unnamed protein product [Mus musculus]
Protein Classification
glycoside hydrolase family protein( domain architecture ID 721)
glycoside hydrolase (GH) family protein may catalyze the hydrolysis of glycosidic bonds in complex sugars; may be a member of glycosyl hydrolase families GH47, GH76, GH88, or GH127
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| LanC_like super family | cl04955 | Cyclases involved in the biosynthesis of lantibiotics, and similar proteins; LanC is the ... |
1-161 | 2.73e-40 | ||||
Cyclases involved in the biosynthesis of lantibiotics, and similar proteins; LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain thioether cross-links called lanthionines (Lans) or methyllanthionines (MeLans), in addition to 2,3-didehydroalanine (Dha) and (Z)-2,3-didehydrobutyrine (Dhb). These unusual amino acids are introduced by the dehydration of serine and threonine residues, followed by thioether formation via addition of cysteine thiols, catalysed by LanB and LanC or LanM. LanC, the cyclase component, is a zinc metalloprotein, whose bound metal has been proposed to activate the thiol substrate for nucleophilic addition. A related domain is also present in LanM and other pro- and eukaryotic proteins with poorly characterized functions. The actual alignment was detected with superfamily member cd04794: Pssm-ID: 471159 Cd Length: 349 Bit Score: 141.69 E-value: 2.73e-40
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| Name | Accession | Description | Interval | E-value | ||||
| euk_LANCL | cd04794 | Eukaryotic Lanthionine synthetase C-like protein; This family contains the lanthionine ... |
1-161 | 2.73e-40 | ||||
Eukaryotic Lanthionine synthetase C-like protein; This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 and LANCL2 (testes-specific adriamycin sensitivity protein) were thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. More recently, they have been associated with signal transduction processes and insulin sensitization. In particular, LANCL2 has been shown to bind abscisic acid (ABA), and this interaction may play a role in signaling pathways triggered by ABA, such as in human granulocytes and rat insulinoma cells. This eukaryotic LANCL family also includes Arabidopsis GCR2. Pssm-ID: 271202 Cd Length: 349 Bit Score: 141.69 E-value: 2.73e-40
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| LANC_like | pfam05147 | Lanthionine synthetase C-like protein; Lanthionines are thioether bridges that are putatively ... |
15-161 | 7.08e-11 | ||||
Lanthionine synthetase C-like protein; Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats. Pssm-ID: 398697 [Multi-domain] Cd Length: 350 Bit Score: 61.24 E-value: 7.08e-11
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| Name | Accession | Description | Interval | E-value | ||||
| euk_LANCL | cd04794 | Eukaryotic Lanthionine synthetase C-like protein; This family contains the lanthionine ... |
1-161 | 2.73e-40 | ||||
Eukaryotic Lanthionine synthetase C-like protein; This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 and LANCL2 (testes-specific adriamycin sensitivity protein) were thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. More recently, they have been associated with signal transduction processes and insulin sensitization. In particular, LANCL2 has been shown to bind abscisic acid (ABA), and this interaction may play a role in signaling pathways triggered by ABA, such as in human granulocytes and rat insulinoma cells. This eukaryotic LANCL family also includes Arabidopsis GCR2. Pssm-ID: 271202 Cd Length: 349 Bit Score: 141.69 E-value: 2.73e-40
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| LANC_like | pfam05147 | Lanthionine synthetase C-like protein; Lanthionines are thioether bridges that are putatively ... |
15-161 | 7.08e-11 | ||||
Lanthionine synthetase C-like protein; Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats. Pssm-ID: 398697 [Multi-domain] Cd Length: 350 Bit Score: 61.24 E-value: 7.08e-11
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