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Conserved domains on  [gi|26339705|dbj|BAB23764|]
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unnamed protein product [Mus musculus]

Protein Classification

leucine-zipper-like transcriptional regulator 1( domain architecture ID 13286426)

leucine-zipper-like transcriptional regulator 1 (LZTR-1) may act as a transcriptional regulator that plays a crucial role in embryogenesis; contains two BTB/POZ domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 644-769 1.21e-91

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 283.90  E-value: 1.21e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 644 IGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRY 723
Cdd:cd18309   1 IGTTLEQDMEAFLESVGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26339705 724 IYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18309  81 IYYGDVTMPPEDSLYLFSAPYFYGFTNNRLQAYCKQNLEMNVSFEN 126
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 417-568 1.09e-84

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 266.55  E-value: 1.09e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 417 QFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIVQAQEWLAQKLEEDGALAPKEAPGP 496
Cdd:cd18308   1 QFSSYPKCTLHDDFGRLLESRQFCDVEFIVGEEEERIPAHIAFVAARSKWLRNKILQARERQKQKAEQEVEDEGSEADSS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26339705 497 AVGRARPPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKG----HVEDVLLIMDVYKLALSFQLCRLEQLCRQYIE 568
Cdd:cd18308  81 SASKNDSPMLEVRLPEADPEAFELILSFIYTDKIDPTRKGqdpgSNEVVLLMMDVYRLALQFQMSRLEQLCVQYLE 156
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
51-417 3.91e-32

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 126.42  E-value: 3.91e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  51 WRRLPPcdeFVGARRSkHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWcraFTTGTPPAPRYHHSA-VVYGSSMFV 129
Cdd:COG3055   3 WSSLPD---LPTPRSE-AAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTW---SELAPLPGPPRHHAAaVAQDGKLYV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 130 FGGYTGDIYSNSNLknkNDLFEYKFATGQWTEwkiEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWtigLQDREL 209
Cdd:COG3055  76 FGGFTGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVE---VYDPAT 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 210 TCWEEVAqsgEIPPSCCNFPVAVCRD-KMFVFSGQSGakitnnlfqfEFKDKTWTRIptehllrgsPPPPQRRYGHTMVA 288
Cdd:COG3055 147 GTWTQLA---PLPTPRDHLAAAVLPDgKILVIGGRNG----------SGFSNTWTTL---------APLPTARAGHAAAV 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 289 FDRHLYVFGGaaDNTLPNELHCYDVDFQTWEVVqpssdsevggaemperasssedastltseerssfkksrdvfgldfgt 368
Cdd:COG3055 205 LGGKILVFGG--ESGFSDEVEAYDPATNTWTAL----------------------------------------------- 235

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 26339705 369 tsakqpvhlaSELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ 417
Cdd:COG3055 236 ----------GELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
BACK1_LZTR1 cd18505
first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 572-630 1.29e-31

first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


:

Pssm-ID: 350580  Cd Length: 59  Bit Score: 117.38  E-value: 1.29e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 26339705 572 DLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQ 630
Cdd:cd18505   1 NVRNVLVALENASKLNLDQLKEHCLNFIVKESNYNQIVMSKEFEHLDQPLMVEIVRRRQ 59
BACK2_LZTR1 cd18506
second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 765-825 9.96e-27

second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


:

Pssm-ID: 350581  Cd Length: 61  Bit Score: 103.20  E-value: 9.96e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705 765 VTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRLLSQQLLLDIIDSLASHI 825
Cdd:cd18506   1 VSFENVLQILEAADKIQALDMKKHALHIIVHHFPKVARLPKLRSLSRELLLDIIDALADHM 61
 
Name Accession Description Interval E-value
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 644-769 1.21e-91

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 283.90  E-value: 1.21e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 644 IGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRY 723
Cdd:cd18309   1 IGTTLEQDMEAFLESVGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26339705 724 IYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18309  81 IYYGDVTMPPEDSLYLFSAPYFYGFTNNRLQAYCKQNLEMNVSFEN 126
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 417-568 1.09e-84

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 266.55  E-value: 1.09e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 417 QFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIVQAQEWLAQKLEEDGALAPKEAPGP 496
Cdd:cd18308   1 QFSSYPKCTLHDDFGRLLESRQFCDVEFIVGEEEERIPAHIAFVAARSKWLRNKILQARERQKQKAEQEVEDEGSEADSS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26339705 497 AVGRARPPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKG----HVEDVLLIMDVYKLALSFQLCRLEQLCRQYIE 568
Cdd:cd18308  81 SASKNDSPMLEVRLPEADPEAFELILSFIYTDKIDPTRKGqdpgSNEVVLLMMDVYRLALQFQMSRLEQLCVQYLE 156
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
51-417 3.91e-32

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 126.42  E-value: 3.91e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  51 WRRLPPcdeFVGARRSkHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWcraFTTGTPPAPRYHHSA-VVYGSSMFV 129
Cdd:COG3055   3 WSSLPD---LPTPRSE-AAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTW---SELAPLPGPPRHHAAaVAQDGKLYV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 130 FGGYTGDIYSNSNLknkNDLFEYKFATGQWTEwkiEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWtigLQDREL 209
Cdd:COG3055  76 FGGFTGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVE---VYDPAT 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 210 TCWEEVAqsgEIPPSCCNFPVAVCRD-KMFVFSGQSGakitnnlfqfEFKDKTWTRIptehllrgsPPPPQRRYGHTMVA 288
Cdd:COG3055 147 GTWTQLA---PLPTPRDHLAAAVLPDgKILVIGGRNG----------SGFSNTWTTL---------APLPTARAGHAAAV 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 289 FDRHLYVFGGaaDNTLPNELHCYDVDFQTWEVVqpssdsevggaemperasssedastltseerssfkksrdvfgldfgt 368
Cdd:COG3055 205 LGGKILVFGG--ESGFSDEVEAYDPATNTWTAL----------------------------------------------- 235

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 26339705 369 tsakqpvhlaSELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ 417
Cdd:COG3055 236 ----------GELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
BACK1_LZTR1 cd18505
first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 572-630 1.29e-31

first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


Pssm-ID: 350580  Cd Length: 59  Bit Score: 117.38  E-value: 1.29e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 26339705 572 DLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQ 630
Cdd:cd18505   1 NVRNVLVALENASKLNLDQLKEHCLNFIVKESNYNQIVMSKEFEHLDQPLMVEIVRRRQ 59
BACK2_LZTR1 cd18506
second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 765-825 9.96e-27

second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


Pssm-ID: 350581  Cd Length: 61  Bit Score: 103.20  E-value: 9.96e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705 765 VTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRLLSQQLLLDIIDSLASHI 825
Cdd:cd18506   1 VSFENVLQILEAADKIQALDMKKHALHIIVHHFPKVARLPKLRSLSRELLLDIIDALADHM 61
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 662-761 8.16e-22

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 91.16  E-value: 8.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVnMPPEDSLYLFA 741
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPE--DFEALLEFMYTGKL-ISEENVDDLLA 85

                          90       100
                  ....*....|....*....|
gi 26339705   742 APYYYGFYnnRLQAYCKQNL 761
Cdd:pfam00651  86 AADKLQIP--SLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 665-762 1.26e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 78.50  E-value: 1.26e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705    665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPY 744
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDV--SPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*...
gi 26339705    745 YYGfyNNRLQAYCKQNLE 762
Cdd:smart00225  79 YLQ--IPGLVELCEEFLL 94
PLN02153 PLN02153
epithiospecifier protein
 65-347 5.32e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 65.01  E-value: 5.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   65 RSKHTVVAYKDAIYVFGGD--NGKTMLNDLLRFDVKDCSWCRAFTTGTPPA-PRYHHSAVVYGSSMFVFGGytgdiySNS 141
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGElkPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGG------RDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  142 NlKNKNDLFEYKFATGQW---TEWKIEGRlPVARSAHGATVYSDKLWIFAGYDGNARLND---MWTIGLQDRELTCWEEV 215
Cdd:PLN02153  97 K-REFSDFYSYDTVKNEWtflTKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTperFRTIEAYNIADGKWVQL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  216 AQSGEippsccNFP------VAVCRDKMFVFSGQSGAKI--------TNNLFQFEFKDKTWTRIPTEhllrGSPPPPQRR 281
Cdd:PLN02153 175 PDPGE------NFEkrggagFAVVQGKIWVVYGFATSILpggksdyeSNAVQFFDPASGKWTEVETT----GAKPSARSV 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26339705  282 YGHTMVAfdRHLYVFGGA---------ADNTLPNELHCYDVDFQTWEVVqpssdSEVGGAEMPeRASSSEDASTL 347
Cdd:PLN02153 245 FAHAVVG--KYIIIFGGEvwpdlkghlGPGTLSNEGYALDTETLVWEKL-----GECGEPAMP-RGWTAYTTATV 311
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 158-328 2.04e-07

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 53.64  E-value: 2.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   158 QWTEwkiEGRLPVArSAHGATVYSDKLWIFAG-YDGNARLNDMWTIGLQDRELTCWEEVAqsGEIPPSCCNFPVAVCRDK 236
Cdd:TIGR03548  53 KWVK---AGQLPYE-IAYGASVSTPYGIYYVGgSPSSESFSDVLLLSLDDTKEALIIETL--PSLPVAFDNGSATYKDGK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   237 MFVFSGQSGAKITNNLFQFEFKDKT--WTRIPTEhllrgsppPPQRRYGHTMVAFDRHLYVFGGAA---DNTLPNELHCY 311
Cdd:TIGR03548 127 IYVGGGNANGKPSNKFYCLDLSNDTsgWEELPEF--------PGEARVQPVCQALHGKLYVFGGFQlggDAIIYTDGYAY 198

                         170
                  ....*....|....*....
gi 26339705   312 DVDFQTWEVVQ--PSSDSE 328
Cdd:TIGR03548 199 SPKTNTWQTVAdpVLSDGE 217
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 280-323 8.00e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.45  E-value: 8.00e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 26339705   280 RRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQP 323
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 430-570 8.63e-05

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 42.63  E-value: 8.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   430 YGRLWEGRQFCDVEFVLGEKEecVQGHVAIVTARSRWLRRKivqaqewLAQKLEEDgalapkeapgpavgrarpPLLRVA 509
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKE--FRAHKAVLAACSPYFKAL-------FSGQESES------------------SVSEIT 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705   510 IREAEARPFEVLMQFLYTDKIKYPRKghvedvllIMDVYKLALSFQLCRLEQLCRQYIEAS 570
Cdd:pfam00651  54 LDDVSPEDFEALLEFMYTGKLISEEN--------VDDLLAAADKLQIPSLVDKCEEFLIKS 106
PHA03098 PHA03098
kelch-like protein; Provisional
 663-742 3.87e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  663 FCDITLLL--DGQPRPAHKAILAARSSYFEAMFRSFMPEDgQVNISIGEmvpsrQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:PHA03098   9 FCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNNFKEN-EINLNIDY-----DSFNEVIKYIYTGKINITSNNVKDIL 82


                 ..
gi 26339705  741 AA 742
Cdd:PHA03098  83 SI 84
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 576-628 5.35e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 37.32  E-value: 5.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 26339705    576 VLVVCESAARLQLGQLKEHCLNFIVKesHFNQVIMMKEFERLSSPLIVEIVRR 628
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQ--NFSEVSSSEEFLELPLEQLLELLSS 51
 
Name Accession Description Interval E-value
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 644-769 1.21e-91

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 283.90  E-value: 1.21e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 644 IGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRY 723
Cdd:cd18309   1 IGTTLEQDMEAFLESVGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26339705 724 IYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18309  81 IYYGDVTMPPEDSLYLFSAPYFYGFTNNRLQAYCKQNLEMNVSFEN 126
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 417-568 1.09e-84

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 266.55  E-value: 1.09e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 417 QFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIVQAQEWLAQKLEEDGALAPKEAPGP 496
Cdd:cd18308   1 QFSSYPKCTLHDDFGRLLESRQFCDVEFIVGEEEERIPAHIAFVAARSKWLRNKILQARERQKQKAEQEVEDEGSEADSS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26339705 497 AVGRARPPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKG----HVEDVLLIMDVYKLALSFQLCRLEQLCRQYIE 568
Cdd:cd18308  81 SASKNDSPMLEVRLPEADPEAFELILSFIYTDKIDPTRKGqdpgSNEVVLLMMDVYRLALQFQMSRLEQLCVQYLE 156
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
51-417 3.91e-32

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 126.42  E-value: 3.91e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  51 WRRLPPcdeFVGARRSkHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWcraFTTGTPPAPRYHHSA-VVYGSSMFV 129
Cdd:COG3055   3 WSSLPD---LPTPRSE-AAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTW---SELAPLPGPPRHHAAaVAQDGKLYV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 130 FGGYTGDIYSNSNLknkNDLFEYKFATGQWTEwkiEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWtigLQDREL 209
Cdd:COG3055  76 FGGFTGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVE---VYDPAT 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 210 TCWEEVAqsgEIPPSCCNFPVAVCRD-KMFVFSGQSGakitnnlfqfEFKDKTWTRIptehllrgsPPPPQRRYGHTMVA 288
Cdd:COG3055 147 GTWTQLA---PLPTPRDHLAAAVLPDgKILVIGGRNG----------SGFSNTWTTL---------APLPTARAGHAAAV 204

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 289 FDRHLYVFGGaaDNTLPNELHCYDVDFQTWEVVqpssdsevggaemperasssedastltseerssfkksrdvfgldfgt 368
Cdd:COG3055 205 LGGKILVFGG--ESGFSDEVEAYDPATNTWTAL----------------------------------------------- 235

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 26339705 369 tsakqpvhlaSELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQ 417
Cdd:COG3055 236 ----------GELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
BACK1_LZTR1 cd18505
first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 572-630 1.29e-31

first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


Pssm-ID: 350580  Cd Length: 59  Bit Score: 117.38  E-value: 1.29e-31
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 26339705 572 DLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQ 630
Cdd:cd18505   1 NVRNVLVALENASKLNLDQLKEHCLNFIVKESNYNQIVMSKEFEHLDQPLMVEIVRRRQ 59
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
50-302 3.23e-31

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 123.73  E-value: 3.23e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  50 RWRRLPPcdeFVGARRSKHTVVAYKDAIYVFGGDNGK----TMLNDLLRFDVKDCSWcraFTTGTPPAPRYHHSAVVYGS 125
Cdd:COG3055  49 TWSELAP---LPGPPRHHAAAVAQDGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPTPRGGATALLLDG 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 126 SMFVFGGYTGDiysnsnlKNKNDLFEYKFATGQWTEwkiEGRLPVARSAHGATV-YSDKLWIFAGYDGNARlNDMWTIGl 204
Cdd:COG3055 123 KIYVVGGWDDG-------GNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVlPDGKILVIGGRNGSGF-SNTWTTL- 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 205 qdreltcweevaqsGEIPPSCCNFPVAVCRDKMFVFSGQSGAkiTNNLFQFEFKDKTWTRIPtehllrgspPPPQRRYGH 284
Cdd:COG3055 191 --------------APLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALG---------ELPTPRHGH 245

                       250
                ....*....|....*...
gi 26339705 285 TMVAFDRHLYVFGGAADN 302
Cdd:COG3055 246 AAVLTDGKVYVIGGETKP 263
BACK2_LZTR1 cd18506
second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 765-825 9.96e-27

second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


Pssm-ID: 350581  Cd Length: 61  Bit Score: 103.20  E-value: 9.96e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705 765 VTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRLLSQQLLLDIIDSLASHI 825
Cdd:cd18506   1 VSFENVLQILEAADKIQALDMKKHALHIIVHHFPKVARLPKLRSLSRELLLDIIDALADHM 61
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-746 4.95e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 96.47  E-value: 4.95e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDV--SPEAFEALLDYIYTGELELSEENVEELLAA 78


                ....
gi 26339705 743 PYYY 746
Cdd:cd18186  79 ADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 662-761 8.16e-22

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 91.16  E-value: 8.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVnMPPEDSLYLFA 741
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPE--DFEALLEFMYTGKL-ISEENVDDLLA 85

                          90       100
                  ....*....|....*....|
gi 26339705   742 APYYYGFYnnRLQAYCKQNL 761
Cdd:pfam00651  86 AADKLQIP--SLVDKCEEFL 103
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 642-749 2.28e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 84.60  E-value: 2.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 642 VDIGTSLIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEmvPSRQAFESML 721
Cdd:cd18287   3 IDHVHFLSEDIGALFLN--EEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKD--TNAEAFKALL 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 26339705 722 RYIYYGEVNM--PPEDSL--YLFAApYYYGFY 749
Cdd:cd18287  79 KYIYTGRLTLtdLKEDVLldVLGLA-HQYGFE 109
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 665-762 1.26e-17

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 78.50  E-value: 1.26e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705    665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPY 744
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDV--SPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*...
gi 26339705    745 YYGfyNNRLQAYCKQNLE 762
Cdd:smart00225  79 YLQ--IPGLVELCEEFLL 94
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-770 4.24e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 72.19  E-value: 4.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVnmPPEDSLY-- 738
Cdd:cd18345  16 SAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDV--DHEVMREMLRFIYTGKA--PNLDKMAdd 91

                        90       100       110
                ....*....|....*....|....*....|..
gi 26339705 739 LFAAPYYYGFynNRLQAYCKQNLEMNVTVQNV 770
Cdd:cd18345  92 LLAAADKYAL--ERLKVMCEEALCSNLSVENV 121
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 648-747 5.47e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 71.51  E-value: 5.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 648 LIQDMKAYLEGagSEFCDITLLL--DGQPRPAHKAILAARSSYFEAMFRS-FMPEDGQVNISIGEMVPsrQAFESMLRYI 724
Cdd:cd18294   1 FAADMKSLINN--PEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTgPQKESTQSPLVLSDIEP--EVFRAVLEFI 76

                        90       100
                ....*....|....*....|...
gi 26339705 725 YYGEVNMPPEDSLYLFAAPYYYG 747
Cdd:cd18294  77 YTNCVTLSNHTVIEVLAAAVEYG 99
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 648-769 6.64e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 71.96  E-value: 6.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 648 LIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYG 727
Cdd:cd18343   8 LAEDLGNLWEN--SRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDP--EVFKEMMRFIYTG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 26339705 728 EVnmPPEDSLY--LFAAPYYYGFynNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18343  84 KA--PNLDKMAdnLLAAADKYAL--ERLKVMCEEALCNNLSVEN 123
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 648-769 1.41e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 70.64  E-value: 1.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 648 LIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYG 727
Cdd:cd18279   5 LAEDLGNLWEN--SRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDP--EVFKEMMRFIYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 26339705 728 evNMPPEDSLY--LFAAPYYYGFYnnRLQAYCKQNLEMNVTVQN 769
Cdd:cd18279  81 --KAPNLDKMAddLLAAADKYALE--RLKVMCEDALCSNLSVEN 120
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-769 5.66e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 68.84  E-value: 5.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEV---NMPPEDSL 737
Cdd:cd18297  10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDI--RYDIFQLMMQYLYTGGVeslDVAQDDAL 87

                        90       100       110
                ....*....|....*....|....*....|..
gi 26339705 738 YLFAAPYYYGFynNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18297  88 ELLRAASFFQL--DGLKRHCEILLSQQIDLDN 117
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-796 8.43e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 68.62  E-value: 8.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVnmppedslylf 740
Cdd:cd18242  19 NTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTAS--TMEILLDFVYTETV----------- 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 26339705 741 aapyyygfynnrlqayckqnlemNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQ 796
Cdd:cd18242  86 -----------------------HVTVENVQELLPAACLLQLKGVKQACCEFLESQ 118
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 663-735 2.72e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 66.03  E-value: 2.72e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVnISIGEmVPSRqAFESMLRYIYYGEVNMPPED 735
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPV-IILPD-VPYS-ELKALLDFIYTGEVNVSQEQ 70
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 643-737 1.23e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 65.36  E-value: 1.23e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 643 DIGTSLIQdmkAYLEGAGSefcDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLR 722
Cdd:cd18286   3 RLGKDLLQ---LFLNGEDS---DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGV--SHAAVSFVLL 74

                        90
                ....*....|....*
gi 26339705 723 YIYYGEVNMPPEDSL 737
Cdd:cd18286  75 FIYGGVLDLPDDVNL 89
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-734 2.10e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 64.28  E-value: 2.10e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPE 734
Cdd:cd18245  14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED 85
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 650-735 4.12e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 63.89  E-value: 4.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 650 QDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEV 729
Cdd:cd18280   3 QHFGALLES--EEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPP--VFKALLHFIYKDEL 78


                ....*.
gi 26339705 730 nmpPED 735
Cdd:cd18280  79 ---PDD 81
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 662-759 4.48e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 63.41  E-value: 4.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPE-DSLYLF 740
Cdd:cd18300   8 LFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGV--SKETFLALLEYLYTDQAPILEDgDCVGLI 85

                        90
                ....*....|....*....
gi 26339705 741 AAPYYYGFynNRLQAYCKQ 759
Cdd:cd18300  86 VLANRLCL--PRLVALCEQ 102
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-789 5.92e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 63.07  E-value: 5.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVnmppedslylfaap 743
Cdd:cd18247  20 CDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPS--ALEALINFAYSGRI-------------- 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26339705 744 yyygfynnrlqayckqnlemNVTVQNVLQILEAADKTQALDMKRHC 789
Cdd:cd18247  84 --------------------AIDTSNVQSLLVGASFLQLQSVKDAC 109
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 659-789 7.18e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 63.19  E-value: 7.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 659 AGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVnmppedsly 738
Cdd:cd18256  16 GQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPD--IFHILLDFIYTGVV--------- 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 26339705 739 lfaapyyygfynnrlqayckqnlemNVTVQNVLQILEAADKTQALDMKRHC 789
Cdd:cd18256  85 -------------------------EVTVSNVQELLVAADMLQLTEVVEIC 110
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-769 3.26e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 61.51  E-value: 3.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNMPPEDSLY-- 738
Cdd:cd18344  21 SLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDP--QVFKEMMGFIYTGKAPHLHSHSMAcd 98

                        90       100       110
                ....*....|....*....|....*....|.
gi 26339705 739 LFAAPYYYGFYNnrLQAYCKQNLEMNVTVQN 769
Cdd:cd18344  99 VLAAADKYGLEG--LKVLCEDALCRNLSVEN 127
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 647-789 4.61e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 60.38  E-value: 4.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 647 SLIQDMKAYLegAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVN-ISIGEMVPSRQAFESMLRYIY 725
Cdd:cd18292   3 EFLQDIAQLY--NNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSeIELVEDPECAAVFEKFLRYLY 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26339705 726 YGEVnmppedslylfaapyyygfynnrlqayckqnlemNVTVQNVLQILEAADKTQALDMKRHC 789
Cdd:cd18292  81 TGQI----------------------------------SVNLETALPLLMLADKYNVTDLKQLC 110
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-771 5.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 60.94  E-value: 5.00e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKV--SAAAMEVLLDYMYGGGLRIQEDNVESVLEA 100

                        90       100
                ....*....|....*....|....*....
gi 26339705 743 PYYYGFynNRLQAYCKQNLEMNVTVQNVL 771
Cdd:cd18265 101 SDLLQV--SKLREACVRFLEGQLHPCNCL 127
PLN02153 PLN02153
epithiospecifier protein
 65-347 5.32e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 65.01  E-value: 5.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   65 RSKHTVVAYKDAIYVFGGD--NGKTMLNDLLRFDVKDCSWCRAFTTGTPPA-PRYHHSAVVYGSSMFVFGGytgdiySNS 141
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGElkPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGG------RDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  142 NlKNKNDLFEYKFATGQW---TEWKIEGRlPVARSAHGATVYSDKLWIFAGYDGNARLND---MWTIGLQDRELTCWEEV 215
Cdd:PLN02153  97 K-REFSDFYSYDTVKNEWtflTKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTperFRTIEAYNIADGKWVQL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  216 AQSGEippsccNFP------VAVCRDKMFVFSGQSGAKI--------TNNLFQFEFKDKTWTRIPTEhllrGSPPPPQRR 281
Cdd:PLN02153 175 PDPGE------NFEkrggagFAVVQGKIWVVYGFATSILpggksdyeSNAVQFFDPASGKWTEVETT----GAKPSARSV 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26339705  282 YGHTMVAfdRHLYVFGGA---------ADNTLPNELHCYDVDFQTWEVVqpssdSEVGGAEMPeRASSSEDASTL 347
Cdd:PLN02153 245 FAHAVVG--KYIIIFGGEvwpdlkghlGPGTLSNEGYALDTETLVWEKL-----GECGEPAMP-RGWTAYTTATV 311
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-759 7.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 59.96  E-value: 7.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18353  18 PETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQF--SYPVYRAFLEYLYTDSVDLPPEDAIGLL 95

                        90
                ....*....|....*....
gi 26339705 741 AAPYYYgfYNNRLQAYCKQ 759
Cdd:cd18353  96 DLATSY--CENRLKKLCQH 112
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-742 9.67e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 60.00  E-value: 9.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPED--SLyL 739
Cdd:cd18238  14 ELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI--DEEAVELLVDFAYTGKLTLTVDNvqSL-L 90


                ...
gi 26339705 740 FAA 742
Cdd:cd18238  91 YAA 93
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-769 1.28e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 59.73  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18342  20 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPE--VFKEMMCFIYTGKAPNLDKMADDLL 97

                        90       100
                ....*....|....*....|....*....
gi 26339705 741 AAPYYYGFynNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18342  98 AAADKYAL--ERLKVMCEDALCSNLSVEN 124
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-769 2.28e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 58.88  E-value: 2.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18240  15 GKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPE--MMELIIEYAYTRTVPITAENVEELL 92

                        90       100
                ....*....|....*....|....*....
gi 26339705 741 AAPYYygFYNNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18240  93 PAADQ--FNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 645-729 2.32e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 58.94  E-value: 2.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 645 GTSLIQDMKAYLegAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYI 724
Cdd:cd18255   2 SVTLLQGLNALR--AKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGV--SAKGLKHILDFA 77


                ....*
gi 26339705 725 YYGEV 729
Cdd:cd18255  78 YTSEL 82
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-742 3.00e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 58.59  E-value: 3.00e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18235  22 CDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDG--KALLLLIDYVYTAEIQVTEENVQVLLPA 98
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-742 3.74e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 58.31  E-value: 3.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18253  18 FTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILA--EAMDCFLQYVYTGKVKITTENVQYLFET 95
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 676-745 3.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 57.79  E-value: 3.81e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705 676 PAHKAILAARSSYFEAMFRSFMPEDGQvNISIGEMVPsrQAFESMLRYIYYGEVNMPPEDSL-YLFAAPYY 745
Cdd:cd18282  24 PAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEP--AAFLNLLRYLYCDEIDLEPDTVLaTLYAAKKY 91
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 665-740 3.85e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 57.65  E-value: 3.85e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26339705 665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18298  14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQY--SYPVYYAFLRYLYTDQVDLPPEDAIGLL 87
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 661-748 5.94e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 56.97  E-value: 5.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18314   4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEP--EIFETVLKYMYTGQVTLSEENVLDLL 81


                ....*...
gi 26339705 741 AAPYYYGF 748
Cdd:cd18314  82 MLASKYQV 89
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-773 7.72e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 57.27  E-value: 7.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLFA 741
Cdd:cd18306  17 QFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPD--AVEVLVNYAYTSRLEVPADLVKSVYS 94

                        90       100       110
                ....*....|....*....|....*....|..
gi 26339705 742 APYYYGFynNRLQAYCKQNLEMNVTVQNVLQI 773
Cdd:cd18306  95 AAKKLKM--DRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 646-735 1.21e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 57.32  E-value: 1.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 646 TSLIQDMKAYLEGAGSEFCDITLLLD-GQPRPAHKAILAARSSYFEAMF--RSFMPEDGQVNISIGEMVP----SRQAFE 718
Cdd:cd18310   1 KKLSSDLENLLDSPDLFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFasAKAEGANTKPKLELRELIPggivGYDAFM 80

                        90
                ....*....|....*..
gi 26339705 719 SMLRYIYYGEVNMPPED 735
Cdd:cd18310  81 LVLSYLYSGRLRLVPKE 97
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 661-735 1.29e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 56.49  E-value: 1.29e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISiGEMVpSRQAFESMLRYIYYGEVNMPPED 735
Cdd:cd18295  17 GSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLK-HPLV-NPDAFRALLQYLYTGRLEIHVDD 89
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 665-770 2.92e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 55.56  E-value: 2.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPY 744
Cdd:cd18352  15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNI--RWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92

                        90       100
                ....*....|....*....|....*.
gi 26339705 745 YYGFYNnrLQAYCKQNLEMNVTVQNV 770
Cdd:cd18352  93 QYLLEG--LKRLCEYTIAQDLTLENI 116
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 655-794 3.50e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 55.60  E-value: 3.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 655 YLEGAgseFCDITLLL-DGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVnmpp 733
Cdd:cd18252  16 YLDGL---FTDITLQCaSGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGI--DHDILEALVNYVYTSQI---- 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705 734 edslylfaapyyygfynnrlqayckqnlemNVTVQNVLQILEAADKTQALDMKRHCLHIIV 794
Cdd:cd18252  87 ------------------------------CITERNVQSLLEAADLLQFISVKKACEQFLV 117
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-748 3.59e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 55.57  E-value: 3.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLFA 741
Cdd:cd18237  20 TLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPD--IIELLVEFAYTARISVNSNNVQSLLD 97


                ....*..
gi 26339705 742 APYYYGF 748
Cdd:cd18237  98 AANQYQI 104
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 663-731 3.83e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 54.26  E-value: 3.83e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FC-DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNM 731
Cdd:cd18283   1 YCtDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGS 70
PLN02153 PLN02153
epithiospecifier protein
 157-404 6.06e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 58.46  E-value: 6.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  157 GQWTewKIE---GRLPVARSAHGATVYSDKLWIFAG-YDGNARLN-DMWTIglqDRELTCWEEVAQSGEIPP-SCCNFPV 230
Cdd:PLN02153   7 GGWI--KVEqkgGKGPGPRCSHGIAVVGDKLYSFGGeLKPNEHIDkDLYVF---DFNTHTWSIAPANGDVPRiSCLGVRM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  231 AVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGspppPQRRYGHTMVAFDRHLYVFGGAADNTLPN---- 306
Cdd:PLN02153  82 VAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGG----PEARTFHSMASDENHVYVFGGVSKGGLMKtper 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  307 --ELHCYDVDFQTW-EVVQPSSDSEV-GGAEMPERASS----SEDASTLTSEERSSFKKSRDVFgldFGTTSAK-QPVHL 377
Cdd:PLN02153 158 frTIEAYNIADGKWvQLPDPGENFEKrGGAGFAVVQGKiwvvYGFATSILPGGKSDYESNAVQF---FDPASGKwTEVET 234

                        250       260
                 ....*....|....*....|....*..
gi 26339705  378 ASELPSGRLFHAAAVISDAMYIFGGTV 404
Cdd:PLN02153 235 TGAKPSARSVFAHAVVGKYIIIFGGEV 261
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 666-746 6.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 53.44  E-value: 6.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 666 ITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEmvPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYY 745
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRD--ISPEDFRALLEFLYGGKRDLDASNLLELLEAANF 78


                .
gi 26339705 746 Y 746
Cdd:cd01165  79 L 79
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-769 9.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 54.80  E-value: 9.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIgeMVPSRQAFESMLRYIYYGEVNMPP---EDSLYlf 740
Cdd:cd18264  29 CDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHL--PVVSAAGLQRVLDFIYTSWLSLSLdtlEDTLE-- 104

                        90       100
                ....*....|....*....|....*....
gi 26339705 741 AAPYYYGFYNNRLqayCKQNLEMNVTVQN 769
Cdd:cd18264 105 AASYLQVTEAIGL---CSQYLINNLAPEN 130
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-765 9.24e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 54.17  E-value: 9.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFeamfRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFA 741
Cdd:cd18354  19 DTADLKFLVDGKYIYVHKVLLKIRCEHF----RSLLNENEEEIIEMSQF--SYPVYRAFLEYLYTDSISLSPEDAIGLLD 92

                        90       100
                ....*....|....*....|....
gi 26339705 742 APYYYgfYNNRLQAYCKQNLEMNV 765
Cdd:cd18354  93 LATFY--RENRLKKLCQQTIKQGI 114
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 422-575 1.61e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 53.47  E-value: 1.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 422 PKCTLHEDYGRLWEGRQFCDVEFVLGEKEecVQGHVAIVTARSrwlrrKIVQAQewLAQKLEEdgalAPKEapgpavgra 501
Cdd:cd18343   4 PECRLAEDLGNLWENSRFTDCSLFVGGQE--FKAHKSILAARS-----PVFNAM--FEHEMEE----SKKN--------- 61

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26339705 502 rppllRVAIREAEARPFEVLMQFLYTDKIkyPRKGHVEDVLLimdvyKLALSFQLCRLEQLCRQYIEASVDLQN 575
Cdd:cd18343  62 -----RVEINDVDPEVFKEMMRFIYTGKA--PNLDKMADNLL-----AAADKYALERLKVMCEEALCNNLSVEN 123
PLN02153 PLN02153
epithiospecifier protein
 41-220 1.80e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 57.30  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   41 NFGPFETVHR-WRRLPPCDEFVGAR-RSKHTVVAYKDAIYVFGGDNGKTMLNDLLRF------DVKDCSWCRAFTTGTPP 112
Cdd:PLN02153 102 DFYSYDTVKNeWTFLTKLDEEGGPEaRTFHSMASDENHVYVFGGVSKGGLMKTPERFrtieayNIADGKWVQLPDPGENF 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  113 APRYHHS-AVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGY- 190
Cdd:PLN02153 182 EKRGGAGfAVVQGKIWVVYGFATSILPGGKSDYESNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGGEv 261

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 26339705  191 --DGNARL------NDMWTIglqDRELTCWEEVAQSGE 220
Cdd:PLN02153 262 wpDLKGHLgpgtlsNEGYAL---DTETLVWEKLGECGE 296
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-774 1.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 53.74  E-value: 1.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18272  32 FADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDV--SESVFQLLVDYIYHGTVKLRVEELQETYEV 109

                        90       100       110
                ....*....|....*....|....*....|..
gi 26339705 743 PYYYGFynNRLQAYCKQNLEMNVTVQNVLQIL 774
Cdd:cd18272 110 ADMYQL--TALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-777 2.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 53.74  E-value: 2.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNIsigEMV-PSRQAFESMLRYIYYGEVNMPPEDSLYLFA 741
Cdd:cd18266  25 FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEV---ELVgASYIGLKAVIDFLYSSELPLDGGNIDYVLE 101

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 26339705 742 APYYYGFYnnRLQAYCKQNLEMNVTVQNVLQILEAA 777
Cdd:cd18266 102 TAHLLQIW--KVVDFCCEYLENEVSEENYLYLQELA 135
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 572-628 2.72e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 50.74  E-value: 2.72e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 26339705 572 DLQNVLVVCESAARLQLGQLKEHCLNFIVKesHFNQVIMMKEFERLSSPLIVEIVRR 628
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILE--NFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-741 3.58e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 52.49  E-value: 3.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFrsfmPEDGQVNISI---GEMVPsrQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18212  24 CDITLIVENVQFRAHKALLAASSEYFSMMF----ADEGEVGQSIymlEGMVA--ETFGALLEFIYTGCLQVGEKSLEQIL 97


                .
gi 26339705 741 A 741
Cdd:cd18212  98 A 98
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 643-774 4.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 52.70  E-value: 4.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 643 DIGTSLIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLR 722
Cdd:cd18270   8 EYAVSLLEQLKFFYEQ--QLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAA--TLQIIIT 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 26339705 723 YIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQayCKQNLEMNVTVQNVLQIL 774
Cdd:cd18270  84 YAYTGNLAINDSTVEQLYETACFLQVEDVLQR--CREYLIKKINAENCVRLL 133
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-750 5.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 51.75  E-value: 5.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISigEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAP 743
Cdd:cd18192  22 CDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLS--NMKISAECFDLILQFMYLGKIMTAPSDFEQLKVAM 99


                ....*..
gi 26339705 744 YYYGFYN 750
Cdd:cd18192 100 NYLQLYY 106
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-748 5.91e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 51.96  E-value: 5.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIgemvpSRQAFESMLRYIYYGEVNMPPEDSLYLFaa 742
Cdd:cd18290  27 YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAV-----QPQSFQQILSFCYTGRLSMNVGDQFLLM-- 99


                ....*.
gi 26339705 743 pYYYGF 748
Cdd:cd18290 100 -YTAGF 104
PRK14131 PRK14131
N-acetylneuraminate epimerase;
50-189 6.06e-08

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 55.79  E-value: 6.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   50 RWRRLPpcdEFVGARRSKHTVVAYKDAIYVFGGdNGKT-------MLNDLLRFDVKDCSWCRAFTTgtppAPRY---HHS 119
Cdd:PRK14131  63 GWTKIA---AFPGGPREQAVAAFIDGKLYVFGG-IGKTnsegspqVFDDVYKYDPKTNSWQKLDTR----SPVGlagHVA 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  120 AVVYGSSMFVFGGYTGDIY-----------SNSNLKNK--NDLFEYKFATGQWT-----------EWKIEGRLPVARSAH 175
Cdd:PRK14131 135 VSLHNGKAYITGGVNKNIFdgyfedlaaagKDKTPKDKinDAYFDKKPEDYFFNkevlsydpstnQWKNAGESPFLGTAG 214

                        170
                 ....*....|....*
gi 26339705  176 GATVYSD-KLWIFAG 189
Cdd:PRK14131 215 SAVVIKGnKLWLING 229
PLN02193 PLN02193
nitrile-specifier protein
 157-318 6.88e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.73  E-value: 6.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  157 GQWTEWKIEGRLPVARSAHGATVYSDKLWIFAG-YDGNARLND-MWTIGLQDREltcWEEVAQSGEIPP-SCCNFPVAVC 233
Cdd:PLN02193 151 GKWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGeFTPNQPIDKhLYVFDLETRT---WSISPATGDVPHlSCLGVRMVSI 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  234 RDKMFVFSGQSGAKITNNLFQFEFKDKTWTRI-PTEHllrgSPPPpqrRYGHTMVAFDRHLYVFGGAADNTLPNELHCYD 312
Cdd:PLN02193 228 GSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLtPVEE----GPTP---RSFHSMAADEENVYVFGGVSATARLKTLDSYN 300


                 ....*.
gi 26339705  313 VDFQTW 318
Cdd:PLN02193 301 IVDKKW 306
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 665-731 7.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 52.27  E-value: 7.32e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26339705 665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNM 731
Cdd:cd18244  32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTAT--GFSHVLQFMYYGTIEL 96
PLN02153 PLN02153
epithiospecifier protein
 55-243 7.50e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.38  E-value: 7.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   55 PPCDEFVGARrskhtVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWcrAFTT-----GTPPApRYHHSAVVYGSSMFV 129
Cdd:PLN02153  71 VPRISCLGVR-----MVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEW--TFLTkldeeGGPEA-RTFHSMASDENHVYV 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  130 FGGytgdiYSNSNLKNKNDLFE----YKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGN---ARLNDMWTI 202
Cdd:PLN02153 143 FGG-----VSKGGLMKTPERFRtieaYNIADGKWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFATSilpGGKSDYESN 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 26339705  203 GLQ--DRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQ 243
Cdd:PLN02153 218 AVQffDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGGE 260
PHA03098 PHA03098
kelch-like protein; Provisional
 65-263 8.45e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 55.54  E-value: 8.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   65 RSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWcraftTGTPP--APRYHHSAVVYGSSMFVFGGytgdIYSNSN 142
Cdd:PHA03098 333 RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKW-----REEPPliFPRYNPCVVNVNNLIYVIGG----ISKNDE 403

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  143 LKNKNDLFEYKFatgqwTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVaqsgeip 222
Cdd:PHA03098 404 LLKTVECFSLNT-----NKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVESYNPVTNKWTEL------- 471

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 26339705  223 pSCCNFP-----VAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWT 263
Cdd:PHA03098 472 -SSLNFPrinasLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 637-742 9.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 51.76  E-value: 9.87e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 637 PSDQPVDIGTSLIQD-MKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQ 715
Cdd:cd18340   2 QVEELRLYQQTLLQDgLKDLLDH--NKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVM 79

                        90       100
                ....*....|....*....|....*..
gi 26339705 716 AfeSMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18340  80 G--KILHYIYTSEIEITEQNVQDIFAA 104
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-733 1.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 51.51  E-value: 1.06e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPP 733
Cdd:cd18261  28 LCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGV--TSLGLKQALDFAYTGQILLEP 96
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-745 1.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 51.08  E-value: 1.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18330  18 FCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTS-EAFSIILDFLYSGKLDLCSENVIEVMSA 96


                ...
gi 26339705 743 PYY 745
Cdd:cd18330  97 ASY 99
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 660-730 1.36e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 50.44  E-value: 1.36e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 660 GSEFCDITLL-LDGQPRPAHKAILAARSSYFEAMFRSFMPEdGQVNISIgEMVPSRQAFESMLRYIYYGEVN 730
Cdd:cd18302   2 HSDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIE-ASSCSAL-TMPIPSDILEIILDYLYTDEAS 71
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-731 2.01e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 50.06  E-value: 2.01e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNM 731
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDP--DALWTLVQYCYTGRLEL 67
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 158-328 2.04e-07

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 53.64  E-value: 2.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   158 QWTEwkiEGRLPVArSAHGATVYSDKLWIFAG-YDGNARLNDMWTIGLQDRELTCWEEVAqsGEIPPSCCNFPVAVCRDK 236
Cdd:TIGR03548  53 KWVK---AGQLPYE-IAYGASVSTPYGIYYVGgSPSSESFSDVLLLSLDDTKEALIIETL--PSLPVAFDNGSATYKDGK 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   237 MFVFSGQSGAKITNNLFQFEFKDKT--WTRIPTEhllrgsppPPQRRYGHTMVAFDRHLYVFGGAA---DNTLPNELHCY 311
Cdd:TIGR03548 127 IYVGGGNANGKPSNKFYCLDLSNDTsgWEELPEF--------PGEARVQPVCQALHGKLYVFGGFQlggDAIIYTDGYAY 198

                         170
                  ....*....|....*....
gi 26339705   312 DVDFQTWEVVQ--PSSDSE 328
Cdd:TIGR03548 199 SPKTNTWQTVAdpVLSDGE 217
PLN02193 PLN02193
nitrile-specifier protein
 70-314 2.27e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 54.19  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   70 VVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYtgdiysnSNLKNKNDL 149
Cdd:PLN02193 224 MVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGV-------SATARLKTL 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  150 FEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGnARLNDMWTIG-LQDReltcWEEVAQSGEIPPSCCNF 228
Cdd:PLN02193 297 DSYNIVDKKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDpVQDK----WTQVETFGVRPSERSVF 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  229 PVAVCRDKMFVFSGQSG---------AKITNNLFQFEFKDKTWTRIptEHLLRGSPPPPQRRY-GHTMVAFD--RHLYVF 296
Cdd:PLN02193 372 ASAAVGKHIVIFGGEIAmdplahvgpGQLTDGTFALDTETLQWERL--DKFGEEEETPSSRGWtASTTGTIDgkKGLVMH 449

                        250
                 ....*....|....*....
gi 26339705  297 GGAA-DNTLPNELHCYDVD 314
Cdd:PLN02193 450 GGKApTNDRFDDLFFYGID 468
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-729 2.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 50.80  E-value: 2.37e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEV 729
Cdd:cd18246  39 LCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDP--QALEQLVQYAYTAEI 103
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-693 2.42e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 50.23  E-value: 2.42e-07
                        10        20        30
                ....*....|....*....|....*....|...
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMF 693
Cdd:cd18202  17 NQFCDVTLLIEGEEYKAHKSVLAANSEYFRELF 49
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 649-742 2.49e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 50.43  E-value: 2.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 649 IQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGE 728
Cdd:cd18336   7 FRKMENYLQH--KQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDP--DALKALVHYAYTGV 82

                        90
                ....*....|....
gi 26339705 729 VNMPPEDSLYLFAA 742
Cdd:cd18336  83 LELKEDTIESLLAA 96
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 643-771 3.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 50.17  E-value: 3.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 643 DIGTSLIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLR 722
Cdd:cd18268   5 DLSSELLRQLNSLRQE--RILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDS--DVLDQIVD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 26339705 723 YIYYGEVNMPPEDSLYLFAAPYYYGfYNNRLQAyCKQNLEMNVTVQNVL 771
Cdd:cd18268  81 YVYTGEILITRDNVLPLMEAASMLQ-YPKLFEA-CSLYLQDQLTPENCL 127
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 646-742 3.31e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 50.10  E-value: 3.31e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 646 TSLIQD-MKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYI 724
Cdd:cd18269  11 QTLLQDgLKDLLDE--NKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPD--VMGMILKYL 86

                        90
                ....*....|....*...
gi 26339705 725 YYGEVNMPPEDSLYLFAA 742
Cdd:cd18269  87 YTSEIDLNDQNVQDIFAL 104
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-731 3.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 49.69  E-value: 3.59e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 664 CDITLLLDGQPR----PAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNM 731
Cdd:cd18248  22 CDVTLKVKYQDPkeefMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHP--CVMSRLIEFAYTASISV 91
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 422-564 3.70e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 49.45  E-value: 3.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 422 PKCTLHEDYGRLWEGRQFCDVEFVLGEKEecVQGHVAIVTARSRWLRrkivqaqEWLAQKLEEDgalapkeapgpavgra 501
Cdd:cd18279   1 PECRLAEDLGNLWENSRFTDCCLCVGGQE--FQAHKAILAARSPVFS-------AMFEHEMEES---------------- 55

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26339705 502 rpPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKgHVEDVLLIMDVYKLALSFQLCRlEQLCR 564
Cdd:cd18279  56 --KKNRVEINDVDPEVFKEMMRFIYTGKAPNLDK-MADDLLAAADKYALERLKVMCE-DALCS 114
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-735 4.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 49.29  E-value: 4.30e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAmfRSFMPEDGQVNISIGEMVpSRQAFESMLRYIYYGEVNMPPED 735
Cdd:cd18277  27 LCDVTILVEGQRFRAHRSVLAACSSYFHS--RIVGQADAELNITLPEEV-TVKGFEPLIQFAYTAKLILSKDN 96
PLN02193 PLN02193
nitrile-specifier protein
 47-220 6.60e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.65  E-value: 6.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   47 TVHRWRRLPPCDEfvGAR-RSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGS 125
Cdd:PLN02193 252 TTNEWKLLTPVEE--GPTpRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAGLEVVQG 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  126 SMFVFGGYTGdiysnsnlKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAG--------YDGNARLN 197
Cdd:PLN02193 330 KVWVVYGFNG--------CEVDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGeiamdplaHVGPGQLT 401

                        170       180
                 ....*....|....*....|...
gi 26339705  198 DmWTIGLqDRELTCWEEVAQSGE 220
Cdd:PLN02193 402 D-GTFAL-DTETLQWERLDKFGE 422
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-769 6.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 48.97  E-value: 6.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLL---DGQPR-PAHKAILAARSSYFEAMFRSFMPEDGQvNISIGEMVPSrqAFESMLRYIYYGEVNMPPED---S 736
Cdd:cd18281  23 SDVHFIVgkgDNEQRiPAHKFVLSIGSAVFDAMFNGGMATTSA-EIELPDVEPA--AFLALLRFLYSDEVQIGPETvmtT 99

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 26339705 737 LYL---FAAPyyygfynnRLQAYCKQNLEMNVTVQN 769
Cdd:cd18281 100 LYTakkYAVP--------ALESACVEFLKKNLSSDN 127
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-748 7.22e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 49.26  E-value: 7.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSfmpeDGQVNISIGEMVPSrQAFESMLRYIYYGEVNMPPEDSLYLFaa 742
Cdd:cd18289  29 YCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG----NSKSAFELPATVPP-ACFQQILSFCYTGKLTMAASEQLVVM-- 101


                ....*.
gi 26339705 743 pYYYGF 748
Cdd:cd18289 102 -YTAGF 106
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 280-323 8.00e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 46.45  E-value: 8.00e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 26339705   280 RRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQP 323
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-789 1.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 48.69  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMF--RSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNmppedslyl 739
Cdd:cd18350  23 EMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLtnKSEQESQGSKTIEISDI--KYHIFQMLMQYLYYGGTE--------- 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 26339705 740 faapyyygfynnrlqayckqnlEMNVTVQNVLQILEAADKTQALDMKRHC 789
Cdd:cd18350  92 ----------------------SMEIPIADVLELLSAASLFQLDALQRHC 119
BACK2_LZTR1 cd18506
second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 571-627 1.63e-06

second BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


Pssm-ID: 350581  Cd Length: 61  Bit Score: 45.80  E-value: 1.63e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 26339705 571 VDLQNVLVVCESAARLQLGQLKEHCLNFIVKesHFNQVIMMKEFERLSSPLIVEIVR 627
Cdd:cd18506   1 VSFENVLQILEAADKIQALDMKKHALHIIVH--HFPKVARLPKLRSLSRELLLDIID 55
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-773 1.75e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 47.91  E-value: 1.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPE--DGQVNISigemVPSRQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18271  24 FFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKErdDGSVTIS----NLSPKAVKAFLDYAYTGKAEITDDNVEMFF 99

                        90       100       110
                ....*....|....*....|....*....|...
gi 26339705 741 AAPYYYGFynNRLQAYCKQNLEMNVTVQNVLQI 773
Cdd:cd18271 100 QMSSFLQV--SLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 650-765 1.77e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 47.93  E-value: 1.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 650 QDMKAYLEGAGSE--FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQ-----AFESMLR 722
Cdd:cd18228   4 QELLGKLNSLRNEghFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPAGKCVLDLHhvtvtGFAPLLE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26339705 723 YIYYGEVNMPPEDSLYLFAAPYYYGFYNnrLQAYCKQNLEMNV 765
Cdd:cd18228  84 YAYTSTLSINTENIIDVLAAASYMQMFN--VANTCSEFMKSSI 124
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 428-567 1.79e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 47.24  E-value: 1.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 428 EDYGRLWEGRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKivqaqewLAQKLEEDGALAPkeapgpavgrarppllr 507
Cdd:cd18294   3 ADMKSLINNPEFSDVKFLVGPERQEIFAHKCILAARCEVFRAM-------FLTGPQKESTQSP----------------- 58

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 508 VAIREAEARPFEVLMQFLYTDKIKyprkghvEDVLLIMDVYKLALSFQLCRLEQLCRQYI 567
Cdd:cd18294  59 LVLSDIEPEVFRAVLEFIYTNCVT-------LSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 665-745 2.05e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 47.18  E-value: 2.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSfmpeDGQVNISIGEMVPSRQA--FESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18215  21 DVVLVVGREQFRAHKTVLMACSGLFYSIFTD----QLKNNVSVINLDPEIEPegFRILLDFMYTSRLNLREGNIMAVMAT 96


                ...
gi 26339705 743 PYY 745
Cdd:cd18215  97 AMY 99
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 673-745 2.09e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 47.28  E-value: 2.09e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26339705 673 QPRPAHKAILAARSSYFEAMFRSFMPEdGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSL-YLFAAPYY 745
Cdd:cd18349  22 QRVPAHKYVLAVGSSVFYAMFYGDLAE-VKSEIHIPDVEPA--AFLILLKYMYSDEIDLEADTVLaTLYAAKKY 92
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-731 2.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 47.06  E-value: 2.17e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26339705 664 CDITLLL-DGQPRpAHKAILAARSSYFEAMFRSfmpeDGQVNISIGEMVPSRQAFESMLRYIYYGEVNM 731
Cdd:cd18217  19 CDCTIVIgQFQFK-AHRNVLAAFSEYFGAQYKD----TEDNIVFLDQSQVSADGFQKLLEFIYTGNLNL 82
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 639-776 2.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 47.33  E-value: 2.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 639 DQPVDIGTSLIQDMKAYLEGagsEFCDITLLLDGQPRPAHKAILAARSSYFEAmfRSFMPEDGQVNISIgemVPSRQAFE 718
Cdd:cd18220   4 DVPEYSNTVLSQLNELRLQG---KLCDIIVHIQGQPFRAHKAVLAASSPYFRD--HSALSTMSGLSISV---IKNPNVFE 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 26339705 719 SMLRYIYYGEVNMPPEDSLYLFAAPYYygfynnrlqayckqnLEMNVTVQNVLQILEA 776
Cdd:cd18220  76 QLLSFCYTGRMSLQLKDVVSFLTAASF---------------LQMQCVIDKCTQILES 118
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 649-729 2.38e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 47.11  E-value: 2.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 649 IQDMKA-YLEGAGsefCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYG 727
Cdd:cd18263   1 LQSIEGlWEKGVG---CDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPA--KDLRLLISFAYSG 75


                ..
gi 26339705 728 EV 729
Cdd:cd18263  76 IL 77
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-725 2.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 46.69  E-value: 2.43e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAmfRSFMPEDGQVNISIGEMVPSRqAFESMLRYIY 725
Cdd:cd18955   2 CDVTIVVEDQRFRAHRAVLAACSDYFLS--RVVGQTDGDLVITLPEEVTVK-GFEPLLQFAY 60
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-742 2.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 47.02  E-value: 2.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18339  21 LCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDV--DGQTLSKLIDYIYTAEIEVTEENVQVLLPA 98
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-771 3.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 47.31  E-value: 3.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPE--DGQVNISiGEMVPsrQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18254  22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLREslDSTVNFH-DSLHP--EVLELLLDFAYSSRIIINEENAESLL 98

                        90       100       110
                ....*....|....*....|....*....|.
gi 26339705 741 AAPYYYGFYNNRLQAycKQNLEMNVTVQNVL 771
Cdd:cd18254  99 EAGDMLQFHDVRDAA--AEFLEKNLYPSNCL 127
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-742 3.28e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 46.99  E-value: 3.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18338  21 LCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEV--DGWTLKMLIDYVYTAEIQVTEENVQVLLPA 98
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-770 3.70e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 46.69  E-value: 3.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18250  21 FFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAE--ILGLLLDFSYTGRVTVTQDNVEALLRA 98

                        90       100
                ....*....|....*....|....*...
gi 26339705 743 PYYYGFYNNRlQAyCKQNLEMNVTVQNV 770
Cdd:cd18250  99 ADLFQFPSVK-EA-CCAYLQQRLDVSNC 124
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 663-745 3.92e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 46.52  E-value: 3.92e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMV---PSRQAFESMLRYIYYGEVNMPPEDSLY- 738
Cdd:cd18296  17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNGSIPVVTlhdVSPEVFAIVLYYIYTDDTDLPPENAYDv 96


                ....*..
gi 26339705 739 LFAAPYY 745
Cdd:cd18296  97 LYVADMY 103
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-735 4.50e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 46.15  E-value: 4.50e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMpEDGQVNIsigEMVpSRQAFESMLRYIYYGEVNMPPED 735
Cdd:cd18221  17 QFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFT-QEPLVEI---EGV-SNMAFRHLIEFTYTAKLMVQGEE 85
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 672-769 5.37e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 46.59  E-value: 5.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 672 GQPR-PAHKAILAARSSYFEAMFRSFMPEDgQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFyn 750
Cdd:cd18346  40 GAQRiPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPA--AFLALLRFLYSDEVQIGPETVMTTLYTAKKYAV-- 114

                        90
                ....*....|....*....
gi 26339705 751 NRLQAYCKQNLEMNVTVQN 769
Cdd:cd18346 115 PALEAHCVEFLTKHLRADN 133
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-771 5.60e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 46.91  E-value: 5.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPE--DGQVNISiGEMVPsrQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18267  40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKEsqDSEVNFH-DSIHP--EVLELLLDYAYSSRVIINEENAESLL 116

                        90       100       110
                ....*....|....*....|....*....|.
gi 26339705 741 AAPYYYGFYNNRlqAYCKQNLEMNVTVQNVL 771
Cdd:cd18267 117 EAGDMLEFQDIR--DACAEFLEKNLHPTNCL 145
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 64-105 7.07e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 7.07e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 26339705    64 RRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRA 105
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 648-725 7.94e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 45.36  E-value: 7.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 648 LIQDMKAYLEGA--GSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPE------DGQVNIsigEMVPSrQAFES 719
Cdd:cd18301   1 FQEDFKKLLDEAdeGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTsedavgCDVVHI---EKVPP-EIFEQ 76


                ....*.
gi 26339705 720 MLRYIY 725
Cdd:cd18301  77 LLQFIY 82
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-742 8.13e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 45.94  E-value: 8.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18293  15 FCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQGLKA-HTLLKLVDFLYTSELEVSSEEAQDVLAA 93
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-725 8.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 45.63  E-value: 8.53e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDgQVNISIGEMVPSrqAFESMLRYIY 725
Cdd:cd18209  17 QLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPD--AFENVLNYIY 77
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-731 9.18e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 45.98  E-value: 9.18e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNM 731
Cdd:cd18259  31 KLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDP--AVMESLIDFAYTGKLTI 98
PLN02193 PLN02193
nitrile-specifier protein
 209-323 9.62e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.18  E-value: 9.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  209 LTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQ--SGAKITNNLFQFEFKDKTWTRIPTEhllrgSPPPPQRRYGHTM 286
Cdd:PLN02193 150 LGKWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGEftPNQPIDKHLYVFDLETRTWSISPAT-----GDVPHLSCLGVRM 224

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 26339705  287 VAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQP 323
Cdd:PLN02193 225 VSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTP 261
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-725 1.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 45.52  E-value: 1.01e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIY 725
Cdd:cd18249  22 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDI--DERAMELLIDFAY 83
Kelch_3 pfam13415
Galactose oxidase, central domain;
74-123 1.09e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.05  E-value: 1.09e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 26339705    74 KDAIYVFGG--DNGKTMLNDLLRFDVKDCSWcraFTTGTPPAPRYHHSAVVY 123
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-725 1.16e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 45.31  E-value: 1.16e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQvNISIGEMVpSRQAFESMLRYIY 725
Cdd:cd18326  25 LCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQ-NVYEIDFV-SAEALTALLDFAY 85
PLN02153 PLN02153
epithiospecifier protein
 109-327 1.33e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 48.06  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  109 GTPPAPRYHHSAVVYGSSMFVFGgytGDIYSNSNLknKNDLFEYKFATGQWTEWKIEGRLPVArSAHGATVYS--DKLWI 186
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFG---GELKPNEHI--DKDLYVFDFNTHTWSIAPANGDVPRI-SCLGVRMVAvgTKLYI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  187 FAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEiPPSCCNFPVAVCRDKMFVFSGQS--GAKITNNLFQ----FEFKDK 260
Cdd:PLN02153  91 FGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGG-PEARTFHSMASDENHVYVFGGVSkgGLMKTPERFRtieaYNIADG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  261 TWTRIPT--EHLlrgsppppQRRYGHTMVAFDRHLYVFGGAADNTLP--------NELHCYDVDFQTWEVVQ-----PSS 325
Cdd:PLN02153 170 KWVQLPDpgENF--------EKRGGAGFAVVQGKIWVVYGFATSILPggksdyesNAVQFFDPASGKWTEVEttgakPSA 241


                 ..
gi 26339705  326 DS 327
Cdd:PLN02153 242 RS 243
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 656-735 1.60e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 44.64  E-value: 1.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 656 LEGagsEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVnISIGEMvpSRQAFESMLRYIYYGEVNMPPED 735
Cdd:cd18204  14 LEG---EFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFL--RSDIFEEVLNYMYTAKISVKKED 87
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-733 1.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 44.82  E-value: 1.76e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSsyfeAMFRSFMpeDGQVNISIGEMVPSRQAFESMLRYIYYGEVnmPP 733
Cdd:cd18225  22 QFCDCTIFIGTFHFRAHKLVLAASS----LLFKSLL--DSTDTISIDASVVSPEEFALLLEMVYTGKL--PP 85
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 653-734 1.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 44.46  E-value: 1.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 653 KAYLEGagsEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSfmpedGQVNISIGEMVPSRQAFESMLRYIYYGEVNMP 732
Cdd:cd18200  11 KHRLEG---KFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLL-----NDTNCLVLPSVIEAAAFENLLQLIYSGRLTLC 82


                ..
gi 26339705 733 PE 734
Cdd:cd18200  83 MD 84
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-745 2.07e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 44.34  E-value: 2.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18199  18 FCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVF-SSDAFSIILDFVYSGKLSLTSQNVIEVMSA 96


                ...
gi 26339705 743 PYY 745
Cdd:cd18199  97 ASY 99
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 660-702 2.13e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 44.96  E-value: 2.13e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 26339705 660 GSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQ 702
Cdd:cd18207  24 GGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT 66
Kelch_4 pfam13418
Galactose oxidase, central domain;
64-107 2.89e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 42.21  E-value: 2.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 26339705    64 RRSKHTVVA-YKDAIYVFGGDNGK-TMLNDLLRFDVKDCSWCRAFT 107
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 646-773 3.22e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 44.45  E-value: 3.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 646 TSLIQD-MKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYI 724
Cdd:cd18341  11 STLLQDgLKELLDE--NKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPN--IMDMILKYL 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 26339705 725 YYGEVNMPPEDSLYLFAAPyyygfynNRLQ-----AYCKQNLEMNVTVQNVLQI 773
Cdd:cd18341  87 YSAEIDLNDGNVQDIFALA-------SRFQipsvfTVCVTYLQKRLSPANCLAI 133
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-769 3.33e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 44.29  E-value: 3.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLL----LDGQPRPAHKAILAARSSYFEAMFRSFMPEDgQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLY 738
Cdd:cd18347  22 LSDVHFLvgkgLGSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPA--AFLALLKFLYSDEVQIGPETVMT 98

                        90       100       110
                ....*....|....*....|....*....|.
gi 26339705 739 LFAAPYYYGFynNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18347  99 TLYTAKKYAV--PALEAHCVEFLKKNLRADN 127
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 643-735 3.85e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 43.68  E-value: 3.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 643 DIGTSLIQDM-KAYLEGagsEFCDITLLLDGQPRPAHKAILAARSSYF--EAMFRsfmpedGQVNISI-GEMVPsrQAFE 718
Cdd:cd18210   3 EITSSLLESLnQQRMEG---KLCDISIHVQGRVFRAHRAVLAASSPYFhdQVLLK------NMSSISLpGVMDP--GAFE 71

                        90
                ....*....|....*..
gi 26339705 719 SMLRYIYYGEVNMPPED 735
Cdd:cd18210  72 SVLASAYTGKLTMLADE 88
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-761 3.88e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 44.03  E-value: 3.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSfMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNM---PPEDSLylf 740
Cdd:cd18956  24 CDCTVLVGDARFPAHRAVLAACSVYFHLFYRD-RPAGGRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLrslPVEDVL--- 99

                        90       100
                ....*....|....*....|.
gi 26339705 741 AAPYYYGFYNnrLQAYCKQNL 761
Cdd:cd18956 100 AAASYLHMYD--IVKVCKGRL 118
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-739 3.95e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 43.85  E-value: 3.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEamfrsfmPEDGQvniSIGEMVPSR---QAFESMLRYIYYGEVNMPPEDSLYL 739
Cdd:cd18303  18 YSDITIKLADKSIPAHKFVLAARSEKWS-------NENLA---STNELDLSDisyEVVLALLRWLYTDELDLTLDDEFLL 87
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-775 4.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 43.88  E-value: 4.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYfeamFRSFMPEDGQVNISIgEMVPSRQAFESMLRYIYYGEVNMPPEDSL-YLFA 741
Cdd:cd18222  25 LCDIVVNVQGQSFRAHKVVLAASSPY----FRDHMSLNEMSTVSI-SVIKNPTVFEQLLSFCYTGRICLQLADIIsYLTA 99

                        90       100       110
                ....*....|....*....|....*....|....
gi 26339705 742 APYyygfynnrlqayckqnLEMNVTVQNVLQILE 775
Cdd:cd18222 100 ASF----------------LQMQHIIDKCTQILE 117
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 673-774 4.81e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 43.85  E-value: 4.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 673 QPRPAHKAILAARSSYFEAMFRSFMPEDGQvNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSL-YLFAAPYYYGFYnn 751
Cdd:cd18348  35 QRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPA--AFLAMLKYIYCDEIDLAADTVLaTLYAAKKYIVPH-- 109

                        90       100
                ....*....|....*....|...
gi 26339705 752 rLQAYCKQNLEMNVTVQNVLQIL 774
Cdd:cd18348 110 -LARACVNFLETSLSAKNACVLL 131
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-729 4.94e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 43.30  E-value: 4.94e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNI---SIGEmvpsrQAFESMLRYIYYGEV 729
Cdd:cd18257  17 ELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVefqCIDE-----TALQAIVEYAYTGTV 82
Kelch_6 pfam13964
Kelch motif;
281-323 5.41e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 5.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 26339705   281 RYGHTMVAFDRHLYVFGGAADNTLP-NELHCYDVDFQTWEVVQP 323
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPAlNKLEVYNPLTKSWEELPP 45
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-750 5.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 43.66  E-value: 5.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISiGEMVpSRQAFESMLRYIYYGEV---NMPPEDSLylf 740
Cdd:cd18194  24 CDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLN-SDIV-TAPAFGLLLDFMYEGRLalrDLPVEDVL--- 98

                        90
                ....*....|
gi 26339705 741 AAPYYYGFYN 750
Cdd:cd18194  99 AAASYLHMYD 108
PHA02713 PHA02713
hypothetical protein; Provisional
 175-298 6.32e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.54  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  175 HGATVYSDKLWIFAGYD-GNARLNDMWTIGLQDRelTCWEevaqsgeIPPSC---CNFPVAVCRDKMFVFSGQSGAKITN 250
Cdd:PHA02713 297 YASAIVDNEIIIAGGYNfNNPSLNKVYKINIENK--IHVE-------LPPMIknrCRFSLAVIDDTIYAIGGQNGTNVER 367

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 26339705  251 NLFQFEFKDKTWTRIPtehllrgSPPPPQRRYGhtMVAFDRHLYVFGG 298
Cdd:PHA02713 368 TIECYTMGDDKWKMLP-------DMPIALSSYG--MCVLDQYIYIIGG 406
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 650-742 6.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 43.49  E-value: 6.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 650 QDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEV 729
Cdd:cd18335   8 RKMESYLKQ--QQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPN--ALWDLVQFAYTGCL 83

                        90
                ....*....|...
gi 26339705 730 NMPPEDSLYLFAA 742
Cdd:cd18335  84 ELKEDTIENLLAA 96
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 112-142 6.87e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 40.63  E-value: 6.87e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 26339705   112 PAPRYHHSAVVYGSSMFVFGGYTGDIYSNSN 142
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSD 31
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 650-764 7.33e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 43.03  E-value: 7.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 650 QDMKAYLegagsefCDITLLLDGQPRPAHKAILAARSSYfeamFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEV 729
Cdd:cd18334  15 QRAKGFL-------CDVIIVVENALFRAHKNILAASSMY----FKSLVLHDNLINLDTDMVNPT--VFRQILDFIYTGKL 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26339705 730 ---NMPPEDSL-YLFAAPYYYGFYNnrLQAYCKQNLEMN 764
Cdd:cd18334  82 ltsDQPGEQNFnALLTAASYLQLHD--LAALCRKKLKRN 118
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-729 7.55e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 42.90  E-value: 7.55e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPeDGQVNISIGEMVPSRqaFESMLRYIYYGEV 729
Cdd:cd18224  27 CDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTEL-DVARTYVVDFITPAN--FEKVLSFIYTSEL 89
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 422-576 8.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 42.91  E-value: 8.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 422 PKCTLHEDYGRLWEGRQFCDVEFVLGEKEecVQGHVAIVTARSrwlrrKIVQAQewLAQKLEEDgalapkeapgpavgra 501
Cdd:cd18345   1 PECRLSDDLGLLFERSAFSDVTLCVGGRE--FQAHKAILAARS-----PVFNAM--FEHEMEER---------------- 55

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26339705 502 rpPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKgHVEDVLLIMDVYKLAlsfqlcRLEQLCRQYIEASVDLQNV 576
Cdd:cd18345  56 --KQNRVEITDVDHEVMREMLRFIYTGKAPNLDK-MADDLLAAADKYALE------RLKVMCEEALCSNLSVENV 121
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 663-730 8.47e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 42.20  E-value: 8.47e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26339705 663 FCDITLLLDGQPR-PAHKAILAARSSYFEAMFRSfmpedgQVNISIGEMVpSRQAFESMLRYIYYGEVN 730
Cdd:cd18299  12 CADVVFILQGGVRiFAHRIVLAAASSVFADLFLM------MTVVTLDSDI-TPEAFRRVLEFLYTGVLD 73
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 430-570 8.63e-05

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 42.63  E-value: 8.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705   430 YGRLWEGRQFCDVEFVLGEKEecVQGHVAIVTARSRWLRRKivqaqewLAQKLEEDgalapkeapgpavgrarpPLLRVA 509
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKE--FRAHKAVLAACSPYFKAL-------FSGQESES------------------SVSEIT 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26339705   510 IREAEARPFEVLMQFLYTDKIKYPRKghvedvllIMDVYKLALSFQLCRLEQLCRQYIEAS 570
Cdd:pfam00651  54 LDDVSPEDFEALLEFMYTGKLISEEN--------VDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-768 8.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 43.49  E-value: 8.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLL-DGQPRpAHKAILAARSSYFEAMFRSFMpeDGQVNISIGEMVPSRQAFESMLRYIYYGEV---NMPPEDSLy 738
Cdd:cd18324  23 LCDCTVLVgDAQFR-AHRAVLASCSMYFHLFYKDQL--DKRDIVHLNSDIVTAPAFALLLEFMYEGKLqfkDLPIEDVL- 98

                        90       100       110
                ....*....|....*....|....*....|
gi 26339705 739 lfAAPYYYGFYNnrLQAYCKQNLEMNVTVQ 768
Cdd:cd18324  99 --AAASYLHMYD--IVKVCKKKLKEKATTE 124
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-744 9.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 42.62  E-value: 9.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYF--EAMFRSfmpedgQVNISIGEMVPSRqAFESMLRYIYYGEVNMP-PEDSLY 738
Cdd:cd18227  24 QLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKN------SRRIVLPDVMNPR-VFENILLSCYTGRLVLPaPEIVSY 96


                ....*.
gi 26339705 739 LFAAPY 744
Cdd:cd18227  97 LTAASF 102
PHA03098 PHA03098
kelch-like protein; Provisional
 176-331 1.28e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 45.53  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  176 GATVYSDKLWIFAGYDGNA-RLNDMWTIGLQDREltcWEEVAqsgEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQ 254
Cdd:PHA03098 289 GSVVLNNVIYFIGGMNKNNlSVNSVVSYDTKTKS---WNKVP---ELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVES 362

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26339705  255 FEFKDKTWTRiptehllrgSPPPPQRRYGHTMVAFDRHLYVFGGAADN-TLPNELHCYDVDFQTWEVVQPSSDSEVGG 331
Cdd:PHA03098 363 WKPGESKWRE---------EPPLIFPRYNPCVVNVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSPLPISHYGG 431
Kelch_3 pfam13415
Galactose oxidase, central domain;
124-180 1.35e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.97  E-value: 1.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 26339705   124 GSSMFVFGGYTGDiySNSNLknkNDLFEYKFATGQWTEwkIeGRLPVARSAHGATVY 180
Cdd:pfam13415   1 GDKLYIFGGLGFD--GQTRL---NDLYVYDLDTNTWTQ--I-GDLPPPRSGHSATYI 49
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-742 1.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 42.50  E-value: 1.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPR--------PAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPED 735
Cdd:cd18273  27 TDVTIEVNGPGSgpgsgrlfPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSE--SMALIIDYCYTGRVTLSEAN 104


                ....*..
gi 26339705 736 SLYLFAA 742
Cdd:cd18273 105 VQRLYAA 111
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-725 1.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 42.10  E-value: 1.64e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIY 725
Cdd:cd18276  20 ELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDI--TAESVSIILNYMY 81
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 645-744 1.76e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 42.12  E-value: 1.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 645 GTSLIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFrsFMPEDGQVNISIgemVPSRQAFESMLRYI 724
Cdd:cd18214   9 GDSMLQKMNKLREQ--NKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQF--LLNDSREVQISI---LQNSEVGRQLLLSC 81

                        90       100
                ....*....|....*....|.
gi 26339705 725 YYGEVNMPP-EDSLYLFAAPY 744
Cdd:cd18214  82 YTGVLEFPEmELVNYLTAASF 102
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-762 1.81e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 41.94  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMpeDGQVNISIGEMVPSRQAFESMLRYIYYGEV---NMPPEDSLyl 739
Cdd:cd18325  23 LCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQL--DKRDIVHLNSDIVTAPAFSLLLEFMYEGKLefsSLPVEDVL-- 98

                        90       100
                ....*....|....*....|...
gi 26339705 740 fAAPYYYGFYNnrLQAYCKQNLE 762
Cdd:cd18325  99 -AAASYLHMYD--IVKVCKGKLK 118
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 114-161 1.83e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 39.52  E-value: 1.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 26339705   114 PRYHHSAVVYGSSMFVFGGYTGDIYSNSnlknkndLFEYKFATGQWTE 161
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNS-------VEVYDPETNTWSK 41
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 647-773 1.85e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 42.28  E-value: 1.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 647 SLIQDMKA-YLEGagsEFCDITLLLD-GQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYI 724
Cdd:cd18274   8 SILQQLKAmYDEG---QLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGV--EAESMHLVLDYA 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 26339705 725 YYGEVNMPPEDSLYLFAAPYYygFYNNRLQAYCKQNLEMNVTVQNVLQI 773
Cdd:cd18274  83 YTSRVTLTEANVQALFTAASI--FQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 665-789 1.98e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 42.14  E-value: 1.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVnmppedslylfaapy 744
Cdd:cd18236  26 DVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGV--DAETMQILLDYTYTSKV--------------- 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26339705 745 yygfynnrlqayckqnlemNVTVQNVLQILEAADKTQALDMKRHC 789
Cdd:cd18236  89 -------------------LITKQNVQRVLEAASLFQFLRMVDAC 114
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-745 2.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 41.73  E-value: 2.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEmVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18329  21 FCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFD-VFSPDTFTIILDFVYSGKLSLTSQNVIEVMSA 99


                ...
gi 26339705 743 PYY 745
Cdd:cd18329 100 ASY 102
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-735 3.02e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 41.07  E-value: 3.02e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMfrsFMPEDGQVNISIGEMVpsrqAFESMLRYIYYGEVNMPPED 735
Cdd:cd18206  22 LCDCTFVVDGVDFKAHKAVLAACSEYFRML---FVDQKDVVHLDISNAA----GLGQVLEFMYTAKLSLSPEN 87
Kelch_3 pfam13415
Galactose oxidase, central domain;
234-289 3.08e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.20  E-value: 3.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 26339705   234 RDKMFVFSG--QSGAKITNNLFQFEFKDKTWTRIptehllrGSPPPPqrRYGHTMVAF 289
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQI-------GDLPPP--RSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 225-267 3.53e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 3.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 26339705   225 CCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPT 267
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_6 pfam13964
Kelch motif;
65-115 3.83e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.86  E-value: 3.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 26339705    65 RSKHTVVAYKDAIYVFGG-DNGKTMLNDLLRFDVKDCSWcraFTTGTPPAPR 115
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSW---EELPPLPTPR 50
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-764 4.49e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 40.66  E-value: 4.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYfeamFRSFMPEDGQVNISiGEMVpSRQAFESMLRYIYYG---EVNMPPEDSL-Y 738
Cdd:cd18333  21 LCDVIIVVQNALFRAHKNILAASSVY----LKSLVVHDNLINLD-HEMV-SPGIFRLILDYIYTGrlsEGDPGSEQNLgA 94

                        90       100
                ....*....|....*....|....*.
gi 26339705 739 LFAAPYYYGFYNnrLQAYCKQNLEMN 764
Cdd:cd18333  95 VLAAASYLQIPD--LVALCKKKLKRN 118
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-742 4.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 40.54  E-value: 4.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSfmPE---DGQVnISIGEMvpSRQAFESMLRYIYYGEVNMP-PEDSLY 738
Cdd:cd18223  18 LCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSS--QEiwiSSHV-LELPDL--KAEVFAEILNFIYSSKVVVKrQETVTD 92


                ....
gi 26339705 739 LFAA 742
Cdd:cd18223  93 LVAA 96
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-769 4.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 41.12  E-value: 4.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 662 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVnISIGEMvpSRQAFESMLRYIYYG---EVNMPPEDSLY 738
Cdd:cd18351  23 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTC-IEISYV--KYHIFQLVMQYLYCGgteSLLIKNNEIME 99

                        90       100       110
                ....*....|....*....|....*....|.
gi 26339705 739 LFAAPYYygFYNNRLQAYCKQNLEMNVTVQN 769
Cdd:cd18351 100 LLSAAKF--FQLEALQRHCEIICAKSINTEN 128
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 640-735 5.63e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 40.81  E-value: 5.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 640 QPVDIGTSLIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFES 719
Cdd:cd18337   2 QALNHAEQTFKKMENYLRH--KQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPN--ALWA 77

                        90
                ....*....|....*.
gi 26339705 720 MLRYIYYGEVNMPPED 735
Cdd:cd18337  78 LVQYAYTGRLELKEDN 93
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-738 6.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 40.61  E-value: 6.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRP----AHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQaFESMLRYIYYGEVNMpPEDSLY 738
Cdd:cd18211  25 LCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTAD-FASFLEFVYTAKVEV-EEDRVQ 102
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-732 7.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 40.26  E-value: 7.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQ-----------AFESMLRYIYYGEVNM 731
Cdd:cd18195  18 FCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATQSPErvlelpgvkagVFSDVLNFIYSSRVAL 97


                .
gi 26339705 732 P 732
Cdd:cd18195  98 P 98
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 661-728 8.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 39.78  E-value: 8.40e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26339705 661 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFrSFMPEDGQVniSIGEMvpSRQAFESMLRYIYYGE 728
Cdd:cd18226  20 SSFCDLVITVEGKEFSAHKVVVAVGSSYFHACL-SKNPNTDAV--TLDHV--SYSVFQHLLEFLYTSE 82
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 766-804 8.58e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 38.03  E-value: 8.58e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 26339705 766 TVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLP 804
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSE 39
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 647-731 1.07e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 39.80  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 647 SLIQDMKAyLEGAGSEFcDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYY 726
Cdd:cd18251   9 ALLDGLVA-LRDSGILF-DVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGV--SYNAMCKILDFIYT 84


                ....*
gi 26339705 727 GEVNM 731
Cdd:cd18251  85 SELEL 89
Kelch_4 pfam13418
Galactose oxidase, central domain;
114-162 1.16e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 26339705   114 PRYHHSAV-VYGSSMFVFGGYtgdiysNSNLKNKNDLFEYKFATGQWTEW 162
Cdd:pfam13418   1 PRAYHTSTsIPDDTIYLFGGE------GEDGTLLSDLWVFDLSTNEWTRL 44
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 518-575 1.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 39.56  E-value: 1.17e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 518 FEVLMQFLYTdkikyprkGHVEDVLL----IMDVYKLALSFQLCRLEQLCRQYIEASVDLQN 575
Cdd:cd18297  64 FQLMMQYLYT--------GGVESLDVaqddALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-725 1.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 39.46  E-value: 1.26e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIY 725
Cdd:cd18198  26 CDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSP--EALTALLEFAY 85
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-762 1.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 39.81  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISiGEMVpSRQAFESMLRYIYYGEVNM---PPEDSLylf 740
Cdd:cd18323  24 CDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCIN-NEIV-TAPAFSLLLEFMYEGRLSFndtPVEDVL--- 98

                        90       100
                ....*....|....*....|..
gi 26339705 741 AAPYYygFYNNRLQAYCKQNLE 762
Cdd:cd18323  99 AAASY--LHMNDIVKVCKKRLQ 118
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-745 1.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 39.55  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFrSFMPEDG--QVNISIGEMVpSRQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:cd18201  21 LCDVNIVVSGKVFRAHKNILVAGSRFFKTLY-CFTNKEScdQTTVTHLDVV-AVQGFSVILDFMYSGNLVLTSQNAIEVM 98


                ....*
gi 26339705 741 AAPYY 745
Cdd:cd18201  99 SVASY 103
Kelch_4 pfam13418
Galactose oxidase, central domain;
280-324 1.33e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.21  E-value: 1.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 26339705   280 RRYGHTMVAFDRH-LYVFGGA-ADNTLPNELHCYDVDFQTWEVVQPS 324
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEgEDGTLLSDLWVFDLSTNEWTRLGSL 47
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 645-744 1.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 39.08  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 645 GTSLIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFrsFMPEDGQVNISIgemVPSRQAFESMLRYI 724
Cdd:cd18197   9 GDAVLQKMNLLRQQ--NLFCDVSIYINDTEFHGHKVILAACSTFMRDQF--LLNQSKQVRITI---LQSAEVGRKLLLSC 81

                        90       100
                ....*....|....*....|.
gi 26339705 725 YYGEVNMPPEDSL-YLFAAPY 744
Cdd:cd18197  82 YTGALEVKKKELLkYLTAASY 102
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-725 1.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 39.16  E-value: 1.60e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDgqVNISIGEMVPSRqAFESMLRYIY 725
Cdd:cd18278  31 LCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTEND--LVVSLPEEVTAR-GFGPLLQFAY 90
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 665-745 1.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 39.07  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 665 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVnISIGEMVPSRqAFESMLRYIYYGEVNMPPEDSLYLFAAPY 744
Cdd:cd18332  21 DVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSV-LTLPSGLEAR-GFQLLLDFMYTSRLPLTPRTVPAVLAAAT 98


                .
gi 26339705 745 Y 745
Cdd:cd18332  99 Y 99
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 664-769 1.81e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 39.40  E-value: 1.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 664 CDITLLL-DGQPR-PAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEV--NMppeDSLY- 738
Cdd:cd18239  24 CDVTLVPgDGDETfPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGV--SKIGLKNIIDFIYTAKLslNM---DNLQd 98

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26339705 739 -LFAAPYyygfynnrLQA-----YCKQNLEMNVTVQN 769
Cdd:cd18239  99 tLEAASF--------LQIlpvldFCKVLLISGVTLEN 127
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 679-724 2.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 37.79  E-value: 2.30e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 26339705 679 KAILAARSSYFEAMFRSFMPEDGQVNISIGEmvPSRQAFESMLRYI 724
Cdd:cd18320  17 KALLVENSEYFRALFRSGMRECTQDEIRLQG--LSARGFRIMLRVL 60
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-745 2.58e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 38.89  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrQAFESMLRYIYYGEVNMPPEDSLYLFAA 742
Cdd:cd18230  21 LCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTA-QGFKAIIDFMYSAHLALTSKNVIEVMSA 99


                ...
gi 26339705 743 PYY 745
Cdd:cd18230 100 ASY 102
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-757 2.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 37.86  E-value: 2.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 663 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRS-FMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFA 741
Cdd:cd18307   1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSnDMKATDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                        90
                ....*....|....*.
gi 26339705 742 APYYygFYNNRLQAYC 757
Cdd:cd18307  81 GAKY--FNIPRLKDHC 94
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 662-725 2.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 38.36  E-value: 2.82e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26339705 662 EFCDITLLLDGQPR--PAHKAILAARSSYFEAMFrSFMPEDGQVNISIGEMVPsrQAFESMLRYIY 725
Cdd:cd18231  13 DLCDVDIVLVRQRStfPAHKGVLAAYSQFFHSLF-TQNKQLQRVELSLEALTS--QGLQQILNFIY 75
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 579-627 2.89e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 37.29  E-value: 2.89e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 26339705 579 VCE---SAARLQLGQLKEHCLNFIvkESHFNQVIMMKEFERLSSPLIVEIVR 627
Cdd:cd18494   5 ACEalqAAVTYGQDELKERCLAFI--EEHTEEVFKTKGFHELSDEALSVILR 54
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 663-733 3.04e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 38.68  E-value: 3.04e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26339705 663 FCDITLLLDGQPR---PAHKAILAARSSYFEAMFRSFMPED--GQVNIS--IGEMVPSRQAFESMLRYIYYGEVNMPP 733
Cdd:cd18241  23 FCDITLAFGGAGGrefRAHRSVLAAATEYFTPLLSGQFSESrsGRVEMRkwSSEPGPDPDTVEAVIQYMYTGRIRVST 100
PHA03098 PHA03098
kelch-like protein; Provisional
 663-742 3.87e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 40.52  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705  663 FCDITLLL--DGQPRPAHKAILAARSSYFEAMFRSFMPEDgQVNISIGEmvpsrQAFESMLRYIYYGEVNMPPEDSLYLF 740
Cdd:PHA03098   9 FCDESIIIvnGGGIIKVHKIILSSSSEYFKKMFKNNFKEN-EINLNIDY-----DSFNEVIKYIYTGKINITSNNVKDIL 82


                 ..
gi 26339705  741 AA 742
Cdd:PHA03098  83 SI 84
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 576-628 5.35e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 37.32  E-value: 5.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 26339705    576 VLVVCESAARLQLGQLKEHCLNFIVKesHFNQVIMMKEFERLSSPLIVEIVRR 628
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQ--NFSEVSSSEEFLELPLEQLLELLSS 51
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 648-737 5.51e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 37.33  E-value: 5.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26339705 648 LIQDMKAYLEgagSE-FCDITLLLDGQPRPAHKAILAARSSYFeamFRSFMP----EDGQVNISIGEMVPSRqaFESMLR 722
Cdd:cd18285   2 LSQDLLRLLR---EElHTDVTFYVGSTLFKAHKAILLARVPEF---FSHIIGklssLEDQEPINIENLEASE--FKTFLR 73

                        90
                ....*....|....*..
gi 26339705 723 YIYYGEVN--MPPEDSL 737
Cdd:cd18285  74 QVYTSDKNikMLEEEIL 90
BACK1_LZTR1 cd18505
first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional ...
 766-794 6.21e-03

first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.


Pssm-ID: 350580  Cd Length: 59  Bit Score: 35.72  E-value: 6.21e-03
                        10        20
                ....*....|....*....|....*....
gi 26339705 766 TVQNVLQILEAADKTQALDMKRHCLHIIV 794
Cdd:cd18505   1 NVRNVLVALENASKLNLDQLKEHCLNFIV 29
Kelch_4 pfam13418
Galactose oxidase, central domain;
171-220 6.62e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 6.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 26339705   171 ARSAHGAT-VYSDKLWIFAGYDGNA-RLNDMWTIGLQDREltcWEEVAQSGE 220
Cdd:pfam13418   1 PRAYHTSTsIPDDTIYLFGGEGEDGtLLSDLWVFDLSTNE---WTRLGSLPS 49
Kelch_6 pfam13964
Kelch motif;
114-172 6.68e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.39  E-value: 6.68e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 26339705   114 PRYHHSAVVYGSSMFVFGGYTGDIYSnsnlknKNDLFEYKFATGQWTEWkieGRLPVAR 172
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPA------LNKLEVYNPLTKSWEEL---PPLPTPR 50
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 665-735 7.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 37.08  E-value: 7.17e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26339705 665 DITLLLDGQPRPAHKAILAARSSYFEA-MFRSFMPEDGQvnisigemvpSRQAFESMLRYIYYGEVNMPPED 735
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRArLSRDILKVKGL----------SYATLRLLVDYVYSGRMAVSKDN 67
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 114-161 7.63e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 7.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 26339705   114 PRYHHSAVVYGSSMFVFGGYTGdiysnSNLKNKNDLFEYKFATGQWTE 161
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDG-----LGDLSSSDVLVYDPETNVWTE 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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