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Conserved domains on  [gi|26329237|dbj|BAC28357|]
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unnamed protein product [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 23-116 4.13e-34

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


:

Pssm-ID: 129004  Cd Length: 93  Bit Score: 122.17  E-value: 4.13e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237     23 SAGQNCLTKS--LEDVVIDIQSSLSKGIRG-NEPIHLATQEDCIGACCSTKDiagdkaCNLMIFDTRKTDRQPNCYLFFC 99
Cdd:smart00765   1 SPGEDCLGRFrvLENAIIRTEESLSAGARFlKSPIAVNTWEDCVRACCSTPN------CNLAVFELRREDAEGNCYLFNC 74

                           90
                   ....*....|....*....
gi 26329237    100 --PSEDACPLKPAKGLVTY 116
Cdd:smart00765  75 tyPGKEVCKFKPHEGYTSY 93
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 246-413 1.76e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.88  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237   246 TSISVTAKTLKQKEATTASPVTTV-TSKLPGVPgSTSFTpvvTHQAALTNTfqAHTDSKGILETmPFQGGSTLTSdprhG 324
Cdd:pfam17823 343 TNLAVVTTTKAQAKEPSASPVPVLhTSMIPEVE-ATSPT---TQPSPLLPT--QGAAGPGILLA-PEQVATEATA----G 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237   325 KSS---TSESSITNKTASWEDRRVSVGSASLNKGPKSQHGLSFEKWLLIGTLLCGVLFLVIGLVLLGRMLVEALRRKRYS 401
Cdd:pfam17823 412 TASagpTPRSSGDPKTLAMASCQLSTQGQYLVVTTDPLTPALVDKMFLLVVLILGMTLFIAVLMLFALQAYESYKKKDYT 491

                         170
                  ....*....|..
gi 26329237   402 RLDYLINGIYVD 413
Cdd:pfam17823 492 QVDYLINEMYAD 503
 
Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 23-116 4.13e-34

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 122.17  E-value: 4.13e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237     23 SAGQNCLTKS--LEDVVIDIQSSLSKGIRG-NEPIHLATQEDCIGACCSTKDiagdkaCNLMIFDTRKTDRQPNCYLFFC 99
Cdd:smart00765   1 SPGEDCLGRFrvLENAIIRTEESLSAGARFlKSPIAVNTWEDCVRACCSTPN------CNLAVFELRREDAEGNCYLFNC 74

                           90
                   ....*....|....*....
gi 26329237    100 --PSEDACPLKPAKGLVTY 116
Cdd:smart00765  75 tyPGKEVCKFKPHEGYTSY 93
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 26-115 2.04e-27

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 104.31  E-value: 2.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237    26 QNCLTK--SLEDVVIDIQSSLSKGIRGNEPIHLATQEDCIGACCSTkdiagdKACNLMIFDTRKT--DRQPNCYLFFC-- 99
Cdd:pfam07502   1 ESCLEDftGVEDFIIDTEDSVKNGATFLSSPEVSSARDCVRACCST------PRCNLAVFEERPGgeDAIPSCYLFNCly 74

                          90
                  ....*....|....*.
gi 26329237   100 PSEDACPLKPAKGLVT 115
Cdd:pfam07502  75 PSRFVCKFAPHKGYTS 90
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 246-413 1.76e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.88  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237   246 TSISVTAKTLKQKEATTASPVTTV-TSKLPGVPgSTSFTpvvTHQAALTNTfqAHTDSKGILETmPFQGGSTLTSdprhG 324
Cdd:pfam17823 343 TNLAVVTTTKAQAKEPSASPVPVLhTSMIPEVE-ATSPT---TQPSPLLPT--QGAAGPGILLA-PEQVATEATA----G 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237   325 KSS---TSESSITNKTASWEDRRVSVGSASLNKGPKSQHGLSFEKWLLIGTLLCGVLFLVIGLVLLGRMLVEALRRKRYS 401
Cdd:pfam17823 412 TASagpTPRSSGDPKTLAMASCQLSTQGQYLVVTTDPLTPALVDKMFLLVVLILGMTLFIAVLMLFALQAYESYKKKDYT 491

                         170
                  ....*....|..
gi 26329237   402 RLDYLINGIYVD 413
Cdd:pfam17823 492 QVDYLINEMYAD 503
 
Name Accession Description Interval E-value
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 23-116 4.13e-34

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 122.17  E-value: 4.13e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237     23 SAGQNCLTKS--LEDVVIDIQSSLSKGIRG-NEPIHLATQEDCIGACCSTKDiagdkaCNLMIFDTRKTDRQPNCYLFFC 99
Cdd:smart00765   1 SPGEDCLGRFrvLENAIIRTEESLSAGARFlKSPIAVNTWEDCVRACCSTPN------CNLAVFELRREDAEGNCYLFNC 74

                           90
                   ....*....|....*....
gi 26329237    100 --PSEDACPLKPAKGLVTY 116
Cdd:smart00765  75 tyPGKEVCKFKPHEGYTSY 93
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 26-115 2.04e-27

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 104.31  E-value: 2.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237    26 QNCLTK--SLEDVVIDIQSSLSKGIRGNEPIHLATQEDCIGACCSTkdiagdKACNLMIFDTRKT--DRQPNCYLFFC-- 99
Cdd:pfam07502   1 ESCLEDftGVEDFIIDTEDSVKNGATFLSSPEVSSARDCVRACCST------PRCNLAVFEERPGgeDAIPSCYLFNCly 74

                          90
                  ....*....|....*.
gi 26329237   100 PSEDACPLKPAKGLVT 115
Cdd:pfam07502  75 PSRFVCKFAPHKGYTS 90
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 246-413 1.76e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.88  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237   246 TSISVTAKTLKQKEATTASPVTTV-TSKLPGVPgSTSFTpvvTHQAALTNTfqAHTDSKGILETmPFQGGSTLTSdprhG 324
Cdd:pfam17823 343 TNLAVVTTTKAQAKEPSASPVPVLhTSMIPEVE-ATSPT---TQPSPLLPT--QGAAGPGILLA-PEQVATEATA----G 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26329237   325 KSS---TSESSITNKTASWEDRRVSVGSASLNKGPKSQHGLSFEKWLLIGTLLCGVLFLVIGLVLLGRMLVEALRRKRYS 401
Cdd:pfam17823 412 TASagpTPRSSGDPKTLAMASCQLSTQGQYLVVTTDPLTPALVDKMFLLVVLILGMTLFIAVLMLFALQAYESYKKKDYT 491

                         170
                  ....*....|..
gi 26329237   402 RLDYLINGIYVD 413
Cdd:pfam17823 492 QVDYLINEMYAD 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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