  453 IDHKYLYVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAW 510
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
97-150 5.49e-14

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 67.18  E-value: 5.49e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 62087448      97 NCNKHKSCSECLTATDPHCGWCHSLQRCTFQGDCvhSENLENWLDISsgakkCP 150
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERC--DSRRQNWLSGG-----CP 47
Sema smart00630
semaphorin domain;
2-78 1.30e-13

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 74.33  E-value: 1.30e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448       2 QPERVQPIASSTLIHSDLTSVYGTVVM---NRTVLFLGTGDGQLLKVILGENLTSNCPEVIYEIKeetpVFYKlvPDPVK 78
Cdd:smart00630  317 QPLTGRPLFVKTDSNYLLTSIAVDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSESVVLEEIS----VFPD--GSPIS 390
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
397-483 1.27e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.00  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    397 PHCSLIFPATTWISGGQNITMMGRNFDVID---NLIISHELKGNINVSEYCVAtycgFLAPSLKSSKVRTNVTVKLrvQD 473
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIV----CTTPPGTSGLVNVSVTVGG--GG 74
                           90
                   ....*....|
gi 62087448    474 TYLDCGTLQY 483
Cdd:pfam01833   75 ISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
396-484 2.35e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.42  E-value: 2.35e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448     396 LPHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHELKGN----INVSEycVATYCgfLAPSLKSSKVRTNV-TVKLR 470
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEApctfSPSSS--TAIVC--KTPPYHNIPGSVPVrTVGLR 76
                            90
                    ....*....|....
gi 62087448     471 VQDTYLDCGTLQYR 484
Cdd:smart00429   77 NGGVPSSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
397-485 5.91e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 48.61  E-value: 5.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  397 PHCSLIFPATTWISGGQNITMMGRNFDVIDNLIISHelKGNINVS-EYCVATYCGFLAPSLKSS-KVRTNVTVKLRVQDT 474
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTF--GGGVPCSvLSVSSTAIVCTTPPYANPgPGPVEVTVDRGNGGI 78
                         90
                 ....*....|.
gi 62087448  475 YLDCGTLQYRE 485
Cdd:cd00102   79 TSSPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
397-485 3.40e-06

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 46.29  E-value: 3.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  397 PHCSLIFPATTWISGGQNITMMGRNFDVID-NLIISHelkGNIN-VSEYCVATYCGFLAPSLKS-SKVRTNVTVKLR-VQ 472
Cdd:cd00603    1 PVITSISPSSGPLSGGTRLTITGSNLGSGSpRVRVTV---GGVPcKVLNVSSTEIVCRTPAAATpGEGPVEVTVDGAnVS 77
                         90
                 ....*....|...
gi 62087448  473 DTYLDCGTLQYRE 485
Cdd:cd00603   78 ARVLSNTTFTYVE 90
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
234-278 6.08e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 44.46  E-value: 6.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 62087448     234 NCSSLKECPACVETG---CAWCKSARRCIHPfTACDPSDYERNQEQCP 278
Cdd:smart00423    1 RCSKYTSCSECLLARdpyCAWCSSQGRCTSG-ERCDSRRQNWLSGGCP 47
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
6-96 6.21e-06

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 50.23  E-value: 6.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    6 VQPI-ASSTLIHSDLTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSNCPEVIyEIKEETPVFYKLVPDPVKNIYIYL 84
Cdd:cd11247  393 LQPLkATPVFRAPGLTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSV-TVAYGEPVHHVMQFDPSDSTYLYL 471
                         90
                 ....*....|..
gi 62087448   85 TAGKEVRRIRVA 96
Cdd:cd11247  472 MTSHQMTRVKVA 483
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
234-278 6.40e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 44.62  E-value: 6.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 62087448    234 NCSSLKECPACVE---TGCAWCKSARRCIHP----FTACDPSDYERNQEQCP 278
Cdd:pfam01437    1 RCSQYTSCSSCLAardPYCGWCSSEGRCVRRsacgAPEGNCEEWEQASSKCP 52
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
1-80 1.82e-05

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 46.49  E-value: 1.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448      1 DQPERVQPIASST----LIHSD--LTSVYGTVVM----NRTVLFLGTGDGQLLKVIlgeNLTSNCPEVIyeikEETPVFy 70
Cdd:pfam01403   96 DHPLMDEAVQPVGgrplLVRTGvrLTSIAVDRVQaldgNYTVLFLGTDDGRLHKVV---LVGSEESHII----EEIQVF- 167
                           90
                   ....*....|
gi 62087448     71 kLVPDPVKNI 80
Cdd:pfam01403  168 -PEPQPVLNL 176
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
307-393 5.46e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 42.82  E-value: 5.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448    307 IKSIEPQRVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMKDVCIQFDGGN-C 385
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPC------TVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiS 76

                   ....*...
gi 62087448    386 SSVGSLSY 393
Cdd:pfam01833   77 SSPLTFTY 84
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
19-95 1.21e-04

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 45.92  E-value: 1.21e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62087448   19 LTSVYGTVVMNRTVLFLGTGDGQLLKVILgenltSNCPEVIYEIKEET--PVFYKLVPDPVKNiYIYLTAGKEVRRIRV 95
Cdd:cd11276  376 LTAVTVAVENGHTVAFLGTSDGRILKVHL-----SPDPEEYNSILIEKnkPVNKDLVLDKTLE-HLYIMTEDKVFRLPV 448
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
990-1134 1.60e-04

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 44.79  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  990 KEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNsRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNP 1069
Cdd:cd04519  114 KLPVGEDLEENLENLLELVNKLVDRILSSLD-RLPPELRYVFKILREFLAERFPEEPDEAYQAVSGFLFLRFICPAIVSP 192
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62087448 1070 QFVFDIKKTPHIDG--CLSVIAQAFMDAFSLTEqqlgkeaPTNKLLYAKD----IPTYKEEVKSYYKAIRD 1134
Cdd:cd04519  193 ELFGLVPDEPSEQArrNLTLISKVLQSLANGVE-------FGDKEPFMKPlndfIKSNKPKLKQFLDELSS 256
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
19-96 2.56e-03

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 41.84  E-value: 2.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62087448   19 LTSVYGTVVMNRTVLFLGTGDGQLLKVILGENLTSncPEVIYEIKEETPVFYKLVPDPVKNiYIYLTAGKEVRRIRVA 96
Cdd:cd11245  366 LTAVAVAVENGHTIAFLGDSGGQLHKVYLDPNHTD--FYSTIPGDQDSAVNKDLLFDSTLN-HLYVMTGKKISKVPVQ 440
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
307-390 4.30e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 37.44  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62087448  307 IKSIEPQRVSTLGKSNVIVTGANFTRASNITMILKGTSTCdkdviqVSHVLNDTHMKFSLPSSRKEMK-DVCIQFDGGNC 385
Cdd:cd00102    3 ITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPC------SVLSVSSTAIVCTTPPYANPGPgPVEVTVDRGNG 76

                 ....*
gi 62087448  386 SSVGS 390
Cdd:cd00102   77 GITSS 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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