NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|26353028|dbj|BAC40144|]
View 

unnamed protein product [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-471 1.63e-111

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 338.41  E-value: 1.63e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028    8 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028   87 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  167 INLDDMHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 245
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  246 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 325
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  326 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDLK 403
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELM 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  404 VVKKNILDSKPaanKKSELSCAPKKPTDTASV-----------------QNEAKLDEILKEIKSIKETICSQDERISKLE 466
Cdd:PTZ00421 397 GASALSPSGKP---RHSGVSVPASTSAMTHSFddntskhadpcamgvkrMDEGILDERLGRLQALSEKLRTQHEEIKRCR 473


                 ....*
gi 26353028  467 QQLAK 471
Cdd:PTZ00421 474 EALQK 478
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 8-471 1.63e-111

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 338.41  E-value: 1.63e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028    8 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028   87 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  167 INLDDMHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 245
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  246 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 325
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  326 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDLK 403
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELM 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  404 VVKKNILDSKPaanKKSELSCAPKKPTDTASV-----------------QNEAKLDEILKEIKSIKETICSQDERISKLE 466
Cdd:PTZ00421 397 GASALSPSGKP---RHSGVSVPASTSAMTHSFddntskhadpcamgvkrMDEGILDERLGRLQALSEKLRTQHEEIKRCR 473


                 ....*
gi 26353028  467 QQLAK 471
Cdd:PTZ00421 474 EALQK 478
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-68 2.18e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 2.18e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26353028     3 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 68
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-300 4.01e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 4.01e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  75 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 154
Cdd:cd00200  46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 155 IIIWNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 233
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 234 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 300
Cdd:cd00200 193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
78-252 1.84e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 1.84e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 158 WNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 237
Cdd:COG2319 231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                       170
                ....*....|....*
gi 26353028 238 srMSERQLALWNPKN 252
Cdd:COG2319 307 --SDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-108 7.49e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.49e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 26353028     78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 108
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 8-471 1.63e-111

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 338.41  E-value: 1.63e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028    8 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028   87 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  167 INLDDMHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 245
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  246 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 325
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  326 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDLK 403
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPELM 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  404 VVKKNILDSKPaanKKSELSCAPKKPTDTASV-----------------QNEAKLDEILKEIKSIKETICSQDERISKLE 466
Cdd:PTZ00421 397 GASALSPSGKP---RHSGVSVPASTSAMTHSFddntskhadpcamgvkrMDEGILDERLGRLQALSEKLRTQHEEIKRCR 473


                 ....*
gi 26353028  467 QQLAK 471
Cdd:PTZ00421 474 EALQK 478
PTZ00420 PTZ00420
coronin; Provisional
 24-407 6.82e-66

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 221.75  E-value: 6.82e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028   24 YDDIRV-SRVTwDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRidksYPTVC---GHTGPVLDIDWCPHNDQVIASG 99
Cdd:PTZ00420  19 FDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCFSEILASG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  100 SEDCTVMVWQIPENGLTLS-LTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAL--INLDDMHSDM 176
Cdd:PTZ00420  94 SEDLTIRVWEIPHNDESVKeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAfqINMPKKLSSL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  177 IYNVSwsrnGSLICTASKDKKVRVIDPRKQEIvAEKEKAHEGARPMRAIFL-----ADGNVFTTGFSRMSERQLALWNPK 251
Cdd:PTZ00420 174 KWNIK----GNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  252 NMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESpyVHYLNTFSSKEPQRGMGYMPKRGLDVNKCE 331
Cdd:PTZ00420 249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26353028  332 IARFFK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHgyipGKNRDLKVVKK 407
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-68 2.18e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 2.18e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26353028     3 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 68
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-300 4.01e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 4.01e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  75 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 154
Cdd:cd00200  46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 155 IIIWNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 233
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 234 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 300
Cdd:cd00200 193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
78-252 1.84e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 1.84e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 158 WNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 237
Cdd:COG2319 231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                       170
                ....*....|....*
gi 26353028 238 srMSERQLALWNPKN 252
Cdd:COG2319 307 --SDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
78-251 1.96e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpENGltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 158 WNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 237
Cdd:COG2319 189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASG- 264

                       170
                ....*....|....
gi 26353028 238 srMSERQLALWNPK 251
Cdd:COG2319 265 --SADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
78-252 6.54e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 6.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRL 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 158 WNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGArPMRAIFLADGNVFTTGf 237
Cdd:COG2319 315 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGA-VTSVAFSPDGRTLASG- 390

                       170
                ....*....|....*
gi 26353028 238 SRmsERQLALWNPKN 252
Cdd:COG2319 391 SA--DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-236 1.86e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.86e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARNvLLSAGCDNAIII 157
Cdd:cd00200 133 GHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 158 WNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGarPMRAI-FLADGNVFTTG 236
Cdd:cd00200 204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN--SVTSLaWSPDGKRLASG 279
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 343-385 3.90e-21

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 86.03  E-value: 3.90e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 26353028   343 CEPIIMTVPRKS-DLFQDDLYPDTAGPEAALEAEEWFEGKNADP 385
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-200 9.63e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 9.63e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028  78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIII 157
Cdd:cd00200 175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD-------LSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26353028 158 WNVGTGEALINLDdMHSDMIYNVSWSRNGSLICTASKDKKVRV 200
Cdd:cd00200 246 WDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-300 7.94e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 7.94e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 126 LEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWNVGTGEALINLDDmHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRK 205
Cdd:cd00200   5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028 206 QEIVAEKEkAHEGarPMRAI-FLADGNVFTTGfsrMSERQLALWNPKNMQEPIAL--HEMDTSNGVllpfYDPDTSIIYl 282
Cdd:cd00200  83 GECVRTLT-GHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLrgHTDWVNSVA----FSPDGTFVA- 151

                       170
                ....*....|....*...
gi 26353028 283 CGKGDSSIRYFEITDESP 300
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKC 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-108 7.49e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.49e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 26353028     78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 108
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
75-108 4.40e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.40e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 26353028    75 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 108
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 121-159 9.56e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 9.56e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 26353028    121 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 159
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-202 9.75e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 9.75e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 26353028    173 HSDMIYNVSWSRNGSLICTASKDKKVRVID 202
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
173-202 2.54e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.54e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 26353028   173 HSDMIYNVSWSRNGSLICTASKDKKVRVID 202
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-109 2.91e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 2.91e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 26353028  65 KTGRIDKsypTVCGHTGPVLDIDWCPHNdQVIASGSEDCTVMVWQ 109
Cdd:cd00200 249 RTGECVQ---TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
121-159 4.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 26353028   121 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 159
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 88-185 6.87e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 6.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26353028    88 WCPHNDqVIASGSEDCTV--------MVWQIPengltlsltepvviLEGHSKRVGIVAWHPTARnVLLSAGCDNAIIIWN 159
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 26353028   160 VGTGEALINLdDMHSDMIYNVSWSRN 185
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
Mt_ATP-synt_D pfam05873
ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D ...
 429-474 1.23e-03

ATP synthase D chain, mitochondrial (ATP5H); This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts.


Pssm-ID: 461764 [Multi-domain]  Cd Length: 154  Bit Score: 39.52  E-value: 1.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 26353028   429 PTDTASVQNEAKLDEILKEIKSIKETIcsqDERISKLEQQLAKMAA 474
Cdd:pfam05873  80 PEDTYTSEVDAQEKEVVKEIKEFIEES---NKRIAEYEKELEKLKN 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH