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Conserved domains on  [gi|29467632|dbj|BAC67207|]
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neuronal transmembrane protein Slitrk4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-242 5.18e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632  88 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 167
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29467632 168 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 242
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 6.91e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 387 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 466
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 467 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 546
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 29467632 547 DQLQSLTQIDLEGN 560
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
242-282 8.45e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 29467632    242 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 282
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 531-592 5.38e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.38e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29467632    531 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 592
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-242 5.18e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632  88 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 167
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29467632 168 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 242
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 6.91e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 387 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 466
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 467 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 546
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 29467632 547 DQLQSLTQIDLEGN 560
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
431-490 1.06e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.06e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632   431 GLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 490
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
112-172 7.43e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 7.43e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29467632   112 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 411-493 2.35e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 411 LHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYNLI 490
Cdd:cd21340   7 LYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80


                ...
gi 29467632 491 KEI 493
Cdd:cd21340  81 SVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 92-262 8.02e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632  92 HLNFQNNflNILYPNTFVNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 171
Cdd:cd21340   6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 172 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 244
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                       170
                ....*....|....*...
gi 29467632 245 NCSCDLLPLKAWLENMPY 262
Cdd:cd21340 152 NQISDLEELLDLLSSWPS 169
LRRCT smart00082
Leucine rich repeat C-terminal domain;
242-282 8.45e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 29467632    242 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 282
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 531-592 5.38e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.38e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29467632    531 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 592
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRRCT smart00082
Leucine rich repeat C-terminal domain;
560-592 3.23e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.23e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 29467632    560 NPWDCTCDLVALKLWLEKLNDGIVVKELKCETP 592
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-242 5.18e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632  88 SNFYHLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQA 167
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL 189

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29467632 168 DYNLIKYIErGAFNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDN 242
Cdd:COG4886 190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNL---EELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-243 1.07e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 1.07e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632  92 HLNFQNNFLNILyPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILrADTFLGIENLEYLQADYNL 171
Cdd:COG4886 140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29467632 172 IKYIERgAFNKLHKLKVLILNDNLISFLPdNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGrvvELQLEDNP 243
Cdd:COG4886 217 LTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLK---TLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
387-560 6.91e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 387 SVNCQEKNIQSMSELTPKPLNAKKLHVNGNNIKDVDiSDFTEFEGLDLLHLGSNQITLIKGEVFhNLTNLRRLYLNGNQI 466
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 467 ERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRNNKFMYLPvsgVL 546
Cdd:COG4886 195 TDL-PEPLGNLTNLEELDLSGNQLTDL------------------------PEPLANLTNLETLDLSNNQLTDLP---EL 246

                       170
                ....*....|....
gi 29467632 547 DQLQSLTQIDLEGN 560
Cdd:COG4886 247 GNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
431-490 1.06e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 1.06e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632   431 GLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 490
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
409-561 6.25e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.42  E-value: 6.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 409 KKLHVNGNNIKDVDISdFTEFEGLDLLHLGSNQITLIkGEVFHNLTNLRRLYLNGNQIERLyPEIFSGLHNLQYLYLEYN 488
Cdd:COG4886 162 KSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29467632 489 LIKEIlaGTFDSMPNlqllylnnnllkslpvyifsgapLARLNLRNNKFMYLPVSGvldQLQSLTQIDLEGNP 561
Cdd:COG4886 239 QLTDL--PELGNLTN-----------------------LEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
112-172 7.43e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 7.43e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29467632   112 SHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQADYNLI 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 411-493 2.35e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.42  E-value: 2.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 411 LHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYNLI 490
Cdd:cd21340   7 LYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80


                ...
gi 29467632 491 KEI 493
Cdd:cd21340  81 SVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 388-579 5.29e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 5.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 388 VNCQEKNIQSMSELTPKPlNAKKLHVNGNNIKDvdISDFTEFEGLDLLHLGSNQITLIKGevFHNLTNLRRLYLNGNQIE 467
Cdd:cd21340   7 LYLNDKNITKIDNLSLCK-NLKVLYLYDNKITK--IENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 468 RLypEIFSGLHNLQYLYLEYNLIKEILAGTFDSmpnlqllylnnnllkslpvyiFSGAPLAR----LNLRNNKFMYLpvs 543
Cdd:cd21340  82 VV--EGLENLTNLEELHIENQRLPPGEKLTFDP---------------------RSLAALSNslrvLNISGNNIDSL--- 135

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 29467632 544 GVLDQLQSLTQIDLEGNP---WDCTCDLVALKLWLEKLN 579
Cdd:cd21340 136 EPLAPLRNLEQLDASNNQisdLEELLDLLSSWPSLRELD 174
LRR_8 pfam13855
Leucine rich repeat;
407-466 2.50e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 2.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632   407 NAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQI 466
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
454-502 2.11e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.11e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 29467632   454 TNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFDSMP 502
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR_8 pfam13855
Leucine rich repeat;
161-219 2.92e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632   161 NLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRI 219
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
138-196 3.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.48e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 29467632   138 LKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLI 196
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 92-262 8.02e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632  92 HLNFQNNflNILYPNTFVNFSHAVSLHLGNNKLQNIEGgaFLGLSALKQLHLNNNelKILRADTFLGIENLEYLQADYNL 171
Cdd:cd21340   6 HLYLNDK--NITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNN--QIEKIENLENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 172 IKYIErgAFNKLHKLKVL-ILNDNL-----ISFLPDNIFRFA-SLTHLDIRGNRIQKLPYIGVLEHIgrvVELQLEDnpw 244
Cdd:cd21340  80 ISVVE--GLENLTNLEELhIENQRLppgekLTFDPRSLAALSnSLRVLNISGNNIDSLEPLAPLRNL---EQLDASN--- 151

                       170
                ....*....|....*...
gi 29467632 245 NCSCDLLPLKAWLENMPY 262
Cdd:cd21340 152 NQISDLEELLDLLSSWPS 169
LRR_8 pfam13855
Leucine rich repeat;
88-148 6.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 6.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29467632    88 SNFYHLNFQNNFLNILYPNTFVNFSHAVSLHLGNNKLQNIEGGAFLGLSALKQLHLNNNEL 148
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
242-282 8.45e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 46.65  E-value: 8.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 29467632    242 NPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYGRLL 282
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLL 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 92-223 1.28e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.17  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632  92 HLNFQNNFLNILypntfVNFSHAVSL---HLGNNKLQNIEGgaFLGLSALKQLHLNNNELK-----ILRADTFLGI-ENL 162
Cdd:cd21340  50 HLYLQNNQIEKI-----ENLENLVNLkklYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAALsNSL 122

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29467632 163 EYLQADYNLIKYIErgAFNKLHKLKVLILNDNLISFLPD---NIFRFASLTHLDIRGNRIQKLP 223
Cdd:cd21340 123 RVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
406-560 1.66e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 1.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 406 LNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNqitlikgEVFHNLTNLRRLYLNGNQIERLyPEIFSGLHNLQYLYL 485
Cdd:COG4886  72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL 143

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29467632 486 EYNLIKEILAgTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSgvLDQLQSLTQIDLEGN 560
Cdd:COG4886 144 SNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGN 215
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 531-592 5.38e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 5.38e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29467632    531 NLRNNKFMYLPvSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWLEKLNDGIVVKELK-CETP 592
Cdd:TIGR00864    1 DISNNKISTIE-EGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAlCAGP 62
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
392-561 9.26e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 9.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 392 EKNIQSMSELTPKPLNAKKLHVNGNNIKDVDISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRL------------ 459
Cdd:COG4886  34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELdlsgneelsnlt 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 460 -----YLNGNQIERLyPEIFSGLHNLQYLYLEYNLIKEIlagtfdsmpnlqllylnnnllkslPVYIFSGAPLARLNLRN 534
Cdd:COG4886 114 nleslDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL------------------------PEPLGNLTNLKSLDLSN 168

                       170       180
                ....*....|....*....|....*..
gi 29467632 535 NKFMYLPVSgvLDQLQSLTQIDLEGNP 561
Cdd:COG4886 169 NQLTDLPEE--LGNLTNLKELDLSNNQ 193
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 122-217 1.31e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632   122 NKLQNIEGGAFLGLSALKQLHLNNNeLKILRADTFLGIeNLEYLQADYNlIKYIERGAFNKLHKLKVLILNDNLISFlPD 201
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPSNLTSI-GS 95

                          90
                  ....*....|....*.
gi 29467632   202 NIFRFASLTHLDIRGN 217
Cdd:pfam13306  96 YAFSNCSLKSITIPSS 111
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 454-488 1.48e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 29467632   454 TNLRRLYLNGNQIERLypEIFSGLHNLQYLYLEYN 488
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
185-243 1.70e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632   185 KLKVLILNDNLISFLPDNIFR-FASLTHLDIRGNRIQKLPYiGVLEHIGRVVELQLEDNP 243
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
560-592 3.23e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 3.23e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 29467632    560 NPWDCTCDLVALKLWLEKLNDGIVVKELKCETP 592
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASP 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-499 4.74e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 4.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 100 LNILYPNTFVNFSHAVSLHLGNNKLQNIeGGAFLGLSALKQLHLNNNELKILRADtFLGIENLEYLQADYNLIKYIERgA 179
Cdd:COG4886 101 LDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-E 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 180 FNKLHKLKVLILNDNLISFLPDNIFRFASLTHLDIRGNRIQKLPyigvlehigrvvelqlednpwncscdllplkAWLEN 259
Cdd:COG4886 178 LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLP-------------------------------EPLAN 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 260 MpyniyigeaicetpsdlygrllketnkqelcpmgtgsdfdvrilppsqqengfttpnghttqTTLHRLvtkppkttnps 339
Cdd:COG4886 227 L--------------------------------------------------------------TNLETL----------- 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 340 kisgivagkalsnrNLSqivsyqtrvppltpcpvpcfckthpsdlglsvNCQEKNIQSMSELTpkplNAKKLHVNGNNIK 419
Cdd:COG4886 234 --------------DLS--------------------------------NNQLTDLPELGNLT----NLEELDLSNNQLT 263

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29467632 420 DvdISDFTEFEGLDLLHLGSNQITLIKGEVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEILAGTFD 499
Cdd:COG4886 264 D--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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