phosphatidylinositol anchor biosynthesis protein PIGW/GWT1 is involved in the addition of the acyl-chain to inositol in an early step of glycosylphosphatidylinositol (GPI) biosynthesis
GWT1; Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to ...
4-378
2.79e-47
GWT1; Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. GWT1 is involved in GPI anchor biosynthesis; it is required for inositol acylation in yeast.
The actual alignment was detected with superfamily member COG5062:
Pssm-ID: 470470 Cd Length: 429 Bit Score: 168.47 E-value: 2.79e-47
GWT1; Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to ...
300-452
6.84e-29
GWT1; Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. GWT1 is involved in GPI anchor biosynthesis; it is required for inositol acylation in yeast.
Pssm-ID: 461907 Cd Length: 138 Bit Score: 110.38 E-value: 6.84e-29
GWT1; Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to ...
300-452
6.84e-29
GWT1; Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. GWT1 is involved in GPI anchor biosynthesis; it is required for inositol acylation in yeast.
Pssm-ID: 461907 Cd Length: 138 Bit Score: 110.38 E-value: 6.84e-29
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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