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Conserved domains on  [gi|11994142|dbj|BAB01163|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA super family cl00062
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 329-462 7.71e-61

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


The actual alignment was detected with superfamily member cd22718:

Pssm-ID: 469597  Cd Length: 149  Bit Score: 196.08  E-value: 7.71e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 329 PSFELSGKLAEETNRYRGITLLFNEPPEARKPSERWRLYVFKDGEPLNVflmyvsvhvkcvgltepLCLHRQSCYLFGRE 408
Cdd:cd22718   1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPV-----------------LYIHRQSAYLLGRD 63

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 11994142 409 RRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGKQVKPYIMDLGSTNKTYIN 462
Cdd:cd22718  64 RKIADIPIDHPSCSKQHAVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLN 117
Ribosomal_L22e super family cl03348
Ribosomal L22e protein family;
49-76 4.72e-05

Ribosomal L22e protein family;


The actual alignment was detected with superfamily member pfam01776:

Pssm-ID: 470784  Cd Length: 100  Bit Score: 42.12  E-value: 4.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 11994142    49 FLHERIKVGGKPGAL-------CYNQNKITVTSDG 76
Cdd:pfam01776  22 FLQERIKVNGKTGNLgdnvtisRKGKNKITVTSEI 56
 
Name Accession Description Interval E-value
FHA_SNIP1 cd22718
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and ...
 329-462 7.71e-61

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438770  Cd Length: 149  Bit Score: 196.08  E-value: 7.71e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 329 PSFELSGKLAEETNRYRGITLLFNEPPEARKPSERWRLYVFKDGEPLNVflmyvsvhvkcvgltepLCLHRQSCYLFGRE 408
Cdd:cd22718   1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPV-----------------LYIHRQSAYLLGRD 63

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 11994142 409 RRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGKQVKPYIMDLGSTNKTYIN 462
Cdd:cd22718  64 RKIADIPIDHPSCSKQHAVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLN 117
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 403-462 1.33e-09

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 54.12  E-value: 1.33e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142   403 YLFGRERRiADIPTDHPSCSKQHAVIQYREmekekpdgmmgkQVKPYIMDLGSTNKTYIN 462
Cdd:pfam00498   1 VTIGRSPD-CDIVLDDPSVSRRHAEIRYDG------------GGRFYLEDLGSTNGTFVN 47
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 403-462 1.16e-08

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 51.02  E-value: 1.16e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142    403 YLFGRERRIADIPTDHPSCSKQHAVIQYREmekekpdgmmgkQVKPYIMDLGSTNKTYIN 462
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPSISRRHAVIVYDG------------GGRFYLIDLGSTNGTFVN 48
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
403-470 4.10e-06

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 45.33  E-value: 4.10e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 11994142 403 YLFGRERRiADIPTDHPSCSKQHAVIQYRemekekpdgmmGKQVkpYIMDLGSTNKTYIN-PRVRTVAR 470
Cdd:COG1716  23 LTIGRAPD-NDIVLDDPTVSRRHARIRRD-----------GGGW--VLEDLGSTNGTFVNgQRVTEPAP 77
Ribosomal_L22e pfam01776
Ribosomal L22e protein family;
49-76 4.72e-05

Ribosomal L22e protein family;


Pssm-ID: 460321  Cd Length: 100  Bit Score: 42.12  E-value: 4.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 11994142    49 FLHERIKVGGKPGAL-------CYNQNKITVTSDG 76
Cdd:pfam01776  22 FLQERIKVNGKTGNLgdnvtisRKGKNKITVTSEI 56
 
Name Accession Description Interval E-value
FHA_SNIP1 cd22718
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and ...
 329-462 7.71e-61

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438770  Cd Length: 149  Bit Score: 196.08  E-value: 7.71e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 329 PSFELSGKLAEETNRYRGITLLFNEPPEARKPSERWRLYVFKDGEPLNVflmyvsvhvkcvgltepLCLHRQSCYLFGRE 408
Cdd:cd22718   1 PNFGLSGALAEDTNTFRGVVIKYSEPPEARKPKKRWRLYPFKGDEALPV-----------------LYIHRQSAYLLGRD 63

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 11994142 409 RRIADIPTDHPSCSKQHAVIQYREMEKEKPDGMMGKQVKPYIMDLGSTNKTYIN 462
Cdd:cd22718  64 RKIADIPIDHPSCSKQHAVLQYRLVEYTRPDGTKGRRVRPYIIDLESANGTFLN 117
FHA_DDL-like cd22719
forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein ...
 349-462 1.29e-59

forkhead associated (FHA) domain found in Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins; DDL, also called protein DAWDLE, is involved in microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438771 [Multi-domain]  Cd Length: 130  Bit Score: 192.32  E-value: 1.29e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 349 LLFNEPPEARKPSERWRLYVFKDGEPLNvflmyvsvhvkcvgltEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVI 428
Cdd:cd22719   1 LLFVEPPEARKPSKRWRLYVFKDGEPLN----------------EPLHIHRQSCYLFGRERKVADIPTDHPSCSKQHAVI 64

                        90       100       110
                ....*....|....*....|....*....|....
gi 11994142 429 QYREMEKEKPDGMMGKQVKPYIMDLGSTNKTYIN 462
Cdd:cd22719  65 QYRLTEKEGGDGMMGKAVRPYIMDLGSTNGTFLN 98
FHA_SNIP1_DDL-like cd22676
forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA ...
 364-477 1.12e-42

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438728 [Multi-domain]  Cd Length: 111  Bit Score: 147.06  E-value: 1.12e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 364 WRLYVFKDGEPLnvflmyvsvhvkcvgltEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKEKPDGmMG 443
Cdd:cd22676   1 WRLYVFKGGEQL-----------------ETIDIHRQSAYLIGRDRRVADIPLDHPSCSKQHAVIQFREVEKRNEGD-VI 62

                        90       100       110
                ....*....|....*....|....*....|....
gi 11994142 444 KQVKPYIMDLGSTNKTYINpRVRTVAREFCRVNE 477
Cdd:cd22676  63 ENIRPYIIDLGSTNGTFLN-GEKIEPRRYYELRE 95
FHA_PML1-like cd22681
forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 ...
 397-462 6.08e-15

forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438733 [Multi-domain]  Cd Length: 129  Bit Score: 71.32  E-value: 6.08e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 11994142 397 LHRQSCYLFGRERR------IADIPTDHPSCSKQHAVIQYREMEKEkpdgmmgkqVKPYIMDLGSTNKTYIN 462
Cdd:cd22681  36 LNSPSCYLIGREKGesteivVADIGIPEETCSKQHCVIQFRNVKGI---------LKPYIMDLDSSNGTCLN 98
FHA_Kanadaptin cd22677
forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also ...
 393-490 1.66e-14

forkhead associated (FHA) domain found in kanadaptin and similar proteins; Kanadaptin, also called human lung cancer oncogene 3 protein (HLC-3), kidney anion exchanger adapter protein, or solute carrier family 4 anion exchanger member 1 adapter protein (SLC4A1AP), is a nuclear protein widely expressed in mammalian tissues. It was originally isolated as a kidney Cl-/HCO3- anion exchanger 1 (kAE1)-binding protein. It is a highly mobile nucleocytoplasmic shuttling and multilocalizing protein. Its role in mammalian cells remains unclear. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438729 [Multi-domain]  Cd Length: 106  Bit Score: 69.51  E-value: 1.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 393 EPLCLHRQSCYLFGRERrIADIPTDHPSCSKQHAVIQYREMEKEKPDGMmgkqvkpYIMDLGSTNKTYINpRVRTVAREF 472
Cdd:cd22677  14 ETLDLNGKSFYVFGRLP-GCDVVLEHPSISRYHAVLQYRGDADDHDGGF-------YLYDLGSTHGTFLN-KQRIPPKQY 84

                        90
                ....*....|....*...
gi 11994142 473 CRVneirvkqkRVNHKIR 490
Cdd:cd22677  85 YRL--------RVGHVLK 94
FHA_PPP1R8 cd22674
forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 ...
 359-463 1.28e-12

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438726 [Multi-domain]  Cd Length: 108  Bit Score: 64.21  E-value: 1.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 359 KPSERWRLYVFKDGEplnvflmyvsvhvkcvgLTEPLCLHRQSCYLFGRERRIADIPTDHPSCSKQHAVIQYREMEKekp 438
Cdd:cd22674   2 KPPPGLHLDVVKDGK-----------------LIEKLMIDEKKYYLFGRNSDVCDFVLDHPSCSRVHAALVYHKHLN--- 61

                        90       100
                ....*....|....*....|....*
gi 11994142 439 dgmmgkqvKPYIMDLGSTNKTYINP 463
Cdd:cd22674  62 --------RVFLIDLGSTHGTFVGG 78
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 403-462 1.33e-09

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 54.12  E-value: 1.33e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142   403 YLFGRERRiADIPTDHPSCSKQHAVIQYREmekekpdgmmgkQVKPYIMDLGSTNKTYIN 462
Cdd:pfam00498   1 VTIGRSPD-CDIVLDDPSVSRRHAEIRYDG------------GGRFYLEDLGSTNGTFVN 47
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 399-462 9.62e-09

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 52.66  E-value: 9.62e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11994142 399 RQSCYLFGRERRiADIPTDHPSCSKQHAVIQYRemekekpdgmmGKQVkpYIMDLGSTNKTYIN 462
Cdd:cd00060  17 TKGVVTIGRSPD-CDIVLDDPSVSRRHARIEVD-----------GGGV--YLEDLGSTNGTFVN 66
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 403-462 1.16e-08

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 51.02  E-value: 1.16e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142    403 YLFGRERRIADIPTDHPSCSKQHAVIQYREmekekpdgmmgkQVKPYIMDLGSTNKTYIN 462
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPSISRRHAVIVYDG------------GGRFYLIDLGSTNGTFVN 48
FHA_Par42-like cd22675
forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar ...
 382-462 3.80e-07

forkhead associated (FHA) domain found in Trypanosoma brucei Parvulin 42 (TbPar42) and similar proteins; TbPar42 is a nuclear protein that plays a key role in parasite cell proliferation. It exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Its PPIase domain adopts a parvulin fold and reflects structural elements of Pin1-type proteins but is catalytically inactive. Its FHA domain may be involved in the binding of phosphorylated target proteins. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438727 [Multi-domain]  Cd Length: 113  Bit Score: 48.71  E-value: 3.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11994142 382 VSVHVKCV--GL-TEPLCLHRQSCYLFGRERrIADIPTDHPSCSKQHAVIQYRemekekpdgmmGKQVKPYIMDLGSTNK 458
Cdd:cd22675   7 VACHLQCLrdGVpLPPLGLDRFPFYLFGRSP-VCDYVLEHPSISSVHAVLVFH-----------GEQKCFVLMDLGSTNG 74


                ....
gi 11994142 459 TYIN 462
Cdd:cd22675  75 VKLN 78
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
 413-466 1.47e-06

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 46.45  E-value: 1.47e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 11994142 413 DIPTDHPSCSKQHAVIQYREMEkekpdgmmgkqvkPYIMDLGSTNKTYINPRVR 466
Cdd:cd22665  32 SVVLPDKSVSKQHACIEVDGGT-------------HLIEDLGSTNGTRIGNKVR 72
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
403-470 4.10e-06

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 45.33  E-value: 4.10e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 11994142 403 YLFGRERRiADIPTDHPSCSKQHAVIQYRemekekpdgmmGKQVkpYIMDLGSTNKTYIN-PRVRTVAR 470
Cdd:COG1716  23 LTIGRAPD-NDIVLDDPTVSRRHARIRRD-----------GGGW--VLEDLGSTNGTFVNgQRVTEPAP 77
Ribosomal_L22e pfam01776
Ribosomal L22e protein family;
49-76 4.72e-05

Ribosomal L22e protein family;


Pssm-ID: 460321  Cd Length: 100  Bit Score: 42.12  E-value: 4.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 11994142    49 FLHERIKVGGKPGAL-------CYNQNKITVTSDG 76
Cdd:pfam01776  22 FLQERIKVNGKTGNLgdnvtisRKGKNKITVTSEI 56
FHA_Rv1747-like_rpt1 cd22694
first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ...
 392-468 1.43e-03

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438746 [Multi-domain]  Cd Length: 93  Bit Score: 38.08  E-value: 1.43e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11994142 392 TEPLCLHRQSCYLFGRERRiADIPTDHPSCSKQHAVIQYRemekekPDGMmgkqvkpYIMDLGSTNKTYIN-PRVRTV 468
Cdd:cd22694   7 GGELRFDPGSSVRIGRDPD-ADVRLDDPRVSRRHALLEFD------GDGW-------VYTDLGSRNGTYLNgRRVQQV 70
FHA_Cep170 cd22704
forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) ...
 397-462 4.73e-03

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438756 [Multi-domain]  Cd Length: 102  Bit Score: 36.53  E-value: 4.73e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11994142 397 LHR--QSCYLFGRERriADIPTDHPSCSKQHAVIQYREMEKEKpdgmmgkqvkpYIMDLGSTNKTYIN 462
Cdd:cd22704  11 RHRlpRSMLFVGRED--CDLILQSRSVDKQHAVITYDQIDNEF-----------KIKDLGSLNGTFVN 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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