NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9759476|dbj|BAB10481|]
View 

unnamed protein product [Arabidopsis thaliana]

Protein Classification

SET domain-containing protein( domain architecture ID 14442795)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1252-1399 3.09e-98

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


:

Pssm-ID: 380946  Cd Length: 148  Bit Score: 310.81  E-value: 3.09e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1252 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1331
Cdd:cd19169    1 DLLKFNQLKFRKKQLKFAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1332 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPNVY 1399
Cdd:cd19169   81 TKCGNLARFINHSCNPNCYAKIITVESQKKIVIYSKRPIAVNEEITYDYKFPIEDEKIPCLCGAPQCR 148
PTZ00121 super family cl31754
MAEBL; Provisional
 746-961 2.95e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    746 LKGSHQVSRKETLALKKRKTVTRNKKLVQSNISNQTAEKLRKpcvgASEKVLVKRSKKLSDSHSMKEVLKVDTPSIDLSV 825
Cdd:PTZ00121 1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKK----AEEAKKADEAKKAEEKKKADELKKAEELKKAEEK 1563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    826 RKPSQQKM----RNTDRRDHCIIKDATKLHKEKVGKdAFSKVICDKSQDLEMEDEfddallitrlrriSRNKTKELRECR 901
Cdd:PTZ00121 1564 KKAEEAKKaeedKNMALRKAEEAKKAEEARIEEVMK-LYEEEKKMKAEEAKKAEE-------------AKIKAEELKKAE 1629

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9759476    902 NAAKSCEEISVT-AEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKNLSDARDEGTKS 961
Cdd:PTZ00121 1630 EEKKKVEQLKKKeAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA 1690
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 871-1112 7.24e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.19  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    871 LEMEDEFDDALLITRLRRISRNKTKELREcRNAAKSCEEISVTAEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKN 950
Cdd:PTZ00108 1141 LEEQEEVEEKEIAKEQRLKSKTKGKASKL-RKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSN 1219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    951 LSDARDEGTKSCNGAVKSFTEISGK-EGDTESLGLAISDKVSHQNLSKRRKSKIALflfpgfeNTSRKCFTKLLSPEDAA 1029
Cdd:PTZ00108 1220 SSGSDQEDDEEQKTKPKKSSVKRLKsKKNNSSKSSEDNDEFSSDDLSKEGKPKNAP-------KRVSAVQYSPPPPSKRP 1292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476   1030 KNGQDMSNPTGNPPRLAEGKKFVEKSACSISQKGPSQSSILKRK------HQLDEKISNVPSRRRLSLSSTDSEDAVIKE 1103
Cdd:PTZ00108 1293 DGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKsktrvkQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372


                  ....*....
gi 9759476   1104 DYDVRNEEK 1112
Cdd:PTZ00108 1373 VDDSEDEDD 1381
 
Name Accession Description Interval E-value
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1252-1399 3.09e-98

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 310.81  E-value: 3.09e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1252 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1331
Cdd:cd19169    1 DLLKFNQLKFRKKQLKFAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1332 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPNVY 1399
Cdd:cd19169   81 TKCGNLARFINHSCNPNCYAKIITVESQKKIVIYSKRPIAVNEEITYDYKFPIEDEKIPCLCGAPQCR 148
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1264-1387 7.86e-43

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 152.49  E-value: 7.86e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476     1264 KHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINH 1343
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 9759476     1344 SCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD 1387
Cdd:smart00317   81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1256-1393 8.47e-36

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 132.78  E-value: 8.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1256 MSQLKarkKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIrsSISEIRERqYEKMGIGSSYLFRLDDGYVLDATKRG 1335
Cdd:COG2940    1 MAMLH---PRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVI--TWAEAERR-EPHKEPLHTYLFELDDDGVIDGALGG 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1336 GIARFINHSCEPNCYTkiisVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNC 1393
Cdd:COG2940   75 NPARFINHSCDPNCEA----DEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYPCRC 128
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1276-1381 8.02e-31

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 117.62  E-value: 8.02e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    1276 WGLVALEPIEAEDFVIEYVGE-LIRSSISEIRERQYEKMGIG---SSYLFRLDD--GYVLDAT--KRGGIARFINHSCEP 1347
Cdd:pfam00856    2 RGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELrlwGPYLFTLDEdsEYCIDARalYYGNWARFINHSCDP 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 9759476    1348 NCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYK 1381
Cdd:pfam00856   82 NCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
PTZ00121 PTZ00121
MAEBL; Provisional
 746-961 2.95e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    746 LKGSHQVSRKETLALKKRKTVTRNKKLVQSNISNQTAEKLRKpcvgASEKVLVKRSKKLSDSHSMKEVLKVDTPSIDLSV 825
Cdd:PTZ00121 1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKK----AEEAKKADEAKKAEEKKKADELKKAEELKKAEEK 1563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    826 RKPSQQKM----RNTDRRDHCIIKDATKLHKEKVGKdAFSKVICDKSQDLEMEDEfddallitrlrriSRNKTKELRECR 901
Cdd:PTZ00121 1564 KKAEEAKKaeedKNMALRKAEEAKKAEEARIEEVMK-LYEEEKKMKAEEAKKAEE-------------AKIKAEELKKAE 1629

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9759476    902 NAAKSCEEISVT-AEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKNLSDARDEGTKS 961
Cdd:PTZ00121 1630 EEKKKVEQLKKKeAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA 1690
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 871-1112 7.24e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.19  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    871 LEMEDEFDDALLITRLRRISRNKTKELREcRNAAKSCEEISVTAEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKN 950
Cdd:PTZ00108 1141 LEEQEEVEEKEIAKEQRLKSKTKGKASKL-RKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSN 1219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    951 LSDARDEGTKSCNGAVKSFTEISGK-EGDTESLGLAISDKVSHQNLSKRRKSKIALflfpgfeNTSRKCFTKLLSPEDAA 1029
Cdd:PTZ00108 1220 SSGSDQEDDEEQKTKPKKSSVKRLKsKKNNSSKSSEDNDEFSSDDLSKEGKPKNAP-------KRVSAVQYSPPPPSKRP 1292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476   1030 KNGQDMSNPTGNPPRLAEGKKFVEKSACSISQKGPSQSSILKRK------HQLDEKISNVPSRRRLSLSSTDSEDAVIKE 1103
Cdd:PTZ00108 1293 DGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKsktrvkQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372


                  ....*....
gi 9759476   1104 DYDVRNEEK 1112
Cdd:PTZ00108 1373 VDDSEDEDD 1381
 
Name Accession Description Interval E-value
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1252-1399 3.09e-98

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 310.81  E-value: 3.09e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1252 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1331
Cdd:cd19169    1 DLLKFNQLKFRKKQLKFAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1332 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPNVY 1399
Cdd:cd19169   81 TKCGNLARFINHSCNPNCYAKIITVESQKKIVIYSKRPIAVNEEITYDYKFPIEDEKIPCLCGAPQCR 148
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 1252-1397 3.56e-74

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 243.10  E-value: 3.56e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1252 DVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDA 1331
Cdd:cd20072    1 DLLRFNQLKKRKKQLKFARSAIHNWGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGIGSSYLFRIDDDTVVDA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9759476  1332 TKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPN 1397
Cdd:cd20072   81 TKKGNIARFINHCCDPNCTAKIIKVEGEKRIVIYAKRDIAAGEELTYDYKFPREEDKIPCLCGAPN 146
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 1254-1397 1.49e-73

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 241.35  E-value: 1.49e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1254 LKMSQLKARKKH-LRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDAT 1332
Cdd:cd10518    3 KRFRQLRSRLKErLRVGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGGGTYMFRIDEDLVIDAT 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9759476  1333 KRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD-KIPCNCGAPN 1397
Cdd:cd10518   83 KKGNIARFINHSCDPNCYAKIITVDGEKHIVIFAKRDIAPGEELTYDYKFPIEDEeKIPCLCGAPN 148
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 1251-1397 3.98e-63

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 211.81  E-value: 3.98e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1251 ADVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLD 1330
Cdd:cd19204    1 SDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIGSSYLFRVDHDTIID 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9759476  1331 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPN 1397
Cdd:cd19204   81 ATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVNEEITYDYKFPIEDNKIPCLCGTEN 147
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 1251-1397 4.50e-59

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 199.90  E-value: 4.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1251 ADVLKMSQLKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLD 1330
Cdd:cd19205    1 SDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIID 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9759476  1331 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPN 1397
Cdd:cd19205   81 ATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSEN 147
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 1262-1395 1.26e-56

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 192.99  E-value: 1.26e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1262 RKKHLR--------FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATK 1333
Cdd:cd19170    4 RFRHLRktakeavgVYRSPIHGRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYESKGIGC-YMFRIDDDEVVDATM 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9759476  1334 RGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGA 1395
Cdd:cd19170   83 HGNAARFINHSCEPNCYSRVVNIDGKKHIVIFALRRILRGEELTYDYKFPIEDVKIPCTCGS 144
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 1255-1397 1.37e-51

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 178.39  E-value: 1.37e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1255 KMSQLKARKKHLR----FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLD 1330
Cdd:cd19171    1 KSSQYRKLKTEWRsnvyLARSRIQGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQNRGI-YMFRIDNDWVID 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9759476  1331 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD--KIPCNCGAPN 1397
Cdd:cd19171   80 ATMTGGPARYINHSCNPNCVAEVVTFDKEKKIIIISNRRIAKGEELTYDYKFDFEDDqhKIPCLCGAPN 148
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 1260-1395 1.93e-43

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 155.18  E-value: 1.93e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1260 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIAR 1339
Cdd:cd19206   10 KTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIGC-YMFRIDDSEVVDATMHGNAAR 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1340 FINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLED--DKIPCNCGA 1395
Cdd:cd19206   89 FINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDasNKLPCNCGA 146
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1264-1387 7.86e-43

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 152.49  E-value: 7.86e-43
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476     1264 KHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINH 1343
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 9759476     1344 SCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD 1387
Cdd:smart00317   81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 1264-1380 1.86e-42

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 150.86  E-value: 1.86e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1264 KHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDDGYVLDATKRGGIARFINH 1343
Cdd:cd10519    1 KRLLLGKSDVAGWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYN--SSYLFNLNDQFVVDATRKGNKIRFANH 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 9759476  1344 SCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10519   79 SSNPNCYAKVMMVNGDHRIGIFAKRDIEAGEELFFDY 115
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 1276-1397 2.01e-40

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 145.86  E-value: 2.01e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIrsSISEIRER--QYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKI 1353
Cdd:cd10531   12 WGVKAKEDIQKGEFIIEYVGEVI--DKKEFKERldEYEELGKSNFYILSLSDDVVIDATRKGNLSRFINHSCEPNCETQK 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 9759476  1354 ISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD-KIPCNCGAPN 1397
Cdd:cd10531   90 WIVNGEYRIGIFALRDIPAGEELTFDYNFVNYNEaKQVCLCGAQN 134
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 1260-1395 1.77e-38

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 141.31  E-value: 1.77e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1260 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIAR 1339
Cdd:cd19207   10 KTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGC-YMFRIDDFDVVDATMHGNAAR 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1340 FINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLED--DKIPCNCGA 1395
Cdd:cd19207   89 FINHSCEPNCYSRVIHVEGQKHIVIFALRKIYRGEELTYDYKFPIEDasNKLPCNCGA 146
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 1276-1397 2.11e-37

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 137.33  E-value: 2.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1355
Cdd:cd19172   14 WGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEIIDATKKGNLSRFINHSCEPNCETQKWT 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 9759476  1356 VEGKKKIFIYAKRHIDAGEEISYNYKFPL-EDDKIPCNCGAPN 1397
Cdd:cd19172   94 VNGELRVGFFAKRDIPAGEELTFDYQFERyGKEAQKCYCGSPN 136
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 1263-1397 2.77e-36

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 134.75  E-value: 2.77e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1263 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIARFIN 1342
Cdd:cd19208   14 KSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGV-YMFRIDNDHVIDATLTGGPARYIN 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 9759476  1343 HSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDD--KIPCNCGAPN 1397
Cdd:cd19208   93 HSCAPNCVAEVVTFEKGHKIIISSSRRIQKGEELCYDYKFDFEDDqhKIPCHCGAVN 149
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1256-1393 8.47e-36

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 132.78  E-value: 8.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1256 MSQLKarkKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIrsSISEIRERqYEKMGIGSSYLFRLDDGYVLDATKRG 1335
Cdd:COG2940    1 MAMLH---PRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVI--TWAEAERR-EPHKEPLHTYLFELDDDGVIDGALGG 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1336 GIARFINHSCEPNCYTkiisVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNC 1393
Cdd:COG2940   75 NPARFINHSCDPNCEA----DEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYPCRC 128
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 1276-1397 7.22e-34

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 127.41  E-value: 7.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIrsSISEIRER---QYEKMGigSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTK 1352
Cdd:cd19174   12 WGVRTKEPIKAGQFIIEYVGEVV--SEQEFRRRmieQYHNHS--HHYCLNLDSGMVIDGYRMGNEARFVNHSCDPNCEMQ 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 9759476  1353 IISVEGKKKIFIYAKRHIDAGEEISYNYKFPL--EDDKIPCNCGAPN 1397
Cdd:cd19174   88 KWSVNGVYRIGLFALKDIPAGEELTYDYNFHSfnVEKQQPCKCGSPN 134
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 1276-1397 1.39e-33

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 126.66  E-value: 1.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1355
Cdd:cd19173   14 WGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITNFYMLTLDKDRIIDAGPKGNLSRFMNHSCQPNCETQKWT 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 9759476  1356 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPN 1397
Cdd:cd19173   94 VNGDTRVGLFAVRDIPAGEELTFNYNLDcLGNEKKVCRCGAPN 136
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 1276-1397 1.79e-33

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 126.38  E-value: 1.79e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1355
Cdd:cd19175   12 WGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMCEIDKDMVIDATFKGNLSRFINHSCDPNCELQKWQ 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 9759476  1356 VEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDKIPCNCGAPN 1397
Cdd:cd19175   92 VDGETRIGVFAIRDIKKGEELTYDYQFVQFGADQDCHCGSKN 133
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 1263-1397 2.99e-32

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 123.27  E-value: 2.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1263 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSsYLFRLDDGYVLDATKRGGIARFIN 1342
Cdd:cd19209   15 KNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGI-YMFRINNEHVIDATLTGGPARYIN 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 9759476  1343 HSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLEDDK--IPCNCGAPN 1397
Cdd:cd19209   94 HSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQhkIPCHCGAWN 150
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1276-1381 8.02e-31

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 117.62  E-value: 8.02e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    1276 WGLVALEPIEAEDFVIEYVGE-LIRSSISEIRERQYEKMGIG---SSYLFRLDD--GYVLDAT--KRGGIARFINHSCEP 1347
Cdd:pfam00856    2 RGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELrlwGPYLFTLDEdsEYCIDARalYYGNWARFINHSCDP 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 9759476    1348 NCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYK 1381
Cdd:pfam00856   82 NCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 1263-1382 8.86e-29

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 111.93  E-value: 8.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1263 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDDGYVLDATKRGGIARFIN 1342
Cdd:cd19218    3 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYM--CSFLFNLNNDFVVDATRKGNKIRFAN 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 9759476  1343 HSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKF 1382
Cdd:cd19218   81 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 120
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 1276-1401 1.15e-27

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 109.69  E-value: 1.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1355
Cdd:cd19211   14 WGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWT 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 9759476  1356 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPNVYCF 1401
Cdd:cd19211   94 VNGDTRVGLFAVCDIPAGTELTFNYNLDcLGNEKTVCRCGAPNCSGF 140
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 1260-1386 3.95e-27

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 107.85  E-value: 3.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1260 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDDGYVLDATKRGGIAR 1339
Cdd:cd19217    2 RGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYM--SSFLFNLNNDFVVDATRKGNKIR 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 9759476  1340 FINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPLED 1386
Cdd:cd19217   80 FANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDYRYSQAD 126
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1276-1401 5.88e-25

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 101.93  E-value: 5.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1355
Cdd:cd19210   14 WGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWT 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 9759476  1356 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPNVYCF 1401
Cdd:cd19210   94 VNGDTRVGLFALCDIKAGTELTFNYNLEcLGNGKTVCKCGAPNCSGF 140
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1276-1397 7.11e-25

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 105.07  E-value: 7.11e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKmgIGSSYLFRLD-----DGYVLDATKRGGIARFINHSCEPNcy 1350
Cdd:cd10542  100 WGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDA--NGRTYLFDLDyndddCEYTVDAAYYGNISHFINHSCDPN-- 175

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9759476  1351 TKIISV------EGKKKIFIYAKRHIDAGEEISYNYKFPLEDD------------KIPCNCGAPN 1397
Cdd:cd10542  176 LAVYAVwinhldPRLPRIAFFAKRDIKAGEELTFDYLMTGTGGssestipkpkdvRVPCLCGSKN 240
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1259-1380 7.72e-24

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 101.29  E-value: 7.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1259 LKARKKHLRFQQSKIHD--WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGigSSYLFRLDD---------GY 1327
Cdd:cd10538   82 VVQRGLQARLQVFRTSKkgWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSG--GSYLFDLDEfsdsdgdgeEL 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 9759476  1328 VLDATKRGGIARFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10538  160 CVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDlrypRIALFATRDILPGEELTFDY 216
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 1277-1382 1.03e-23

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 97.80  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1277 GLVALEPIEAEDFVIEYVGELIRSSISEirerQYEKMGIGSSYLFRLD-DGYVLDATKRGGIARFINHSCEPNCYTKIIS 1355
Cdd:cd10522   16 GLFAAETIAKGEFVGEYTGEVLDRWEED----RDSVYHYDPLYPFDLNgDILVIDAGKKGNLTRFINHSDQPNLELIVRT 91

                         90       100
                 ....*....|....*....|....*....
gi 9759476  1356 VEGKKKIFIYAKRHIDAGEE--ISYNYKF 1382
Cdd:cd10522   92 LKGEQHIGFVAIRDIKPGEElfISYGPKY 120
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 1277-1380 2.97e-22

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 94.18  E-value: 2.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1277 GLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDG---YVLDATKR-GGIARFINHSC-EPNCYT 1351
Cdd:cd10528   30 GVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKgktYCVDATKEsGRLGRLINHSKkKPNLKT 109

                         90       100
                 ....*....|....*....|....*....
gi 9759476  1352 KIISVEGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10528  110 KLLVIDGVPHLILVAKRDIKPGEELLYDY 138
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 1264-1380 4.13e-22

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 93.02  E-value: 4.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1264 KHLRFQQSKIHD-WGLVALEPIEAEDFVIEYVGELIrsSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFIN 1342
Cdd:cd19168    1 KAVVLGKSQLECgLGLFAAEDIKEGEFVIEYTGELI--SHDEGVRREHRRGDVSYLYLFEEQEGIWVDAAIYGNLSRYIN 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 9759476  1343 HSCEP----NCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd19168   79 HATDKvktgNCMPKIMYVNHEWRIKFTAIKDIKIGEELFFNY 120
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1276-1401 4.14e-22

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 93.84  E-value: 4.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIARFINHSCEPNCYTKIIS 1355
Cdd:cd19212   14 WGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWT 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 9759476  1356 VEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCGAPNVYCF 1401
Cdd:cd19212   94 VNGDVRVGLFALCDIPAGMELTFNYNLDcLGNGRTECHCGADNCSGF 140
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 1276-1397 1.26e-20

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 93.13  E-value: 1.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIrsSISEIRERQYEKMGIGSSYLF----RLDDGYVL----DATKRGGIARFINHSCEP 1347
Cdd:cd10544  102 WGLRTLEFIPKGRFVCEYAGEVI--GFEEARRRTKSQTKGDMNYIIvlreHLSSGKVLetfvDPTYIGNIGRFLNHSCEP 179

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9759476  1348 NCYTKIISVEGK-KKIFIYAKRHIDAGEEISYNY---------------KFPLEDDKiPCNCGAPN 1397
Cdd:cd10544  180 NLFMVPVRVDSMvPKLALFAARDIVAGEELSFDYsgefsnsvesvtlarQDESKSRK-PCLCGAEN 244
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1276-1396 3.20e-20

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 91.25  E-value: 3.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRErqyekmgiGSSYLFRLD----DGYVLDATKRGGIARFINHSCEPNcyt 1351
Cdd:cd10543  103 WGVRALQDIPKGTFVCEYIGELISDSEADSRE--------DDSYLFDLDnkdgETYCIDARRYGNISRFINHLCEPN--- 171

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1352 kIISVegkkKIFI------------YAKRHIDAGEEISYNY--KF-PLEDDKIPCNCGAP 1396
Cdd:cd10543  172 -LIPV----RVFVehqdlrfpriafFASRDIKAGEELGFDYgeKFwRIKGKYFTCRCGSP 226
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1268-1397 5.30e-20

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 91.11  E-value: 5.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1268 FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMgiGSSYLFRLD---DGYVLDATKRGGIARFINHS 1344
Cdd:cd10525   91 FRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQ--GATYLFDLDyveDVYTVDAAYYGNISHFVNHS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1345 CEPN--CYTKIISV--EGKKKIFIYAKRHIDAGEEISYNYKF------------------------PLEDDKIPCNCGAP 1396
Cdd:cd10525  169 CDPNlqVYNVFIDNldERLPRIALFATRTIRAGEELTFDYNMqvdpvdaestkmdsnfglaglpgsPKKRVRIECKCGVR 248


                 .
gi 9759476  1397 N 1397
Cdd:cd10525  249 S 249
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1259-1396 1.15e-19

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 89.61  E-value: 1.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1259 LKARkkhLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERqyekmgigSSYLFRLD--DG--YVLDATKR 1334
Cdd:cd10535   89 LRAR---LQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREE--------DSYLFDLDnkDGevYCIDARFY 157

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9759476  1335 GGIARFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNYKFPLEDDK---IPCNCGAP 1396
Cdd:cd10535  158 GNVSRFINHHCEPNLVPVRVFMAHQDlrfpRIAFFSTRLIEAGEQLGFDYGERFWDIKgklFSCRCGSP 226
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1268-1395 9.75e-19

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 87.25  E-value: 9.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1268 FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIgsSYLFRLD---DGYVLDATKRGGIARFINHS 1344
Cdd:cd10532   89 FRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGI--TYLFDLDyesDEFTVDAARYGNVSHFVNHS 166

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1345 CEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNYKFPLEDD---------------KIPCNCGA 1395
Cdd:cd10532  167 CDPNLQVFNVFIDNLDtrlpRIALFSTRTIKAGEELTFDYQMKGSGDlssdsidnspakkrvRTVCKCGA 236
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 1304-1380 4.35e-17

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 76.91  E-value: 4.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1304 EIRERQYEKMGIGssyLFrlddgyVLDATKRG---GIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd08161    1 EIRPSTIPGAGFG---LF------ATRDIPKGeviGLARFINHSCEPNCEFEEVYVGGKPRVFIVALRDIKAGEELTVDY 71
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 1277-1380 7.00e-17

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 78.47  E-value: 7.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1277 GLVALEPIEAEDFVIEYVGELirSSISEIRErQYEKMGIGSSYLFrLDDGY-----VLDATKRGGIARFINHSCEPNCYT 1351
Cdd:cd10529   18 GLVATEDISPGEPILEYKGEV--SLRSEFKE-DNGFFKRPSPFVF-FYDGFeglplCVDARKYGNEARFIRRSCRPNAEL 93

                         90       100       110
                 ....*....|....*....|....*....|....
gi 9759476  1352 KIISVEGKK-KIFIYAKRHIDAGEEI----SYNY 1380
Cdd:cd10529   94 RHVVVSNGElRLFIFALKDIRKGTEItipfDYDY 127
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 1260-1397 1.91e-16

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 81.08  E-value: 1.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1260 KARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIgsSYLFRLD-------DGYVLDAT 1332
Cdd:cd20073   89 RGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGV--TYLFDLDlfedqvdEYYTVDAQ 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1333 KRGGIARFINHSCEPNCYTKIISVE-GKKKIF---IYAKRHIDAGEEISYNYKFPLEDD------------------KIP 1390
Cdd:cd20073  167 YCGDVTRFINHSCDPNLAIYSVLRDkSDSKIYdlaFFAIKDIPALEELTFDYSGRNNFDqlgfignrsnskyinlknKRP 246


                 ....*..
gi 9759476  1391 CNCGAPN 1397
Cdd:cd20073  247 CYCGSAN 253
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1263-1395 7.27e-16

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 78.91  E-value: 7.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1263 KKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRErqyekmgiGSSYLFRLD--DG--YVLDATKRGGIA 1338
Cdd:cd10533   90 KVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE--------DDSYLFDLDnkDGevYCIDARYYGNIS 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9759476  1339 RFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNYKFPLEDDK---IPCNCGA 1395
Cdd:cd10533  162 RFINHLCDPNIIPVRVFMLHQDlrfpRIAFFSSRDIRTGEELGFDYGDRFWDIKskyFTCQCGS 225
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1276-1397 1.88e-15

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 78.48  E-value: 1.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYekmgiGSSYLFRLD---------DG---------YVLDATKRGGI 1337
Cdd:cd10517  141 WGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQY-----GDEYFAELDyievveklkEGyesdveehcYIIDAKSEGNL 215

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9759476  1338 ARFINHSCEPNCYTKIISVEGKKKIF----IYAKRHIDAGEEISYNYKFPL---EDDKIPCNCGAPN 1397
Cdd:cd10517  216 GRYLNHSCSPNLFVQNVFVDTHDLRFpwvaFFASRYIRAGTELTWDYNYEVgsvPGKVLYCYCGSSN 282
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 1268-1397 3.88e-14

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 74.28  E-value: 3.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1268 FQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLD--------------DGYVLDATK 1333
Cdd:cd19473  110 FRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATIAQRKDVYLFALDkfsdpdsldprlrgDPYEIDGEF 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1334 RGGIARFINHSCEPNcyTKIISVEG---KKKIF---IYAKRHIDAGEEISYNY------------KFPLEDDKIPCNCGA 1395
Cdd:cd19473  190 MSGPTRFINHSCDPN--LRIFARVGdhaDKHIHdlaFFAIKDIPRGTELTFDYvdgvtgldddagDEEKEKEMTKCLCGS 267


                 ..
gi 9759476  1396 PN 1397
Cdd:cd19473  268 PK 269
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 1253-1380 7.85e-14

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 72.44  E-value: 7.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1253 VLKMSQlKARKKHLRFQQSKIHDWGLVALEPIEAEDFVIEYVGELIRSSISEIRE-----------RQYEKMGIGSSYLF 1321
Cdd:cd10545   76 YNRVTQ-KGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSgnddylfdidnRQTNRGWDGGQRLD 154

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9759476  1322 RLDD-------------GYVLDATKRGGIARFINHSCEPNCYTKIISVEGKK----KIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10545  155 VGMSdgerssaedeessEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDlrlpRVMLFAADNIPPLQELTYDY 230
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 1275-1384 3.28e-13

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 69.35  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1275 DWGLVALEPIEAEDFVIEYVGEL-IRSSISEIRERQYEKMGIGSSYLFRLDDG-YVLDATKRGGIARFINHSCEPNC--Y 1350
Cdd:cd19183   13 RFGLFADRPIPAGDPIQELLGEIgLQSEYIADPENQYQILGAPKPHVFFHPQSpLYIDTRRSGSVARFIRRSCRPNAelV 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 9759476  1351 TKIISVEGKKKIFIYAKRHIDAGEEISYNYKFPL 1384
Cdd:cd19183   93 TVASDSGSVLKFVLYASRDISPGEEITIGWDWDN 126
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 1266-1397 2.35e-12

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 69.09  E-value: 2.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1266 LRFQQSKIHD--WGLVALEPIEAEDFVIEYVGELIRSSISEI------------RERQYEKMGIGSSYLFRLDDG-YVLD 1330
Cdd:cd10523  108 VRLQVFKTEKkgWGVRCLDDIDKGTFVCIYAGRVLSRARSPTeplppklelpseNEVEVVTSWLILSKKRKLRENvCFLD 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9759476  1331 ATKRGGIARFINHSCEPNCYTKIISVEGKKKIF----IYAKRHIDAGEEISYNYKF---PLEDDKIPCNCGAPN 1397
Cdd:cd10523  188 ASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFpwvaFFTNRVVKAGTELTWDYSYdagTSPEQEIPCLCGVNK 261
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 1276-1395 2.54e-11

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 65.26  E-value: 2.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1276 WGLVALEPIEAEDFVIEYVGELIRSSISEireRQYEKMGigSSYLFRLD----DGYVLDATKRGGIARFINHSCEPNCYT 1351
Cdd:cd10541  104 WGIRCLDDIAKGTFVCIYAGKILTDDFAD---KEGLEMG--DEYFANLDhieeSCYIIDAKLEGNLGRYLNHSCSPNLFV 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 9759476  1352 KIISVEGKKKIF----IYAKRHIDAGEEISYNYKF---PLEDDKIPCNCGA 1395
Cdd:cd10541  179 QNVFVDTHDLRFpwvaFFASKRIKAGTELTWDYNYevgSVEGKELLCCCGS 229
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 1271-1380 3.20e-09

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 56.23  E-value: 3.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1271 SKIHDWGLVALEPIEAEDFVIEY--VGELIRSSISEIRERQYEKMGigssyLFRLddgyvldatkrggiARFINHSCEPN 1348
Cdd:cd20071    6 EGSKGRGLVATRDIEPGELILVEkpLVSVPSNSFSLTDGLNEIGVG-----LFPL--------------ASLLNHSCDPN 66

                         90       100       110
                 ....*....|....*....|....*....|..
gi 9759476  1349 CytkIISVEGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd20071   67 A---VVVFDGNGTLRVRALRDIKAGEELTISY 95
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 1277-1380 4.20e-09

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 55.72  E-value: 4.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1277 GLVALEPIEAEDfVIEYVGELIRSsiseIRERQYEKMGIGSSYLFRLDDGYVLDATKRGGIArfiNHSCEPNCYTKIisV 1356
Cdd:cd10540   13 GVFATRPIKKGE-VIEEAPVIVLP----KEEYQHLCKTVLDHYVFSWGDGCLALALGYGSMF---NHSYTPNAEYEI--D 82

                         90       100
                 ....*....|....*....|....
gi 9759476  1357 EGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10540   83 FENQTIVFYALRDIEAGEELTINY 106
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 1336-1380 2.11e-08

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 54.59  E-value: 2.11e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 9759476  1336 GIARFINHSCEPNCytKIISVeGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10524   75 GPAAFINHDCRPNC--KFVPT-GKSTACVKVLRDIEPGEEITVYY 116
SET_KMT5C cd19185
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...
 1296-1404 4.20e-06

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380962  Cd Length: 142  Bit Score: 47.73  E-value: 4.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1296 ELIRSSISEIRERQYEKMGIGSsylfrlDDGYVLDATKRG------GIARFINHSCEPNCytKIISVEGKKKIfIYAKRH 1369
Cdd:cd19185   35 ELLVGCIAELREEDEGLLRAGE------NDFSIMYSTRKRsaqlwlGPAAFINHDCKPNC--KFVPADGNAAC-VKVLRD 105

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 9759476  1370 IDAGEEIS--YNYKFPLEDDKIpCNCgapnvyCFCEQ 1404
Cdd:cd19185  106 IEPGDEVTcfYGEGFFGEKNEH-CEC------HTCER 135
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 1278-1382 6.03e-06

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 47.19  E-value: 6.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1278 LVALEPIEAEDFVIEYVGELIrssiseIRErQYEKMGigssYLFRLDDGYVL------------DATKRGGIARFINHSC 1345
Cdd:cd19182   21 LKAAKDLPPDTLIIEYRGKFM------LRE-QFEANG----YFFKRPYPFVLfyskfhglemcvDARTFGNEARFIRRSC 89

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 9759476  1346 EPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKF 1382
Cdd:cd19182   90 TPNAEVRHVIEDGTIHLYIYSIRSIPKGTEITIAFDF 126
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 1280-1380 4.12e-05

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 44.71  E-value: 4.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1280 ALEPIEAEDFVIEYVGElirssISEIRERQYEKmgiGSSYLFRLDDG-----YVLDATKRGGIARFI----NHSCE---- 1346
Cdd:cd10539   20 ADGFIKDLTIIAEYTGD-----VDYIRNREFDD---NDSIMTLLLAGdpsksLVICPDKRGNIARFIsginNHTKDgkkk 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 9759476  1347 PNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10539   92 QNCKCVRYSINGEARVLLVATRDIAKGERLYYDY 125
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 1340-1380 4.34e-05

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 46.52  E-value: 4.34e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 9759476  1340 FINHSCEPNCytkIISVEGkKKIFIYAKRHIDAGEEISYNY 1380
Cdd:cd10536  153 LLNHSCDPNT---IRSFYG-NTIVVRATRPIKKGEEITICY 189
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 1278-1400 1.50e-04

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 43.46  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476  1278 LVALEPIEAEDFVIEYVGELIrssiseIRErQYEKMGigssYLFRLDDGYVL------------DATKRGGIARFINHSC 1345
Cdd:cd19181   21 LRAARDLALDTLIIEYRGKVM------LRQ-QFEVNG----HFFKRPYPFVLfyskfngvemcvDARTFGNDARFIRRSC 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 9759476  1346 EPNCYTKIISVEGKKKIFIYAKRHI--DAGEEISYNYKFPLEDDKIPCNCGAPNVYC 1400
Cdd:cd19181   90 TPNAEVRHMIADGMIHLCIYAVAAIakDAEVTIAFDYEYSNCNYKVDCACHKGNRNC 146
SET_Suv4-20 cd19186
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 1336-1403 1.66e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation.


Pssm-ID: 380963  Cd Length: 142  Bit Score: 40.52  E-value: 1.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9759476  1336 GIARFINHSCEPNCytKIISVeGKKKIFIYAKRHIDAGEEISYNYKfpleDDKIpcncGAPNVYCFCE 1403
Cdd:cd19186   76 GPAAFINHDCRPNC--KFVST-GRDTACVQVLRDIEPGEEITCFYG----EDFF----GDNNCYCECE 132
PTZ00121 PTZ00121
MAEBL; Provisional
 746-961 2.95e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 2.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    746 LKGSHQVSRKETLALKKRKTVTRNKKLVQSNISNQTAEKLRKpcvgASEKVLVKRSKKLSDSHSMKEVLKVDTPSIDLSV 825
Cdd:PTZ00121 1488 AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKK----AEEAKKADEAKKAEEKKKADELKKAEELKKAEEK 1563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    826 RKPSQQKM----RNTDRRDHCIIKDATKLHKEKVGKdAFSKVICDKSQDLEMEDEfddallitrlrriSRNKTKELRECR 901
Cdd:PTZ00121 1564 KKAEEAKKaeedKNMALRKAEEAKKAEEARIEEVMK-LYEEEKKMKAEEAKKAEE-------------AKIKAEELKKAE 1629

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9759476    902 NAAKSCEEISVT-AEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKNLSDARDEGTKS 961
Cdd:PTZ00121 1630 EEKKKVEQLKKKeAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA 1690
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 871-1112 7.24e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.19  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    871 LEMEDEFDDALLITRLRRISRNKTKELREcRNAAKSCEEISVTAEESEETVDCKDHEESLSNKPSQKVKKAHTSKLKRKN 950
Cdd:PTZ00108 1141 LEEQEEVEEKEIAKEQRLKSKTKGKASKL-RKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSN 1219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476    951 LSDARDEGTKSCNGAVKSFTEISGK-EGDTESLGLAISDKVSHQNLSKRRKSKIALflfpgfeNTSRKCFTKLLSPEDAA 1029
Cdd:PTZ00108 1220 SSGSDQEDDEEQKTKPKKSSVKRLKsKKNNSSKSSEDNDEFSSDDLSKEGKPKNAP-------KRVSAVQYSPPPPSKRP 1292

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9759476   1030 KNGQDMSNPTGNPPRLAEGKKFVEKSACSISQKGPSQSSILKRK------HQLDEKISNVPSRRRLSLSSTDSEDAVIKE 1103
Cdd:PTZ00108 1293 DGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKsktrvkQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372


                  ....*....
gi 9759476   1104 DYDVRNEEK 1112
Cdd:PTZ00108 1373 VDDSEDEDD 1381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH