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Conserved domains on  [gi|9293938|dbj|BAB01841|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

MATE family efflux transporter( domain architecture ID 10192067)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Arabidopsis thaliana MATE proteins which confer aluminum tolerance

Gene Ontology:  GO:0016020|GO:0015297|GO:0022857
PubMed:  26246409|33774036|31866287
TCDB:  2.A.66

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 45-479 1.99e-170

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


:

Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 487.47  E-value: 1.99e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   45 ETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVAGFSFGIMLGMGSALETLCGQAFGAGKLSMLG 124
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAV 204
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  205 ALVIHVPLTWFVIVKLQWGMPGLAVVLNASWCFIDMAQLVYI-FSGTCGEAWSGFSWEAFHNLWSFVRLSLASAVMLCLE 283
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIfFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  284 VWYFMAIILFAGYLKnAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVS 363
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  364 MILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLLLGYKL 443
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 9293938  444 NYGVMGIWCGMLTGTVVQTIVLTWMICKTNWDTEAS 479
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAE 435
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 45-479 1.99e-170

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 487.47  E-value: 1.99e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   45 ETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVAGFSFGIMLGMGSALETLCGQAFGAGKLSMLG 124
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAV 204
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  205 ALVIHVPLTWFVIVKLQWGMPGLAVVLNASWCFIDMAQLVYI-FSGTCGEAWSGFSWEAFHNLWSFVRLSLASAVMLCLE 283
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIfFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  284 VWYFMAIILFAGYLKnAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVS 363
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  364 MILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLLLGYKL 443
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 9293938  444 NYGVMGIWCGMLTGTVVQTIVLTWMICKTNWDTEAS 479
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAE 435
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 55-395 3.40e-55

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 188.22  E-value: 3.40e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938     55 PAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVaGFSFGIMLGMGSALETLCGQAFGAGKLSMLGVYLQRSWVIL 134
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVF-MFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    135 NVTALILSLLYIFAAPILASIGQTA-AISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAVALVIHVPLT 213
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGADgEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    214 W-FVIVKL-QWGMPGLAVVLNASWCFIDMAQLVYIFSG-TCGEAWSGFSWEAFHNLWSFVRLSLASAVMLCLEVWYFMAI 290
Cdd:TIGR00797 160 YiLIFGKFgFLGIVGAALATVISYWLMFLLLLYYIKKAkKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    291 ILFAGYLKnaEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVSMILLIFR 370
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317

                         330       340
                  ....*....|....*....|....*
gi 9293938    371 DQYPSLFVKDEKVIILVKELTPILA 395
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
46-468 6.55e-52

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 181.88  E-value: 6.55e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   46 TKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVV-AGFSFGIMLGMGSAleTLCGQAFGAGKLSMLG 124
Cdd:COG0534   7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFfLLIALGIGLGVGGT--ALVAQALGAGDREEAR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLL-YIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISA 203
Cdd:COG0534  85 RVLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  204 VALVIHVPLTWFVIVKLQWGMPGLAVVLNASWCFIDMAQLVYIFSGTCGEAWSGFSWEA-FHNLWSFVRLSLASAVMLCL 282
Cdd:COG0534 165 IGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPdRKILKRILRIGLPAGLQQLA 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  283 EVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIV 362
Cdd:COG0534 245 ESLGFLVLNALVARL--GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLL 322

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  363 SMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLLLGYk 442
Cdd:COG0534 323 ALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF- 401

                       410       420
                ....*....|....*....|....*.
gi 9293938  443 LNYGVMGIWCGMLTGTVVQTIVLTWM 468
Cdd:COG0534 402 LGLGLTGVWLALPIGEVLRALLLLLR 427
MatE pfam01554
MatE; The MatE domain
 276-438 1.59e-29

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 113.43  E-value: 1.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    276 SAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITS 355
Cdd:pfam01554   2 IALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    356 TLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACyYVFGIPF 435
Cdd:pfam01554  80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPL 158


                  ...
gi 9293938    436 GLL 438
Cdd:pfam01554 159 NYL 161
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 40-467 5.44e-26

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 110.29  E-value: 5.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    40 REFNVETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENS----VVAGFSfGIMLgmgsALETLCGQAF 115
Cdd:PRK01766   5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiwlpVILFGH-GLLL----ALTPIVAQLN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   116 GAGKLSMLG-VYLQRSWVILNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSK 194
Cdd:PRK01766  80 GAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   195 IMVMAVISAVALVIHVPLTWFVIVKLqWGMP-----GLAVVLNASWCFIDMAQLVYIFSGT------CGEAWSGFSWEAF 263
Cdd:PRK01766 160 TKPTMVIGFLGLLINIPLNYIFIYGK-FGFPelggvGCGVATAIVYWVMFLAMLIYIKRARrfrdfrLFKGLYKPDWAVI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   264 HNLWsfvRLSLASAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRT 343
Cdd:PRK01766 239 KRLL---KLGLPIGLAIFFEVSLFAVVTLLVSPL--GTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLD 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   344 AKFSLLVAVITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYV 423
Cdd:PRK01766 314 ARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFI 393

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 9293938   424 NIACYYVFGIPFGLLLGYKLNYGVMGIWCGMLTGTVVQTIVLTW 467
Cdd:PRK01766 394 TFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 45-479 1.99e-170

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 487.47  E-value: 1.99e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   45 ETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVAGFSFGIMLGMGSALETLCGQAFGAGKLSMLG 124
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAV 204
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  205 ALVIHVPLTWFVIVKLQWGMPGLAVVLNASWCFIDMAQLVYI-FSGTCGEAWSGFSWEAFHNLWSFVRLSLASAVMLCLE 283
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIfFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  284 VWYFMAIILFAGYLKnAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVS 363
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  364 MILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLLLGYKL 443
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 9293938  444 NYGVMGIWCGMLTGTVVQTIVLTWMICKTNWDTEAS 479
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAE 435
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 55-395 3.40e-55

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 188.22  E-value: 3.40e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938     55 PAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVaGFSFGIMLGMGSALETLCGQAFGAGKLSMLGVYLQRSWVIL 134
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVF-MFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    135 NVTALILSLLYIFAAPILASIGQTA-AISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAVALVIHVPLT 213
Cdd:TIGR00797  80 LLLGLPVLLVGYFFIDPLLSLMGADgEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    214 W-FVIVKL-QWGMPGLAVVLNASWCFIDMAQLVYIFSG-TCGEAWSGFSWEAFHNLWSFVRLSLASAVMLCLEVWYFMAI 290
Cdd:TIGR00797 160 YiLIFGKFgFLGIVGAALATVISYWLMFLLLLYYIKKAkKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    291 ILFAGYLKnaEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVSMILLIFR 370
Cdd:TIGR00797 240 ALLVARLG--SIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317

                         330       340
                  ....*....|....*....|....*
gi 9293938    371 DQYPSLFVKDEKVIILVKELTPILA 395
Cdd:TIGR00797 318 EFIARLFTNDPEVLELAAIYLIFVA 342
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
46-468 6.55e-52

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 181.88  E-value: 6.55e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   46 TKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVV-AGFSFGIMLGMGSAleTLCGQAFGAGKLSMLG 124
Cdd:COG0534   7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFfLLIALGIGLGVGGT--ALVAQALGAGDREEAR 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLL-YIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISA 203
Cdd:COG0534  85 RVLGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIML 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  204 VALVIHVPLTWFVIVKLQWGMPGLAVVLNASWCFIDMAQLVYIFSGTCGEAWSGFSWEA-FHNLWSFVRLSLASAVMLCL 282
Cdd:COG0534 165 IGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPdRKILKRILRIGLPAGLQQLA 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  283 EVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIV 362
Cdd:COG0534 245 ESLGFLVLNALVARL--GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLL 322

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  363 SMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLLLGYk 442
Cdd:COG0534 323 ALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF- 401

                       410       420
                ....*....|....*....|....*.
gi 9293938  443 LNYGVMGIWCGMLTGTVVQTIVLTWM 468
Cdd:COG0534 402 LGLGLTGVWLALPIGEVLRALLLLLR 427
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 45-467 1.98e-45

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 164.59  E-value: 1.98e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   45 ETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVAGFSFGIMlGMGSALETLCGQAFGAGKLSMLG 124
Cdd:cd13131   1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGM-GLLLAVTPLVAQAHGAGDRRRIR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAV 204
Cdd:cd13131  80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  205 ALVIHVPLTWfVIVKLQWGMPGLAVV------LNASWC-FIDMAQLVY---------IFSGtcgeaWSGFSWEAFHNLWs 268
Cdd:cd13131 160 ALVLNIPLNY-VLIFGKFGLPALGGAgaglatAIVYWLmFLALAFYIRrhkrfrryrLFAR-----FWRPDWARLKELL- 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  269 fvRLSLASAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSL 348
Cdd:cd13131 233 --RLGLPIGLTIFFEVSLFAAVALLMGRL--GTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAG 308

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  349 LVAVITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACY 428
Cdd:cd13131 309 LVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISY 388

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 9293938  429 YVFGIPFGLLLGYKLNYGVMGIWCGMLTGTVVQTIVLTW 467
Cdd:cd13131 389 WGIGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 47-474 1.09e-37

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 143.42  E-value: 1.09e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   47 KKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVaGFSFGIMLGMGSALETLCGQAFGAGKLSMLGVY 126
Cdd:cd13137   1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVL-WLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  127 LQRSWVILNVTALILSLL-YIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAVA 205
Cdd:cd13137  80 LGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  206 LVIHVPLTWFVIVKLqWGMPGLAVVLNA-----SWCFIDMAQLVYIFSGTCG--EAWSGFSWEaFHNLWSFVRLSLASAV 278
Cdd:cd13137 160 NVLNIVLDYVLIFGL-WGFPGLGVAGAAlatviSRVVGALLLLFLLLRGRLPikISFKGFRLD-RKIIKKLLRIGLPAGL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  279 MLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLI 358
Cdd:cd13137 238 EQLLRSLGFLVLLAIVASY--GTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLF 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  359 GFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLL 438
Cdd:cd13137 316 MGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYL 395

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 9293938  439 LGYKLNYGVMGIWCGMLTGTVVQTIVLTWMICKTNW 474
Cdd:cd13137 396 LGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 46-474 1.34e-29

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 120.26  E-value: 1.34e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   46 TKKLWYLAGPAIFTSVNQYSLGAITQVFAGHI-STIALAAVSVeNSVVAGFSFGIMLGMGSALETLCGQAFGAGKLSMLG 124
Cdd:cd13138   2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGQFlGVAALAAVSN-GSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLL-YIFAAPILASIGQTAAISSAAGIF-SIYMIPQIFAYAINFPTAkFLQSQ--SKIMVMAV 200
Cdd:cd13138  81 KAVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYlRICFLGIPFIFGYNAYSA-ILRGLgdSKTPLYFV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  201 IsaVALVIHVPLTWFVIVKLQWGMPGLAV------VLNASWCFIDMAQLVYIFSgtcgeawsgFSWEAFH----NLWSFV 270
Cdd:cd13138 160 I--IACVLNIILDLLFIAVFHMGVAGAALatviaqAISVLLALYYLRKKKLPFK---------LSLKDFRfdkeILKEIL 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  271 RLSLASAVMlclevwyfMAIILFAGYLKNAEIS------VAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTA 344
Cdd:cd13138 229 KIGLPSALQ--------QSLVSISFLIINSIVNsygvvaSAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERA 300

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  345 KFSLLVAVITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVN 424
Cdd:cd13138 301 KKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIIS 380

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|
gi 9293938  425 IACYYVFGIPFGLLLGYKLNYGVMGIWCGMLTGTVVQTIVLTWMICKTNW 474
Cdd:cd13138 381 ILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
MatE pfam01554
MatE; The MatE domain
 276-438 1.59e-29

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 113.43  E-value: 1.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    276 SAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITS 355
Cdd:pfam01554   2 IALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    356 TLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACyYVFGIPF 435
Cdd:pfam01554  80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPL 158


                  ...
gi 9293938    436 GLL 438
Cdd:pfam01554 159 NYL 161
MatE pfam01554
MatE; The MatE domain
 55-215 8.54e-29

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 111.50  E-value: 8.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938     55 PAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVvAGFSFGIMLGMGSALETLCGQAFGAGKLSMLGVYLQRSWVIL 134
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSI-ASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    135 NVTALILSLLYIFAAPILASI-GQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAVALVIHVPLT 213
Cdd:pfam01554  80 LLLSLPIALLVLLFSEPILSLfGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 9293938    214 WF 215
Cdd:pfam01554 160 YL 161
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 53-466 1.64e-27

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 114.34  E-value: 1.64e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   53 AGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVAGFSFGIMlGMGSALETLCGQAFGAGKLSMLGVYLQRSWV 132
Cdd:cd12082   1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGV-GLSVGTSALISQAIGAGDEEKARRVLVQSIV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  133 ILNVTALILSLLYIFAAPILASI-GQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAVALVIHVP 211
Cdd:cd12082  80 LAILLGLLLAALLLFFSPLILSLlGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  212 LTWFVIV---KLQWGMPGLAVVLNASWCFIDMAQLVYIFSGTcgeAWSGFSWEAFH----NLWSFVRLSLASAVMLCLEV 284
Cdd:cd12082 160 LDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGK---KILKFKLSLLKpdleLLRRLLRIGLPSAIQNSLLS 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  285 WYFMAIILFAGYLKNAEiSVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVSM 364
Cdd:cd12082 237 LGLLIIVAIVAAFGGAA-ALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGL 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  365 ILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLLLGYkLN 444
Cdd:cd12082 316 LILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LG 394

                       410       420
                ....*....|....*....|..
gi 9293938  445 YGVMGIWCGMLTGTVVQTIVLT 466
Cdd:cd12082 395 LGLYGIWLALVISLILAALVLL 416
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 47-451 8.90e-27

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 112.22  E-value: 8.90e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   47 KKLWYLAGPAIFTSVNQYSLGAITQVFAGH-ISTIALAAVSVENSVVAG-FSFGIMLGMGSAleTLCGQAFGAGKLSMLG 124
Cdd:cd13143   4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLVFPIIMLlMALGLMIGVGGA--SLISRRLGAGDREKAN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRS-WVILNVTALILSLLYIFAAPILASIGQTAAISSAA----GIFSIYMIPQIFAYAINFptakFLQSQSKIMVMA 199
Cdd:cd13143  82 RIFSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAvdylRIILLGAPFTILSSVLNN----LLRAEGKPKLAM 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  200 VISAVALVIHVPLTWFVIVKLQWGMPGLAVVLNASWCFIDMAQLVYIFSGTCGEAWSGFSWE-AFHNLWSFVRLSLASAV 278
Cdd:cd13143 158 LGMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKlSLKIIKEILALGFPSFL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  279 M-LCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTL 357
Cdd:cd13143 238 MqLSSSVVTIVLNLTLLGYG--GDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALI 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  358 IGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSG--VAVGAGWQAVVayVNIACYYVFGIPF 435
Cdd:cd13143 316 YGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGyfQAIGKAKRAAL--LSLLRQGLFLIPL 393

                       410
                ....*....|....*.
gi 9293938  436 GLLLGYKlnYGVMGIW 451
Cdd:cd13143 394 LLILPRL--FGLDGIW 407
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 40-467 5.44e-26

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 110.29  E-value: 5.44e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    40 REFNVETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENS----VVAGFSfGIMLgmgsALETLCGQAF 115
Cdd:PRK01766   5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiwlpVILFGH-GLLL----ALTPIVAQLN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   116 GAGKLSMLG-VYLQRSWVILNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSK 194
Cdd:PRK01766  80 GAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   195 IMVMAVISAVALVIHVPLTWFVIVKLqWGMP-----GLAVVLNASWCFIDMAQLVYIFSGT------CGEAWSGFSWEAF 263
Cdd:PRK01766 160 TKPTMVIGFLGLLINIPLNYIFIYGK-FGFPelggvGCGVATAIVYWVMFLAMLIYIKRARrfrdfrLFKGLYKPDWAVI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   264 HNLWsfvRLSLASAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRT 343
Cdd:PRK01766 239 KRLL---KLGLPIGLAIFFEVSLFAVVTLLVSPL--GTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLD 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   344 AKFSLLVAVITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYV 423
Cdd:PRK01766 314 ARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFI 393

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 9293938   424 NIACYYVFGIPFGLLLGYKLNYGVMGIWCGMLTGTVVQTIVLTW 467
Cdd:PRK01766 394 TFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 46-474 6.41e-26

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 109.92  E-value: 6.41e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   46 TKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAV---SVENSVVAGFSFGIMLGMGsaleTLCGQAFGAGKLSM 122
Cdd:cd13133   4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASgpaGVLYFAILMLFFGLSSGVQ----VFVAQYNGAGRYSR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  123 LGVYLQRSWVILNVTALILSLLYIFAAP-ILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVI 201
Cdd:cd13133  80 IGRVLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  202 SAVALVIHVPLTWFVIVKlQWGMPGLAVVLNA-----SWCFIDMAQLVYIFSGTCGE-----AWSGFSWEAFhnlWSFVR 271
Cdd:cd13133 160 NLVMVVVNIVLDYALIFG-KLGFPAMGIAGAAiatviAEAVSLLFFLLLLFRRKNRRrfglrRAWRFDRELL---RRILR 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  272 LSLASAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVA 351
Cdd:cd13133 236 LGLPSGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRG 313

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  352 VITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPIL---ALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACY 428
Cdd:cd13133 314 LKLALAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLLrfvAAYILFDALALVFAGALRGAGDTRFVMLAELIVA 393

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*.
gi 9293938  429 YVFGIPFGLLLGYkLNYGVMGIWCGMLTGTVVQTIVLTWMICKTNW 474
Cdd:cd13133 394 WLYLLPPAYLLVV-LGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 47-474 6.11e-24

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 104.20  E-value: 6.11e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   47 KKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVVaGFSFGIMLGMGSALETLCGQAFGAGKLSMLGVY 126
Cdd:cd13142  11 RTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANKV 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  127 LQRSWVILNVTALILSLL-YIFAAPILASIGQTAA--ISSAAGIFSIYMIPQIFAYAINFPTAkFLQSQSKIMVMAVISA 203
Cdd:cd13142  90 AGQTFSFVIILSLILAVLgYILSRPLLLLLIGAPEevYPLALAYLRIIFLGLPFMFIFFVFNS-LLRGIGDTKTPMKIMF 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  204 VALVIHVPLTWFVIVKLqWGMPGLAVvLNASWC-----FIDMAQLVYI-FSGTCG------EAWSGFSWeafhnLWSFVR 271
Cdd:cd13142 169 GSVLLNVILDPLLIFGI-GPFPGLGV-AGAALAtvisrGIAAVIGLYLlFKGRVGlkislrDLKPDWEW-----LKKIFR 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  272 LSLASAVMLCLEVWYFMAII-LFAGYlknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLV 350
Cdd:cd13142 242 IGLPSSIEQSARALGFTVMTaLVAGF---GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKK 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  351 AVITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYV 430
Cdd:cd13142 319 AALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWV 398

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 9293938  431 FGIPFGLLLGYKLNYGVMGIWCGMLTGTVVQTIVLTWMICKTNW 474
Cdd:cd13142 399 IRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 46-467 3.94e-23

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 101.81  E-value: 3.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   46 TKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVvagFSFGIML--GMGSALETLCGQAFGAGKLSML 123
Cdd:cd13134   2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQI---LFLLILIfsFISTGTSILIAQYLGAKDKKKA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  124 GVYLQRSWVILNVTALILSLL-YIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVIS 202
Cdd:cd13134  79 RQIAGVALLFNLLLGLVFSLLlLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVS 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  203 AVALVIHVPLTWFVIVKL----QWGMPGLAVVLNASWCFIDMAQLVYIFsgtCGEAWSGFSWEAFHNLWSFVRLSLASAV 278
Cdd:cd13134 159 LIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLF---RKLKIRFRLKDLRPFPKKLLKKILKIGL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  279 MLCLE--VWYFMAIILFAGYLKNAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITST 356
Cdd:cd13134 236 PSAGEelSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGL 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  357 LIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFG 436
Cdd:cd13134 316 LVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLA 395

                       410       420       430
                ....*....|....*....|....*....|.
gi 9293938  437 LLLGYKLNYGVMGIWCGMLTGTVVQTIVLTW 467
Cdd:cd13134 396 YLLGIVLGLGLLGVWIAFAADEWVRGIIMLW 426
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 47-471 2.83e-16

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 80.68  E-value: 2.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   47 KKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIA-LAAVSVE----NSVVAGFSFgimLGMGSAleTLCGQAFGAGKLS 121
Cdd:cd13136   3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGttifNTLFWLFGF---LRMGTT--GLVAQALGAGDRE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  122 MLGVYLQRS-WVILNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAV 200
Cdd:cd13136  78 EAIALLVRAlLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  201 ISAVALVIHVPLTWFVIVKLQWGMPG--LAVVLNASWCFIDMaqLVYIFSGTCGEAWSG----FSWEAFHNLWSFVRLSL 274
Cdd:cd13136 158 LQIVGNVVNIVLDPLFVFGLGWGVAGaaLATVIAQYLGALLG--LWLLRRRVRLLGKSLsrrlPSKAALKRLFKLNRDIF 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  275 ASAVMLCLevwyFMAIILFAGyLKNAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVIT 354
Cdd:cd13136 236 IRTLALLA----AFLFFTALA-ARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQW 310

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  355 STLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIP 434
Cdd:cd13136 311 GLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPL 390

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 9293938  435 FGLLLGYklnYGVMGIWCGMLTGTVVQTIVLTWMICK 471
Cdd:cd13136 391 LFLLVPL---WGNHGLWLALILFMLLRGLTLALRLPR 424
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 73-476 3.53e-16

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 80.73  E-value: 3.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   73 FAGHISTIALAAVSVENSVVAgFSFGIMLGMGSALETLCGQAFGAGKLSMLGV-YLQRSWVILNVTALILSLLYIFAAPI 151
Cdd:cd13139  40 FVSRLGALAIATVGLTESVLT-IVYSIAIGLSMAATALVARRIGEKDPEGAGFaAVQAILLGVALSLILSILGYFFAEDI 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  152 LASIGQTAAI------------SSAAGIFSIYMIPQIFAYAINFPTAKflqsqsKIMVMAVISAVALVIHVPLTWFVIVK 219
Cdd:cd13139 119 LSLMGASPAViaegygytrimfGGNGFIMLLFLINGIFRGAGDAAIAM------RSLWLANGLNIILDPLFIFGLGPIPA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  220 lqWGMPGLAVVLNASWCFIDMAQLVYIFSG----TCGEAWSGFSWEAfhnLWSFVRLSLASAVMLCLEV--WYFMAIILf 293
Cdd:cd13139 193 --MGVTGAAIATTIGRSIGVLYQLYHLFKGkgriQIRRRHLKLDWAI---IKKIIKIAVGGILQFLIASssWIFLVRII- 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  294 agyLKNAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVSMILLIFRDQY 373
Cdd:cd13139 267 ---AEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVFFLFAEPL 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  374 PSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVFGIPFGLLLGYKLNYGVMGIWCG 453
Cdd:cd13139 344 VSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNLGPKGVFIA 423

                       410       420
                ....*....|....*....|...
gi 9293938  454 MLTGTVVQTIVLTWMICKTNWDT 476
Cdd:cd13139 424 IPIAETVLAIAAIILFRRGKWKT 446
PRK00187 PRK00187
NorM family multidrug efflux MATE transporter;
44-467 1.24e-12

NorM family multidrug efflux MATE transporter;


Pssm-ID: 166843 [Multi-domain]  Cd Length: 464  Bit Score: 69.77  E-value: 1.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    44 VETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAV---SVENSVVAGFSFGIMLGMGS--ALETLCGQAFGAG 118
Cdd:PRK00187   7 TELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGglgAASYSFVSIFCVGVIAAVGTlvAIRHGAGDIEGAT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   119 KLSMLGVYLqrSWVILNVTALILSLLyifaAPILASIGQTAAISSAAGIFSI---YMIPQIFAYAI--NFPTAkfLQSQS 193
Cdd:PRK00187  87 RLAQAGLWL--AWLLALVAALLLWNL----KPLLLLFGQAPQNVDAAMQFLHllpFALPGYLSFMAlrGFTSA--LGRAG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   194 KIMVMAVISAVA-LVIHVPLT--WFVIVKLQWGMPGL--AVVLNAswcfIDMAQLVYIFSGTCGEAW---SGFSWEAFHN 265
Cdd:PRK00187 159 PVMVISLAGAVAnLLLNYALIegWFGLPKLGLMGIGLvtALVSNG----MALALALYIRRHPAYAAYplrKGLSRPSRAA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   266 LWSFVRLSLASAVMLCLEVWYFMAIILFAGYLKNAEIsvAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAK 345
Cdd:PRK00187 235 LRELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQL--AAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEAR 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   346 FSLLVAVITSTLIGFIVSMILLIFRDQYPSLFVKDE-----KVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVV 420
Cdd:PRK00187 313 RAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLDRNdpafaEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTT 392

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 9293938   421 AYVNIACYYVFGIPFGLLLGYKLNYGVMGIWCGMLTGTVVQTIVLTW 467
Cdd:PRK00187 393 FLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 46-474 2.63e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 65.62  E-value: 2.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   46 TKKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVeNSVVAGFSFGIMLGMGSALETLCGQAFGAGKLSMLGV 125
Cdd:cd13140   4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGT-AGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  126 YLQRSWVILNVTALILSLLYIFAAPILAS---IGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFlQSQSKIMVMAVIS 202
Cdd:cd13140  83 YARNALQLNLLLGILYGLLLLLFAKPLIGffnLGDAEVISLAITYLRIVALGLIFSFLNPVFTGIF-NALGDSKTPFIIN 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  203 AVALVIHVPLTWFVI----VKLQWGMPGLA---VVLNASWCFIDMAQLVYIFSGTCGeaWSGFSWEAFHNLWSFVRLSLA 275
Cdd:cd13140 162 AIGLVLNIILDPLLIfgfgPFPALGVAGAAlatVLAQAIVFLLFLYALKKKKGLFLK--IRILKRPDRKYIKEILKLGLP 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  276 SAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITS 355
Cdd:cd13140 240 VALQSILFALISMILARIIASF--GPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIA 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  356 TLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACyYVFGIPF 435
Cdd:cd13140 318 SAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVF-NGLRIPL 396

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 9293938  436 GLLLGYkLNYGVMGIWCGMLTGTVVQTIVLTWMICKTNW 474
Cdd:cd13140 397 ALLLSP-TGLGLNGIWWAISISSILKGIILTIWFLLYKK 434
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 67-470 1.38e-10

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 63.19  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   67 GAITQVFAGHISTIALAAVSVENSVVAG--------------FSFGIMLGMGSaletLCGQAFGAGKLSMLGVYLQRSWV 132
Cdd:cd13146  20 GQLFQLLYNITDTIWISMIDPSDPALVGgiglvfplgmiflaLGNGIQVGVSS----LLARAIGAQRAKELDQAADSGLA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  133 I-LNVTALILSLLYIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAVALVIHVP 211
Cdd:cd13146  96 LaLLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIV 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  212 LTWFVIVKLQWGMPGLAVVLNASwCFIDMAQLVYIFSGTCGE-----AWSGFSWEAFHNLwsfvrLSLASAVMLCLEVWY 286
Cdd:cd13146 176 LDPILIFVFDMGVKGAALATVLA-QAISLLYLLYVFLIGKSNvtihiKLSNISSSVIVEI-----LRVGLPQMLLQLISS 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  287 FMAIILFAGYLKNAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLIGFIVSMIL 366
Cdd:cd13146 250 ISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGY 329

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  367 LIFRDQYPSLFVKDEKVIILVKELTPILALSIVInnVQPVLSGV----AVGAGWQAVVayVNIACYYVFGIPFGLLLGYK 442
Cdd:cd13146 330 VLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPF--VAISILVTeffqAIGKAWPSLL--LTLIRHVFLSVPVVYLLAYV 405

                       410       420
                ....*....|....*....|....*...
gi 9293938  443 LNYGVMGIWCGMLTGTVVqTIVLTWMIC 470
Cdd:cd13146 406 FGKGITGVYFGIVSANFF-TALLAMFWG 432
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 56-247 4.40e-09

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 58.49  E-value: 4.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   56 AIFTSVNQYSLGAITQVFAGHISTIALAAVSVENSVvAGFSFGIMLGMGSALETLCGQAFGAGKLSMLGVYLQRSWVILN 135
Cdd:cd12082 229 AIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRI-ASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGL 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  136 VTALILSLL-YIFAAPILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVISAVALVIHVPLTW 214
Cdd:cd12082 308 LIGAVLGLLiLLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLA 387

                       170       180       190
                ....*....|....*....|....*....|...
gi 9293938  215 FVIVKLQWGMPGLAVVLNASWCFIDMAQLVYIF 247
Cdd:cd12082 388 YVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 73-469 4.90e-09

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 58.38  E-value: 4.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   73 FAGHISTIALAAVSVENSVVagfsFGIM---LGMGSALETLCGQAFGAGKLSMLGVYLQRSWVILNVTALILSLLYIFAA 149
Cdd:cd13145  35 FAGKISTEALAALSLSFPIF----FIIIaigVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  150 PILASIGQTAAISSAAGIfsIYMIPqIFAYAINFPTAKF----LQSQSKIMVMAVISAVALVIHVPLT-WFVIVKLQW-- 222
Cdd:cd13145 111 PPLFRLLGAEGDYLDLAL--EYMDV-IFAGSIFFLLNFGlngiLNAQGDTKSYRNFLIIGFFLNIILDpLFIFGGGGIpa 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  223 -GMPGLAVvlnaSWCFIDMAQLVYIF-----SGT-CGEAWSGF--SWEAFHNLwsFVRLSLASAVMLCLEVWYFmAIILF 293
Cdd:cd13145 188 mGVSGIAL----ATIISQFIGMFYLLykvrkSGIiSGCRLRDFipRLDVYKEI--LKQGFPASLNMMTIGLGIF-VITYF 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  294 AGylKNAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANH----PRTAKFSLLVAVITSTLIGFivsmILLIF 369
Cdd:cd13145 261 VG--QFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKydrvRETYKKALKYGFVIMVVATV----FLLFF 334

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  370 RDQYPSLFVKDEKVIILVKELTPILALS----IVINNVQPVLSGVAvgagwQAVVA-YVNIACYYVFGIPFGLLLGYKLN 444
Cdd:cd13145 335 AEPLMSLFTNDPAVIAIGAGYLRIDALIfyayVVLFISVSVLQGLK-----RPIFAlWIGLYRQLVGPALVFWLLVNVLG 409

                       410       420
                ....*....|....*....|....*
gi 9293938  445 YGVMGIWCGMLTGTVVQTIVLTWMI 469
Cdd:cd13145 410 LGVTGIWWGIFTIVWSAAIIALLYT 434
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 47-465 3.13e-08

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 55.76  E-value: 3.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   47 KKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAV-SVENSVVAGFSFGIMLGMGSALetLCGQAFGAGKLSMLGV 125
Cdd:cd13135   1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVgNVTTPFNTITGFLGSISIGFTI--LGSQSVGAKDIKRIND 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  126 YLQRSWVILNVTALILSLLYIFAAPILASI----GQTAAISSA-AGIFSIYMIPQifayAINFPTAKFLQ--SQSKIMVM 198
Cdd:cd13135  79 YAISSIVYNSIIGVILFLLWLFGARIIFVLfgvdGQILGYSINyVRIFSIYLLLL----GILFTFSSILQgiGETKPIMY 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  199 AVISAValVIHVPLTWFVIVKlQWGMPGL-----------AVVLNASWCFIDMAQLVYIFSGTCGEAWSGFSWEAFHNLw 267
Cdd:cd13135 155 GGIIKN--LLNVILDYVLIFG-NFGFPRLgiigaaiattiANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFT- 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  268 sfVRLSLASAVMLCLEVWYFMAIILFAGYLknAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFS 347
Cdd:cd13135 231 --IKLGLPLGGEEFLWNIGNLAVIRILNRI--GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRI 306

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  348 LLVAVITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIilvKELTPILALSIVINNVQPVlsGVAVGAGWQAVVAYVNIAC 427
Cdd:cd13135 307 GNICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELI---NYSIPYLIFIIIILFFKSI--NIVYGFAIRAIGDTKWMLY 381

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 9293938  428 YYVFG----IPFGLLLGYKLNYGVMGIWCGMLTGTVVQTIVL 465
Cdd:cd13135 382 TQIIGtiivVSVALLLIFVFKLGLAGVYITLFIDEIIRAIIN 423
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 47-451 1.14e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 41.45  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   47 KKLWYLAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVS----VENSVVAgfsfgIMLGMGSALETLCGQAFGAGKLSM 122
Cdd:cd13144   8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSlafpIQNLMIA-----VAVGTGVGVNALLSRSLGEKDQKE 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  123 LGVYLQRSWVILNVTALILSLLYIFAA-PILASIGQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVI 201
Cdd:cd13144  83 ANKAANNGLLLALLSYLLFLLLGLFGVkPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  202 SAVALVIHVPL------TWFVIVKlqWGMPGLAVVLNASWcFIDMAQLVYIFSGTCGEawSGFSWEAFHNLWSFVR---- 271
Cdd:cd13144 163 QLIGAIINIILdpilifGLFGFPA--MGIAGAAIATVIGQ-ILAMFLAFFFLLRKNKD--VQPDLRLFRPSLRIIKeiya 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  272 LSLASAVMLCLEVwyFMAIILFAGYLKNAEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVA 351
Cdd:cd13144 238 VGLPSIIMQAISS--VMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYA 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  352 VITSTLIGFIVSMILLIFRDQYPSLFVKDEKVIILVKELTPILALSIVINNVQPVLSGVAVGAGWQAVVAYVNIACYYVF 431
Cdd:cd13144 316 ILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVV 395

                       410       420
                ....*....|....*....|
gi 9293938  432 GIPFGLLLGYKLnyGVMGIW 451
Cdd:cd13144 396 LLPLAWLLAKMF--GLNGVW 413
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 47-214 1.25e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 41.14  E-value: 1.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   47 KKLWYLAGPAIFTSV-NQYSLGAITQVFAGH-ISTIALAAVSvenSVVAGFSFGIMLGMGSALETLCGQAFGAGKLSMLG 124
Cdd:cd13149 234 KDILSIGIPAALSNIlTPLSAAFITALVATYgPAAVAAFGVA---TRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQ 310

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  125 VYLQRSWVILNVTALILSLLYIFAAPILASI--GQTAAISSAAGIFSIYMIPQIFAYAINFPTAKFLQSQSKIMVMAVIS 202
Cdd:cd13149 311 EGLKISLKFSLIYGAILGIVLALFAGWLASLfsAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNL 390

                       170
                ....*....|..
gi 9293938  203 AVALVIHVPLTW 214
Cdd:cd13149 391 IRVFLLYIPLAY 402
MATE_like_3 cd13148
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 52-384 5.32e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240553 [Multi-domain]  Cd Length: 441  Bit Score: 39.18  E-value: 5.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938   52 LAGPAIFTSVNQYSLGAITQVFAGHISTIALAAVSVensVVAGFSFGIML---GMGSALETLCGQAFGAGKLSMLGVYLQ 128
Cdd:cd13148  17 LALPNILALLVQTLVGLAETYFVGQLGTDALAGVAL---VFPLLMLTQMMsngAMGGGVSSAIARALGAGDRERAEALVW 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  129 RSWVILNVTALILSLLY-IFAAPILASIGQTAAISSAAGIFSIYMIP-QIFAYAINFpTAKFLQSQSKIMVMAVISAVAL 206
Cdd:cd13148  94 HALVIALAGGLVFSLLFlLFGPALYRLLGGRGEALDAALAYSNVLFSgAILIWLVNL-LAAALRGTGNMRVPALVTLVGA 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  207 VIHVPLTWFVIVKL----QWGMPGLAVVLNASWCFIDMAQLVYIFSG----TCGEAWSGFSWEAFHNLWSFVRLSLASAV 278
Cdd:cd13148 173 VVQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLASGrsrlRLRLRALRLERRLFRDILRVGLLAALSPL 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938  279 MLCLEVWYFMAIILFAGylknaEISVAALSICMNILGWTAMIAIGMNTAVSVRVSNELGANHPRTAKFSLLVAVITSTLI 358
Cdd:cd13148 253 QTNLTVLLLTGLVGRFG-----TAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAVL 327

                       330       340
                ....*....|....*....|....*.
gi 9293938  359 GFIVSMILLIFRDQYPSLFVKDEKVI 384
Cdd:cd13148 328 AGAIGLVLALFPELWLGLFTHDPAVL 353
PRK10367 PRK10367
DNA-damage-inducible SOS response protein; Provisional
 40-168 9.97e-03

DNA-damage-inducible SOS response protein; Provisional


Pssm-ID: 182413 [Multi-domain]  Cd Length: 441  Bit Score: 38.18  E-value: 9.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9293938    40 REFNVETKKLWYLAGPAIFTSVNQYSLGAITQVFAGHI-STIALAAVSVeNSVVAGFSFGIMLGMGSALETLCGQAFGAG 118
Cdd:PRK10367   2 AFLTSSDKALWRLALPMIFSNITVPLLGLVDTAVIGHLdSPVYLGGVAV-GATATSFLFMLLLFLRMSTTGLTAQAFGAK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 9293938   119 KLSMLGVYLQRSWVI-LNVTALILSLLYIFAAPILASIGQTAAISSAAGIF 168
Cdd:PRK10367  81 NPQALARALVQPLLLaLGAGALIALLRTPLIDLALHIVGGSEAVLEQARRF 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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