Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183 268 TEVVEVGHFWGYRIDENNSEILKKLTAEINQLTLVPLPTHPHPDLVCLAPFADFDKQRYFRAQVLYVSGNSAEVFFVDYG 347
Cdd:cd20431   1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQRQLVPLTTKPVPNLLCLAPFTDADMKKYYRAKILYVSGSSAEVFFVDYG 80

                        90       100
                ....*....|....*....|.
gi 21757183 348 NKSHVDLHLLMEIPCQFLELP 368
Cdd:cd20431  81 NTSQVPSSLLREIPETLLTLP 101

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183 268 TEVVEVGHFWGYRIDENNSEILKKLTAEINQLTLVPLPTHPHPDLVCLAPFADFDKQRYFRAQVLYVSGNSAEVFFVDYG 347
Cdd:cd20431   1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQRQLVPLTTKPVPNLLCLAPFTDADMKKYYRAKILYVSGSSAEVFFVDYG 80

                        90       100
                ....*....|....*....|.
gi 21757183 348 NKSHVDLHLLMEIPCQFLELP 368
Cdd:cd20431  81 NTSQVPSSLLREIPETLLTLP 101

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 21757183    313 VCLAPFADfdkQRYFRAQVLYVSGN-SAEVFFVDYGNKSHVDLHLLMEIPCQF 364
Cdd:smart00333   8 KVAARWED---GEWYRARIVKVDGEqLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183 268 TEVVEVGHFWGYRIDENNSEILKKLTAEINQLTLVPLPTHPHPDLVCLAPFADFDKQRYFRAQVLYVSGNSAEVFFVDYG 347
Cdd:cd20431   1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQRQLVPLTTKPVPNLLCLAPFTDADMKKYYRAKILYVSGSSAEVFFVDYG 80

                        90       100
                ....*....|....*....|.
gi 21757183 348 NKSHVDLHLLMEIPCQFLELP 368
Cdd:cd20431  81 NTSQVPSSLLREIPETLLTLP 101

Tudor domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183   267 VTEVVEVGHFWgyRIDENNSEILKKLTAEINQL--TLVPLPTHPHPDLVCLAPFADfdKQRYFRAQVLY-VSGNSAEVFF 343
Cdd:pfam00567   7 VSHIESPSTFY--IQPKSDSKKLEKLTEELQEYyaSKPPESLPPAVGDGCVAAFSE--DGKWYRAKITEsLDDGLVEVLF 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 21757183   344 VDYGNKSHVDLHLLMEIPCQFLELPFQALEFKI 376
Cdd:pfam00567  83 IDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183 267 VTEVVEVGHFWGYRIDEN-NSEILKKLTAEINQL---TLVPLPTHPHPDLVCLAPFADfDKQRYfRAQVLYVSGNSAEVF 342
Cdd:cd20411   3 VLEVISPDLFYALPKTGQvNVEKLKALMTELAEYcskQSVPQQFRPRIGDACCARFTG-DKNWY-RAVVLETSDSEVKVL 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21757183 343 FVDYGNKSHVDLHLLMEIPCQFLELPFQALefkICKM 379
Cdd:cd20411  81 YADYGNTETLPLSRILPITKSHLELPFQII---RCSL 114

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21757183 304 LPTHPHPDLVCLAPFADfdkqRYFRAQVLYVSG--NSAEVFFVDYGNKSHVDLHLLMEIPCQFLELPFQALE 373
Cdd:cd20407   1 LPEPIEVGVICAAPVMN----AWYRAQVVGVFEetDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATE 68

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183 267 VTEVVEVGHFWgYRIDENNsEILKKLTAEINQLtlVPLPTHPHPDL----VCLAPFadFDKQRYFRAQVLYVSGNS-AEV 341
Cdd:cd20440  16 ITHVYSPAKFY-CQLDRNT-EILEALMEKIAEI--SKLFNSQILDNcktrLCLAKY--FEDGQWYRALAHPVESSShLSV 89

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21757183 342 FFVDYGNKSHVDLHLLMEIPCQFLEL---PFQALEF 374
Cdd:cd20440  90 YFVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKC 125

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 21757183 310 PDLVCLAPFADFDKqrYFRAQVLYV-SGNSAEVFFVDYGNKSHVDLHLLMEI 360
Cdd:cd20379   1 VGDLCAAKYEEDGK--WYRARVLEVlSNDKVEVFFVDYGNTETVPLSDLRPL 50

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183 287 EILKKLTAEINQLTLVPLpTHPHPDLVCLAPFADfDKQRYfRAQVL-YVSGNSAEVFFVDYGNKSHVDLHLLMEIPCQFL 365
Cdd:cd20409   6 ELQESLSAYCKVAPASSD-FSPAVGEVCCAQFTE-DNQWY-RASVLaYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21757183 267 VTEVVEVGHFWgYRIDENNSE---ILKKLTAEINQLTLVP-LPTHPHPDLVCLAPFADfdKQRYFRAQVLYVSGNSAEVF 342
Cdd:cd20438  11 VEYVLNPSNFW-IRTDEYNNEfqaLMKNIADIYNLCGNDEeLLKKPEPGLLCCARYSK--DRHYYRAVITEVLDLKVSVY 87

                        90       100       110
                ....*....|....*....|....*....|
gi 21757183 343 FVDYGNKSHVDLHLLMEIPCQFLELPFQAL 372
Cdd:cd20438  88 FLDFGNTDTVPFYDVKTLLPEFSELPALAM 117

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21757183 326 YFRAQVLYVSGNSAEVFFVDYGNKSHVDLHLLMEIPCQFLELPFQALEFKICKMRP 381
Cdd:cd20427  38 WLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21757183 308 PHPDLVCLAPFADfdkQRYFRAQVLYVSGNSA-EVFFVDYGNKSHVDLHLLMEIPCQFLELPFQALEFKICKMRP 381
Cdd:cd20415  25 PVQGQACVALFED---GAWYRARIIGLPGHREvEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21757183 327 FRAQVL-YVSGNSAEVFFVDYGNKSHVDLHLLMEIPCQFLELP 368
Cdd:cd20441  55 YRAVITaVLPGKSFKVEFIDYGNTAVVDKSNIYTLQEKFLSLP 97