|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
28-505 |
0e+00 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 865.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 28 SPAVPSDSSAKFSLPVDTEHKAKVFKLLSFEAPHMRTFHLAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVAS 107
Cdd:PLN00028 1 QPASPDPKYSKFALPVDSEHKATEFRLFSFARPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 108 VSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVGGAGGYITVRFMIGFCLATFVSCQYWMSTMFNGQIIGLV 187
Cdd:PLN00028 81 VSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 188 NGTAAGWGNMGGGVTQLLMPMVYEIIRRLGSTSFTAWRMAFFVPGWMHIIMGILVLTLGQDLPDGNRSTLEKKGAVTKDK 267
Cdd:PLN00028 161 NGIAAGWGNLGGGVTQLLMPLVFPLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGNYRELKKSGTMPKDS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 268 FSKVLWYAITNYRTWVFVLLYGYSMGVELTTDNVIAEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDIAARRFG 347
Cdd:PLN00028 241 FSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 348 MRGRLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMILFSLGAQAACGATFAIIPFISRRSLGIISGLTGAGGNFGSGLTQ 427
Cdd:PLN00028 321 MRGRLWALWIVQTLGGVFCIWLGRANSLGAAIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQ 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10176905 428 LVFFSTSTFSTEQGLTWMGVMIMACTLPVTLVHFPQWGSMFLPSTEDEVkstEEYYYMKEWTETEKRKGMHEGSLKFA 505
Cdd:PLN00028 401 LLFFTGSSYSTETGISLMGVMIIACTLPVAFIHFPQWGGMFFGPSKDAV---EEDYYASEWTEEEKEKGLHQGSLKFA 475
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
65-458 |
3.28e-142 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 414.73 E-value: 3.28e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 65 FHLAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPR-YGCAFLVMLSAPTVF 143
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRrVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 144 SMSFVGGAGGYITVRFMIGFCLATFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIRRLGstSFTA 223
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDG--GFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 224 WRMAFFVPGWMHIIMGILVLTLGQDLPDGNRSTLEkkgavtkdkFSKVLWYAITNYRTWVFVLLYGYSMGVELTTDNVIA 303
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALE---------FLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 304 EYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFGMRGRLWTLWIIQTLGGFFCLWLGR--ATTLPTAVVF 381
Cdd:cd17341 230 TYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RFGGRRRLWWLFIVMTIGAALLSLSLPtsGTNLVLFLAL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10176905 382 MILFSLGAQAACGATFAIIPFISRRSLGIISGLTGAGGNFGSGLTQLVFFSTS--TFSTEQGLTWMGVMIMACTLPVTL 458
Cdd:cd17341 306 FVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSAlmTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
63-422 |
2.32e-80 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 254.92 E-value: 2.32e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 63 RTFHLAWISFFTCFISTFAAAPLVP-IIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPT 141
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVfLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 142 VFSMSFVGG-AGGYITVRFMIGFCLATFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMP-MVYEIIRRLGST 219
Cdd:TIGR00886 81 CLWAGLAVQsYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPpIIGSLIFGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 220 SFTAWRMAF-FVPGWMHIIMGILVLTLGQDLPDGNRSTLekkgavtKDKFSKVLWyAITNYRTWVFVLLYGYSMGVELTT 298
Cdd:TIGR00886 161 AHLAWGWAFvIVPAGILLLPALLIFFVGADTPPGKPATG-------KLSFKEALK-VFGNRHTWILALLYSVTFGSFLGV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 299 DNVIAEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDIAARRfgmrgRLWTLWIIQTLGGFFCLWLG--RATTLP 376
Cdd:TIGR00886 233 SSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGA-----RKLLMNFLGVAMGAFLVVLGlvSDGSLA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 10176905 377 TAVVFMILFSLGAQAACGATFAIIPFISRRSLGIISGLTGAGGNFG 422
Cdd:TIGR00886 308 AFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLG 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
61-454 |
2.26e-50 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 177.38 E-value: 2.26e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 61 HMRTFHLAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAP 140
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 141 TVFSMSFVGGAGGYITVRFMIGFCL-ATFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIrrlgst 219
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 220 sftAWRMAFFVPGWMHIIMGILVLTLGQDLPDGNRstlekkgAVTKDKFSKVLwYAITNYRTWVFVLLYGYSMGVELTTD 299
Cdd:COG2223 157 ---GWRNAFLILGILLLVVAVLAWLFLRDPPAGAA-------AAAKASLRDQL-EALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 300 NVIAEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFGMRGRLWTLWIIQTLGGFFCLWLGraTTLPTAV 379
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD----RIGGRRVLLIVFALMALGLLLLALAL--GSLWLFL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 10176905 380 VFMILFSLGAQAACGATFAIIPFI-SRRSLGIISGLTGAGGNFGSGLTQLVF--FSTSTFSTEQGLTWMGVMIMACTL 454
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFgaLLDATGSYTAAFLVFAVLALVALV 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
67-459 |
1.77e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 98.79 E-value: 1.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 67 LAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 146
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 147 FVGGAGGYITVRFMIGFCLA-TFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVyeiirrlgsTSFTAWR 225
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL---------LAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 226 MAFFVPGWMHIIMGILvltlgqdlpdgnrstlekkgavtkdkfskvlwyaitnyRTWVFVLLYGYSMGVELTTDNVIAEY 305
Cdd:COG2271 165 AAFLILGLPGLLLALL--------------------------------------RFWLLALAYFLVYFALYGFLTWLPTY 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 306 FFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFGmRGRLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMILF 385
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD----RLG-RRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLA 281
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 10176905 386 SLGAQAACGATFAIIP-FISRRSLGIISGLTGAGGNFGSGLTQLVF-FSTSTFSTEQGLTWMGVMIMACTLPVTLV 459
Cdd:COG2271 282 GFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
67-425 |
4.39e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 82.47 E-value: 4.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 67 LAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 146
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 147 FVGGAGGYITVRFMIGFCLA-TFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIRrlgstsftaWR 225
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---------WR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 226 MAFFVPGWMHIIMGILVLTLGQDLPDGNRSTLEKKGAVTKDKFSKVLwyaiTNYRTWVFVLLYGYSMGVELTTdnVIAEY 305
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALL----RDPVLWLLLALLLFGFAFFGLL--TYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 306 FFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFGMRGRLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMILF 385
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 10176905 386 SLGAQAACGATFAIIP-FISRRSLGIISGLTGAGGNFGSGL 425
Cdd:pfam07690 302 GFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
67-425 |
1.49e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.17 E-value: 1.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 67 LAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 146
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 147 FVGGAGGYITVRFMIGFCLATFVS-CQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIrrlgstsftAWR 225
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAGALFPaALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---------GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 226 MAFFVPGWMHIIMGILVLTLgqdlpdgnrstLEKKGAVTKDKFSKVLWYAITNYRTWVFVLLYGYSMGVELTTDNVIAEY 305
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRL-----------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 306 FFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFGMRgrlWTLWIIQTLGGFFCLWLGRATTLPTAVVFMILF 385
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRR---RLLLIGLLLLALGLLLLALAGSLWLLLLALFLL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 10176905 386 SLGAQAACGATFAIIP-FISRRSLGIISGLTGAGGNFGSGL 425
Cdd:COG2814 307 GFGFGLLFPLLQALVAeLAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
68-458 |
3.62e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.16 E-value: 3.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 68 AWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSF 147
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 148 VGGAGGYITVRFMIGFCLA-TFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIrrlgstsFTAWRM 226
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-------GFGWRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 227 AFFVPGWMHIIMGILVLTLgqdLPDGNRSTLEKKGAVTKDKFSKVLWYAITNYRTWVFVLLYGYSMGVELTTDNVIAEYF 306
Cdd:cd06174 154 VFLIAAALALLAAILLLLV---VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 307 FDRFHLKLHTAGIIAASFGMANFFARPIGGWASDIAarrfgmRGRLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMILFS 386
Cdd:cd06174 231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 10176905 387 LGAQAACGATFAIIPFI-SRRSLGIISGLTGAGGNFGSGLTQLVF-FSTSTFSTEQGLTWMGVMIMACTLPVTL 458
Cdd:cd06174 305 FGLGGLLPLSFALIAELfPPEIRGTAFGLLNTFGFLGGAIGPLLAgFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
87-458 |
1.74e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 65.67 E-value: 1.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 87 PIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYG-CAFLVMLSAPTVFsMSFVGGAGGYITVRFMIGFCL 165
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVlAVSMLLWSLFTAL-TGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 166 ATFVSC-----QYWMSTMFNGQIIGLVNgTAAGWGNMgggvtqLLMPMVYEIIRRLGstsftaWRMAFFVPGWMHIIMGI 240
Cdd:cd17319 106 AGFFPGaikalAEWFPARERGRATGLFN-SGAPLGAA------IGPPLSGWLLLLFG------WRWAFIIEGLLGLLLAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 241 LVLTLgqdlpdgnrstlekkgavtkdkFSKVLWYAITnyrtWVFVLLYGYSMGVELTTdnviaeYFFDRFHLKLHTAGII 320
Cdd:cd17319 173 LWWFY----------------------LRQVWGLALG----YFGINYALYGLLTWLPT------YLKQARGFSLKQVGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 321 AASFGMANFFARPIGGWASDiaarRFGMRGRLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMILFSLGAQAACGATFAII 400
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSD----RLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLP 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10176905 401 P-FISRRSLGIISGLTGAGGNFGSGLTQLV--FFSTSTFSTEQGLTWMGV-MIMACTLPVTL 458
Cdd:cd17319 297 AdLLPGEAAATAGGLINSGGNLGGFVAPLLigYLVDATGSYTAAFLFLAAvALLAALLVLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
61-389 |
3.47e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.79 E-value: 3.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 61 HMRTFHLAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAP 140
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 141 TVFSMSFVGGAGGYITVRFMIGFCLATF-VSCQYWMSTMFNGQIIGLVNGTAAGWGnMGGGVTQLLMPMVyeiirrLGST 219
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLL------ILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 220 SFTAWRMAFFVPGWMHIIMGILVLTlgQDLPDGNRSTLEKKGAVTKDKFskvlwyAITNYRTWVFVLLYGYSMGVELTTD 299
Cdd:COG0738 159 LSLSWHLPYLILAVLLLLLALLFLR--SKLPEIEEEEEEAAGSAASLKS------LLKNPRLLLGGLAIFLYVGAEGAIG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 300 NVIAEYFFDRFHLKLHTAGIIAASFgmanFFARPIGGWASDIAARRFgmrGRLWTLWIIQTLGGFFCLWLGRATTLPTAV 379
Cdd:COG0738 231 DWLPLYLKDVLGLSEATAALGLSLF----WGGMTIGRFLGGFLLKRF---GPVRLLRLSALLAAVGLLLALLAPGPWLAL 303
|
330
....*....|
gi 10176905 380 VFMILFSLGA 389
Cdd:COG0738 304 IGLALVGLGL 313
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
71-451 |
2.46e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 2.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 71 SFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYG--------CAFLVMLSAPTV 142
Cdd:COG2211 19 DLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGrrrpwiliGAIPLALSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 143 FSMSFVGGAGGYITvrFMIGFCLATFVScqywmsTMFNGQIIGLVN---------GTAAGWGNMGGGVTQLLMP-MVYEI 212
Cdd:COG2211 99 FTAPDLSPTGKLIY--ALVTYLLLGLAY------TLVNIPYSALGAeltpdyeerTRLSSWRFAFAGLGGLLASvLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 213 IRRLGSTSFTAWRMAFFVPGwmhIIMGILVLTLGqdlpdgnRSTLEKKGAVTKDKFSKVLWYAITNYRTWVFVLLYGYSM 292
Cdd:COG2211 171 VAAFGGDAALGYRLTALIFA---VLGLLAFLLTF-------FGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 293 GVELTTDNVIAEYFF-DRFHLKLHTAGIIAASFGMANFFARPIGGWAsdiaARRFGMRgRLWTLWIIQTLGGFFCLWLGR 371
Cdd:COG2211 241 FLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRL----AKRFGKK-KAFIIGLLLAALGLLLLFFLG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 372 ATTLPTAVVFMILFSLGAQAACGATFAIIPFIS--------RRSLGIISGLTGAGGNFGSGLTQLVF--------FSTST 435
Cdd:COG2211 316 PGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALAglllalfgYVAGA 395
|
410
....*....|....*.
gi 10176905 436 FSTEQGLTWMGVMIMA 451
Cdd:COG2211 396 AQSPSALTGIRLLFFL 411
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
68-430 |
2.81e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.79 E-value: 2.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 68 AWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSF 147
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 148 VGGAGGYITVRFMIGFCLATFV-SCQYWMSTMFNGQIIGLVNG---TAAgwgNMGGGVTQLLMPmvyEIIRRLGstsfta 223
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQpGGGRAIMRWFPPRERGLAMGirqTGV---PLGGALAAALLP---PLALHYG------ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 224 WRMAFFVPGWMHIIMGILVLTLGQDLPDGNRSTLEKKGAVTKDKfskvlwyAITNYRTWVFVLLYGYSM-GVELTTDNVI 302
Cdd:cd17475 149 WRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLK-------EVLRNRDVWLIAIAGALLvAPQFALLTFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 303 AEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaaRRFGMRGRLWTLWIIQTLGGFFCL--WLGRATTLPTAVV 380
Cdd:cd17475 222 LLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD---RVFGGRRRPVLVITAAIAAAALLVlsLLSPGTPLWLLVL 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 10176905 381 FMILFSLGAQAACGATFAIIP-FISRRSLGIISGLTGAGGNFGSGLTQLVF 430
Cdd:cd17475 299 LLILLGLFAIGWNGLYLTLVAeSAGPEQAGTALGLANTINFIGIAIGPPLF 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
73-425 |
1.55e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.79 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 73 FTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVGGAG 152
Cdd:cd17324 9 FAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 153 GYITVRFMIGFCLATFVSCQY-WMSTMFNGQIIGLVNGTAAGwGNMGGGVTQLLmpmvyeiirrLGS--TSFTAWRMAFF 229
Cdd:cd17324 89 LLLLARALAGLAHGGFWAIAAaYAADLVPPEKRGRAIGLVFS-GLTLGLVLGRP----------LGGllGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 230 VPGWMHIIMGILVLTLGQDLPDGNRSTLEKKGAVTKDKFSKVLWYAITNYRTWVFVLLYGYSmgvelttdnVIAEYFFDR 309
Cdd:cd17324 158 AIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYT---------YLAPFLTDV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 310 FHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFGMRGRLWTLWIIQTLGGFFCLWlgrATTLPTAVVFMILFSLGA 389
Cdd:cd17324 229 PGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD----RGGRRALLIALLLLAAALLLLTLL---GPSPLLLLVGLVLWGLGF 301
|
330 340 350
....*....|....*....|....*....|....*.
gi 10176905 390 QAACGATFAIIPFISRRSLGIISGLTGAGGNFGSGL 425
Cdd:cd17324 302 FAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGAL 337
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
69-430 |
8.72e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 54.30 E-value: 8.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 69 WISFFTCFI--STFAAAplVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 146
Cdd:TIGR00881 1 FIGYAAYYLvrKNFALA--MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 147 FVGGAGGYITVRFMIGFCLAT-FVSC----QYWMSTMFNGQIIGLVNGTAagwgNMGGGvtqLLMPMVYEIIRRLGStsf 221
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMgWPPCgrtvTKWFSRSERGTWVSFWNCSH----NVGGG---LLPPLVLFGIAELYS--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 222 taWRMAFFVPGWMHIIMGILVLTLGQDLP-------------DGNRSTLEKKGAVTKDKFSKvLWYAITNYRTWVFVLLY 288
Cdd:TIGR00881 149 --WHWVFIVPGIIAIIVSLICFLLLRDSPqscglppaeempnEEPDGDAEKKEEELTKKQIF-LQYVLLNKVLWYISLGY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 289 GYSMGVELTTDNVIAEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASD--IAARRFGMrGRLWTLWIIQTLGGFfc 366
Cdd:TIGR00881 226 VFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDklFNGRRGPL-AVFFMALIIVSLLVY-- 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10176905 367 lWLGRATTLPTAVVFMIL---FSLGAQAACGAtfAIIPFISRRSLGIISGLTGAGGNFGSGLTQLVF 430
Cdd:TIGR00881 303 -WLNPAANPLMDLICLFAlgfLVYGPQMLIGV--IASELAPKKAAGTAAGFVGFFAYLGGILAGLPL 366
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
101-250 |
1.09e-07 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 54.33 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 101 GNAGVASVSGSI---FSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVGGAGGYITVRFMIGF------------CL 165
Cdd:PRK11273 63 GDLGFALSGISIaygFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFlcgwfqgmgwppCG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 166 ATFVscqYWMSTMFNGQIIGLVNGTAagwgNMGGGVTQLLMpmvyeiirRLGSTSFTAWRMAFFVPGWMHIIMGILVLTL 245
Cdd:PRK11273 143 RTMV---HWWSQKERGGIVSVWNCAH----NVGGGLPPLLF--------LLGMAWFNDWHAALYMPAFAAILVALFAFAM 207
|
....*
gi 10176905 246 GQDLP 250
Cdd:PRK11273 208 MRDTP 212
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
69-454 |
1.20e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.65 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 69 WISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYgcaFLVM---LSAPTVFSM 145
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR---LLLLgllLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 146 SFVGGAGGYITVRFMIGFCLA-TFVSCQYWMSTMFNGQIIGlvngTAAGWGNMGGGVTQLLMPMVYEIIrrlgsTSFTAW 224
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERG----RAMGIFSSAIGLGFLIGPLLGGLL-----ADALGY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 225 RMAFFVPGWMHIIMGILVLTLgqdLPDGNRStlEKKGAVTKDKFSKVLWYAITNYRTWVFVLLYGYSMGVELTTDNVIAE 304
Cdd:cd17325 150 RAPFLVCAALALLALVLALLL---LPEPRPP--PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 305 YFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFgmrGRLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMIL 384
Cdd:cd17325 225 YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD----RI---GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 10176905 385 FSLGAQAACGATFAII-PFISRRSLGIISGLTGAGGNFGSGLTQLVF-FSTSTFSTEQGLTWMGVMIMACTL 454
Cdd:cd17325 298 LGLGLGLVFPATLALLaDIVPPEGRGTAMGLFNTAFSLGMVLGPLLGgFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
63-246 |
5.06e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.71 E-value: 5.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 63 RTFHLAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVM--LSAP 140
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGllLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 141 TVFSMSFVGGAGGYITVRFMIGFCLATFVSCQY-WMSTMFNGQIIGlvngTAAGWGNMGGGVTQLLMPMVYEIIrrlgsT 219
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWaLAAELFPKKARG----TASGLVNTFGFLGGALGPLLVGYL-----L 331
|
170 180
....*....|....*....|....*..
gi 10176905 220 SFTAWRMAFFVPGWMHIIMGILVLTLG 246
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
69-250 |
7.23e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.39 E-value: 7.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 69 WISFFTCFI---------STFAAAplVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSA 139
Cdd:cd17345 2 WQVFLGIFIgyagyylvrNNFSLA--QPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 140 PTVFSMSFVGGAGGYITVRFMIGFCL---------ATFVSCQYWMSTMFNGQIIGLVNGTAagwgNMGGGvtqLLMPMVY 210
Cdd:cd17345 80 IINILIGFVPSATSSVGLMFILLFLNgwfqgmgwpPSGRTMVHWFSKKERGTWTSIWNISH----NVGGG---LVGPLAG 152
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 10176905 211 eiirrLGSTSFTA--WRMAFFVPGWMHIIMGILVLTLGQDLP 250
Cdd:cd17345 153 -----LGLAIFGDgwWRGAFIFPAIIAIIVAVIVLFLGKDTP 189
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
69-430 |
9.83e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 9.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 69 WISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPR---------YGCAFLVMLSA 139
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtlilglllISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 140 PTVFSMSFVGgaggyitvrFMIGFCLATFVSCqywmSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMvyeIIRRLGST 219
Cdd:cd17333 82 PSIYLFVVLM---------FLAGLGAGILDTG----ANTFVGALFEESSATRLNVLHGFFGLGALIGPL---IATSLLTS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 220 SFTaWRMAFFVPGWMHIIMGILVL--TLGQDLPDGN---RSTLEKKGAVTKDKFSKVLWYAItnyrtwvFVLLYgysMGV 294
Cdd:cd17333 146 ELS-WSWAYLIIGLIYLLLAILILltLFPELPSARNpqqSVGAFSASASRLLRNPSIILGAL-------ALFLY---VGA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 295 ELTTDNVIAEYFFDRFHLKLHTAGIIAASFgmanFFARPIGGWASDIAARRFGMRgRLWTLWIIQTLGGFFCLWLGRATT 374
Cdd:cd17333 215 ETAFSSWVPSYLVEKKHVSDGLAGYLLSGF----WVGITIGRLLGGPISRRIKPH-TLLVLSGSGALLGLLILLLAPTLV 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 10176905 375 LPTAVVFMILFSLGAQAACGATFAI--IPFISRRSLGIISGLTGAGGNFGSGLTQLVF 430
Cdd:cd17333 290 VGLVATALLGLFMAALFPTILSLGIsnLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
275-430 |
2.37e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.79 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 275 AITNYRTWVFVLLY-GYSM-GVELTTDNVIAEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarRFGMRgrl 352
Cdd:COG2271 3 APSRYRWRILALLFlAYFLnYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD----RFGRR--- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 10176905 353 WTLWIIQTLGGFFCLWLGRATTLPTAVVFMILFSLGAQAACGATFAIIP-FISRRSLGIISGLTGAGGNFGSGLTQLVF 430
Cdd:COG2271 76 RVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAeWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
125-400 |
3.35e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.09 E-value: 3.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 125 LGPRYGCAFLVMLSAPTVFSMSFVGGAGGYITVRFMIGFCLA-TFVSCQYWMSTMFNGQIIGLVNG---TAAGWGNMGGG 200
Cdd:cd17327 68 FPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESgVFPGFILYLGMWYKREEQAKRIAffyAAAGLGSIFGG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 201 VtqllmpMVYEIIRRLGSTSFTAWRMAFFVPGWMHIIMGILVLTLGQDLPDGNR--STLEKKGAVTK----------DKF 268
Cdd:cd17327 148 L------LAYGVFKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWflTEEEKELAVERlranqtgkgdQKF 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 269 S-KVLWYAITNYRTWVFVLLYGYSMGVELTTDN----VIAEYFFDRFHLKLHTAGIiaASFGMANFFarpIGGWASDiaa 343
Cdd:cd17327 222 KwKQIKEAFKDPRTWLLFLFFFCSQITNNGISNflplILKSLGFYSLQTNLLSVPI--GALGAVSLL---IAALLSD--- 293
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 10176905 344 rRFGMRGRLWTLWIIQTLGGffCLWLGRATTLPTAVVFMILFSLGaqaaCGATFAII 400
Cdd:cd17327 294 -RFKKRGLFAIFACVLALVG--SIILLAAPNPPGAYFAAYILGGG----SYAGFPIL 343
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
61-430 |
1.42e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.19 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 61 HMRTFHLAWISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAP 140
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 141 TVFSMSFVGGAGGYITVRFMIGFCLAT-FVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVyeiirrlgsT 219
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASL---------A 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 220 SFTAWRMAFFVPGWMHIIMGILVLTLGQDLPdgnrstlekkgavtkdkfsKVLWYAITNYrtwVFVLLYGYSMGVELTTd 299
Cdd:cd17312 152 SYYGWRAAFLVPGIVGLVVAIILFFFLRDSP-------------------PYVWVLSLAY---AFVYIVRYACLDWGPL- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 300 nviaeYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDIAARrfGMRGRLWTLWIIQTLGGFFCLWLGRATTLPTAV 379
Cdd:cd17312 209 -----YLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG--GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIV 281
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 10176905 380 V-FMILFSLGAQAACGATFAIIPFISRRSLGIISGLTGAGGNFGSGLTQLVF 430
Cdd:cd17312 282 LlFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPL 333
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
67-458 |
1.60e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 67 LAWIS-FFTCFISTFAAAPLVPIirDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAF-LVMLSAPTVFS 144
Cdd:cd17316 6 LGWFFdAYDFFLIGFVAPVLAAE--FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILtLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 145 MsFVGGAGGYITVRFMIGFCL-ATFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIrrlgsTSFTA 223
Cdd:cd17316 84 G-LLPTPILLLVLRFLQGIGIgGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL-----SGDWG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 224 WRMAFFVPGWMHIIMGILvltlgqdlpdgnrstlekkgavtkdkfskvlwyaitNYRTWVFVLLYGYSMGVELTTDNVIA 303
Cdd:cd17316 158 WRILFLIGALPALLALLL------------------------------------RRRTLLLILLWFFISFGYYGLTTFLP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 304 EYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDIAARRFGMrgrLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMI 383
Cdd:cd17316 202 TYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL---VIGLILSGILALPLFYLLSGSPTLLLLLLFIL 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10176905 384 LF-SLGAQAACGATFAIIPFISRRSLGiiSGLTGAGGNFGSGLTQ-LVFFSTSTFSTEQGLTWMGVMIMACTLPVTL 458
Cdd:cd17316 279 SFfVGGVWGALYAYLAELFPTEVRATG--VGLSYNLGRLGGGGAPpLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
83-419 |
4.90e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 4.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 83 APLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVGGAGGYITVRFMIG 162
Cdd:cd17478 16 PALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 163 FCLATFVSCQYWMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIRRLGSTSFTAWrmaffvPGwmhIIMGILV 242
Cdd:cd17478 96 IGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII------PG---LAVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 243 LTLGQDLP--DGNRSTLEKKGAVTKDKFSKVLWYAITNY-RTWVFvllygYSMGVELTTdnviaeYFFDRFhLKLHTAGI 319
Cdd:cd17478 167 LRLRPLKKpeAKKAAAKSSARSTLKGVWRALLLLLIIVFlRSWVL-----SSLTTFLPF------YLVQRG-YSLVFAGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 320 IAASFGMANFFARPIGGWASDiaarRFgmrGRLWTLWIIqTLGGFFCLWLGRATTLPTAVVFMILFSLGAQAACGATFAI 399
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSD----RF---GRRRVIIAS-LLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVL 306
|
330 340
....*....|....*....|....*
gi 10176905 400 IPFISRRSLGIISGLT-----GAGG 419
Cdd:cd17478 307 AQELLPGNVGLASGLMmglsfGLGG 331
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
305-461 |
6.33e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 6.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 305 YFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDIAARRFGMRgRLWTLWIIQTLGGFFCL-----WLGRATTLPTAV 379
Cdd:COG2211 36 FYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRR-RPWILIGAIPLALSFVLlftapDLSPTGKLIYAL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 380 VFMILFSLGAQAACGATFAIIPFIS-----RRSLGIISGLTGAGGNFGSGLTQLVFFSTSTFSTEQGLTWMGVMIMACTL 454
Cdd:COG2211 115 VTYLLLGLAYTLVNIPYSALGAELTpdyeeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGL 194
|
....*..
gi 10176905 455 PVTLVHF 461
Cdd:COG2211 195 LAFLLTF 201
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-388 |
8.46e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 8.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 69 WISFFTCFISTFAAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFV 148
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 149 GGAGGYITVRFMIGFCLATFVSCqywMSTMFNGQIIGLVNGTAAGWGNMGGGVTQLLMPMVYEIIRRLGStsftaWRMAF 228
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTA---AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-----FAVLF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 229 FVPGWMHIIMGILVLTLGQDLPdgnrsTLEKKGAVTKDKFSKVLWYAITNYRTWVFVLLYGYSmgvelTTDNVIAEYFFD 308
Cdd:cd17489 154 IVAAVLALLALLLVFLVKDPPP-----VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG-----AISTFLPLYAAE 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 309 RFHlklHTAGIIAASFGMANFFARPIGGWASDIaarrfgmRGRLWTLWIIQTLGGFFCLWLGRATTLPTAVVFMILFSLG 388
Cdd:cd17489 224 RGI---SNAGLFFTVYAIALLLSRPFSGKLSDR-------KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG 293
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
221-454 |
9.39e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.41 E-value: 9.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 221 FTAWRMAFFVPGWMHIIMGILVLT-LGQDLPDGNRSTLEKKgavtkdkFSKVLWYAITNYRTWVFVLLYGYSMGVELTTD 299
Cdd:cd17320 149 FFGWRAIFVFLALLGLLLLLLVLLfLPETLPEEKRKPLLSS-------LLRAYKRVLKNRRFLGYALALGLSFAGLFAYL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 300 NVIAEYFFDRFHLklhTAGIIAASFGMaNFFARPIGGWASDIAARRFGMRGRLWTLWIIQTLGGFFCL--WLGRATTLPT 377
Cdd:cd17320 222 AAAPFIYIEQLGL---SPAQFGLLFAL-NAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLlaALLGGLSLWP 297
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10176905 378 AVVFMILFSLGAQAACGATFAIIPFISRRSLGIISGLTGAGGNFGSGLTQLVffstSTFSTEQGLTWMGVMIMACTL 454
Cdd:cd17320 298 LVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGAL----VGLLPNGTALPMGLLILVLGL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
81-407 |
1.29e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.01 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 81 AAAPLVPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVGGAGGYITVRFM 160
Cdd:COG2807 36 SVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 161 IGFCLA-TFVSCQYWMSTMFNGQIiGLVNGTAAGWGNMGGGVTQLLMPMVyeiirrlgsTSFTAWRMAFFVpgWMHIIMG 239
Cdd:COG2807 116 IGAGIAvGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPL---------AAALGWRGALAV--WALLALL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 240 ILVLTLGQdlpdgnrsTLEKKGAVTKDKFSKVLWYAITNYRTWVFVLLYGYSMGVELTTDNVIAEYFFDRfHLKLHTAGI 319
Cdd:COG2807 184 ALLLWLPL--------LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 320 IAASFGMANFFARPIGGWasdIAARrfgMRGRLWTLWIIQTLG--GFFCLWLGratTLPTAVVFMILFSLGAqaacGATF 397
Cdd:COG2807 255 LLSLFQLAGIPGSLLVPL---LADR---LGDRRPLLLLLGLLGlaGLLGLLLA---PGSLPWLWAVLLGLGQ----GGLF 321
|
330
....*....|.
gi 10176905 398 AIIP-FISRRS 407
Cdd:COG2807 322 PLALtLIGLRA 332
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
189-425 |
1.76e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 189 GTAAGWGNMGGGVTQLLM-PMVYEIIRRLGstsftaWRMAFFVPGWMHIIMGILVLTLGQDLPDGnrstlEKKGAVTKDK 267
Cdd:cd17355 127 GLALGILTAGGGLGSLVFlPLGAALIEAFG------WRTALLVLALLALLVLVPVLLLLRRRPAD-----LALRAYDDAS 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 268 FSKVLWYAITNYRTWVFVLLYGYSMGVELTTDNVIAEY--FFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDiaarR 345
Cdd:cd17355 196 PASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLvpYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD----R 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 346 FGMRgrlWTLWIIQTLGGFFCLWLGRATTLPTAV-VFMILFSLGAQAACGATFAII-PFISRRSLGIISGLTGAGGNFGS 423
Cdd:cd17355 272 YSPR---RLLAASYALRALGLALLLLLPFPPLALlLFAALFGLGWGATVPLTAALAaRYFGARSYGTLFGLVFAPHQLGS 348
|
..
gi 10176905 424 GL 425
Cdd:cd17355 349 AL 350
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
41-417 |
3.38e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 40.03 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 41 LPVDTEHKaKVFKllsfeaPHMRTFHLAWISFFTCFI--STFAAAPlvPIIRDNLNLTRQDVGNAGVASVSGSIFSRLVM 118
Cdd:PRK09556 14 LPLEVQRK-MWFK------PFMQSYLVVFIGYLTMYLirKNFKAAQ--NDMISTYGLSTTELGMIGLGFSITYGVGKTLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 119 GAVCDLLGPRYGCAFLVMLSAPTVFSMSFVGGAGGyITVRFMI------GFCLATFVSCQY-----WMSTMFNGQIIGLV 187
Cdd:PRK09556 85 GYYADGKNTKQFLPFLLILSAICMLGFGASLGSGS-VSLGLMIalwalsGFFQSTGGPCSYstitrWTPRRKRGRFLGFW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 188 NGTAagwgNMGGgvtqllmpMVYEIIRRLGSTSFTAWRMA--FFVPGWMHIIMGILVLTLGQDLPD-----------GNR 254
Cdd:PRK09556 164 NISH----NLGG--------AGAGGVALWGANYFFDGHVIgmFIFPSIIALIIGFIGLRYGSDSPEelgwgkaeeifGEP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 255 STLEKKGAVTKD--KFSKVLWYAITNYRTWVF----VLLYGYSMGVelttDNVIAEYFFDRFHLKLHTAGIIAASFGMAN 328
Cdd:PRK09556 232 ISEEDKETESTDmtKWQIFVEYVLKNPVIWLLcfanIFLYIVRIGI----DNWSPVYAFQELGFSKEDAINTFTLFEIGA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 329 FFARPIGGWASDIaarrfgMRGRLWTLWIIQTLGGFFCLWLGRATTLPTaVVFMILFSLGA-----QAACGAtfAIIPFI 403
Cdd:PRK09556 308 LVGSLLWGWLSDL------ANGRRALVACIALALIIFTLGVYQHATSEY-MYLASLFALGFlvfgpQLLIGV--AAVGFV 378
|
410
....*....|....
gi 10176905 404 SRRSLGIISGLTGA 417
Cdd:PRK09556 379 PKKAIGVANGIKGT 392
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
132-425 |
4.60e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.51 E-value: 4.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 132 AFLVMLSAPTVFS--MSFVGGAGGYITVRFMIGFCLATFVSCQYW-----MSTmfNGQIIGLVNGTAAGWGNMGGGVTQL 204
Cdd:cd17332 77 AIPLALLFVLLFTtpDGSGTGKLIYALITYILLDLLYTLVNIPYTalipeLTD--DPEERTSLTSWRMFFATIGGLLVTV 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 205 LMPMVYEIIrrLGSTSFTAWRMAFFVpgwMHIIMGILVLTLGQDLPDGNRSTLEKKgavTKDKFSKVLWYAITNyRTWVF 284
Cdd:cd17332 155 LPPPLVAYF--GGGNASRGYFLTALI---IGIIGIILLLICFFGTRERVVPPEEEK---SKLPLLKSLKALLKN-RPFLI 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 285 VLLYGYSMGVELTTDNVIAEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASdiaaRRFGmrgRLWTLWIIQTLGGF 364
Cdd:cd17332 226 LLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLK----KRFG---KKKAFFIGLLLAIL 298
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 10176905 365 FCLWLGRAT--TLPTAVVFMILFSLGAQAACGATFAIIPFIS--------RRSLGIISGLTGAGGNFGSGL 425
Cdd:cd17332 299 GLLLLFFLPpgNLVLILVLAVLAGIGYGGANLLPWAMLADVIdygelktgKRREGIFYSVMTFFRKLGLAL 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
305-464 |
5.65e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.07 E-value: 5.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 305 YFFDRFHLKLHTAGIIAASFGMANFFARPIGGWAsdiaARRFGMRGRLWTLWIIQTLGgffCLWLGRATTLPTAVVFMIL 384
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRL----IDRFGYKRGLLLGLLLMALG---LLLFALAPSYPLLLLALFL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 385 FSLGA---QAACGATFAII-PFISRRSLGIISGLTGAGGNFGSGLTQLVFFSTSTFSTEQGLTWMGVMIMACTLPVTLVH 460
Cdd:COG0738 106 LGLGLgllDVAANPYVAALgPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK 185
|
....
gi 10176905 461 FPQW 464
Cdd:COG0738 186 LPEI 189
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
224-403 |
5.81e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.14 E-value: 5.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 224 WRMAFFVPGWMHIIMGILVLTLGQDLPDGNRSTlEKKGAVTKDKFSKVLWYAITNyRTWVFVLLyGYSmGVELTTDNV-- 301
Cdd:cd17328 153 WRWAFRVTGVLGVLLAILLLLFVREPPRGAAEG-GVMAKSTATSFLADLKALAKN-PSFILSTL-GFT-AVSFVTGALaf 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10176905 302 -IAEYFFDRFHLKLHTAGIIAASFGMANFFARPIGGWASDIAARRFGMRGRLWTLWI--IQTLGGFFCLWLGRATTLPTA 378
Cdd:cd17328 229 wAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVcaVGLLAAAPFLFLALVLALSNL 308
|
170 180
....*....|....*....|....*
gi 10176905 379 VVFMILFSLGAQAACgATFAIIPFI 403
Cdd:cd17328 309 LLAWVLLFLGEFLLS-LNWAPVFAI 332
|
|
| |
