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Conserved domains on  [gi|50511099|dbj|BAD32535|]
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mKIAA1766 protein, partial [Mus musculus]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655294)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 155-337 1.56e-64

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 210.12  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099   155 FAPKSLVLVSRLDYPEIFRACLGLIYTVYVDSM-SVSLESLIANLCAC-LVPAAGGSQKLFSLGAGDRQLIQTPLHDSLP 232
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlPNPIERFIANLLYEvPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099   233 VTGTSVALLFQQLGIQNVLNLFCAVLTENKVLLHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFI 312
Cdd:pfam02141  81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                         170       180
                  ....*....|....*....|....*.
gi 50511099   313 IGVHS-IFKTDVHELLDVIIADLDGG 337
Cdd:pfam02141 161 IGVHSrYFDLLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 46-126 2.87e-26

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 102.41  E-value: 2.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099     46 DYFIVVGYDHEKPGPGEG-LGKIIQRFPQQDWDDTPFPQGIELFCQPGGWHL--SRERKQPTFFVVVLTDIDSDRHYCSC 122
Cdd:smart00800   6 DYFVVVGLDSDTGPLGRSyKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFvtQTSSKDPQFFSFVLTDIDGSRRYGFC 85


                   ....
gi 50511099    123 LTFY 126
Cdd:smart00800  86 LRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 391-459 2.02e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 82.34  E-value: 2.02e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50511099    391 DKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLNGMAFAGFVSER 459
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 155-337 1.56e-64

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 210.12  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099   155 FAPKSLVLVSRLDYPEIFRACLGLIYTVYVDSM-SVSLESLIANLCAC-LVPAAGGSQKLFSLGAGDRQLIQTPLHDSLP 232
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlPNPIERFIANLLYEvPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099   233 VTGTSVALLFQQLGIQNVLNLFCAVLTENKVLLHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFI 312
Cdd:pfam02141  81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                         170       180
                  ....*....|....*....|....*.
gi 50511099   313 IGVHS-IFKTDVHELLDVIIADLDGG 337
Cdd:pfam02141 161 IGVHSrYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 156-337 4.63e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 206.28  E-value: 4.63e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099    156 APKSLVLVSRLDYPEIFRACLGLIYTVYVDSMSVSLEsLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPVTG 235
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLE-LLISLLLYPVPPPGGSLVLVSLGPGDLIELQRPLDSSLPLID 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099    236 TSVALLFQQLGIQNVLNLFCAVLTENKVLLHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGV 315
Cdd:smart00799  80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                          170       180
                   ....*....|....*....|....
gi 50511099    316 HSIFKTDVHELL--DVIIADLDGG 337
Cdd:smart00799 160 HSSYFEEVKELPdeDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 46-126 2.87e-26

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 102.41  E-value: 2.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099     46 DYFIVVGYDHEKPGPGEG-LGKIIQRFPQQDWDDTPFPQGIELFCQPGGWHL--SRERKQPTFFVVVLTDIDSDRHYCSC 122
Cdd:smart00800   6 DYFVVVGLDSDTGPLGRSyKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFvtQTSSKDPQFFSFVLTDIDGSRRYGFC 85


                   ....
gi 50511099    123 LTFY 126
Cdd:smart00800  86 LRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 65-124 9.45e-23

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 91.52  E-value: 9.45e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099    65 GKIIQRFPQQDWDDTPFPQGIELFCQPGGWHLSRERKqPTFFVVVLTDIDSDRHYCSCLT 124
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLPDGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 391-459 2.02e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 82.34  E-value: 2.02e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50511099    391 DKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLNGMAFAGFVSER 459
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 426-472 2.77e-05

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 41.80  E-value: 2.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 50511099   426 FHKTAFLGQRGLVENDFLTKVLNGMAFAGFVSERG-PPYRACDLFDEL 472
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLeSSDPSIDLFDEE 48
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 155-337 1.56e-64

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 210.12  E-value: 1.56e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099   155 FAPKSLVLVSRLDYPEIFRACLGLIYTVYVDSM-SVSLESLIANLCAC-LVPAAGGSQKLFSLGAGDRQLIQTPLHDSLP 232
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlPNPIERFIANLLYEvPFPPPGRTQKLKPLGGTEPILLQRPEDSELP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099   233 VTGTSVALLFQQLGIQNVLNLFCAVLTENKVLLHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFI 312
Cdd:pfam02141  81 LEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFI 160

                         170       180
                  ....*....|....*....|....*.
gi 50511099   313 IGVHS-IFKTDVHELLDVIIADLDGG 337
Cdd:pfam02141 161 IGVHSrYFDLLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 156-337 4.63e-63

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 206.28  E-value: 4.63e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099    156 APKSLVLVSRLDYPEIFRACLGLIYTVYVDSMSVSLEsLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPVTG 235
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLE-LLISLLLYPVPPPGGSLVLVSLGPGDLIELQRPLDSSLPLID 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099    236 TSVALLFQQLGIQNVLNLFCAVLTENKVLLHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGV 315
Cdd:smart00799  80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159

                          170       180
                   ....*....|....*....|....
gi 50511099    316 HSIFKTDVHELL--DVIIADLDGG 337
Cdd:smart00799 160 HSSYFEEVKELPdeDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 46-126 2.87e-26

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 102.41  E-value: 2.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099     46 DYFIVVGYDHEKPGPGEG-LGKIIQRFPQQDWDDTPFPQGIELFCQPGGWHL--SRERKQPTFFVVVLTDIDSDRHYCSC 122
Cdd:smart00800   6 DYFVVVGLDSDTGPLGRSyKPEILQRYPEKDFEDFPLPDSIPLFCFPEGLDFvtQTSSKDPQFFSFVLTDIDGSRRYGFC 85


                   ....
gi 50511099    123 LTFY 126
Cdd:smart00800  86 LRFY 89
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 65-124 9.45e-23

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 91.52  E-value: 9.45e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099    65 GKIIQRFPQQDWDDTPFPQGIELFCQPGGWHLSRERKqPTFFVVVLTDIDSDRHYCSCLT 124
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPLPDGIPMFCFPEGLETLSSRE-PTFFSFVLTDEDGSRLYGACLT 59
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 391-459 2.02e-19

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 82.34  E-value: 2.02e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50511099    391 DKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLNGMAFAGFVSER 459
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 426-472 2.77e-05

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 41.80  E-value: 2.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 50511099   426 FHKTAFLGQRGLVENDFLTKVLNGMAFAGFVSERG-PPYRACDLFDEL 472
Cdd:pfam03455   1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLeSSDPSIDLFDEE 48
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 247-341 2.22e-03

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 38.04  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50511099   247 IQNVLNLFCAVLTENKVLL--HSASFQRLSDACRALESLMFPL-------KYSYPYIPIlpaQLLEVLSSPTPFIIGVHS 317
Cdd:pfam08616  12 TPPIILLINALLTSKRIIFlsYQRSAGEVSEFVLALCNLISGGfvlrgftNNSFPYVDL---SKLDALRKVPGYIAGVTN 88

                          90       100
                  ....*....|....*....|....
gi 50511099   318 IFKTDVHELLDVIIaDLDGGTIKI 341
Cdd:pfam08616  89 PIFENQDQWWDVLC-DLDSGSVKL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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