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Conserved domains on  [gi|26339634|dbj|BAC33488|]
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unnamed protein product [Mus musculus]

Protein Classification

kelch-like protein 42( domain architecture ID 13034538)

kelch-like protein 42 (KLHL42) is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 113-225 2.14e-51

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


:

Pssm-ID: 350553  Cd Length: 103  Bit Score: 169.95  E-value: 2.14e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 113 VRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSppqapgdcSLKQRLREARMRGTPVLVALGDFLG 192
Cdd:cd18478   1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPS--------SLKQQLRERRLRGTPALVALGDFLG 72

                        90       100       110
                ....*....|....*....|....*....|...
gi 26339634 193 GPLAphPYQGEPPSMLRYEETTERWFPLANNLP 225
Cdd:cd18478  73 TPLD--PYQDEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-101 4.58e-48

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 160.81  E-value: 4.58e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   4 EEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDE 83
Cdd:cd18319   1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES-----GEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDT 75

                        90
                ....*....|....*...
gi 26339634  84 LAEASVLSEMVEAASFLQ 101
Cdd:cd18319  76 LEENELLEDLVEAASFLQ 93
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
223-469 7.78e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.70  E-value: 7.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 223 NLPPDLVNVRGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPITNEWLQVASMNQK-RSNFKLVAVNSKLYAIGG----- 296
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGftgan 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 297 ---QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWTlfETCDVHIRKQQ 373
Cdd:COG3055  84 pssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT--QLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 374 M---VSVEETIYIVGGcLHELGPNRRSSQSEDMLTVQSYNTVtrqwlylkentsksglnltcALHNDGIYIMSRDVTLST 450
Cdd:COG3055 162 LaaaVLPDGKILVIGG-RNGSGFSNTWTTLAPLPTARAGHAA--------------------AVLGGKILVFGGESGFSD 220

                       250
                ....*....|....*....
gi 26339634 451 SLEhrvflKYNIFADSWEA 469
Cdd:COG3055 221 EVE-----AYDPATNTWTA 234
 
Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 113-225 2.14e-51

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 169.95  E-value: 2.14e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 113 VRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSppqapgdcSLKQRLREARMRGTPVLVALGDFLG 192
Cdd:cd18478   1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPS--------SLKQQLRERRLRGTPALVALGDFLG 72

                        90       100       110
                ....*....|....*....|....*....|...
gi 26339634 193 GPLAphPYQGEPPSMLRYEETTERWFPLANNLP 225
Cdd:cd18478  73 TPLD--PYQDEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-101 4.58e-48

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 160.81  E-value: 4.58e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   4 EEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDE 83
Cdd:cd18319   1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES-----GEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDT 75

                        90
                ....*....|....*...
gi 26339634  84 LAEASVLSEMVEAASFLQ 101
Cdd:cd18319  76 LEENELLEDLVEAASFLQ 93
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
223-469 7.78e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.70  E-value: 7.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 223 NLPPDLVNVRGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPITNEWLQVASMNQK-RSNFKLVAVNSKLYAIGG----- 296
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGftgan 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 297 ---QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWTlfETCDVHIRKQQ 373
Cdd:COG3055  84 pssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT--QLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 374 M---VSVEETIYIVGGcLHELGPNRRSSQSEDMLTVQSYNTVtrqwlylkentsksglnltcALHNDGIYIMSRDVTLST 450
Cdd:COG3055 162 LaaaVLPDGKILVIGG-RNGSGFSNTWTTLAPLPTARAGHAA--------------------AVLGGKILVFGGESGFSD 220

                       250
                ....*....|....*....
gi 26339634 451 SLEhrvflKYNIFADSWEA 469
Cdd:COG3055 221 EVE-----AYDPATNTWTA 234
PHA03098 PHA03098
kelch-like protein; Provisional
 198-485 2.68e-24

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 106.01  E-value: 2.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  198 HPYQGEPPSMLRYEETTERWFPLANNlppdlVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPITNEWLQVASMNQ 277
Cdd:PHA03098 257 ITMSIFTYNYITNYSPLSEINTIIDI-----HYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIY 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  278 KRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQ-Y 352
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGiynsISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVEcF 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  353 CPSADLWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSsqsedmlTVQSYNTVTRQWlylkenTSKSGLNLT- 431
Cdd:PHA03098 412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYN-------IVESYNPVTNKW------TELSSLNFPr 478

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 26339634  432 -----CALHNDgIYIMSRDVTLSTSLEHRVflkYNIFADSWEAFRRFPAFGHNLLISSL 485
Cdd:PHA03098 479 inaslCIFNNK-IYVVGGDKYEYYINEIEV---YDDKTNTWTLFCKFPKVIGSLEKNIF 533
Kelch smart00612
Kelch domain;
290-332 9.01e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 54.10  E-value: 9.01e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 26339634    290 KLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKG 332
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 279-319 3.68e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.23  E-value: 3.68e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 26339634   279 RSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLP 319
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 118-162 1.74e-06

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 46.57  E-value: 1.74e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 26339634    118 CLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFpLLLSPPQ 162
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEF-LELPLEQ 44
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 7-108 1.96e-05

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 43.45  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634      7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGARegwgLSEDElae 86
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEI-----YLDDVSPEDFRALLNFLYTGKLD----LPEEN--- 69

                           90       100
                   ....*....|....*....|..
gi 26339634     87 asvLSEMVEAASFLQVTALLRL 108
Cdd:smart00225  70 ---VEELLELADYLQIPGLVEL 88
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 7-108 3.35e-05

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 43.01  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634     7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggareGWGLSEDELAE 86
Cdd:pfam00651  13 VTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI-----TLDDVSPEDFEALLEFMYT-----GKLISEENVDD 82

                          90       100
                  ....*....|....*....|..
gi 26339634    87 asVLsemvEAASFLQVTALLRL 108
Cdd:pfam00651  83 --LL----AAADKLQIPSLVDK 98
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 118-160 4.77e-04

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 39.45  E-value: 4.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 26339634   118 CLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFpLLLSP 160
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEF-LELSL 42
 
Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 113-225 2.14e-51

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 169.95  E-value: 2.14e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 113 VRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSppqapgdcSLKQRLREARMRGTPVLVALGDFLG 192
Cdd:cd18478   1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPS--------SLKQQLRERRLRGTPALVALGDFLG 72

                        90       100       110
                ....*....|....*....|....*....|...
gi 26339634 193 GPLAphPYQGEPPSMLRYEETTERWFPLANNLP 225
Cdd:cd18478  73 TPLD--PYQDEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-101 4.58e-48

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 160.81  E-value: 4.58e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   4 EEMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAGGAREGWGLSEDE 83
Cdd:cd18319   1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES-----GEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDT 75

                        90
                ....*....|....*...
gi 26339634  84 LAEASVLSEMVEAASFLQ 101
Cdd:cd18319  76 LEENELLEDLVEAASFLQ 93
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
223-469 7.78e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 103.70  E-value: 7.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 223 NLPPDLVNVRGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPITNEWLQVASMNQK-RSNFKLVAVNSKLYAIGG----- 296
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGftgan 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 297 ---QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWTlfETCDVHIRKQQ 373
Cdd:COG3055  84 pssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT--QLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 374 M---VSVEETIYIVGGcLHELGPNRRSSQSEDMLTVQSYNTVtrqwlylkentsksglnltcALHNDGIYIMSRDVTLST 450
Cdd:COG3055 162 LaaaVLPDGKILVIGG-RNGSGFSNTWTTLAPLPTARAGHAA--------------------AVLGGKILVFGGESGFSD 220

                       250
                ....*....|....*....
gi 26339634 451 SLEhrvflKYNIFADSWEA 469
Cdd:COG3055 221 EVE-----AYDPATNTWTA 234
PHA03098 PHA03098
kelch-like protein; Provisional
 198-485 2.68e-24

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 106.01  E-value: 2.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  198 HPYQGEPPSMLRYEETTERWFPLANNlppdlVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPITNEWLQVASMNQ 277
Cdd:PHA03098 257 ITMSIFTYNYITNYSPLSEINTIIDI-----HYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIY 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  278 KRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQ-Y 352
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGiynsISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVEcF 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  353 CPSADLWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSsqsedmlTVQSYNTVTRQWlylkenTSKSGLNLT- 431
Cdd:PHA03098 412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYN-------IVESYNPVTNKW------TELSSLNFPr 478

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 26339634  432 -----CALHNDgIYIMSRDVTLSTSLEHRVflkYNIFADSWEAFRRFPAFGHNLLISSL 485
Cdd:PHA03098 479 inaslCIFNNK-IYVVGGDKYEYYINEIEV---YDDKTNTWTLFCKFPKVIGSLEKNIF 533
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
268-442 1.24e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.12  E-value: 1.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 268 EWLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSAC-ECKGKIYVIGGYTT 342
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLsggsASNSFEVYDPATNTWSELAPLPGPPRHHAAAvAQDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 343 RDRNMNIL----QYCPSADLWTLFETCDVHIRKQQMVSVEETIYIVGGClHELGPNRrssqsedmlTVQSYNTVTRQWly 418
Cdd:COG3055  82 ANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGW-DDGGNVA---------WVEVYDPATGTW-- 149

                       170       180       190
                ....*....|....*....|....*....|
gi 26339634 419 lkenTSKSGL-----NLTCALHNDG-IYIM 442
Cdd:COG3055 150 ----TQLAPLptprdHLAAAVLPDGkILVI 175
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
179-343 1.54e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.73  E-value: 1.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 179 RGTPVLVALGD---FLGGPLAPHPYQGEPPSMLRYEETTERWFPLANnLPpdlVNVRGYGSAILDNYLFIVGGYRiTSQE 255
Cdd:COG3055  61 RHHAAAVAQDGklyVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAP-MP---TPRGGATALLLDGKIYVVGGWD-DGGN 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 256 ISAAHSYNPITNEWLQVASMNQKRSNFK-LVAVNSKLYAIGGQAVS---------------------------------- 300
Cdd:COG3055 136 VAWVEVYDPATGTWTQLAPLPTPRDHLAaAVLPDGKILVIGGRNGSgfsntwttlaplptaraghaaavlggkilvfgge 215

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 26339634 301 -----NVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTR 343
Cdd:COG3055 216 sgfsdEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA02713 PHA02713
hypothetical protein; Provisional
 205-384 2.05e-14

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 75.43  E-value: 2.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  205 PSMLRYEETTERwFPLANNLPPDLVNvrgYGSAILDNYLFIVGGYRITSQEISAAHSYNPITNEWLQVASMNQKRSNFKL 284
Cdd:PHA02713 272 PCILVYNINTME-YSVISTIPNHIIN---YASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSL 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  285 VAVNSKLYAIGGQAVSNV----ECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYT-----TRDRNMN------- 348
Cdd:PHA02713 348 AVIDDTIYAIGGQNGTNVertiECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehidyTSVHHMNsidmeed 427

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 26339634  349 ------ILQYCPSADLW-TLFETCDVHIRKqQMVSVEETIYIV 384
Cdd:PHA02713 428 thssnkVIRYDTVNNIWeTLPNFWTGTIRP-GVVSHKDDIYVV 469
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 7-100 5.28e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 66.92  E-value: 5.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAGGAREgwglsedelaE 86
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRES-----GQAEINLRDISPEDFRALLEFLYGGKRDL----------D 65

                        90
                ....*....|....
gi 26339634  87 ASVLSEMVEAASFL 100
Cdd:cd01165  66 ASNLLELLEAANFL 79
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-101 5.32e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 67.07  E-value: 5.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   5 EMVQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggarEGWGLSEDEL 84
Cdd:cd18320   2 QKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEI-----RLQGLSARGFRIMLRVLAG----ERPILNGEEI 72

                        90
                ....*....|....*..
gi 26339634  85 AEAsvlsemVEAASFLQ 101
Cdd:cd18320  73 LQA------IECAAFLQ 83
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-118 1.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 62.03  E-value: 1.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  12 EDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggaregwglSEDELAEASVlS 91
Cdd:cd18255  26 DGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEI-----ELKGVSAKGLKHILDFAYT---------SELTLDLDCI-Q 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 26339634  92 EMVEAASFLQVTALLRL----LLSHVRLGNC 118
Cdd:cd18255  91 DVLGAAVHLQMLPVVELceefLKSAMSVENC 121
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
311-469 3.75e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 63.64  E-value: 3.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 311 AWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWTLFETCDVHIRKQ-QMVSVEETIYIVGGClh 389
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGF-- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 390 elgpNRRSSQSEDMLTVQSYNTVTRQWLYLkENTSKSGLNLTCALHNDGIYimsrdVTLSTSLEHRV--FLKYNIFADSW 467
Cdd:COG3055  80 ----TGANPSSTPLNDVYVYDPATNTWTKL-APMPTPRGGATALLLDGKIY-----VVGGWDDGGNVawVEVYDPATGTW 149


                ..
gi 26339634 468 EA 469
Cdd:COG3055 150 TQ 151
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-118 5.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 57.12  E-value: 5.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  13 DRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGAregwGLSEDElaeasvLSE 92
Cdd:cd18239  34 DETFPVHRAMMASASDYFKAMFTGGMKEQELMCI-----KLHGVSKIGLKNIIDFIYTAKL----SLNMDN------LQD 98

                        90       100       110
                ....*....|....*....|....*....|
gi 26339634  93 MVEAASFLQVTALL----RLLLSHVRLGNC 118
Cdd:cd18239  99 TLEAASFLQILPVLdfckVLLISGVTLENC 128
Kelch smart00612
Kelch domain;
290-332 9.01e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 54.10  E-value: 9.01e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 26339634    290 KLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKG 332
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 279-319 3.68e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.23  E-value: 3.68e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 26339634   279 RSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLP 319
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-68 5.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 52.94  E-value: 5.64e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFI 68
Cdd:cd18186   4 VTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEI-----ELDDVSPEAFEALLDYI 60
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
223-306 7.23e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 56.70  E-value: 7.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634 223 NLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAahsYNPITNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---- 298
Cdd:COG3055 189 TLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEA---YDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETkpgv 265

                        90
                ....*....|..
gi 26339634 299 ----VSNVECYN 306
Cdd:COG3055 266 rtplVTSAEVYD 277
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 117-162 1.05e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 51.12  E-value: 1.05e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 26339634 117 NCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFpLLLSPPQ 162
Cdd:cd14733   4 NCLGILELADLYNLEELKEKALKFILENFEEVSKSEEF-LELSVEL 48
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-121 1.54e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 53.42  E-value: 1.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGAregwglsedELAE 86
Cdd:cd18244  33 VTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKI-----HLKGLTATGFSHVLQFMYYGTI---------ELSM 98

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26339634  87 ASVlSEMVEAASFLQVTALLR----LLLSHVRLGNCLEL 121
Cdd:cd18244  99 LTV-HEILQAAMYVQLTEVVKfccsFLLAKICLDNCAEI 136
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-118 4.52e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 52.11  E-value: 4.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  16 YPVSKSKLIEQSDYFRALYRSGMREAvrpevGPEVQQLRGLSAPGLRLVLDFINAggareGW-GLSEDelaeasVLSEMV 94
Cdd:cd18264  40 FPAHRSLLACSSDYFRALFKDYTQES-----KARVIHLPVVSAAGLQRVLDFIYT-----SWlSLSLD------TLEDTL 103

                        90       100
                ....*....|....*....|....*...
gi 26339634  95 EAASFLQVTALLRL----LLSHVRLGNC 118
Cdd:cd18264 104 EAASYLQVTEAIGLcsqyLINNLAPENC 131
PLN02153 PLN02153
epithiospecifier protein
 184-421 7.00e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 7.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  184 LVALGDFL---GGPLAPHPYQGEppSMLRYEETTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGyRITSQEISAAH 260
Cdd:PLN02153  28 IAVVGDKLysfGGELKPNEHIDK--DLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGG-RDEKREFSDFY 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  261 SYNPITNEW-----LQVASMNQKRSNFKLVAVNSKLYAIGG----------QAVSNVECYNPEQDAWnfvAPLPNPLAEF 325
Cdd:PLN02153 105 SYDTVKNEWtfltkLDEEGGPEARTFHSMASDENHVYVFGGvskgglmktpERFRTIEAYNIADGKW---VQLPDPGENF 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  326 SA------CECKGKIYVIGGYTTR-------DRNMNILQYC-PSADLWTLFETCDVHIRKQQMVS---VEETIYIVGGcl 388
Cdd:PLN02153 182 EKrggagfAVVQGKIWVVYGFATSilpggksDYESNAVQFFdPASGKWTEVETTGAKPSARSVFAhavVGKYIIIFGG-- 259

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 26339634  389 hELGPNRRSSQSEDMLTVQSY--NTVTRQWLYLKE 421
Cdd:PLN02153 260 -EVWPDLKGHLGPGTLSNEGYalDTETLVWEKLGE 293
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-119 1.23e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 47.46  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGmreavRPEVGPEVQQLRGLSAPGLRLVLDFINAGGARegwgLSEDELae 86
Cdd:cd18265  26 VVLLVDGKDFPCHRATLSANSAYFRAMFGGH-----LKESRQAVVEIQKVSAAAMEVLLDYMYGGGLR----IQEDNV-- 94

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26339634  87 ASVLsemvEAASFLQVTAL----LRLLLSHVRLGNCL 119
Cdd:cd18265  95 ESVL----EASDLLQVSKLreacVRFLEGQLHPCNCL 127
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-121 1.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 47.52  E-value: 1.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   9 IRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwglsEDELAEAS 88
Cdd:cd18271  29 IIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSV-----TISNLSPKAVKAFLDYAYTG---------KAEITDDN 94

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 26339634  89 VlsEMV-EAASFLQVTALLR----LLLSHVRLGNCLEL 121
Cdd:cd18271  95 V--EMFfQMSSFLQVSLLSKacsdFLIKSIDLTNCLQL 130
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 118-162 1.74e-06

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 46.57  E-value: 1.74e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 26339634    118 CLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFpLLLSPPQ 162
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEF-LELPLEQ 44
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-118 3.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 46.28  E-value: 3.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggaregwglsedELAE 86
Cdd:cd18242  24 VTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV-----ELQGLTASTMEILLDFVYT------------ETVH 86

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 26339634  87 ASV--LSEMVEAASFLQVT----ALLRLLLSHVRLGNC 118
Cdd:cd18242  87 VTVenVQELLPAACLLQLKgvkqACCEFLESQLDPSNC 124
Kelch_3 pfam13415
Galactose oxidase, central domain;
240-287 3.24e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.20  E-value: 3.24e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 26339634   240 DNYLFIVGGYRITSQE-ISAAHSYNPITNEWLQVASMNQKRSNFKLVAV 287
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-110 3.39e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 45.96  E-value: 3.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  27 SDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGAREGWGlsedELAEASvlsemvEAASFLQVTALL 106
Cdd:cd18263  36 SDYFRAMFTSGMKESTQSVV-----QLPTIPAKDLRLLISFAYSGILHLSWE----NLFEAT------CTALQLQISGAL 100


                ....
gi 26339634 107 RLLL 110
Cdd:cd18263 101 ALCL 104
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 232-276 3.73e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 3.73e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 26339634   232 RGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPITNEWLQVASMN 276
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFD-GNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
243-288 3.84e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 43.70  E-value: 3.84e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 26339634    243 LFIVGGYrITSQEISAAHSYNPITNEWLQVASMNQKRSNFKLVAVN 288
Cdd:smart00612   2 IYVVGGF-DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-108 4.55e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 46.11  E-value: 4.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  12 EDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGAregwglsedeLAEASVLS 91
Cdd:cd18261  36 EEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEV-----NLHGVTSLGLKQALDFAYTGQI----------LLEPGVIQ 100

                        90
                ....*....|....*..
gi 26339634  92 EMVEAASFLQVTALLRL 108
Cdd:cd18261 101 DVLAAGSHLQLLELLSL 117
Kelch_6 pfam13964
Kelch motif;
233-279 1.18e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 1.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 26339634   233 GYGSAILDNYLFIVGGYRITSQEISAAHSYNPITNEWLQVASMNQKR 279
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-136 1.80e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 44.15  E-value: 1.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwglsedelae 86
Cdd:cd18287  25 VTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEI-----ELKDTNAEAFKALLKYIYTG--------------- 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 26339634  87 asvlsemveaasflqvtallRLLLSHVRLGNCLELYRLAQVYGLPDLQDA 136
Cdd:cd18287  85 --------------------RLTLTDLKEDVLLDVLGLAHQYGFEELEAA 114
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-119 1.88e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 43.93  E-value: 1.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwglsEDELAE 86
Cdd:cd18256  23 VQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVV-----QIHGVEPDIFHILLDFIYTG---------VVEVTV 88

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26339634  87 ASVlSEMVEAASFLQVTALLRL----LLSHVRLGNCL 119
Cdd:cd18256  89 SNV-QELLVAADMLQLTEVVEIccefLKGQLHPSNCI 124
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 7-108 1.96e-05

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 43.45  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634      7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGGARegwgLSEDElae 86
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEI-----YLDDVSPEDFRALLNFLYTGKLD----LPEEN--- 69

                           90       100
                   ....*....|....*....|..
gi 26339634     87 asvLSEMVEAASFLQVTALLRL 108
Cdd:smart00225  70 ---VEELLELADYLQIPGLVEL 88
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 113-154 2.08e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 42.70  E-value: 2.08e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 26339634 113 VRLGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQF 154
Cdd:cd18480   1 LDLSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEF 42
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 117-154 3.11e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 42.00  E-value: 3.11e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 26339634 117 NCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQF 154
Cdd:cd18463   6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEF 43
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 7-108 3.35e-05

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 43.01  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634     7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAggareGWGLSEDELAE 86
Cdd:pfam00651  13 VTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI-----TLDDVSPEDFEALLEFMYT-----GKLISEENVDD 82

                          90       100
                  ....*....|....*....|..
gi 26339634    87 asVLsemvEAASFLQVTALLRL 108
Cdd:pfam00651  83 --LL----AAADKLQIPSLVDK 98
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 115-154 4.10e-05

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 41.77  E-value: 4.10e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 26339634 115 LGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQF 154
Cdd:cd18497   3 EDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEF 42
PHA02790 PHA02790
Kelch-like protein; Provisional
 243-359 4.84e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 45.80  E-value: 4.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  243 LFIVGGYrITSQEISAAHSYNPITNEWLQVASMNQKRSNFKLVAVNSKLYAIGG-QAVSNVECYNPEQDAWNFVAPLPNP 321
Cdd:PHA02790 274 VYLIGGW-MNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGlPNPTSVERWFHGDAAWVNMPSLLKP 352

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 26339634  322 LAEFSACECKGKIYVIGGYTTRDRNMNILqyCPSADLW 359
Cdd:PHA02790 353 RCNPAVASINNVIYVIGGHSETDTTTEYL--LPNHDQW 388
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-121 5.19e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 42.47  E-value: 5.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  20 KSKLIEQSDYFRAlyrsgmrEAVRpevgpEVQQLRGLSAPGLRLVLDFINAGGAregwGLSEDELAeasvlsEMVEAASF 99
Cdd:cd18275  20 KSVLAAKSDYFRA-------RLSR-----DILKVKGLSYATLRLLVDYVYSGRM----AVSKDNVV------EVVAGARF 77

                        90       100
                ....*....|....*....|....*.
gi 26339634 100 LQVTALLRLLLSHVR----LGNCLEL 121
Cdd:cd18275  78 LQMPCAAQCAVDAVRaqlcLGNCYEV 103
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-121 5.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 43.07  E-value: 5.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  11 LEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwGLSEDElaeaSVL 90
Cdd:cd18270  33 VEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHV-----HLRNVDAATLQIIITYAYTG------NLAIND----STV 97

                        90       100       110
                ....*....|....*....|....*....|....*
gi 26339634  91 SEMVEAASFLQVTALLRL----LLSHVRLGNCLEL 121
Cdd:cd18270  98 EQLYETACFLQVEDVLQRcreyLIKKINAENCVRL 132
Kelch_6 pfam13964
Kelch motif;
279-321 5.55e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 5.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 26339634   279 RSNFKLVAVNSKLYAIGG-----QAVSNVECYNPEQDAWNFVAPLPNP 321
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGytnasPALNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-145 1.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 41.90  E-value: 1.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  27 SDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFinaggaregwglsedelAEASvlsemveaasflqvtall 106
Cdd:cd18274  46 SPYFRSMFTSGLTESTQKEV-----RIVGVEAESMHLVLDY-----------------AYTS------------------ 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26339634 107 RLLLSHVrlgNCLELYRLAQVYGLPDLQDACLRFMVLRF 145
Cdd:cd18274  86 RVTLTEA---NVQALFTAASIFQIPSLQDQCAQFMISRL 121
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-121 1.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 41.80  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRpevgpEVQQLRGLSAPGLRLVLDFINAGGARegwgLSEDElae 86
Cdd:cd18272  35 VTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARN-----RVIELKDVSESVFQLLVDYIYHGTVK----LRVEE--- 102

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26339634  87 asvLSEMVEAASFLQVTALL----RLLLSHVRLGNCLEL 121
Cdd:cd18272 103 ---LQETYEVADMYQLTALFeecsRFLARTVQVRNCLQV 138
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 115-177 2.70e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 39.67  E-value: 2.70e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26339634 115 LGNCLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLLSPPQApgDCSLKQRLREAR 177
Cdd:cd18484   3 LGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAER--ELILRRRLEAGR 63
PLN02193 PLN02193
nitrile-specifier protein
 184-344 4.36e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 42.64  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  184 LVALGDFL---GGPLAPHPYQGeppsMLRYEETTERW---FPLANNLPPdlvnvRGYGSAILD-NYLFIVGGYRITSQeI 256
Cdd:PLN02193 224 MVSIGSTLyvfGGRDASRQYNG----FYSFDTTTNEWkllTPVEEGPTP-----RSFHSMAADeENVYVFGGVSATAR-L 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  257 SAAHSYNPITNEWLQVASMNQK---RSNFKLVAVNSKL---YAIGGQAVSNVECYNPEQDAWNFVAPL---PNPLAEFSA 327
Cdd:PLN02193 294 KTLDSYNIVDKKWFHCSTPGDSfsiRGGAGLEVVQGKVwvvYGFNGCEVDDVHYYDPVQDKWTQVETFgvrPSERSVFAS 373

                        170
                 ....*....|....*..
gi 26339634  328 CECKGKIYVIGGYTTRD 344
Cdd:PLN02193 374 AAVGKHIVIFGGEIAMD 390
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 118-160 4.77e-04

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 39.45  E-value: 4.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 26339634   118 CLELYRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFpLLLSP 160
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEF-LELSL 42
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-71 5.39e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 40.26  E-value: 5.39e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634  12 EDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAG 71
Cdd:cd18266  33 DEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEV-----ELVGASYIGLKAVIDFLYSS 87
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-121 5.99e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 39.77  E-value: 5.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFINAGgaregwglsEDELAE 86
Cdd:cd18268  26 VILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKV-----DLKGIDSDVLDQIVDYVYTG---------EILITR 91

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26339634  87 ASVLSEMvEAASFLQVTALL----RLLLSHVRLGNCLEL 121
Cdd:cd18268  92 DNVLPLM-EAASMLQYPKLFeacsLYLQDQLTPENCLSM 129
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 122-157 6.41e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 38.33  E-value: 6.41e-04
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 26339634 122 YRLAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLL 157
Cdd:cd18493   9 LQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNL 44
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-68 7.68e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 39.23  E-value: 7.68e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpevqQLRGLSAPGLRLVLDFI 68
Cdd:cd18240  20 VVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVY-----KIPGVSPEMMELIIEYA 76
BACK_BTBD8 cd18490
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); ...
 118-167 3.83e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.


Pssm-ID: 350565  Cd Length: 64  Bit Score: 35.71  E-value: 3.83e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 26339634 118 CLELyrlAQVYGLPDLQDACLRFMVLRFHQVLCQPQFPLLlsPPQAPGDC 167
Cdd:cd18490   8 CLPL---AHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASL--PPELQEKC 52
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 7-68 5.45e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 36.89  E-value: 5.45e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339634   7 VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVGPEVQQLRGLSAPGLRLVLDFI 68
Cdd:cd18296  20 VCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNGSIPVVTLHDVSPEVFAIVLYYI 81
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 321-360 5.79e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 5.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 26339634   321 PLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSADLWT 360
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-108 6.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 36.48  E-value: 6.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   4 EEM--VQIRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVgpEVQQLRglsAPGLRLVLDFINAGGAregwglsE 81
Cdd:cd18297  10 PEMsdVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVI--EIPDIR---YDIFQLMMQYLYTGGV-------E 77

                        90       100
                ....*....|....*....|....*..
gi 26339634  82 DELAEASVLSEMVEAASFLQVTALLRL 108
Cdd:cd18297  78 SLDVAQDDALELLRAASFFQLDGLKRH 104
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-106 7.92e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 36.34  E-value: 7.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339634   9 IRLEDRCYPVSKSKLIEQSDYFRALYRSGMREAVRPEVGpevqQLRGLSAPGLRLVLDFINAGgaregwglsEDELAEAS 88
Cdd:cd18329  26 ILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVA----TFDVFSPDTFTIILDFVYSG---------KLSLTSQN 92

                        90
                ....*....|....*...
gi 26339634  89 VLsEMVEAASFLQVTALL 106
Cdd:cd18329  93 VI-EVMSAASYLQMTDVI 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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