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Conserved domains on  [gi|34526285|dbj|BAC85218|]
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unnamed protein product [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-475 2.53e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 2.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285  60 KPYECIECGKAFSQSAHLAQHQRIHTGEKPFECT--ECGKAFSQNAHLVQHQRVHTGEKPY-QCKQCNKAFSQLAHlaqh 136
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS---- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 137 qrvhtgekpYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPF------DCIDCGK 210
Cdd:COG5048 108 ---------SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNslhpplPANSLSK 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 211 AFTDHIGLIQHKRIHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICekAFSHRGSLTLHQRVHTGEK--PYE 288
Cdd:COG5048 179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdsSSS 256

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 289 CKECG------KAFRQSTHLAHHQRIHTG-EKPYECKECSKTFSQNAHLAQHQ--KIHTGE--KPYECKE--CGKAFSQI 355
Cdd:COG5048 257 ASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRN 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 356 AHLVQHQRVHTGEKPYECI--ECGKAFSDGSY-----LVQHQRLHSGKRPYECL--ECGKAFRQRASLICHQRCHTGEKP 426
Cdd:COG5048 337 DALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRP 416

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 34526285 427 YECN--VCGKAFSHRKSLTLHQRIHTGEKPYECkECSKAFSQVAHLTLHKR 475
Cdd:COG5048 417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 3.29e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 34526285   469 HLTLHKRIHTGERPYECKECGKAFRQ 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-475 2.53e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 2.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285  60 KPYECIECGKAFSQSAHLAQHQRIHTGEKPFECT--ECGKAFSQNAHLVQHQRVHTGEKPY-QCKQCNKAFSQLAHlaqh 136
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS---- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 137 qrvhtgekpYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPF------DCIDCGK 210
Cdd:COG5048 108 ---------SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNslhpplPANSLSK 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 211 AFTDHIGLIQHKRIHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICekAFSHRGSLTLHQRVHTGEK--PYE 288
Cdd:COG5048 179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdsSSS 256

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 289 CKECG------KAFRQSTHLAHHQRIHTG-EKPYECKECSKTFSQNAHLAQHQ--KIHTGE--KPYECKE--CGKAFSQI 355
Cdd:COG5048 257 ASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRN 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 356 AHLVQHQRVHTGEKPYECI--ECGKAFSDGSY-----LVQHQRLHSGKRPYECL--ECGKAFRQRASLICHQRCHTGEKP 426
Cdd:COG5048 337 DALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRP 416

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 34526285 427 YECN--VCGKAFSHRKSLTLHQRIHTGEKPYECkECSKAFSQVAHLTLHKR 475
Cdd:COG5048 417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 201-253 5.61e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.77  E-value: 5.61e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 34526285 201 KPFdCIDCGKAFTDHIGLIQHKRIHTgerpYKCNVCGKAFSHGSSLTVH-QRIH 253
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
76-101 7.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 34526285    76 HLAQHQRIHTGEKPFECTECGKAFSQ 101
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 3.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 34526285   469 HLTLHKRIHTGERPYECKECGKAFRQ 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
60-475 2.53e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 81.28  E-value: 2.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285  60 KPYECIECGKAFSQSAHLAQHQRIHTGEKPFECT--ECGKAFSQNAHLVQHQRVHTGEKPY-QCKQCNKAFSQLAHlaqh 136
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASS---- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 137 qrvhtgekpYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPF------DCIDCGK 210
Cdd:COG5048 108 ---------SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNslhpplPANSLSK 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 211 AFTDHIGLIQHKRIHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICekAFSHRGSLTLHQRVHTGEK--PYE 288
Cdd:COG5048 179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdsSSS 256

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 289 CKECG------KAFRQSTHLAHHQRIHTG-EKPYECKECSKTFSQNAHLAQHQ--KIHTGE--KPYECKE--CGKAFSQI 355
Cdd:COG5048 257 ASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRN 336

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 356 AHLVQHQRVHTGEKPYECI--ECGKAFSDGSY-----LVQHQRLHSGKRPYECL--ECGKAFRQRASLICHQRCHTGEKP 426
Cdd:COG5048 337 DALKRHILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRP 416

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 34526285 427 YECN--VCGKAFSHRKSLTLHQRIHTGEKPYECkECSKAFSQVAHLTLHKR 475
Cdd:COG5048 417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-501 5.03e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 5.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 116 KPYQCKQCNKAFSQLAHLAQHQRVHTGEKPYEC--IECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHR 193
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 194 RYYHTGEKPFDCIDCGKAFT------------DHIGLIQHKRIHTGERPYKC----------NVCGKAFSHGSSLTVHQR 251
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllsiSNLRNNPLPGNNSSSVNTPQsnslhpplpaNSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 252 IHTGEKPYECNICEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSTHLAHHQRIHTGEKPYECKECSKTFSQNAHLA 331
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 332 QHQKIHTGE-------KPYECKECGKAFSQIAHLVQHQR--VHTGE--KPYEC--IECGKAFSDGSYLVQHQRLHSGKRP 398
Cdd:COG5048 272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 399 YEC--LECGKAFRQ-----RASLICHQRCHTGEKPYECNV--CGKAFSHRKSLTLHQRIHTGEKPYECKECSKAFSQVAH 469
Cdd:COG5048 352 AKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|....
gi 34526285 470 LTL--HKRIHTGERPYECkECGKAFRQSVHLAHH 501
Cdd:COG5048 432 YNLipHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
23-417 2.42e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 2.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285  23 KHKQDRGEKKLLKCNDCEKIFSKISTLTLHQRIHTGEKPYEC--IECGKAFSQSAHLAQHQRIHTGEKPFEC-------- 92
Cdd:COG5048  23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsn 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285  93 --------TECGKAFSQNAHLVQHQRVHTGEKPYQCKQCNKAFSQLAHLAQHQRVHTGEKPYECI--------ECGKAFS 156
Cdd:COG5048 103 skasssslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpansLSKDPSS 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 157 DCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPFDCIDCGKAFTDhIGLIQHKRIHTGERPYKCNVC 236
Cdd:COG5048 183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL-LSQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 237 GKAFSH-GSSLTVHQRIHTGE-----KPYECNICEKAFSHRGSLTLHQR--VHTGE--KPYECKE--CGKAFRQSTHLAH 304
Cdd:COG5048 262 RSSLPTaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 305 HQRIHTGEKPYECK--ECSKTFSQNAH-----LAQHQKIHTGEKPYEC--KECGKAFSQIAHLVQHQRVHTGEKPYEC-- 373
Cdd:COG5048 342 HILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCkn 421

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 34526285 374 IECGKAFSDGSYLVQHQRLHSGKRPYEClECGKAFRQRASLICH 417
Cdd:COG5048 422 PPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-505 8.81e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 171 KRPYECIDCGKAFRQNASLIRHRRyYHTGEKPFDCID--CGKAFTDHIGLIQHKRIHTGERPYKCNvcgKAFSHGSSLTV 248
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIR-SHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKAS 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 249 H-QRIHTGEKPYECNICEK---AFSHRGSLT--LHQRVHTGEKPYE-CKECGKAFRQSTHLAHhqrihtgekPYECKECS 321
Cdd:COG5048 107 SsSLSSSSSNSNDNNLLSShslPPSSRDPQLpdLLSISNLRNNPLPgNNSSSVNTPQSNSLHP---------PLPANSLS 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 322 KTFSQNAHLAQHQKIHTGEKPYECKECGKAFSQIAHLVQHQRVHTGEKPYECIECGKAFSDGSYLVQHQRLHSGKRPYEC 401
Cdd:COG5048 178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 402 LEC-----GKAFRQRASLIC-----HQRCHTgekPYECNVCGKAFSHRKSLTLHQR--IHTGE--KPYECKE--CSKAFS 465
Cdd:COG5048 258 SESprsslPTASSQSSSPNEsdsssEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFS 334

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 34526285 466 QVAHLTLHKRIHTGERPYECK--ECGKAFRQSVHLAHHQRIH 505
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQ 376
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 201-253 5.61e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.77  E-value: 5.61e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 34526285 201 KPFdCIDCGKAFTDHIGLIQHKRIHTgerpYKCNVCGKAFSHGSSLTVH-QRIH 253
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 239-335 5.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 239 AFSHGSSLTVH---QRIHT-GEKPYECNI--CEKAFSHRGSLTLHqRVHtgekpyecKECGKAFRQSTHLAHHQRIHTGE 312
Cdd:COG5189 326 KLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKD 396

                        90       100
                ....*....|....*....|...
gi 34526285 313 KPYECKECSKTFSQNAHLAQHQK 335
Cdd:COG5189 397 KPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
76-101 7.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 34526285    76 HLAQHQRIHTGEKPFECTECGKAFSQ 101
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-354 7.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 34526285   329 HLAQHQKIHTGEKPYECKECGKAFSQ 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
132-156 2.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.33e-03
                          10        20
                  ....*....|....*....|....*
gi 34526285   132 HLAQHQRVHTGEKPYECIECGKAFS 156
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-242 2.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*
gi 34526285   218 LIQHKRIHTGERPYKCNVCGKAFSH 242
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-381 2.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.75e-03
                          10        20
                  ....*....|....*....|....*
gi 34526285   357 HLVQHQRVHTGEKPYECIECGKAFS 381
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 267-366 3.07e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 267 AFSHRGSLTL----HQRVHTGEKPYECK--ECGKAFRQSTHLAHHqRIHtgekpyecKECSKTFSQNAHLAQHQKIHTGE 340
Cdd:COG5189 326 KLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKD 396

                        90       100
                ....*....|....*....|....*.
gi 34526285 341 KPYECKECGKAFSQIAHLVQHqRVHT 366
Cdd:COG5189 397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
469-494 3.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 34526285   469 HLTLHKRIHTGERPYECKECGKAFRQ 494
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-510 3.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 229 RPYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECN--ICEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSThlAHHQ 306
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA--SSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 307 RIHTGEKP-YECKECSKTFSQNAHLAQH----QKIHTGEKPYE-CKECGKAFSQIAHLVQHQRVHtgekpyecIECGKAF 380
Cdd:COG5048 110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLpdllSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPAN--------SLSKDPS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 381 SDGSYLVQHQRLHSGKRPYECLECGKAFRQRASLIcHQRCHTGEKPYECNVCGKAFSHRKSLTLHQRIHTGEKPYECKEC 460
Cdd:COG5048 182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 34526285 461 SKAFSQVAHLTLHKRIHTGER-------PYECKECGKAFRQSVHLAHHQR--IHTGESS 510
Cdd:COG5048 261 PRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESL 319
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 165-249 3.63e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 165 RRIHT-GKRPYEC--IDCGKAFRQNASLIRHRRYYHtgekpfdcidCGKAFTDHIGLIQHKRIHTGERPYKCNVCGKAFS 241
Cdd:COG5189 340 RMLKVkDGKPYKCpvEGCNKKYKNQNGLKYHMLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                ....*...
gi 34526285 242 HGSSLTVH 249
Cdd:COG5189 410 NLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-466 3.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 34526285   441 SLTLHQRIHTGEKPYECKECSKAFSQ 466
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
49-73 4.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.20e-03
                          10        20
                  ....*....|....*....|....*
gi 34526285    49 LTLHQRIHTGEKPYECIECGKAFSQ 73
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
104-129 4.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 34526285   104 HLVQHQRVHTGEKPYQCKQCNKAFSQ 129
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 367-445 5.46e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 5.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34526285 367 GEKPYEC--IECGKAFSDGSYLVQHqRLHSgkrpyeclECGKAFRQRASLICHQRCHTGEKPYECNVCGKAFSHRKSLTL 444
Cdd:COG5189 346 DGKPYKCpvEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 34526285 445 H 445
Cdd:COG5189 417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 142-197 6.84e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 6.84e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34526285 142 GEKPYEC--IECGKAFSDCSSLAHHRR-------------------IHTGKRPYECIDCGKAFRQNASLIRHRRYYH 197
Cdd:COG5189 346 DGKPYKCpvEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 7.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.88e-03
                          10        20
                  ....*....|....*....|....*.
gi 34526285   273 SLTLHQRVHTGEKPYECKECGKAFRQ 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 8.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 34526285   245 SLTVHQRIHTGEKPYECNICEKAFSH 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-326 9.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.13e-03
                          10        20
                  ....*....|....*....|..
gi 34526285   305 HQRIHTGEKPYECKECSKTFSQ 326
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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