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Conserved domains on  [gi|10178169|dbj|BAB11582|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-672 6.86e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 6.86e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 357 QEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVveseRKGELLSMDKQEDGSINlfllangspePVSMSPKrrGR-- 434
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTGHSGAVT----------SVAFSPD--GKll 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 435 -TSFSRKSVSLDNVlvpeavfgLSEKPVCSFVGHLDDVLDLSWS-KSQHLLSSSMDKTVRLWDLSSKTCLKVFS-HSDYV 511
Cdd:COG2319 178 aSGSDDGTVRLWDL--------ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 512 TCIQFNPvDDNYFISGSLDAKVRIWSIPDHQVVDWNDLHEM-VTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQRREi 590
Cdd:COG2319 250 RSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 591 nlknrkkkTHHKKITGFQFVAgSSSEVLVTSADSRTRV--VDGVDLVHKFKGFRNTNSqiSASLTSNGKFLVSASEDSNV 668
Cdd:COG2319 328 --------GHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLASGSADGTV 396


                ....
gi 10178169 669 YVWN 672
Cdd:COG2319 397 RLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-672 6.86e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 6.86e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 357 QEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVveseRKGELLSMDKQEDGSINlfllangspePVSMSPKrrGR-- 434
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTGHSGAVT----------SVAFSPD--GKll 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 435 -TSFSRKSVSLDNVlvpeavfgLSEKPVCSFVGHLDDVLDLSWS-KSQHLLSSSMDKTVRLWDLSSKTCLKVFS-HSDYV 511
Cdd:COG2319 178 aSGSDDGTVRLWDL--------ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 512 TCIQFNPvDDNYFISGSLDAKVRIWSIPDHQVVDWNDLHEM-VTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQRREi 590
Cdd:COG2319 250 RSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 591 nlknrkkkTHHKKITGFQFVAgSSSEVLVTSADSRTRV--VDGVDLVHKFKGFRNTNSqiSASLTSNGKFLVSASEDSNV 668
Cdd:COG2319 328 --------GHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLASGSADGTV 396


                ....
gi 10178169 669 YVWN 672
Cdd:COG2319 397 RLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 356-672 6.99e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 6.99e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 356 SQEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVveseRKGELLSMDKQEDGSINLFLLangspepvsmspkrrgrT 435
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL----ETGELLRTLKGHTGPVRDVAA-----------------S 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 436 SFSRK--SVSLDNVLVpeaVFGL-SEKPVCSFVGHLDDVLDLSWSKSQHLLSSSM-DKTVRLWDLSSKTCLKVF-SHSDY 510
Cdd:cd00200  61 ADGTYlaSGSSDKTIR---LWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLrGHTDW 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 511 VTCIQFNPvDDNYFISGSLDAKVRIWSIPDHQVVDWNDLHEM-VTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQRRE 589
Cdd:cd00200 138 VNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 590 INLKnrkkkthhkkitGFQFVAGSSSEVLVTSA--DSRTRV--VDGVDLVHKFKGfrNTNSQISASLTSNGKFLVSASED 665
Cdd:cd00200 217 GHEN------------GVNSVAFSPDGYLLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 10178169 666 SNVYVWN 672
Cdd:cd00200 283 GTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-391 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 10178169    357 QEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWK 391
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
459-495 4.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 4.77e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 10178169   459 KPVCSFVGHLDDVLDLSWSK-SQHLLSSSMDKTVRLWD 495
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 378-536 7.48e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 7.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169  378 LASAGEDCVIQIWKVVESERKGELLSMDKQ----EDGSINLFLLANGSPE-PVSMSPKRRGRTSFSRKS-VSLDNVLVPE 451
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRvwsiDYSSADPTLLASGSDDgSVKLWSINQGVSIGTIKTkANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169  452 A-----VFGLSEK------------PVCSFVGHLDDVLDLSWSKSQHLLSSSMDKTVRLWDLS------SKTCLKVFS-H 507
Cdd:PLN00181 628 EsgrslAFGSADHkvyyydlrnpklPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMgH 707

                        170       180
                 ....*....|....*....|....*....
gi 10178169  508 SDYVTCIQFNpVDDNYFISGSLDAKVRIW 536
Cdd:PLN00181 708 TNVKNFVGLS-VSDGYIATGSETNEVFVY 735
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
357-672 6.86e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.82  E-value: 6.86e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 357 QEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVveseRKGELLSMDKQEDGSINlfllangspePVSMSPKrrGR-- 434
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL----ATGKLLRTLTGHSGAVT----------SVAFSPD--GKll 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 435 -TSFSRKSVSLDNVlvpeavfgLSEKPVCSFVGHLDDVLDLSWS-KSQHLLSSSMDKTVRLWDLSSKTCLKVFS-HSDYV 511
Cdd:COG2319 178 aSGSDDGTVRLWDL--------ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSV 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 512 TCIQFNPvDDNYFISGSLDAKVRIWSIPDHQVVDWNDLHEM-VTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQRREi 590
Cdd:COG2319 250 RSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 591 nlknrkkkTHHKKITGFQFVAgSSSEVLVTSADSRTRV--VDGVDLVHKFKGFRNTNSqiSASLTSNGKFLVSASEDSNV 668
Cdd:COG2319 328 --------GHTGAVRSVAFSP-DGKTLASGSDDGTVRLwdLATGELLRTLTGHTGAVT--SVAFSPDGRTLASGSADGTV 396


                ....
gi 10178169 669 YVWN 672
Cdd:COG2319 397 RLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 356-672 6.99e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 6.99e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 356 SQEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVveseRKGELLSMDKQEDGSINLFLLangspepvsmspkrrgrT 435
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL----ETGELLRTLKGHTGPVRDVAA-----------------S 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 436 SFSRK--SVSLDNVLVpeaVFGL-SEKPVCSFVGHLDDVLDLSWSKSQHLLSSSM-DKTVRLWDLSSKTCLKVF-SHSDY 510
Cdd:cd00200  61 ADGTYlaSGSSDKTIR---LWDLeTGECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLrGHTDW 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 511 VTCIQFNPvDDNYFISGSLDAKVRIWSIPDHQVVDWNDLHEM-VTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQRRE 589
Cdd:cd00200 138 VNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 590 INLKnrkkkthhkkitGFQFVAGSSSEVLVTSA--DSRTRV--VDGVDLVHKFKGfrNTNSQISASLTSNGKFLVSASED 665
Cdd:cd00200 217 GHEN------------GVNSVAFSPDGYLLASGseDGTIRVwdLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 10178169 666 SNVYVWN 672
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
357-581 4.90e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 4.90e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 357 QEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVveseRKGELLSMDKQEDGSINlfllangspePVSMSPKrrGRTS 436
Cdd:COG2319 198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL----ATGKLLRTLTGHSGSVR----------SVAFSPD--GRLL 261

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 437 FsrkSVSLDNVLvpeAVFGLSE-KPVCSFVGHLDDVLDLSWSK-SQHLLSSSMDKTVRLWDLSSKTCLKVFS-HSDYVTC 513
Cdd:COG2319 262 A---SGSADGTV---RLWDLATgELLRTLTGHSGGVNSVAFSPdGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRS 335

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10178169 514 IQFNPvDDNYFISGSLDAKVRIWSIPDHQVVDWNDLHE-MVTAACYTPDGQGALVGSYKGTCCLYNTHD 581
Cdd:COG2319 336 VAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTgAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
360-675 3.21e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 3.21e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 360 QAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVveseRKGELLSMDKQEDGSINlfllangspePVSMSPkrRGRT--SF 437
Cdd:COG2319  75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----ATGLLLRTLTGHTGAVR----------SVAFSP--DGKTlaSG 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 438 SR-KSVSLDNVLvpeavfglSEKPVCSFVGHLDDVLDLSWSK-SQHLLSSSMDKTVRLWDLSSKTCLKVFS-HSDYVTCI 514
Cdd:COG2319 139 SAdGTVRLWDLA--------TGKLLRTLTGHSGAVTSVAFSPdGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSV 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 515 QFNPvDDNYFISGSLDAKVRIWSIPDHQVVDWNDLHE-MVTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQRreinlk 593
Cdd:COG2319 211 AFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRT------ 283

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 594 nrkkkthhkkitgfqfVAGSSSEVLvtsadsrtrvvdgvdlvhkfkgfrntnsqiSASLTSNGKFLVSASEDSNVYVWNY 673
Cdd:COG2319 284 ----------------LTGHSGGVN------------------------------SVAFSPDGKLLASGSDDGTVRLWDL 317


                ..
gi 10178169 674 DS 675
Cdd:COG2319 318 AT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 460-677 2.31e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.32  E-value: 2.31e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 460 PVCSFVGHLDDVLDLSWS-KSQHLLSSSMDKTVRLWDLSSKTCLKVFS-HSDYVTCIQFNPvDDNYFISGSLDAKVRIWS 537
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 538 IPDHQVVdwNDLH---EMVTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQrreiNLKNRKKKTHHKKITGF-QFVAGS 613
Cdd:cd00200  80 LETGECV--RTLTghtSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT----TLRGHTDWVNSVAFSPDgTFVASS 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10178169 614 SSevlvtsaDSRTRVVDGVD--LVHKFKGFrntNSQI-SASLTSNGKFLVSASEDSNVYVWNYDSDS 677
Cdd:cd00200 154 SQ-------DGTIKLWDLRTgkCVATLTGH---TGEVnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
463-675 2.71e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 2.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 463 SFVGHLDDVLDLSWSKS-QHLLSSSMDKTVRLWDLSSKTCLKVFS-HSDYVTCIQFNPvDDNYFISGSLDAKVRIWSIPD 540
Cdd:COG2319  31 LLLGLAAAVASLAASPDgARLAAGAGDLTLLLLDAAAGALLATLLgHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 541 HQVVDWNDLHE-MVTAACYTPDGQGALVGSYKGTCCLYNTHDNKLQQRreinlknrkkkthhkkitgfqfVAGSSSEVLv 619
Cdd:COG2319 110 GLLLRTLTGHTgAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT----------------------LTGHSGAVT- 166

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 10178169 620 tsadsrtrvvdgvdlvhkfkgfrntnsqiSASLTSNGKFLVSASEDSNVYVWNYDS 675
Cdd:COG2319 167 -----------------------------SVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-391 1.05e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 10178169    357 QEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWK 391
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 498-537 1.17e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.17e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 10178169    498 SKTCLKVFS-HSDYVTCIQFNPvDDNYFISGSLDAKVRIWS 537
Cdd:smart00320   1 SGELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-495 1.49e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 10178169    457 SEKPVCSFVGHLDDVLDLSWSK-SQHLLSSSMDKTVRLWD 495
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 349-495 2.26e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 2.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169 349 ELTALFKSQEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIWKVVeserkgellsmdkqedgsinlfllangspepvsms 428
Cdd:cd00200 205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR----------------------------------- 249

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10178169 429 pkrrgrtsfsrksvsldnvlvpeavfglSEKPVCSFVGHLDDVLDLSWSKS-QHLLSSSMDKTVRLWD 495
Cdd:cd00200 250 ----------------------------TGECVQTLSGHTNSVTSLAWSPDgKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
459-495 4.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 4.77e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 10178169   459 KPVCSFVGHLDDVLDLSWSK-SQHLLSSSMDKTVRLWD 495
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
357-390 8.94e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 8.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 10178169   357 QEIQAHKGSIWSIKFSLDGRYLASAGEDCVIQIW 390
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
499-537 9.20e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 9.20e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 10178169   499 KTCLKVFS-HSDYVTCIQFNPvDDNYFISGSLDAKVRIWS 537
Cdd:pfam00400   1 GKLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 378-536 7.48e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 7.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169  378 LASAGEDCVIQIWKVVESERKGELLSMDKQ----EDGSINLFLLANGSPE-PVSMSPKRRGRTSFSRKS-VSLDNVLVPE 451
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRvwsiDYSSADPTLLASGSDDgSVKLWSINQGVSIGTIKTkANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169  452 A-----VFGLSEK------------PVCSFVGHLDDVLDLSWSKSQHLLSSSMDKTVRLWDLS------SKTCLKVFS-H 507
Cdd:PLN00181 628 EsgrslAFGSADHkvyyydlrnpklPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMgH 707

                        170       180
                 ....*....|....*....|....*....
gi 10178169  508 SDYVTCIQFNpVDDNYFISGSLDAKVRIW 536
Cdd:PLN00181 708 TNVKNFVGLS-VSDGYIATGSETNEVFVY 735
PTZ00420 PTZ00420
coronin; Provisional
 460-542 1.97e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169  460 PVCSFVGHLDDVLDLSWSK--SQHLLSSSMDKTVRLWDLSSK----------TCLkVFSHSDYVTCIQFNPVddNYFI-- 525
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI-LKGHKKKISIIDWNPM--NYYImc 142

                         90
                 ....*....|....*..
gi 10178169  526 SGSLDAKVRIWSIPDHQ 542
Cdd:PTZ00420 143 SSGFDSFVNIWDIENEK 159
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 475-672 7.85e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 39.68  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169  475 SWSKSQhLLSSSMDKTVRLWDLS-SKTCLKVFSHSDYVTCIQFNPVDDNYFISGSLDAKVRIWSIpdHQVVDWNDLHEMV 553
Cdd:PLN00181 542 SYIKSQ-VASSNFEGVVQVWDVArSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI--NQGVSIGTIKTKA 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10178169  554 TAACY---TPDGQGALVGSYKGTCCLYNTHDNKLQQRREINlknrkkktHHKKITGFQFVagSSSEVLVTSADSRTRVVD 630
Cdd:PLN00181 619 NICCVqfpSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIG--------HSKTVSYVRFV--DSSTLVSSSTDNTLKLWD 688

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 10178169  631 ------GVD--LVHKFKGFRNTNSQISASLtSNGkFLVSASEDSNVYVWN 672
Cdd:PLN00181 689 lsmsisGINetPLHSFMGHTNVKNFVGLSV-SDG-YIATGSETNEVFVYH 736
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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