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Conserved domains on  [gi|9294197|dbj|BAB02099|]
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membrane related protein-like [Arabidopsis thaliana]

Protein Classification

START domain-containing protein( domain architecture ID 10172285)

START (steroidogenic acute regulatory protein (StAR)-related lipid transfer) domain-containing protein may bind lipids

CATH:  3.30.530.20
Gene Ontology:  GO:0008289|GO:0005488
PubMed:  31927098|10322415|18922149|11276083
SCOP:  4002052|3000738

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
START_STARD2_7-like cd08870
Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily ...
 119-329 2.46e-103

Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP), and STARD7 (also known as gestational trophoblastic tumor 1/GTT1). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may also have a mitochondrial function. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of PtdCho to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers. It showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.


:

Pssm-ID: 176879  Cd Length: 209  Bit Score: 305.07  E-value: 2.46e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  119 DVVTEKDLEHLLHLLEAGNASFEWQSMMDKSTPNMSYQAWRHEPE-IGPVVYRSRTVFEDVTPDIVRDFFWDDEFRPKWD 197
Cdd:cd08870   1 GHVSEEDLRDLVQELQEGAEGQAWQQVMDKSTPDMSYQAWRRKPKgTGLYEYLVRGVFEDCTPELLRDFYWDDEYRKKWD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  198 TMLAYFKTLEEDPKTGTTIVHWIKKFPFFCSDREYIIGRRIWES-GRKYYAVTKGVPYKALsKRDKPRRVELYFSSWIIn 276
Cdd:cd08870  81 ETVIEHETLEEDEKSGTEIVRWVKKFPFPLSDREYVIARRLWESdDRSYVCVTKGVPYPSV-PRSGRKRVDDYESSLVI- 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 9294197  277 avESRKGDGQMTACEVSLVHYEDMGIPKDVAKLGVRHGMWGAVKKLNSGLRAY 329
Cdd:cd08870 159 --RAVKGDGQGSACEVTYFHNPDGGIPRELAKLAVKRGMPGFLKKLENALRKY 209
 
Name Accession Description Interval E-value
START_STARD2_7-like cd08870
Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily ...
 119-329 2.46e-103

Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP), and STARD7 (also known as gestational trophoblastic tumor 1/GTT1). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may also have a mitochondrial function. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of PtdCho to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers. It showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.


Pssm-ID: 176879  Cd Length: 209  Bit Score: 305.07  E-value: 2.46e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  119 DVVTEKDLEHLLHLLEAGNASFEWQSMMDKSTPNMSYQAWRHEPE-IGPVVYRSRTVFEDVTPDIVRDFFWDDEFRPKWD 197
Cdd:cd08870   1 GHVSEEDLRDLVQELQEGAEGQAWQQVMDKSTPDMSYQAWRRKPKgTGLYEYLVRGVFEDCTPELLRDFYWDDEYRKKWD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  198 TMLAYFKTLEEDPKTGTTIVHWIKKFPFFCSDREYIIGRRIWES-GRKYYAVTKGVPYKALsKRDKPRRVELYFSSWIIn 276
Cdd:cd08870  81 ETVIEHETLEEDEKSGTEIVRWVKKFPFPLSDREYVIARRLWESdDRSYVCVTKGVPYPSV-PRSGRKRVDDYESSLVI- 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 9294197  277 avESRKGDGQMTACEVSLVHYEDMGIPKDVAKLGVRHGMWGAVKKLNSGLRAY 329
Cdd:cd08870 159 --RAVKGDGQGSACEVTYFHNPDGGIPRELAKLAVKRGMPGFLKKLENALRKY 209
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 142-248 1.33e-09

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 57.44  E-value: 1.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197     142 WQSMMDKSTPNMSYQAWrhEPEIGPV-VYRSRTVFEDVTPDIVRDFFWDDEFRPKWDTMLAYFKTLEEdPKTGTTIVHWI 220
Cdd:smart00234  20 WVLSSENENGDEVRSIF--SPGRKPGeAFRLVGVVPMVCADLVEELMDDLEYRPEWDKNVAKAETLEV-IDNGTVIYHYV 96

                           90       100
                   ....*....|....*....|....*....
gi 9294197     221 KKFPFF-CSDREYIIGRRIWESGRKYYAV 248
Cdd:smart00234  97 SKFAAGpVSPRDFVFVRYWREDEDGSYAV 125
START pfam01852
START domain;
142-248 2.10e-04

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 42.39  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197    142 WQSMMDKSTPNMSYQawrhEPEIGPV-VYRSRTVFEDVTPDIVRDFFWDDEFRPKWDTMLAYFKTLEEdPKTGTTIVHWI 220
Cdd:pfam01852  21 WVLLSSNENGDVVLQ----IVEPDHGeASRASGVVPMVAALLVAELLKDMEYRAQWDKDVRSAETLEV-ISSGGDLQYYV 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 9294197    221 KKFPFFC--SDREYIIGRRIWESGRKYYAV 248
Cdd:pfam01852  96 AALVAPSplSPRDFVFLRYWRRLGGGVYVI 125
 
Name Accession Description Interval E-value
START_STARD2_7-like cd08870
Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily ...
 119-329 2.46e-103

Lipid-binding START domain of mammalian STARD2, -7, and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP), and STARD7 (also known as gestational trophoblastic tumor 1/GTT1). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may also have a mitochondrial function. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of PtdCho to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers. It showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.


Pssm-ID: 176879  Cd Length: 209  Bit Score: 305.07  E-value: 2.46e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  119 DVVTEKDLEHLLHLLEAGNASFEWQSMMDKSTPNMSYQAWRHEPE-IGPVVYRSRTVFEDVTPDIVRDFFWDDEFRPKWD 197
Cdd:cd08870   1 GHVSEEDLRDLVQELQEGAEGQAWQQVMDKSTPDMSYQAWRRKPKgTGLYEYLVRGVFEDCTPELLRDFYWDDEYRKKWD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  198 TMLAYFKTLEEDPKTGTTIVHWIKKFPFFCSDREYIIGRRIWES-GRKYYAVTKGVPYKALsKRDKPRRVELYFSSWIIn 276
Cdd:cd08870  81 ETVIEHETLEEDEKSGTEIVRWVKKFPFPLSDREYVIARRLWESdDRSYVCVTKGVPYPSV-PRSGRKRVDDYESSLVI- 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 9294197  277 avESRKGDGQMTACEVSLVHYEDMGIPKDVAKLGVRHGMWGAVKKLNSGLRAY 329
Cdd:cd08870 159 --RAVKGDGQGSACEVTYFHNPDGGIPRELAKLAVKRGMPGFLKKLENALRKY 209
START_STARD7-like cd08911
Lipid-binding START domain of mammalian STARD7 and related proteins; This subgroup includes ...
 139-280 1.04e-14

Lipid-binding START domain of mammalian STARD7 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD7 (also known as gestational trophoblastic tumor 1/GTT1). It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of phosphatidycholine (PtdCho) to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers, it showed a preference for phosphatidylserine, cholesterol, and phosphatidylglycerol.


Pssm-ID: 176920  Cd Length: 207  Bit Score: 72.71  E-value: 1.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  139 SFEWQSMMDKSTpnmsYQAWRHE-PEIGPVVYRSRTVFEDVTPdivRDFF---WDDEFRPKWDTMLAYFKTLEEDPKTGT 214
Cdd:cd08911  20 PDGWEPFIEKKD----MLVWRREhPGTGLYEYKVYGSFDDVTA---RDFLnvqLDLEYRKKWDATAVELEVVDEDPETGS 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9294197  215 TIVHWIKKFPFFCSDREYIIGRR--IWESGRKYYAVTKGVPYKALSKRDKPRRVELYFSSWIINAVES 280
Cdd:cd08911  93 EIIYWEMQWPKPFANRDYVYVRRyiIDEENKLIVIVSKAVQHPSYPESPKKVRVEDYWSYMVIRPHKS 160
START cd00177
Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family ...
 159-275 2.71e-13

Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins; This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, and related domains, such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family, specific lipids that bind in this pocket are known; these include cholesterol (STARD1/STARD3/ STARD4/STARD5), 25-hydroxycholesterol (STARD5), phosphatidylcholine (STARD2/ STARD7/STARD10), phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments, lipid metabolism, and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer, genetic disorders, and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.


Pssm-ID: 176851 [Multi-domain]  Cd Length: 193  Bit Score: 68.13  E-value: 2.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  159 RHEPEIGPVVYRSRTVFeDVTPDIVRDFFWDDEFRPKWDTMLAYFKTLEEDPKTGTTIVHWIKKfPFFCSDREYIIGR-R 237
Cdd:cd00177  31 KPYEDSGLKLLKAEGVI-PASPEQVFELLMDIDLRKKWDKNFEEFEVIEEIDEHTDIIYYKTKP-PWPVSPRDFVYLRrR 108

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 9294197  238 IWESGRKYYAVTKGVPYKALSKRDKPRRVELYFSSWII 275
Cdd:cd00177 109 RKLDDGTYVIVSKSVDHDSHPKEKGYVRAEIKLSGWII 146
START_STARD2-like cd08910
Lipid-binding START domain of mammalian STARD2 and related proteins; This subgroup includes ...
 142-329 3.09e-12

Lipid-binding START domain of mammalian STARD2 and related proteins; This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP) and related proteins. It belongs to the START domain family, and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein, which traffics PtdCho, the most common class of phospholipids in eukaryotes, between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism, in the development of atherosclerosis, and may have a mitochondrial function.


Pssm-ID: 176919  Cd Length: 207  Bit Score: 65.21  E-value: 3.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  142 WQSMMDKSTPNMsYQAWRHEPeiGPVVYRSRTVFEDVTPDIVRDFFWDDEFRPKWDtmlAYFKTLEEDPKTGTTIVHWIK 221
Cdd:cd08910  27 WELLVESSGISI-YRLLDEQS--GLYEYKVFGVLEDCSPSLLADVYMDLEYRKQWD---QYVKELYEKECDGETVIYWEV 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  222 KFPFFCSDREYII---GRRIWESGRKYYAV-TKGVPYKALSKRDKPRRVELYFSSWiinAVESrkgDGQmTACEVSLVHY 297
Cdd:cd08910 101 KYPFPLSNRDYVYirqRRDLDVEGRKIWVIlARSTSLPQLPEKPGVIRVKQYKQSL---AIES---DGK-KGSKVFMYYF 173

                       170       180       190
                ....*....|....*....|....*....|....
gi 9294197  298 EDMG--IPKDVAKLGVRHGMWGAVKKLNSGLRAY 329
Cdd:cd08910 174 DNPGgmIPSWLINWAAKNGVPNFLKDMQKACQNY 207
START smart00234
in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and ...
 142-248 1.33e-09

in StAR and phosphatidylcholine transfer protein; putative lipid-binding domain in StAR and phosphatidylcholine transfer protein


Pssm-ID: 214575  Cd Length: 205  Bit Score: 57.44  E-value: 1.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197     142 WQSMMDKSTPNMSYQAWrhEPEIGPV-VYRSRTVFEDVTPDIVRDFFWDDEFRPKWDTMLAYFKTLEEdPKTGTTIVHWI 220
Cdd:smart00234  20 WVLSSENENGDEVRSIF--SPGRKPGeAFRLVGVVPMVCADLVEELMDDLEYRPEWDKNVAKAETLEV-IDNGTVIYHYV 96

                           90       100
                   ....*....|....*....|....*....
gi 9294197     221 KKFPFF-CSDREYIIGRRIWESGRKYYAV 248
Cdd:smart00234  97 SKFAAGpVSPRDFVFVRYWREDEDGSYAV 125
START pfam01852
START domain;
142-248 2.10e-04

START domain;


Pssm-ID: 426476  Cd Length: 205  Bit Score: 42.39  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197    142 WQSMMDKSTPNMSYQawrhEPEIGPV-VYRSRTVFEDVTPDIVRDFFWDDEFRPKWDTMLAYFKTLEEdPKTGTTIVHWI 220
Cdd:pfam01852  21 WVLLSSNENGDVVLQ----IVEPDHGeASRASGVVPMVAALLVAELLKDMEYRAQWDKDVRSAETLEV-ISSGGDLQYYV 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 9294197    221 KKFPFFC--SDREYIIGRRIWESGRKYYAV 248
Cdd:pfam01852  96 AALVAPSplSPRDFVFLRYWRRLGGGVYVI 125
START_STARD10-like cd08871
Lipid-binding START domain of mammalian STARD10 and related proteins; This subfamily includes ...
 170-256 2.65e-03

Lipid-binding START domain of mammalian STARD10 and related proteins; This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD10 (also known as CGI-52, PTCP-like, and SDCCAG28). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD10 binds phophatidylcholine and phosphatidylethanolamine. This protein is widely expressed and is synthesized constitutively in many organs. It may function in the liver in the export of phospholipids into bile. It is concentrated in the sperm flagellum, and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk, and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation. It is overexpressed in mammary tumors from Neu/ErbB2 transgenic mice, in several breast carcinoma cell lines, and in 35% of primary human breast cancers, and may cooperate with c-erbB receptor signaling in breast oncogenesis. It is a potential marker of disease outcome in breast cancer; loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course. The lipid transfer activity of STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2).


Pssm-ID: 176880  Cd Length: 222  Bit Score: 39.16  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9294197  170 RSRTVFEDVTPDIVRDFFWDDEFRPKWDT-MLAYFKTLEEDPKtgTTIVHWIKKFPFFCSDREYIIGRRIWESGRKYYAV 248
Cdd:cd08871  50 KVSAIFPDVPAETLYDVLHDPEYRKTWDSnMIESFDICQLNPN--NDIGYYSAKCPKPLKNRDFVNLRSWLEFGGEYIIF 127


                ....*...
gi 9294197  249 TKGVPYKA 256
Cdd:cd08871 128 NHSVKHKK 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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