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Conserved domains on  [gi|20218971|dbj|BAB90980|]
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tail lysozyme [Escherichia phage RB49]

Protein Classification

type VI secretion system Vgr family protein( domain architecture ID 11476042)

type VI secretion system Vgr family protein; type VI secretion system tip protein VgrG is a core component and effector of Type VI secretion systems (T6SSs) that are involved in the pathogenicity of several Gram-negative bacteria

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 2-600 0e+00

baseplate hub subunit and tail lysozyme; Provisional


:

Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 1054.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971    2 LMFNNSVKWFTGIVENREDPLMLGRVQVRIHGIHPSLSAHGDIQGLPTEDLLWITPVQDITSAAISGIGQSPTGIVEGSM 81
Cdd:PHA02596   1 EMINNNLKWFVGVVEDRMDPLKLGRVRVRVHGIHPAQKAKGDVYGIPTEDLPWMSVIQPITSAAISGIGQSPTGIVEGTH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971   82 VFGLALDERYLNCVILGTIAGQYTEKPLTTEGFCDPSGAYPRYIGNDVNILARGGINPETgqttkPDSVYIRDENTGVAV 161
Cdd:PHA02596  81 VYGHFLDKWKQNGLILGTYGGIYREKPNTNEGFSDPTGQYPRYVGNDVNVLARGGEVGYD-----PSSVVIQDANTDVAI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  162 NPDDEPLDQIPVDDNPDFTIEKMLRGDEGYREKWYLDSEGYPTIGIGHLIIYKKTSDLGIINNELSKLVGREVTNGRLTA 241
Cdd:PHA02596 156 NPDDTPLDEIPPDDNPDFTIEKMLRRDEGIRLKVYWDSEGYPTIGIGHLIIREKTRDMAQINKLLSKQVGREVTGGRITA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  242 EEVSKVFADDIEKTRRDMRKHPRIAPVYNKCNASRRMALENMAFQMGVGGLGKFKNSLAAMLAEEWKQAYDGLRQSVWAN 321
Cdd:PHA02596 236 EEASKLFARDLAKVQRDISRHSKVGPVYNKLNRSRQMALENMAFQMGVGGVAKFKNMLAAMLAGDWKKAYDALRDSLWAN 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  322 QTPGRSSRVSKIILTGNLESYGVIAPkkeesisDDPRARLRNAriAAYKTQRAEEEDPEAPFTPQDTRIMFKEPKSSYSA 401
Cdd:PHA02596 316 QTPGRASRVSKIILTGNLESYGVMVP-------DPPGRSLSTI--AAYKTAVATSSDPADPFTPGDTRIMFKEPKSSYSA 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  402 RYPYNHVYESESGHIIEIDDTPSHERYHRKHPSGTFEETRPDGTRVEKIEGDDYLIVKQGRKVNVKGNLQVVVEGDAQVY 481
Cdd:PHA02596 387 EYPYNHVMESESGHIQEFDDTPGHERYRRVHPTGTYEEIRPDGTRVVKIVGDDYYIVKQDRNVNVKGNLKVVVEGDAIYY 466

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  482 YMGNVMQTVDGNVTEFIRGNVNQTVEGTANMHVVGDVTAQLDANLTANVKGNAELMIEGNTTETIKGNYDLTVEGNFNMT 561
Cdd:PHA02596 467 NMGNVLQTIDGNVTIFVRGNVTKTVEGNGTLYVKGNVTVQVDGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEGNFDMT 546

                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 20218971  562 VNGTKSDQVNGDWSrncgasvkdIASGTVKIDGSRIDLG 600
Cdd:PHA02596 547 VGGNWSEQMAGMSS---------IASGTYTIDGSRIDIG 576
 
Name Accession Description Interval E-value
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 2-600 0e+00

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 1054.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971    2 LMFNNSVKWFTGIVENREDPLMLGRVQVRIHGIHPSLSAHGDIQGLPTEDLLWITPVQDITSAAISGIGQSPTGIVEGSM 81
Cdd:PHA02596   1 EMINNNLKWFVGVVEDRMDPLKLGRVRVRVHGIHPAQKAKGDVYGIPTEDLPWMSVIQPITSAAISGIGQSPTGIVEGTH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971   82 VFGLALDERYLNCVILGTIAGQYTEKPLTTEGFCDPSGAYPRYIGNDVNILARGGINPETgqttkPDSVYIRDENTGVAV 161
Cdd:PHA02596  81 VYGHFLDKWKQNGLILGTYGGIYREKPNTNEGFSDPTGQYPRYVGNDVNVLARGGEVGYD-----PSSVVIQDANTDVAI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  162 NPDDEPLDQIPVDDNPDFTIEKMLRGDEGYREKWYLDSEGYPTIGIGHLIIYKKTSDLGIINNELSKLVGREVTNGRLTA 241
Cdd:PHA02596 156 NPDDTPLDEIPPDDNPDFTIEKMLRRDEGIRLKVYWDSEGYPTIGIGHLIIREKTRDMAQINKLLSKQVGREVTGGRITA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  242 EEVSKVFADDIEKTRRDMRKHPRIAPVYNKCNASRRMALENMAFQMGVGGLGKFKNSLAAMLAEEWKQAYDGLRQSVWAN 321
Cdd:PHA02596 236 EEASKLFARDLAKVQRDISRHSKVGPVYNKLNRSRQMALENMAFQMGVGGVAKFKNMLAAMLAGDWKKAYDALRDSLWAN 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  322 QTPGRSSRVSKIILTGNLESYGVIAPkkeesisDDPRARLRNAriAAYKTQRAEEEDPEAPFTPQDTRIMFKEPKSSYSA 401
Cdd:PHA02596 316 QTPGRASRVSKIILTGNLESYGVMVP-------DPPGRSLSTI--AAYKTAVATSSDPADPFTPGDTRIMFKEPKSSYSA 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  402 RYPYNHVYESESGHIIEIDDTPSHERYHRKHPSGTFEETRPDGTRVEKIEGDDYLIVKQGRKVNVKGNLQVVVEGDAQVY 481
Cdd:PHA02596 387 EYPYNHVMESESGHIQEFDDTPGHERYRRVHPTGTYEEIRPDGTRVVKIVGDDYYIVKQDRNVNVKGNLKVVVEGDAIYY 466

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  482 YMGNVMQTVDGNVTEFIRGNVNQTVEGTANMHVVGDVTAQLDANLTANVKGNAELMIEGNTTETIKGNYDLTVEGNFNMT 561
Cdd:PHA02596 467 NMGNVLQTIDGNVTIFVRGNVTKTVEGNGTLYVKGNVTVQVDGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEGNFDMT 546

                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 20218971  562 VNGTKSDQVNGDWSrncgasvkdIASGTVKIDGSRIDLG 600
Cdd:PHA02596 547 VGGNWSEQMAGMSS---------IASGTYTIDGSRIDIG 576
Gp5_OB pfam06714
Gp5 N-terminal OB domain; This domain is found at the N terminus of the Gp5 baseplate protein ...
 33-178 1.56e-81

Gp5 N-terminal OB domain; This domain is found at the N terminus of the Gp5 baseplate protein of bacteriophage T4. This domain binds to the Gp27 protein. This domain has the common OB fold.


Pssm-ID: 148361  Cd Length: 144  Bit Score: 252.39  E-value: 1.56e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971    33 GIHPSLSAHGDIQGLPTEDLLWITPVQDITSAAISGIGQSPTGIVEGSMVFGLALDERYLNCVILGTIAGQYTEKPLTTE 112
Cdd:pfam06714   1 GIHPEQKVKGDVQGIPTEDLLWMSPMQPITSAAVSGIGQSPTGIVEGTHVYGFFLDKWYQNGVILGTYPGIYKEKPNTNK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20218971   113 GFCDPSGAYPRYIGNDVNILARGGINPETGQTTkpDSVYIRDENTGVAVNPDDEPLDQIPVDDNPD 178
Cdd:pfam06714  81 GFSDPNGQYPRYVGNDVNVLARGGKDPEVGYGS--SSNVIQDSNTDVAINPDDTPLDEIPPDDNPD 144
T4-like_lys cd00735
bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1, ...
 180-341 4.91e-74

bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.


Pssm-ID: 381597  Cd Length: 146  Bit Score: 233.03  E-value: 4.91e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 180 TIEKMLRGDEGYREKWYLDSEGYPTIGIGHLIIYKKTSdlgiinnelsklvgreVTNGRLTAEEVSKVFADDIEKTRRDM 259
Cdd:cd00735   1 TIREMLRQDEGYRLKAYKDTEGYPTIGIGHLIGKKGAS----------------LTNGTITKDEAEALFEQDVDRAVRDM 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 260 RKHPRIAPVYNKCNASRRMALENMAFQMGVGGLGKFKNSLAAMLAEEWKQAYDGLRQSVWANQTPGRSSRVSKIILTGNL 339
Cdd:cd00735  65 LRNPKLAPVYAQLNAARRMALINMAFQMGVGGLAKFKNMLAAIKAGDWEEAADGMLNSLWAKQTPNRANRVSAVMRTGTW 144


                ..
gi 20218971 340 ES 341
Cdd:cd00735 145 AP 146
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
189-321 2.18e-07

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 50.61  E-value: 2.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 189 EGYREKWYLDSEGYPTIGIGHLiiykktsdlgiinnelsklvGREVTNG-RLTAEEVSKVFADDIEKTRRDMRKHPRIap 267
Cdd:COG3772  16 EGFRLKAYRDPAGVWTIGYGHT--------------------GKDVKPGdTITEEEAEALLAADLAKAEAAVRRLVKV-- 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 20218971 268 vynKCNASRRMALENMAFQMGVGGLGkfKNSLAAML-AEEWKQAYDGLRQSVWAN 321
Cdd:COG3772  74 ---PLTQNQFDALVSFAYNVGAGAFC--RSTLLRKLnAGDYAGACDELLRWVYAG 123
 
Name Accession Description Interval E-value
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 2-600 0e+00

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 1054.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971    2 LMFNNSVKWFTGIVENREDPLMLGRVQVRIHGIHPSLSAHGDIQGLPTEDLLWITPVQDITSAAISGIGQSPTGIVEGSM 81
Cdd:PHA02596   1 EMINNNLKWFVGVVEDRMDPLKLGRVRVRVHGIHPAQKAKGDVYGIPTEDLPWMSVIQPITSAAISGIGQSPTGIVEGTH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971   82 VFGLALDERYLNCVILGTIAGQYTEKPLTTEGFCDPSGAYPRYIGNDVNILARGGINPETgqttkPDSVYIRDENTGVAV 161
Cdd:PHA02596  81 VYGHFLDKWKQNGLILGTYGGIYREKPNTNEGFSDPTGQYPRYVGNDVNVLARGGEVGYD-----PSSVVIQDANTDVAI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  162 NPDDEPLDQIPVDDNPDFTIEKMLRGDEGYREKWYLDSEGYPTIGIGHLIIYKKTSDLGIINNELSKLVGREVTNGRLTA 241
Cdd:PHA02596 156 NPDDTPLDEIPPDDNPDFTIEKMLRRDEGIRLKVYWDSEGYPTIGIGHLIIREKTRDMAQINKLLSKQVGREVTGGRITA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  242 EEVSKVFADDIEKTRRDMRKHPRIAPVYNKCNASRRMALENMAFQMGVGGLGKFKNSLAAMLAEEWKQAYDGLRQSVWAN 321
Cdd:PHA02596 236 EEASKLFARDLAKVQRDISRHSKVGPVYNKLNRSRQMALENMAFQMGVGGVAKFKNMLAAMLAGDWKKAYDALRDSLWAN 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  322 QTPGRSSRVSKIILTGNLESYGVIAPkkeesisDDPRARLRNAriAAYKTQRAEEEDPEAPFTPQDTRIMFKEPKSSYSA 401
Cdd:PHA02596 316 QTPGRASRVSKIILTGNLESYGVMVP-------DPPGRSLSTI--AAYKTAVATSSDPADPFTPGDTRIMFKEPKSSYSA 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  402 RYPYNHVYESESGHIIEIDDTPSHERYHRKHPSGTFEETRPDGTRVEKIEGDDYLIVKQGRKVNVKGNLQVVVEGDAQVY 481
Cdd:PHA02596 387 EYPYNHVMESESGHIQEFDDTPGHERYRRVHPTGTYEEIRPDGTRVVKIVGDDYYIVKQDRNVNVKGNLKVVVEGDAIYY 466

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971  482 YMGNVMQTVDGNVTEFIRGNVNQTVEGTANMHVVGDVTAQLDANLTANVKGNAELMIEGNTTETIKGNYDLTVEGNFNMT 561
Cdd:PHA02596 467 NMGNVLQTIDGNVTIFVRGNVTKTVEGNGTLYVKGNVTVQVDGNLDATVKGNATTLVEGNQTNTVNGNYKLKVEGNFDMT 546

                        570       580       590
                 ....*....|....*....|....*....|....*....
gi 20218971  562 VNGTKSDQVNGDWSrncgasvkdIASGTVKIDGSRIDLG 600
Cdd:PHA02596 547 VGGNWSEQMAGMSS---------IASGTYTIDGSRIDIG 576
Gp5_OB pfam06714
Gp5 N-terminal OB domain; This domain is found at the N terminus of the Gp5 baseplate protein ...
 33-178 1.56e-81

Gp5 N-terminal OB domain; This domain is found at the N terminus of the Gp5 baseplate protein of bacteriophage T4. This domain binds to the Gp27 protein. This domain has the common OB fold.


Pssm-ID: 148361  Cd Length: 144  Bit Score: 252.39  E-value: 1.56e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971    33 GIHPSLSAHGDIQGLPTEDLLWITPVQDITSAAISGIGQSPTGIVEGSMVFGLALDERYLNCVILGTIAGQYTEKPLTTE 112
Cdd:pfam06714   1 GIHPEQKVKGDVQGIPTEDLLWMSPMQPITSAAVSGIGQSPTGIVEGTHVYGFFLDKWYQNGVILGTYPGIYKEKPNTNK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20218971   113 GFCDPSGAYPRYIGNDVNILARGGINPETGQTTkpDSVYIRDENTGVAVNPDDEPLDQIPVDDNPD 178
Cdd:pfam06714  81 GFSDPNGQYPRYVGNDVNVLARGGKDPEVGYGS--SSNVIQDSNTDVAINPDDTPLDEIPPDDNPD 144
T4-like_lys cd00735
bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1, ...
 180-341 4.91e-74

bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.


Pssm-ID: 381597  Cd Length: 146  Bit Score: 233.03  E-value: 4.91e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 180 TIEKMLRGDEGYREKWYLDSEGYPTIGIGHLIIYKKTSdlgiinnelsklvgreVTNGRLTAEEVSKVFADDIEKTRRDM 259
Cdd:cd00735   1 TIREMLRQDEGYRLKAYKDTEGYPTIGIGHLIGKKGAS----------------LTNGTITKDEAEALFEQDVDRAVRDM 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 260 RKHPRIAPVYNKCNASRRMALENMAFQMGVGGLGKFKNSLAAMLAEEWKQAYDGLRQSVWANQTPGRSSRVSKIILTGNL 339
Cdd:cd00735  65 LRNPKLAPVYAQLNAARRMALINMAFQMGVGGLAKFKNMLAAIKAGDWEEAADGMLNSLWAKQTPNRANRVSAVMRTGTW 144


                ..
gi 20218971 340 ES 341
Cdd:cd00735 145 AP 146
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 202-326 7.18e-11

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 59.29  E-value: 7.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971   202 YPTIGIGHliiykKTSDLGiinnelsklvgrevTNGRLTAEEVSKVFADDIEKTRRDMRKHPRIAPVynkcNASRRMALE 281
Cdd:pfam00959   1 YWTIGIGH-----NGKDVS--------------PHPRATKSEAAGRLQIDLDTAERCINQYHKVKDF----NPNQQDALV 57

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 20218971   282 NMAFQMGVGGLGkFKNSLAAMLAEEWKQAYDGLRQSV----WANQTPGR 326
Cdd:pfam00959  58 SLAFNVGCGKRG-FSTLLRAGNIGQWIKACSAIWKSLkagkVYNGLVNR 105
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 184-321 6.85e-08

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 51.75  E-value: 6.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 184 MLRGDEGYREKWYLDSEGYPTIGIGHLIIYKKTSDLGIinnelsklvgrevtngrlTAEEVSKVFADDIEKTRRDMRKHP 263
Cdd:cd00737   4 LIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPGDTI------------------TEAQAEALLRQDLARFEAAVNRLV 65

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 264 RIAPvynkcNASRRMALENMAFQMGVGGlgkFKNS-LAAML-AEEWKQAYDGLRQSVWAN 321
Cdd:cd00737  66 KVPL-----NQNQFDALVSFAFNVGAGA---FKSStLLRKLnAGDYAGAADEFLRWNKAG 117
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
189-321 2.18e-07

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 50.61  E-value: 2.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 189 EGYREKWYLDSEGYPTIGIGHLiiykktsdlgiinnelsklvGREVTNG-RLTAEEVSKVFADDIEKTRRDMRKHPRIap 267
Cdd:COG3772  16 EGFRLKAYRDPAGVWTIGYGHT--------------------GKDVKPGdTITEEEAEALLAADLAKAEAAVRRLVKV-- 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 20218971 268 vynKCNASRRMALENMAFQMGVGGLGkfKNSLAAML-AEEWKQAYDGLRQSVWAN 321
Cdd:COG3772  74 ---PLTQNQFDALVSFAYNVGAGAFC--RSTLLRKLnAGDYAGACDELLRWVYAG 123
lyz_P1 cd16901
P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the ...
 189-310 3.25e-05

P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the Escherichia coli periplasm where it is membrane bound and inactive. Activation involves the release from the membrane, an intramolecular thiol-disulfide isomerization and extensive structural rearrangement of the N-terminal region. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381620 [Multi-domain]  Cd Length: 140  Bit Score: 44.13  E-value: 3.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971 189 EGYREKWYLDSEGYPTIGIGHliiykkTSdlGIInnelsklvgrevTNGRLTAEEVSKVFADDIEKTRRdmrkhpriapV 268
Cdd:cd16901  14 EGCRRDPYKCPAGVPTIGIGS------TH--GVK------------PGDRYTDEQAAKRLAKDIKKAER----------C 63

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 20218971 269 YNKCNASRRM------ALENMAFQMGVgglGKFKNS--LAAMLAEEWKQA 310
Cdd:cd16901  64 VNRCFNGVPLpqgefdAYVSFAFNVGC---GAFCKStiYKKLQAGDYAAA 110
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 465-557 1.11e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 45.55  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971   465 NVKGNLQVVVEGDAQvyymGNVMQTVDGNVTEFIRGNVNQTVEGTANMHVVGDVTAQLDANLTANVKGNAELMIEGNTTE 544
Cdd:PTZ00341  938 HLKEHAEANIEEDAE----ENVEEDAEENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENIEENVEENVEE 1013

                          90
                  ....*....|...
gi 20218971   545 TIKGNYDLTVEGN 557
Cdd:PTZ00341 1014 NIEENVEEYDEEN 1026
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 458-555 1.18e-04

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 45.16  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971   458 VKQGRKVNVKGNLQVVVEGDAQvyymGNVMQTVDGNVTEFIRGNVNQTVEGTANMHVVGDVTAQLDANLTANVKGNAELM 537
Cdd:PTZ00341  939 LKEHAEANIEEDAEENVEEDAE----ENVEENVEENVEENVEENVEENVEENVEENVEENVEENVEENIEENVEENVEEN 1014

                          90
                  ....*....|....*...
gi 20218971   538 IEGNTTETIKGNYDLTVE 555
Cdd:PTZ00341 1015 IEENVEEYDEENVEEVEE 1032
34 PHA02584
long tail fiber, proximal subunit; Provisional
 485-573 7.06e-04

long tail fiber, proximal subunit; Provisional


Pssm-ID: 222890 [Multi-domain]  Cd Length: 1229  Bit Score: 42.82  E-value: 7.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20218971   485 NVMQTVDGnvTEFIRGNVNQTVEG----TANMHVVGDVTAQLDANLTANVKGNAELMIEGNTTETIKgnYDLTVEGNFNM 560
Cdd:PHA02584  888 LKLDGLDS--AQFIRRDIDQTVNGsltfTKNTNLSAPLVSSSTATFGGSVTANSTLTTQNTSNGTVV--VVDETSIAFYS 963

                          90
                  ....*....|...
gi 20218971   561 TVNGTKSDQVNGD 573
Cdd:PHA02584  964 QNNTTGNIVFNID 976
Gp5_C pfam06715
Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the ...
 476-499 7.70e-03

Gp5 C-terminal repeat (3 copies); This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5. This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerize to form a beta solenoid type structure. This family also includes repeats from bacterial Vgr proteins.


Pssm-ID: 310962 [Multi-domain]  Cd Length: 24  Bit Score: 34.18  E-value: 7.70e-03
                          10        20
                  ....*....|....*....|....
gi 20218971   476 GDAQVYYMGNVMQTVDGNVTEFIR 499
Cdd:pfam06715   1 GNETETVGGNRTVTVGGNETETVG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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