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Conserved domains on  [gi|12845975|dbj|BAB26980|]
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unnamed protein product [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-322 8.63e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 8.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  11 PRFVLRGTQSAVNTLHFCPPSQTagnplLFSGSQNGLVHIWSLQTRRIITTLNGH--WGQGVIWL---KTLpqgqqlLTQ 85
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKT-----LASGSADGTVRLWDLATGKLLRTLTGHsgAVTSVAFSpdgKLL------ASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  86 GQNLQLCLWQLEEGRHSITgissagqcglLKGvHPGQGTAVlmfAVprkSSDEFQILempSKTSECTLKpeadarpgmpm 165
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRT----------LTG-HTGAVRSV---AF---SPDGKLLA---SGSADGTVR----------- 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 166 clgLW--QTNSSLRPL------------------LLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgI 223
Cdd:COG2319 230 ---LWdlATGKLLRTLtghsgsvrsvafspdgrlLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--A 304

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 224 SGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFA 303
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                       330       340
                ....*....|....*....|
gi 12845975 304 ADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 382 PDGrTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-322 8.63e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 8.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  11 PRFVLRGTQSAVNTLHFCPPSQTagnplLFSGSQNGLVHIWSLQTRRIITTLNGH--WGQGVIWL---KTLpqgqqlLTQ 85
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKT-----LASGSADGTVRLWDLATGKLLRTLTGHsgAVTSVAFSpdgKLL------ASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  86 GQNLQLCLWQLEEGRHSITgissagqcglLKGvHPGQGTAVlmfAVprkSSDEFQILempSKTSECTLKpeadarpgmpm 165
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRT----------LTG-HTGAVRSV---AF---SPDGKLLA---SGSADGTVR----------- 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 166 clgLW--QTNSSLRPL------------------LLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgI 223
Cdd:COG2319 230 ---LWdlATGKLLRTLtghsgsvrsvafspdgrlLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--A 304

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 224 SGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFA 303
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                       330       340
                ....*....|....*....|
gi 12845975 304 ADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 382 PDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-321 2.47e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 2.47e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  11 PRFVLRGTQSAVNTLHFCPPSqtagnPLLFSGSQNGLVHIWSLQTRRIITTLNGHwGQGVIWLKTLPQGQQLLTQGQNLQ 90
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-----KLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  91 LCLWQLEEGR--HSITGissagqcgllkgvHPGQGTAVlMFAVPRK-----SSD-EFQILEMPSKTSECTLKPEADArpg 162
Cdd:cd00200  75 IRLWDLETGEcvRTLTG-------------HTSYVSSV-AFSPDGRilsssSRDkTIKVWDVETGKCLTTLRGHTDW--- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 163 mPMCLGLWQTNSslrpLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSL 242
Cdd:cd00200 138 -VNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 243 QVKKTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:cd00200 213 GTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-322 9.28e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 9.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  173 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 251
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12845975  252 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 322
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-321 3.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.19e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 12845975    283 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
284-321 1.50e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.50e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 12845975   284 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-322 8.63e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 8.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  11 PRFVLRGTQSAVNTLHFCPPSQTagnplLFSGSQNGLVHIWSLQTRRIITTLNGH--WGQGVIWL---KTLpqgqqlLTQ 85
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKT-----LASGSADGTVRLWDLATGKLLRTLTGHsgAVTSVAFSpdgKLL------ASG 180

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  86 GQNLQLCLWQLEEGRHSITgissagqcglLKGvHPGQGTAVlmfAVprkSSDEFQILempSKTSECTLKpeadarpgmpm 165
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRT----------LTG-HTGAVRSV---AF---SPDGKLLA---SGSADGTVR----------- 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 166 clgLW--QTNSSLRPL------------------LLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgI 223
Cdd:COG2319 230 ---LWdlATGKLLRTLtghsgsvrsvafspdgrlLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--A 304

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 224 SGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFA 303
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGH---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                       330       340
                ....*....|....*....|
gi 12845975 304 ADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 382 PDGrTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-321 2.47e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 2.47e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  11 PRFVLRGTQSAVNTLHFCPPSqtagnPLLFSGSQNGLVHIWSLQTRRIITTLNGHwGQGVIWLKTLPQGQQLLTQGQNLQ 90
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-----KLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  91 LCLWQLEEGR--HSITGissagqcgllkgvHPGQGTAVlMFAVPRK-----SSD-EFQILEMPSKTSECTLKPEADArpg 162
Cdd:cd00200  75 IRLWDLETGEcvRTLTG-------------HTSYVSSV-AFSPDGRilsssSRDkTIKVWDVETGKCLTTLRGHTDW--- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 163 mPMCLGLWQTNSslrpLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSL 242
Cdd:cd00200 138 -VNSVAFSPDGT----FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 243 QVKKTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:cd00200 213 GTLRGHE---NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-322 3.65e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 3.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 174 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 253
Cdd:cd00200  18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 254 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:cd00200  95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
174-322 4.83e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.67  E-value: 4.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 174 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 253
Cdd:COG2319  45 SPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT---G 121

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 254 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319 122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWDL 191
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-322 1.93e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 1.93e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 202 QITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHELtnpGIAEVTIRPDHKILATAGWDHRIRVFHW 281
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---PVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 12845975 282 RTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 322
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
11-283 1.47e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  11 PRFVLRGTQSAVNTLHFCPPSQTagnplLFSGSQNGLVHIWSLQTRRIITTLNGHWGQ--GVIWL---KTLpqgqqlLTQ 85
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKL-----LASGSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFSpdgRLL------ASG 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  86 GQNLQLCLWQLEEGRHSITgissagqcglLKGvHPGQGTAVlMFAvprkssdefqilempsktsectlkpeADARpgmpm 165
Cdd:COG2319 265 SADGTVRLWDLATGELLRT----------LTG-HSGGVNSV-AFS--------------------------PDGK----- 301

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 166 clglwqtnsslrpLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVK 245
Cdd:COG2319 302 -------------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 12845975 246 KTHEltnPGIAEVTIRPDHKILATAGWDHRIRVFHWRT 283
Cdd:COG2319 369 TGHT---GAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-322 9.28e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 9.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975  173 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 251
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12845975  252 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 322
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-321 3.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.19e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 12845975    283 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
284-321 1.50e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.50e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 12845975   284 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 321
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-325 1.29e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.01  E-value: 1.29e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 12845975 293 HSAPVYCVAFAADG-LLAAGSKDQRISIWSLYPC 325
Cdd:cd00200   8 HTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
238-319 5.68e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 37.75  E-value: 5.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 238 DQQSLQVKKTHELtNPGIAEVTIRPD-HKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPvYCVAFAADG--LLAAGSKD 314
Cdd:COG3391  96 DLATGKVVATIPV-GGGPRGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGkrLYVANSGS 173


                ....*
gi 12845975 315 QRISI 319
Cdd:COG3391 174 NTVSV 178
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-52 6.99e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.99e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 12845975     11 PRFVLRGTQSAVNTLHFCPPSQtagnpLLFSGSQNGLVHIWS 52
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGK-----YLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
220-322 8.00e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.58  E-value: 8.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12845975 220 AKGISGSAGKVLAVWSLDDQQSLQVKKTHELTNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYC 299
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                        90       100
                ....*....|....*....|....
gi 12845975 300 VAFAADG-LLAAGSKDQRISIWSL 322
Cdd:COG2319  84 VAFSPDGrLLASASADGTVRLWDL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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