unnamed protein product [Mus musculus]
tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO( domain architecture ID 15875202)
tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO methylates position 37 (m(6)t(6)A37) to form N6-methyl-N6-threonylcarbamoyladenosine of the tRNA anticodon loop of tRNA(Thr)(GGU) that read codons starting with adenosine
List of domain hits
Name | Accession | Description | Interval | E-value | |||
TrmO | pfam01980 | tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) ... |
45-164 | 1.55e-60 | |||
tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) also known as YaeB, which contains a single-sheeted beta-barrel structure. TrmO is an AdoMet-dependent methyltransferase responsible for m6t6A formation. Its human homolog, is responsible for formation of m6t6A37 in cytoplasmic tRNASer. Lack of TrmO decreases attenuation activity of the thr operon, indicating that N6 methylation of m6t6A37 ensures efficient decoding of ACY codons. In bacteria and eukaryotes, TrmO has a C-terminal domain containing the conserved DPRxxY motif. Where the Asp194 and Arg196 in this motif of E. coli TrmO are necessary for N6-methylation. However, no archaeal YaeB has a C-terminal domain containing the DPRxxY motif that is conserved in bacterial and mammalian TrmO homologs. : Pssm-ID: 460402 Cd Length: 116 Bit Score: 192.23 E-value: 1.55e-60
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TrmO_C super family | cl39727 | TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase ... |
325-387 | 3.72e-05 | |||
TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase proteins. This domain has a RelE fold. The actual alignment was detected with superfamily member pfam18389: Pssm-ID: 465738 Cd Length: 65 Bit Score: 41.44 E-value: 3.72e-05
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Name | Accession | Description | Interval | E-value | |||
TrmO | pfam01980 | tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) ... |
45-164 | 1.55e-60 | |||
tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) also known as YaeB, which contains a single-sheeted beta-barrel structure. TrmO is an AdoMet-dependent methyltransferase responsible for m6t6A formation. Its human homolog, is responsible for formation of m6t6A37 in cytoplasmic tRNASer. Lack of TrmO decreases attenuation activity of the thr operon, indicating that N6 methylation of m6t6A37 ensures efficient decoding of ACY codons. In bacteria and eukaryotes, TrmO has a C-terminal domain containing the conserved DPRxxY motif. Where the Asp194 and Arg196 in this motif of E. coli TrmO are necessary for N6-methylation. However, no archaeal YaeB has a C-terminal domain containing the DPRxxY motif that is conserved in bacterial and mammalian TrmO homologs. Pssm-ID: 460402 Cd Length: 116 Bit Score: 192.23 E-value: 1.55e-60
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TrmO | COG1720 | tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA ... |
31-168 | 1.11e-54 | |||
tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA (Thr-GGU) A37 N6-methylase is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 441326 Cd Length: 152 Bit Score: 178.41 E-value: 1.11e-54
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UPF0066 | cd09281 | Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This ... |
32-159 | 1.74e-53 | |||
Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown. Pssm-ID: 187753 Cd Length: 124 Bit Score: 174.60 E-value: 1.74e-53
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tRNA_TsaA | TIGR00104 | tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA; This protein has been characterized by ... |
31-170 | 2.46e-37 | |||
tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA; This protein has been characterized by crystallography in complex with S-Adenosylmethionine, making it a probable S-adenosylmethionine-dependent methyltransferase. Analysis in EcoGene links this protein to the enzyme characterization mapped to the tsaA gene in Escherichia coli. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 129210 Cd Length: 142 Bit Score: 132.98 E-value: 2.46e-37
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TrmO_C | pfam18389 | TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase ... |
325-387 | 3.72e-05 | |||
TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase proteins. This domain has a RelE fold. Pssm-ID: 465738 Cd Length: 65 Bit Score: 41.44 E-value: 3.72e-05
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Name | Accession | Description | Interval | E-value | |||
TrmO | pfam01980 | tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) ... |
45-164 | 1.55e-60 | |||
tRNA-methyltransferase O; This family includes members such as TrmO (tRNA-methyltransferase O) also known as YaeB, which contains a single-sheeted beta-barrel structure. TrmO is an AdoMet-dependent methyltransferase responsible for m6t6A formation. Its human homolog, is responsible for formation of m6t6A37 in cytoplasmic tRNASer. Lack of TrmO decreases attenuation activity of the thr operon, indicating that N6 methylation of m6t6A37 ensures efficient decoding of ACY codons. In bacteria and eukaryotes, TrmO has a C-terminal domain containing the conserved DPRxxY motif. Where the Asp194 and Arg196 in this motif of E. coli TrmO are necessary for N6-methylation. However, no archaeal YaeB has a C-terminal domain containing the DPRxxY motif that is conserved in bacterial and mammalian TrmO homologs. Pssm-ID: 460402 Cd Length: 116 Bit Score: 192.23 E-value: 1.55e-60
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TrmO | COG1720 | tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA ... |
31-168 | 1.11e-54 | |||
tRNA (Thr-GGU) A37 N6-methylase [Translation, ribosomal structure and biogenesis]; tRNA (Thr-GGU) A37 N6-methylase is part of the Pathway/BioSystem: tRNA modification Pssm-ID: 441326 Cd Length: 152 Bit Score: 178.41 E-value: 1.11e-54
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UPF0066 | cd09281 | Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This ... |
32-159 | 1.74e-53 | |||
Escherichia coli YaeB and related proteins; Uncharacterized protein family UPF0066. This domain includes Escherichia coli YeaB, Archeoglobus fulgidus AF0241, and Agrobacterium tumefaciens VirR. Proteins with this domain are probable S-adenosylmethionine-dependent methyltransferases but they have not been functionally characterized and the substrate is unknown. Pssm-ID: 187753 Cd Length: 124 Bit Score: 174.60 E-value: 1.74e-53
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tRNA_TsaA | TIGR00104 | tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA; This protein has been characterized by ... |
31-170 | 2.46e-37 | |||
tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA; This protein has been characterized by crystallography in complex with S-Adenosylmethionine, making it a probable S-adenosylmethionine-dependent methyltransferase. Analysis in EcoGene links this protein to the enzyme characterization mapped to the tsaA gene in Escherichia coli. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 129210 Cd Length: 142 Bit Score: 132.98 E-value: 2.46e-37
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TrmO_C | pfam18389 | TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase ... |
325-387 | 3.72e-05 | |||
TrmO C-terminal domain; This domain is found at the C-terminus of TrmO tRNA methyltransferase proteins. This domain has a RelE fold. Pssm-ID: 465738 Cd Length: 65 Bit Score: 41.44 E-value: 3.72e-05
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Blast search parameters | ||||
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